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12D miR HR13_24
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Results for Yy1_Yy2
Z-value: 3.43
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Transcription factors associated with Yy1_Yy2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Yy2 | mm10_v2_chrX_-_157598642_157598655 | 0.93 | 3.8e-05 | Click! |
| Yy1 | mm10_v2_chr12_+_108792946_108792988 | 0.90 | 1.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Yy1_Yy2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.7 | GO:0006412 | translation(GO:0006412) |
| 0.2 | 17.1 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.5 | 16.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 2.0 | 14.3 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.3 | 12.9 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 11.7 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
| 0.2 | 11.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.5 | 10.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.4 | 10.6 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.8 | 9.8 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 49.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.6 | 28.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 22.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.0 | 21.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 12.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 2.1 | 12.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.4 | 12.1 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 10.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 10.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 10.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 88.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 32.9 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 19.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.2 | 19.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 16.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 15.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 11.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 10.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 10.3 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.6 | 8.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 23.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 17.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 17.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 10.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 8.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 6.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 6.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 4.9 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 75.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 31.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.6 | 21.8 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.3 | 13.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 11.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 11.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.2 | 10.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 9.9 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.4 | 9.0 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.3 | 8.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |