ISMARA results: Wrnip1_Mta3

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GFI1 WT vs 36n/n vs KD

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Results for Wrnip1_Mta3_Rcor1

Z-value: 5.14

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Transcription factors associated with Wrnip1_Mta3_Rcor1

Gene Symbol	Gene ID	Gene Info
Wrnip1 Ensembl NCBI MGI UniProt	ENSMUSG00000021400.9	Werner helicase interacting protein 1
Mta3 Ensembl NCBI MGI UniProt	ENSMUSG00000055817.19	metastasis associated 3
Rcor1 Ensembl NCBI MGI UniProt	ENSMUSG00000037896.18	REST corepressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mta3	mm39_v1_chr17_+_84013575_84013634	-0.94	1.8e-02	Click!
Wrnip1	mm39_v1_chr13_+_32985990_32986135	0.79	1.2e-01	Click!
Rcor1	mm39_v1_chr12_+_111005768_111005834	0.57	3.2e-01	Click!

Activity profile of Wrnip1_Mta3_Rcor1 motif

Sorted Z-values of Wrnip1_Mta3_Rcor1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_34218301 Show fit	4.84	ENSMUST00000235463.2	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr18_-_10030017 Show fit	4.70	ENSMUST00000116669.2 ENSMUST00000092096.14	Usp14 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 14
chr11_+_87684548 Show fit	4.42	ENSMUST00000143021.9	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr8_+_13076024 Show fit	4.20	ENSMUST00000033820.4	F7 Ensembl NCBI MGI UniProt Show fit	coagulation factor VII
chr10_-_80492905 Show fit	4.18	ENSMUST00000003434.14	Btbd2 Ensembl NCBI MGI UniProt Show fit	BTB (POZ) domain containing 2
chr15_+_4056103 Show fit	4.08	ENSMUST00000138927.2	Oxct1 Ensembl NCBI MGI UniProt Show fit	3-oxoacid CoA transferase 1
chr17_+_35643853 Show fit	4.06	ENSMUST00000113879.4	H2-Q6 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 6
chr7_-_144493560 Show fit	4.04	ENSMUST00000093962.5	Ccnd1 Ensembl NCBI MGI UniProt Show fit	cyclin D1
chr17_+_35643818 Show fit	3.89	ENSMUST00000174699.8	H2-Q6 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 6
chr10_-_85793639 Show fit	3.89	ENSMUST00000001834.4	Rtcb Ensembl NCBI MGI UniProt Show fit	RNA 2',3'-cyclic phosphate and 5'-OH ligase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Wrnip1_Mta3_Rcor1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	25.6	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3	18.9	GO:0006635	fatty acid beta-oxidation(GO:0006635)
0.9	14.1	GO:1904867	protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1	13.2	GO:0006457	protein folding(GO:0006457)
0.2	12.2	GO:0006749	glutathione metabolic process(GO:0006749)
0.7	11.9	GO:0009209	pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209)
0.3	11.5	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2	11.1	GO:0016126	sterol biosynthetic process(GO:0016126)
0.3	10.1	GO:0090662	ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.8	9.7	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)

Showing 1 to 10 of 1,402 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	178.5	GO:0005739	mitochondrion(GO:0005739)
0.2	64.9	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	31.9	GO:0070062	extracellular exosome(GO:0070062)
0.2	29.3	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
2.0	28.1	GO:0042612	MHC class I protein complex(GO:0042612)
0.5	27.0	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	23.1	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	19.7	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4	19.4	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3	18.2	GO:0005758	mitochondrial intermembrane space(GO:0005758)

Showing 1 to 10 of 485 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	50.5	GO:0003735	structural constituent of ribosome(GO:0003735)
1.8	29.6	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.1	27.4	GO:0003924	GTPase activity(GO:0003924)
0.4	20.7	GO:0004601	peroxidase activity(GO:0004601)
0.4	16.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.6	16.2	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	16.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	13.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.2	12.0	GO:0004177	aminopeptidase activity(GO:0004177)
0.5	11.9	GO:0003746	translation elongation factor activity(GO:0003746)

Showing 1 to 10 of 891 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.3	16.3	PID IL23 PATHWAY	IL23-mediated signaling events
0.3	15.4	PID ATR PATHWAY	ATR signaling pathway
0.5	13.6	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2	12.4	PID AURORA B PATHWAY	Aurora B signaling
0.2	12.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	11.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	10.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	9.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	9.0	PID TRAIL PATHWAY	TRAIL signaling pathway

Showing 1 to 10 of 103 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	61.9	REACTOME TRANSLATION	Genes involved in Translation
0.6	41.3	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.3	32.1	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
0.4	31.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.5	26.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.4	24.7	REACTOME G1 PHASE	Genes involved in G1 Phase
0.1	21.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6	18.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.6	17.6	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3	16.6	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 198 entries

Results for Wrnip1_Mta3_Rcor1

Z-value: 5.14

Motif logo

Transcription factors associated with Wrnip1_Mta3_Rcor1

Activity-expression correlation:

Activity profile of Wrnip1_Mta3_Rcor1 motif

Sorted Z-values of Wrnip1_Mta3_Rcor1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Wrnip1_Mta3_Rcor1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: