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GFI1 WT vs 36n/n vs KD
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Results for Elf1_Elf2_Etv2_Elf4
Z-value: 4.33
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Transcription factors associated with Elf1_Elf2_Etv2_Elf4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000036461.17 | E74-like factor 1 | |
| ENSMUSG00000037174.19 | E74-like factor 2 | |
| ENSMUSG00000006311.9 | ets variant 2 | |
| ENSMUSG00000031103.13 | E74-like factor 4 (ets domain transcription factor) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf4 | mm39_v1_chrX_-_47543029_47543071 | -0.93 | 2.0e-02 | Click! |
| Elf2 | mm39_v1_chr3_-_51248032_51248130 | -0.66 | 2.3e-01 | Click! |
| Etv2 | mm39_v1_chr7_-_30335277_30335277 | -0.41 | 4.9e-01 | Click! |
| Elf1 | mm39_v1_chr14_+_79718604_79718634 | 0.39 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_60907698 Show fit | 5.10 |
ENSMUST00000118551.8
|
ribosomal protein S14 |
|
| chr11_-_48707763 Show fit | 4.87 |
ENSMUST00000140800.2
|
tripartite motif-containing 41 |
|
| chr18_+_60907668 Show fit | 4.14 |
ENSMUST00000025511.11
|
ribosomal protein S14 |
|
| chr7_-_126391388 Show fit | 3.82 |
ENSMUST00000206570.2
|
protein phosphatase 4, catalytic subunit |
|
| chr12_-_80690573 Show fit | 3.63 |
ENSMUST00000166931.2
ENSMUST00000218364.2 |
ERH mRNA splicing and mitosis factor |
|
| chr11_+_87684548 Show fit | 3.35 |
ENSMUST00000143021.9
|
myeloperoxidase |
|
| chr17_-_24292453 Show fit | 3.34 |
ENSMUST00000017090.6
|
potassium channel tetramerisation domain containing 5 |
|
| chr1_-_133537953 Show fit | 3.30 |
ENSMUST00000164574.2
ENSMUST00000166291.8 ENSMUST00000164096.2 ENSMUST00000166915.8 |
small nuclear ribonucleoprotein E |
|
| chr17_+_24939072 Show fit | 3.07 |
ENSMUST00000054289.13
|
ribosomal protein S2 |
|
| chr19_+_8919228 Show fit | 2.98 |
ENSMUST00000096240.3
|
metastasis-associated gene family, member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf1_Elf2_Etv2_Elf4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.2 | 11.4 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.2 | 8.8 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 8.0 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.2 | 7.9 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.2 | 7.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.2 | 7.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.5 | 7.0 | GO:1904867 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 2.1 | 6.4 | GO:0002149 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 0.5 | 6.0 | GO:0000478 | endonucleolytic cleavage involved in rRNA processing(GO:0000478) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 41.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 19.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 15.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.3 | 14.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 11.1 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 10.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 10.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 9.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 9.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 21.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 18.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 11.1 | GO:0008186 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.3 | 10.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 9.5 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.8 | 9.2 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 8.7 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.3 | 7.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.2 | 7.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 14.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 10.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 8.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 7.5 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 6.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 6.3 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 4.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 4.7 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 22.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 21.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 14.9 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.4 | 12.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 10.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 9.7 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.2 | 9.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.3 | 7.7 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 7.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |