ISMARA results: E2f4

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avrg: 2D miR_HR1_12

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Results for E2f4

Z-value: 5.65

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Transcription factors associated with E2f4

Gene Symbol	Gene ID	Gene Info
E2f4 Ensembl NCBI MGI UniProt	ENSMUSG00000014859.8	E2F transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f4	mm10_v2_chr8_+_105297663_105297742	0.92	2.9e-05	Click!

Activity profile of E2f4 motif

Sorted Z-values of E2f4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_134510999 Show fit	14.68	ENSMUST00000105866.2	Aunip Ensembl NCBI MGI UniProt Show fit	aurora kinase A and ninein interacting protein
chr18_-_34751502 Show fit	13.12	ENSMUST00000060710.7	Cdc25c Ensembl NCBI MGI UniProt Show fit	cell division cycle 25C
chr1_-_169531343 Show fit	13.08	ENSMUST00000028000.7	Nuf2 Ensembl NCBI MGI UniProt Show fit	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr19_+_6084983 Show fit	12.74	ENSMUST00000025704.2	Cdca5 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 5
chr1_-_169531447 Show fit	12.28	ENSMUST00000111368.1	Nuf2 Ensembl NCBI MGI UniProt Show fit	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_189688074 Show fit	12.02	ENSMUST00000171929.1 ENSMUST00000165962.1	Cenpf Ensembl NCBI MGI UniProt Show fit	centromere protein F
chr14_-_47418407 Show fit	11.86	ENSMUST00000043296.3	Dlgap5 Ensembl NCBI MGI UniProt Show fit	discs, large (Drosophila) homolog-associated protein 5
chr6_+_124830217 Show fit	11.81	ENSMUST00000131847.1 ENSMUST00000151674.1	Cdca3 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 3
chr8_-_53638945 Show fit	10.83	ENSMUST00000047768.4	Neil3 Ensembl NCBI MGI UniProt Show fit	nei like 3 (E. coli)
chrX_+_164980592 Show fit	10.42	ENSMUST00000101082.4 ENSMUST00000167446.1 ENSMUST00000057150.6	Fancb Ensembl NCBI MGI UniProt Show fit	Fanconi anemia, complementation group B

Showing 1 to 10 of 167 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	26.4	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.4	24.4	GO:0051290	protein heterotetramerization(GO:0051290)
0.1	17.3	GO:0007051	spindle organization(GO:0007051)
0.6	16.0	GO:0008340	determination of adult lifespan(GO:0008340)
0.4	13.4	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.4	13.1	GO:1902751	positive regulation of cell cycle G2/M phase transition(GO:1902751)
4.2	12.7	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3	12.0	GO:0051310	metaphase plate congression(GO:0051310)
0.2	10.8	GO:0006284	base-excision repair(GO:0006284)
2.6	10.4	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	25.4	GO:0031262	Ndc80 complex(GO:0031262)
0.2	19.2	GO:0000922	spindle pole(GO:0000922)
0.2	13.1	GO:0000794	condensed nuclear chromosome(GO:0000794)
1.4	12.7	GO:0008278	cohesin complex(GO:0008278)
0.0	12.6	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
1.1	12.4	GO:0031080	nuclear pore outer ring(GO:0031080)
1.1	12.0	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.6	11.9	GO:0031616	spindle pole centrosome(GO:0031616)
0.7	10.7	GO:0001673	male germ cell nucleus(GO:0001673)
0.9	10.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	20.7	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3	13.1	GO:0050699	WW domain binding(GO:0050699)
0.0	13.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.3	12.0	GO:0070840	dynein complex binding(GO:0070840)
2.2	10.8	GO:0000405	bubble DNA binding(GO:0000405)
0.2	10.4	GO:0003684	damaged DNA binding(GO:0003684)
0.0	10.3	GO:0003682	chromatin binding(GO:0003682)
0.3	9.9	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.8	8.9	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	8.7	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)

Showing 1 to 10 of 71 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	28.1	PID ATM PATHWAY	ATM pathway
0.2	19.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.4	17.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	11.9	PID AURORA A PATHWAY	Aurora A signaling
0.5	10.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	10.4	PID ATR PATHWAY	ATR signaling pathway
0.1	7.2	PID E2F PATHWAY	E2F transcription factor network
0.1	3.5	ST GAQ PATHWAY	G alpha q Pathway
0.1	3.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	2.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	24.6	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.2	22.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.3	20.7	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.6	14.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.4	13.8	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
1.3	13.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.2	7.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.5	7.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4	5.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.3	5.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening

Showing 1 to 10 of 32 entries

Results for E2f4

Z-value: 5.65

Motif logo

Transcription factors associated with E2f4

Activity-expression correlation:

Activity profile of E2f4 motif

Sorted Z-values of E2f4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: