Project
avrg: 2D miR_HR1_12
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Results for Ahr
Z-value: 10.05
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Transcription factors associated with Ahr
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ahr | mm10_v2_chr12_-_35534973_35535058 | 0.31 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ahr
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 46.0 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 3.0 | 44.7 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 0.9 | 39.8 | GO:0006284 | base-excision repair(GO:0006284) |
| 1.0 | 31.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.2 | 20.7 | GO:0006352 | DNA-templated transcription, initiation(GO:0006352) |
| 1.5 | 20.4 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
| 1.8 | 20.2 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
| 2.4 | 19.2 | GO:0033313 | meiotic cell cycle checkpoint(GO:0033313) |
| 1.2 | 17.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 3.3 | 16.5 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 89.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 71.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.9 | 70.7 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 65.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.8 | 56.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.7 | 49.3 | GO:0030684 | preribosome(GO:0030684) |
| 5.2 | 41.4 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.7 | 39.7 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.7 | 33.0 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 29.7 | GO:0005813 | centrosome(GO:0005813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 136.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.6 | 98.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 7.8 | 46.5 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 4.0 | 36.2 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.5 | 31.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 28.3 | GO:0042393 | histone binding(GO:0042393) |
| 3.0 | 20.8 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 2.1 | 19.2 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.8 | 19.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.8 | 18.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 119.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 39.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.8 | 38.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 30.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.7 | 25.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.4 | 24.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.6 | 18.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.5 | 16.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 14.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 14.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 88.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.7 | 67.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 41.8 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 5.1 | 40.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.4 | 28.6 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.8 | 27.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.4 | 26.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.5 | 26.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.6 | 22.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 21.5 | REACTOME TRNA AMINOACYLATION | Genes involved in tRNA Aminoacylation |