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GFI1 WT vs 36n/n vs KD
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Results for Nfix
Z-value: 2.12
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Transcription factors associated with Nfix
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfix | mm39_v1_chr8_-_85526972_85527008 | 0.98 | 3.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfix
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.1 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.4 | 3.4 | GO:0071313 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 0.5 | 3.0 | GO:0071918 | urea transmembrane transport(GO:0071918) |
| 0.4 | 2.9 | GO:0007527 | adult somatic muscle development(GO:0007527) |
| 0.0 | 2.7 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.2 | 2.5 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 2.3 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.3 | 2.1 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.2 | 2.1 | GO:0002913 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.5 | 1.9 | GO:0060434 | bronchus morphogenesis(GO:0060434) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.1 | 2.9 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 2.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 1.9 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.1 | 1.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.1 | 1.6 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 1.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.5 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.3 | 1.3 | GO:0070722 | Tle3-Aes complex(GO:0070722) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 3.6 | GO:0070888 | E-box binding(GO:0070888) |
| 1.1 | 3.4 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.1 | 3.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.4 | 3.0 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.2 | 2.1 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 2.1 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 1.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 1.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 1.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 2.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 1.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.9 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 3.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 3.0 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 2.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 1.9 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 1.8 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.6 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.3 | 0.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 0.9 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 0.7 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |