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GFI1 WT vs 36n/n vs KD
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Results for Lhx5_Lmx1b_Lhx1
Z-value: 0.87
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Transcription factors associated with Lhx5_Lmx1b_Lhx1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
Lhx5
|
ENSMUSG00000029595.10 | LIM homeobox protein 5 |
|
Lmx1b
|
ENSMUSG00000038765.15 | LIM homeobox transcription factor 1 beta |
|
Lhx1
|
ENSMUSG00000018698.16 | LIM homeobox protein 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lmx1b | mm39_v1_chr2_-_33530492_33530620 | -0.44 | 4.5e-01 | Click! |
| Lhx5 | mm39_v1_chr5_+_120569764_120569764 | -0.33 | 5.9e-01 | Click! |
| Lhx1 | mm39_v1_chr11_-_84416340_84416369 | -0.28 | 6.4e-01 | Click! |
Activity profile of Lhx5_Lmx1b_Lhx1 motif
Sorted Z-values of Lhx5_Lmx1b_Lhx1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of Lhx5_Lmx1b_Lhx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.1 | 0.5 | GO:0010899 | regulation of phosphatidylcholine catabolic process(GO:0010899) receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.1 | 0.4 | GO:0002148 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 0.1 | 0.3 | GO:2000566 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566) |
| 0.1 | 0.6 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.1 | 0.3 | GO:0061341 | dichotomous subdivision of terminal units involved in lung branching(GO:0060448) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) |
| 0.1 | 0.7 | GO:2001205 | negative regulation of osteoclast development(GO:2001205) |
| 0.1 | 0.6 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 0.3 | GO:0044029 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.1 | 0.5 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) |
| 0.1 | 0.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.1 | 0.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.2 | GO:0042495 | detection of triacyl bacterial lipopeptide(GO:0042495) |
| 0.1 | 0.2 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.1 | 0.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 0.2 | GO:0016062 | adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367) |
| 0.0 | 0.2 | GO:0035660 | MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660) |
| 0.0 | 0.1 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
| 0.0 | 1.2 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
| 0.0 | 0.2 | GO:0046098 | guanine metabolic process(GO:0046098) |
| 0.0 | 0.2 | GO:2000584 | regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584) |
| 0.0 | 0.4 | GO:0072641 | type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
| 0.0 | 0.2 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.0 | 0.2 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.0 | 0.5 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 0.4 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
| 0.0 | 1.0 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.1 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.0 | 0.1 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.0 | 0.1 | GO:1900864 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.0 | 0.1 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) RNA repair(GO:0042245) |
| 0.0 | 0.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.1 | GO:1900673 | olefin metabolic process(GO:1900673) |
| 0.0 | 0.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.1 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.0 | 0.1 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.0 | 0.1 | GO:1900369 | negative regulation of RNA interference(GO:1900369) |
| 0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.0 | 0.2 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 0.1 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 0.0 | 0.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.0 | 0.1 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
| 0.0 | 0.1 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.0 | 0.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.1 | GO:2000852 | regulation of corticosterone secretion(GO:2000852) |
| 0.0 | 0.3 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.0 | 0.2 | GO:0090336 | negative regulation of granulocyte differentiation(GO:0030853) positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.0 | 0.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.1 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.0 | 0.0 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 0.0 | 0.1 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 0.0 | 0.1 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.0 | 0.1 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
| 0.0 | 0.0 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.0 | 0.1 | GO:0032049 | phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin biosynthetic process(GO:0032049) |
| 0.0 | 0.1 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.1 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.0 | 0.1 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
| 0.0 | 0.1 | GO:0072592 | positive regulation of integrin biosynthetic process(GO:0045726) oxygen metabolic process(GO:0072592) |
| 0.0 | 0.2 | GO:0097066 | response to thyroid hormone(GO:0097066) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:1904511 | cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511) |
| 0.2 | 0.8 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.2 | 0.5 | GO:1990666 | PCSK9-LDLR complex(GO:1990666) |
| 0.2 | 1.0 | GO:0042585 | germinal vesicle(GO:0042585) |
| 0.1 | 0.3 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 0.3 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 1.2 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.1 | 0.2 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.0 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.1 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
| 0.0 | 0.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.1 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.2 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 0.3 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.2 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.4 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 0.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.1 | GO:0030312 | external encapsulating structure(GO:0030312) |
| 0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.0 | 0.0 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.0 | 0.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.1 | 0.3 | GO:0004816 | asparagine-tRNA ligase activity(GO:0004816) |
| 0.1 | 0.5 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 0.2 | GO:0042497 | triacyl lipopeptide binding(GO:0042497) |
| 0.1 | 0.2 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.1 | 0.2 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.1 | 0.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.0 | 0.2 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.0 | 0.1 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.0 | 0.2 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.6 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.2 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.0 | 0.1 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.0 | 0.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 0.3 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.1 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.0 | 0.1 | GO:0016034 | maleylacetoacetate isomerase activity(GO:0016034) |
| 0.0 | 0.1 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.0 | 0.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.1 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.0 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.1 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.1 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
| 0.0 | 0.1 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.0 | 0.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.1 | GO:0043734 | DNA-N1-methyladenine dioxygenase activity(GO:0043734) |
| 0.0 | 0.1 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
| 0.0 | 1.2 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.1 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.0 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.3 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.2 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.4 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.4 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 0.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |