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12D miR HR13_24
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Results for Tcf21_Msc
Z-value: 1.80
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Transcription factors associated with Tcf21_Msc
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf21 | mm10_v2_chr10_-_22820126_22820150 | -0.70 | 1.5e-02 | Click! |
| Msc | mm10_v2_chr1_-_14755966_14755998 | -0.70 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_107529717 Show fit | 5.60 |
ENSMUST00000049285.8
|
leucine rich repeat protein 1, neuronal |
|
| chr13_-_71963713 Show fit | 4.16 |
ENSMUST00000077337.8
|
Iroquois related homeobox 1 (Drosophila) |
|
| chr5_-_131538687 Show fit | 4.09 |
ENSMUST00000161374.1
|
autism susceptibility candidate 2 |
|
| chr15_-_101370125 Show fit | 3.85 |
ENSMUST00000077196.4
|
keratin 80 |
|
| chr10_+_69208546 Show fit | 3.76 |
ENSMUST00000164034.1
|
Rho-related BTB domain containing 1 |
|
| chr4_-_106799779 Show fit | 3.45 |
ENSMUST00000145061.1
ENSMUST00000102762.3 |
acyl-CoA thioesterase 11 |
|
| chr16_+_36693972 Show fit | 3.45 |
ENSMUST00000023617.6
ENSMUST00000089618.3 |
immunoglobulin-like domain containing receptor 1 |
|
| chr4_-_133263042 Show fit | 3.27 |
ENSMUST00000105908.3
ENSMUST00000030674.7 |
synaptotagmin-like 1 |
|
| chr11_-_119086221 Show fit | 3.27 |
ENSMUST00000026665.7
|
chromobox 4 |
|
| chr16_+_36694024 Show fit | 2.77 |
ENSMUST00000119464.1
|
immunoglobulin-like domain containing receptor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tcf21_Msc
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 5.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.1 | 4.9 | GO:0009409 | response to cold(GO:0009409) |
| 1.1 | 4.2 | GO:0003165 | Purkinje myocyte development(GO:0003165) |
| 1.0 | 4.2 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 1.4 | 4.1 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.2 | 2.9 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.1 | 2.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.4 | 2.6 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 0.2 | 2.6 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.2 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 5.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 4.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 4.1 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.2 | 3.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 2.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.3 | 2.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 2.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 2.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.4 | GO:0044306 | neuron projection terminus(GO:0044306) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 6.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 1.6 | 6.2 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.0 | 4.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 3.7 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.2 | 3.6 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.1 | 3.6 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 3.6 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 3.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 3.3 | GO:0032183 | SUMO binding(GO:0032183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.4 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 2.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.1 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 2.0 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 2.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 1.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 5.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 4.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 2.5 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.1 | 2.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 2.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.1 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 2.0 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 2.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |