Project

GFI1 WT vs 36n/n vs KD

Navigation
Downloads

Results for Foxo3

Z-value: 0.56

Motif logo

logo of

Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
Foxo3
ENSMUSG00000048756.12 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3mm39_v1_chr10_-_42152684_421527590.847.2e-02Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_64659004 0.75 ENSMUST00000066166.6
Tll1
tolloid-like
chr11_+_45946800 0.74 ENSMUST00000011400.8
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chr2_+_3514071 0.48 ENSMUST00000036350.3
Cdnf
cerebral dopamine neurotrophic factor
chr1_+_172525613 0.47 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr15_+_98390278 0.44 ENSMUST00000205772.3
ENSMUST00000216822.2
Olfr279
olfactory receptor 279
chr3_+_63203235 0.42 ENSMUST00000194134.6
Mme
membrane metallo endopeptidase
chr11_+_60244132 0.36 ENSMUST00000070805.13
ENSMUST00000094140.9
ENSMUST00000108723.9
ENSMUST00000108722.5
Drc3
dynein regulatory complex subunit 3
chr3_+_53396120 0.33 ENSMUST00000029307.4
Stoml3
stomatin (Epb7.2)-like 3
chr2_-_104324035 0.32 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr18_-_80751327 0.28 ENSMUST00000236310.2
ENSMUST00000167977.8
ENSMUST00000035800.8
Nfatc1
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
chr2_-_111400026 0.28 ENSMUST00000217772.2
ENSMUST00000207283.3
Olfr1295
olfactory receptor 1295
chr14_+_51333816 0.28 ENSMUST00000169895.3
Rnase4
ribonuclease, RNase A family 4
chr1_+_17672117 0.27 ENSMUST00000088476.4
Pi15
peptidase inhibitor 15
chr4_-_119272690 0.27 ENSMUST00000238287.2
ENSMUST00000238759.2
ENSMUST00000063642.10
Ccdc30
coiled-coil domain containing 30
chr11_-_65636651 0.26 ENSMUST00000138093.2
Map2k4
mitogen-activated protein kinase kinase 4
chr11_-_60243695 0.25 ENSMUST00000095254.12
ENSMUST00000102683.11
ENSMUST00000093048.13
ENSMUST00000093046.13
ENSMUST00000064019.15
ENSMUST00000102682.5
Tom1l2
target of myb1-like 2 (chicken)
chr1_+_171052623 0.24 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
Apoa2
apolipoprotein A-II
chr10_+_128540049 0.23 ENSMUST00000217836.2
Pmel
premelanosome protein
chr2_+_124452194 0.22 ENSMUST00000051419.15
ENSMUST00000076335.12
ENSMUST00000078621.12
ENSMUST00000077847.12
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_-_30259253 0.22 ENSMUST00000108164.8
Lin37
lin-37 homolog (C. elegans)
chr2_-_51039112 0.22 ENSMUST00000154545.2
ENSMUST00000017288.9
Rnd3
Rho family GTPase 3
chr17_+_41121979 0.21 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhag
Rhesus blood group-associated A glycoprotein
chr19_-_27988393 0.21 ENSMUST00000172907.8
ENSMUST00000046898.17
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr12_+_71063431 0.21 ENSMUST00000125125.2
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr4_+_105014536 0.21 ENSMUST00000064139.8
Plpp3
phospholipid phosphatase 3
chr12_-_31549538 0.21 ENSMUST00000064240.14
ENSMUST00000185739.8
ENSMUST00000188326.3
ENSMUST00000101499.10
ENSMUST00000085487.12
Cbll1
Casitas B-lineage lymphoma-like 1
chr11_+_29413734 0.20 ENSMUST00000155854.8
Ccdc88a
coiled coil domain containing 88A
chr14_+_45457168 0.18 ENSMUST00000227086.2
ENSMUST00000147957.2
Gpr137c
G protein-coupled receptor 137C
chr11_-_86884507 0.18 ENSMUST00000018571.5
Ypel2
yippee like 2
chr13_+_83723743 0.16 ENSMUST00000198217.5
ENSMUST00000199210.5
Mef2c
myocyte enhancer factor 2C
chr17_+_17669082 0.16 ENSMUST00000140134.2
Lix1
limb and CNS expressed 1
chr11_+_85243970 0.16 ENSMUST00000108056.8
ENSMUST00000108061.8
ENSMUST00000108062.8
ENSMUST00000138423.8
ENSMUST00000092821.10
ENSMUST00000074875.11
Bcas3
breast carcinoma amplified sequence 3
chrX_+_7744535 0.16 ENSMUST00000033495.15
Pim2
proviral integration site 2
chr19_-_27988534 0.15 ENSMUST00000174850.8
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr7_-_103463120 0.15 ENSMUST00000098192.4
Hbb-bt
hemoglobin, beta adult t chain
chr9_+_40092216 0.15 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr2_+_91541245 0.14 ENSMUST00000142692.2
ENSMUST00000090608.6
Harbi1
harbinger transposase derived 1
chr19_+_5927876 0.14 ENSMUST00000235340.2
Slc25a45
solute carrier family 25, member 45
chr11_-_94133527 0.13 ENSMUST00000061469.4
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr14_+_30601157 0.13 ENSMUST00000040715.8
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr7_-_119461027 0.13 ENSMUST00000137888.2
ENSMUST00000142120.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr13_+_83720457 0.13 ENSMUST00000196730.5
Mef2c
myocyte enhancer factor 2C
chr11_+_69657275 0.12 ENSMUST00000132528.8
ENSMUST00000153943.2
Zbtb4
zinc finger and BTB domain containing 4
chr18_-_39622932 0.12 ENSMUST00000152853.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr17_+_43700327 0.12 ENSMUST00000113599.2
ENSMUST00000224278.2
ENSMUST00000225466.2
Adgrf5
adhesion G protein-coupled receptor F5
chrX_-_47297746 0.11 ENSMUST00000088935.4
Zdhhc9
zinc finger, DHHC domain containing 9
chr15_-_82796308 0.10 ENSMUST00000109510.10
ENSMUST00000048966.7
Tcf20
transcription factor 20
chr1_+_63655127 0.09 ENSMUST00000226288.2
Gm39653
predicted gene, 39653
chr4_-_44710408 0.09 ENSMUST00000134968.9
ENSMUST00000173821.8
ENSMUST00000174319.8
ENSMUST00000173733.8
ENSMUST00000172866.8
ENSMUST00000165417.9
ENSMUST00000107825.9
ENSMUST00000102932.10
ENSMUST00000107827.9
ENSMUST00000107826.9
ENSMUST00000014174.14
Pax5
paired box 5
chr2_+_84670543 0.09 ENSMUST00000111624.8
Slc43a1
solute carrier family 43, member 1
chr19_-_19088543 0.09 ENSMUST00000112832.8
Rorb
RAR-related orphan receptor beta
chr13_+_83720484 0.09 ENSMUST00000196207.5
Mef2c
myocyte enhancer factor 2C
chr4_-_155430153 0.08 ENSMUST00000103178.11
Prkcz
protein kinase C, zeta
chr7_+_24607042 0.08 ENSMUST00000151121.2
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr7_-_109215754 0.08 ENSMUST00000084738.5
Denn2b
DENN domain containing 2B
chr9_-_37627519 0.08 ENSMUST00000215727.2
ENSMUST00000211952.3
Olfr160
olfactory receptor 160
chr9_+_65268304 0.07 ENSMUST00000147185.3
Ubap1l
ubiquitin-associated protein 1-like
chr7_-_65020655 0.06 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr13_+_60749995 0.06 ENSMUST00000044083.9
Dapk1
death associated protein kinase 1
chr7_-_65020955 0.06 ENSMUST00000102592.10
Tjp1
tight junction protein 1
chr18_-_39622295 0.06 ENSMUST00000131885.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr13_+_83723255 0.06 ENSMUST00000199167.5
ENSMUST00000195904.5
Mef2c
myocyte enhancer factor 2C
chr10_+_25308466 0.05 ENSMUST00000219224.2
ENSMUST00000219166.2
Epb41l2
erythrocyte membrane protein band 4.1 like 2
chr12_-_85317359 0.05 ENSMUST00000166821.8
ENSMUST00000019378.8
ENSMUST00000220854.2
Mlh3
mutL homolog 3
chr1_+_75119472 0.05 ENSMUST00000189650.7
Retreg2
reticulophagy regulator family member 2
chr19_+_34268071 0.05 ENSMUST00000112472.4
ENSMUST00000235232.2
Fas
Fas (TNF receptor superfamily member 6)
chr1_-_127782735 0.05 ENSMUST00000208183.3
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr2_+_124452493 0.05 ENSMUST00000103239.10
ENSMUST00000103240.9
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_+_29991101 0.05 ENSMUST00000150892.2
ENSMUST00000126216.2
ENSMUST00000014065.16
Clip3
CAP-GLY domain containing linker protein 3
chr6_-_69741999 0.04 ENSMUST00000103365.3
Igkv12-46
immunoglobulin kappa variable 12-46
chr2_-_85675827 0.04 ENSMUST00000213515.2
Olfr1019
olfactory receptor 1019
chr6_-_69835868 0.04 ENSMUST00000103369.2
Igkv12-41
immunoglobulin kappa chain variable 12-41
chr8_-_41469332 0.04 ENSMUST00000131965.2
Mtus1
mitochondrial tumor suppressor 1
chr9_+_78020554 0.04 ENSMUST00000009972.6
ENSMUST00000117330.8
ENSMUST00000044551.8
Cilk1
ciliogenesis associated kinase 1
chr4_-_119272667 0.04 ENSMUST00000238609.2
Ccdc30
coiled-coil domain containing 30
chr5_-_18093739 0.04 ENSMUST00000169095.6
ENSMUST00000197574.2
Cd36
CD36 molecule
chr19_-_34856853 0.03 ENSMUST00000036584.13
Pank1
pantothenate kinase 1
chr8_-_26275182 0.03 ENSMUST00000038498.10
Bag4
BCL2-associated athanogene 4
chr10_+_128139227 0.03 ENSMUST00000218315.2
ENSMUST00000219721.2
Pan2
PAN2 poly(A) specific ribonuclease subunit
chr2_-_118558852 0.03 ENSMUST00000102524.8
Plcb2
phospholipase C, beta 2
chr16_+_35590745 0.03 ENSMUST00000231579.2
Hspbap1
Hspb associated protein 1
chr10_+_40225272 0.03 ENSMUST00000044672.11
ENSMUST00000095743.4
Cdk19
cyclin-dependent kinase 19
chr18_-_39622829 0.03 ENSMUST00000025300.13
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr7_-_70010341 0.02 ENSMUST00000032768.15
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr10_+_128139191 0.02 ENSMUST00000005825.8
Pan2
PAN2 poly(A) specific ribonuclease subunit
chrX_+_158480304 0.02 ENSMUST00000123433.8
Sh3kbp1
SH3-domain kinase binding protein 1
chr4_-_58206596 0.02 ENSMUST00000042850.9
Svep1
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr4_+_134042423 0.02 ENSMUST00000105875.8
ENSMUST00000030638.7
Trim63
tripartite motif-containing 63
chr7_+_113365235 0.02 ENSMUST00000046687.16
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_7086066 0.02 ENSMUST00000183209.8
Celf2
CUGBP, Elav-like family member 2
chr3_-_145355725 0.01 ENSMUST00000029846.5
Ccn1
cellular communication network factor 1
chr10_+_103203552 0.01 ENSMUST00000179636.3
ENSMUST00000217905.2
ENSMUST00000074204.12
Slc6a15
solute carrier family 6 (neurotransmitter transporter), member 15
chr1_-_154692678 0.01 ENSMUST00000238369.2
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr3_+_107137924 0.01 ENSMUST00000179399.3
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr7_+_113365356 0.01 ENSMUST00000084696.6
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr8_-_41469786 0.01 ENSMUST00000117735.8
Mtus1
mitochondrial tumor suppressor 1
chr11_-_103844870 0.01 ENSMUST00000103075.11
Nsf
N-ethylmaleimide sensitive fusion protein
chr15_+_79232591 0.01 ENSMUST00000229285.2
Maff
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)
chr12_+_30934320 0.01 ENSMUST00000067087.7
Alkal2
ALK and LTK ligand 2
chr7_-_106423873 0.01 ENSMUST00000208895.3
Olfr702
olfactory receptor 702
chr19_+_5927821 0.00 ENSMUST00000145200.8
ENSMUST00000025732.14
ENSMUST00000125114.8
ENSMUST00000155697.8
Slc25a45
solute carrier family 25, member 45
chr11_+_19874354 0.00 ENSMUST00000093299.13
Spred2
sprouty-related EVH1 domain containing 2
chr11_+_74150634 0.00 ENSMUST00000217016.2
ENSMUST00000214303.2
Olfr406
olfactory receptor 406
chr8_-_33374282 0.00 ENSMUST00000209107.4
ENSMUST00000209022.3
Nrg1
neuregulin 1
chr5_+_8106527 0.00 ENSMUST00000148633.4
Sri
sorcin
chr3_+_63203516 0.00 ENSMUST00000029400.7
Mme
membrane metallo endopeptidase
chr10_+_102348076 0.00 ENSMUST00000219445.2
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060854 patterning of lymph vessels(GO:0060854)
0.1 0.4 GO:0002071 glandular epithelial cell maturation(GO:0002071)
0.1 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.2 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.2 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330)
0.0 0.4 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.2 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.0 GO:0031104 dendrite regeneration(GO:0031104)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.2 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:2000667 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0 0.0 GO:0090367 negative regulation of mRNA modification(GO:0090367)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0005712 chiasma(GO:0005712)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0010428 methyl-CpNpG binding(GO:0010428)
0.0 0.2 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.0 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation