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avrg: 2D miR_HR1_12
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Results for E2f2_E2f5
Z-value: 10.53
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Transcription factors associated with E2f2_E2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.93 | 1.5e-05 | Click! |
| E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.84 | 7.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f2_E2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 88.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 3.1 | 77.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 3.6 | 53.9 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 4.7 | 51.6 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 15.8 | 47.4 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 4.0 | 35.9 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 1.8 | 32.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 3.2 | 32.0 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 7.3 | 29.3 | GO:0006272 | leading strand elongation(GO:0006272) |
| 0.5 | 29.3 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.9 | 133.0 | GO:0042555 | MCM complex(GO:0042555) |
| 1.4 | 74.6 | GO:0005657 | replication fork(GO:0005657) |
| 0.3 | 60.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 42.5 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.8 | 42.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 6.5 | 32.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 25.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 23.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 4.5 | 22.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 4.0 | 19.9 | GO:0031298 | replication fork protection complex(GO:0031298) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 76.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.8 | 62.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 3.9 | 54.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 2.0 | 51.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 7.6 | 45.5 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 7.2 | 43.0 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 2.3 | 40.5 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.1 | 35.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 6.5 | 32.4 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 31.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 142.0 | PID ATR PATHWAY | ATR signaling pathway |
| 1.3 | 105.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 53.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 5.1 | 46.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 2.4 | 33.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.7 | 23.8 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.4 | 20.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 17.0 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.6 | 16.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 14.8 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 151.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 6.9 | 124.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 4.6 | 46.5 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 3.1 | 44.0 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.2 | 37.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 22.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 16.7 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 1.4 | 16.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 1.5 | 13.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 1.1 | 12.0 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |