ISMARA results: Zbtb33

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12D miR HR13_24

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Results for Zbtb33_Chd2

Z-value: 2.16

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Transcription factors associated with Zbtb33_Chd2

Gene Symbol	Gene ID	Gene Info
Zbtb33 Ensembl NCBI MGI UniProt	ENSMUSG00000048047.3	zinc finger and BTB domain containing 33
Chd2 Ensembl NCBI MGI UniProt	ENSMUSG00000078671.4	chromodomain helicase DNA binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Chd2	mm10_v2_chr7_-_73541738_73541758	0.88	3.7e-04	Click!
Zbtb33	mm10_v2_chrX_+_38189780_38189826	0.81	2.6e-03	Click!

Activity profile of Zbtb33_Chd2 motif

Sorted Z-values of Zbtb33_Chd2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_34833631 Show fit	5.37	ENSMUST00000093191.2	Spdl1 Ensembl NCBI MGI UniProt Show fit	spindle apparatus coiled-coil protein 1
chr5_+_45669907 Show fit	5.04	ENSMUST00000117396.1	Ncapg Ensembl NCBI MGI UniProt Show fit	non-SMC condensin I complex, subunit G
chr14_-_57826128 Show fit	4.71	ENSMUST00000022536.2	Ska3 Ensembl NCBI MGI UniProt Show fit	spindle and kinetochore associated complex subunit 3
chr4_+_24496434 Show fit	4.41	ENSMUST00000108222.2 ENSMUST00000138567.2 ENSMUST00000050446.6	Mms22l Ensembl NCBI MGI UniProt Show fit	MMS22-like, DNA repair protein
chr4_-_118437331 Show fit	4.13	ENSMUST00000006565.6	Cdc20 Ensembl NCBI MGI UniProt Show fit	cell division cycle 20
chr17_+_56040350 Show fit	4.02	ENSMUST00000002914.8	Chaf1a Ensembl NCBI MGI UniProt Show fit	chromatin assembly factor 1, subunit A (p150)
chr5_+_110286306 Show fit	3.81	ENSMUST00000007296.5 ENSMUST00000112482.1	Pole Ensembl NCBI MGI UniProt Show fit	polymerase (DNA directed), epsilon
chr19_+_38931008 Show fit	3.41	ENSMUST00000145051.1	Hells Ensembl NCBI MGI UniProt Show fit	helicase, lymphoid specific
chr12_-_72917760 Show fit	3.38	ENSMUST00000110489.2	4930447C04Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930447C04 gene
chr12_-_72917872 Show fit	3.29	ENSMUST00000044000.5	4930447C04Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930447C04 gene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb33_Chd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	9.9	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.5	8.8	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)
2.2	6.7	GO:0010705	meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705)
1.0	6.7	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	6.4	GO:0031109	microtubule polymerization or depolymerization(GO:0031109)
0.2	5.5	GO:0045005	DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
1.0	4.1	GO:0098763	mitotic cell cycle phase(GO:0098763)
1.0	4.0	GO:0060265	positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.1	3.9	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.3	3.8	GO:0045004	DNA replication proofreading(GO:0045004)

Showing 1 to 10 of 165 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	12.4	GO:0000796	condensin complex(GO:0000796)
0.2	12.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.8	10.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	8.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.2	7.2	GO:0005721	pericentric heterochromatin(GO:0005721)
0.7	6.0	GO:0000801	central element(GO:0000801)
1.5	4.4	GO:0035101	FACT complex(GO:0035101)
0.1	4.3	GO:0030992	intraciliary transport particle B(GO:0030992)
0.2	4.2	GO:0005680	anaphase-promoting complex(GO:0005680)
1.3	4.0	GO:0033186	CAF-1 complex(GO:0033186)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	10.3	GO:0004386	helicase activity(GO:0004386)
0.0	7.7	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
1.1	5.4	GO:0043515	kinetochore binding(GO:0043515)
0.1	5.0	GO:0003697	single-stranded DNA binding(GO:0003697)
0.7	4.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.5	4.0	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	4.0	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.5	3.8	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4	3.4	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)

Showing 1 to 10 of 102 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.7	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	5.1	PID PLK1 PATHWAY	PLK1 signaling events
0.1	3.5	PID AURORA A PATHWAY	Aurora A signaling
0.0	3.1	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.2	PID P53 REGULATION PATHWAY	p53 pathway
0.0	1.3	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	1.2	PID ATR PATHWAY	ATR signaling pathway
0.0	1.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	1.1	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	8.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	7.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	5.1	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3	4.2	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2	4.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	4.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	3.9	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	3.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	2.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)

Showing 1 to 10 of 39 entries

Results for Zbtb33_Chd2

Z-value: 2.16

Motif logo

Transcription factors associated with Zbtb33_Chd2

Activity-expression correlation:

Activity profile of Zbtb33_Chd2 motif

Sorted Z-values of Zbtb33_Chd2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb33_Chd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: