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GFI1 WT vs 36n/n vs KD
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Results for Yy1_Yy2
Z-value: 2.79
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Transcription factors associated with Yy1_Yy2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Yy1 | mm39_v1_chr12_+_108758871_108758914 | 0.22 | 7.2e-01 | Click! |
| Yy2 | mm39_v1_chrX_-_156351979_156351987 | -0.17 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_138159333 Show fit | 1.85 |
ENSMUST00000019638.15
ENSMUST00000110951.8 |
COP9 signalosome subunit 6 |
|
| chr13_-_97897139 Show fit | 1.81 |
ENSMUST00000074072.5
|
ribosomal protein S18, pseudogene 6 |
|
| chr7_+_28524627 Show fit | 1.80 |
ENSMUST00000066264.13
|
enoyl coenzyme A hydratase 1, peroxisomal |
|
| chr13_+_55862437 Show fit | 1.61 |
ENSMUST00000021959.11
|
thioredoxin domain containing 15 |
|
| chr8_+_85583611 Show fit | 1.58 |
ENSMUST00000003906.13
ENSMUST00000109754.2 |
phenylalanyl-tRNA synthetase, alpha subunit |
|
| chr15_-_79967543 Show fit | 1.48 |
ENSMUST00000081650.15
|
ribosomal protein L3 |
|
| chr10_-_128384971 Show fit | 1.46 |
ENSMUST00000176906.2
|
ribosomal protein L41 |
|
| chr9_-_50515089 Show fit | 1.30 |
ENSMUST00000000175.6
|
succinate dehydrogenase complex, subunit D, integral membrane protein |
|
| chrX_+_93768175 Show fit | 1.29 |
ENSMUST00000101388.4
|
zinc finger, X-linked, duplicated B |
|
| chr18_+_84106188 Show fit | 1.25 |
ENSMUST00000060223.4
|
zinc binding alcohol dehydrogenase, domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Yy1_Yy2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.1 | 7.0 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.2 | 6.6 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.1 | 5.0 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.2 | 4.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 4.5 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.2 | 4.0 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 3.9 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.1 | 3.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.2 | 3.2 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.6 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 12.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 11.6 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 9.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 8.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 7.5 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.2 | 7.4 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 5.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 4.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 4.4 | GO:0043209 | myelin sheath(GO:0043209) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 6.0 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.0 | 5.9 | GO:0004175 | endopeptidase activity(GO:0004175) |
| 0.1 | 5.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.3 | 4.0 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 3.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.4 | GO:0008233 | peptidase activity(GO:0008233) |
| 0.0 | 3.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.2 | 3.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 3.1 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 2.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.2 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 2.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 1.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 13.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 10.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 6.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 6.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 5.2 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 5.1 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.2 | 4.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 4.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 4.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |