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12D miR HR13_24
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Results for Wrnip1_Mta3_Rcor1
Z-value: 2.00
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Transcription factors associated with Wrnip1_Mta3_Rcor1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Wrnip1 | mm10_v2_chr13_+_32802007_32802152 | 0.80 | 3.1e-03 | Click! |
| Rcor1 | mm10_v2_chr12_+_111039334_111039400 | 0.75 | 7.9e-03 | Click! |
| Mta3 | mm10_v2_chr17_+_83706170_83706200 | 0.69 | 1.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Wrnip1_Mta3_Rcor1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 23.3 | GO:0031283 | negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283) |
| 0.3 | 16.8 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.8 | 13.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.3 | 9.8 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.2 | 9.5 | GO:0006414 | translational elongation(GO:0006414) |
| 0.2 | 8.7 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.1 | 8.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 1.2 | 8.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 8.4 | GO:0006412 | translation(GO:0006412) |
| 0.4 | 8.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 27.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.0 | 25.4 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.4 | 25.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 19.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 15.5 | GO:0044298 | cell body membrane(GO:0044298) |
| 0.1 | 12.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.1 | 12.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.2 | 11.3 | GO:0044391 | ribosomal subunit(GO:0044391) |
| 0.0 | 10.6 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 53.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 22.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 14.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 13.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 9.4 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.3 | 9.4 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 9.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 9.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.4 | 9.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 7.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 16.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 15.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 15.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 14.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 12.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 10.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 10.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 10.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 8.7 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 38.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 16.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 13.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 12.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.4 | 12.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 11.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.7 | 10.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 10.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.4 | 9.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |