ISMARA results: Tgif1

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12D miR HR13_24

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Results for Tgif1_Meis3

Z-value: 1.38

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Transcription factors associated with Tgif1_Meis3

Gene Symbol	Gene ID	Gene Info
Tgif1 Ensembl NCBI MGI UniProt	ENSMUSG00000047407.11	TGFB-induced factor homeobox 1
Meis3 Ensembl NCBI MGI UniProt	ENSMUSG00000041420.12	Meis homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tgif1	mm10_v2_chr17_-_70851189_70851216	-0.65	3.1e-02	Click!
Meis3	mm10_v2_chr7_+_16175085_16175139	-0.34	3.0e-01	Click!

Activity profile of Tgif1_Meis3 motif

Sorted Z-values of Tgif1_Meis3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_46998931 Show fit	2.68	ENSMUST00000178065.1	Gm4791 Ensembl NCBI MGI UniProt Show fit	predicted gene 4791
chr1_-_134235420 Show fit	1.74	ENSMUST00000038191.6 ENSMUST00000086465.4	Adora1 Ensembl NCBI MGI UniProt Show fit	adenosine A1 receptor
chr3_+_27371351 Show fit	1.65	ENSMUST00000057186.1	Ghsr Ensembl NCBI MGI UniProt Show fit	growth hormone secretagogue receptor
chr13_-_71963713 Show fit	1.61	ENSMUST00000077337.8	Irx1 Ensembl NCBI MGI UniProt Show fit	Iroquois related homeobox 1 (Drosophila)
chr4_+_102254993 Show fit	1.58	ENSMUST00000106908.2	Pde4b Ensembl NCBI MGI UniProt Show fit	phosphodiesterase 4B, cAMP specific
chr16_+_5007283 Show fit	1.56	ENSMUST00000184439.1	Smim22 Ensembl NCBI MGI UniProt Show fit	small integral membrane protein 22
chr2_-_30903255 Show fit	1.54	ENSMUST00000102852.3	Ptges Ensembl NCBI MGI UniProt Show fit	prostaglandin E synthase
chr16_+_32756336 Show fit	1.54	ENSMUST00000135753.1	Muc4 Ensembl NCBI MGI UniProt Show fit	mucin 4
chr2_+_180725263 Show fit	1.37	ENSMUST00000094218.3	Slc17a9 Ensembl NCBI MGI UniProt Show fit	solute carrier family 17, member 9
chr19_+_55741810 Show fit	1.28	ENSMUST00000111657.3 ENSMUST00000061496.9 ENSMUST00000041717.7 ENSMUST00000111662.4	Tcf7l2 Ensembl NCBI MGI UniProt Show fit	transcription factor 7 like 2, T cell specific, HMG box

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tgif1_Meis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.2	2.9	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
0.3	2.6	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) embryonic hindgut morphogenesis(GO:0048619)
0.2	2.5	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4	2.3	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	2.2	GO:0050909	sensory perception of taste(GO:0050909)
0.4	2.1	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3	2.0	GO:0002838	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.1	2.0	GO:0032098	regulation of appetite(GO:0032098)
0.6	1.8	GO:0032242	regulation of nucleoside transport(GO:0032242)

Showing 1 to 10 of 505 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.1	GO:0005579	membrane attack complex(GO:0005579)
0.3	2.6	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
0.1	2.6	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	2.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.2	2.0	GO:0042587	glycogen granule(GO:0042587)
0.1	2.0	GO:0032279	asymmetric synapse(GO:0032279)
0.0	1.9	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	1.8	GO:0048786	presynaptic active zone(GO:0048786)
0.0	1.6	GO:0016605	PML body(GO:0016605)
0.1	1.5	GO:0005641	nuclear envelope lumen(GO:0005641)

Showing 1 to 10 of 157 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	3.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	2.4	GO:0045295	gamma-catenin binding(GO:0045295)
0.5	2.3	GO:0004925	prolactin receptor activity(GO:0004925)
0.1	2.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	2.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.7	2.1	GO:0005152	interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 receptor antagonist activity(GO:0005152) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
0.2	2.1	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	2.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.5	1.9	GO:0004667	prostaglandin-D synthase activity(GO:0004667)

Showing 1 to 10 of 312 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	2.9	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	2.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	1.7	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	1.7	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.0	1.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	1.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.3	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.9	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	3.5	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1	3.1	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	2.7	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	2.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.1	1.9	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.1	1.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	1.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	1.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC

Showing 1 to 10 of 94 entries

Results for Tgif1_Meis3

Z-value: 1.38

Motif logo

Transcription factors associated with Tgif1_Meis3

Activity-expression correlation:

Activity profile of Tgif1_Meis3 motif

Sorted Z-values of Tgif1_Meis3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tgif1_Meis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: