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avrg: 2D miR_HR1_12
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Results for Bcl6
Z-value: 3.38
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Transcription factors associated with Bcl6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bcl6 | mm10_v2_chr16_-_23988852_23988852 | 0.12 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Bcl6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 1.0 | 7.2 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.0 | 6.0 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.9 | 4.3 | GO:1903059 | regulation of protein lipidation(GO:1903059) |
| 1.4 | 4.2 | GO:0009073 | tyrosine biosynthetic process(GO:0006571) aromatic amino acid family biosynthetic process(GO:0009073) aromatic amino acid family biosynthetic process, prephenate pathway(GO:0009095) |
| 0.1 | 3.6 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 3.5 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.1 | 3.4 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.6 | 3.2 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.8 | 3.0 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 3.5 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 2.8 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 2.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 1.5 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.4 | 1.4 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 1.4 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.2 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.5 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 1.2 | 8.4 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 2.0 | 6.0 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.0 | 5.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 4.2 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.4 | 3.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 3.4 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.8 | 3.2 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.8 | 3.0 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.8 | 2.4 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 8.7 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 3.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 3.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 2.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.4 | 8.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 6.0 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 5.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 3.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 3.2 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.2 | 3.0 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 2.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 2.2 | REACTOME DEFENSINS | Genes involved in Defensins |