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avrg: 2D miR_HR1_12
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Results for Ebf1
Z-value: 4.44
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Transcription factors associated with Ebf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf1 | mm10_v2_chr11_+_44617310_44617336 | -0.43 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_141242850 Show fit | 5.56 |
ENSMUST00000138096.1
ENSMUST00000006618.2 ENSMUST00000125392.1 |
Rho guanine nucleotide exchange factor (GEF) 19 |
|
| chr17_-_25754327 Show fit | 5.42 |
ENSMUST00000075884.6
|
mesothelin |
|
| chr11_-_102101310 Show fit | 5.10 |
ENSMUST00000170554.2
ENSMUST00000017460.5 |
pancreatic polypeptide |
|
| chr15_-_75566608 Show fit | 4.88 |
ENSMUST00000163116.1
ENSMUST00000023241.5 |
lymphocyte antigen 6 complex, locus H |
|
| chr7_-_101864093 Show fit | 4.85 |
ENSMUST00000106981.1
|
folate receptor 1 (adult) |
|
| chr11_+_115154139 Show fit | 4.80 |
ENSMUST00000021076.5
|
RAB37, member of RAS oncogene family |
|
| chr15_-_75566811 Show fit | 4.53 |
ENSMUST00000065417.8
|
lymphocyte antigen 6 complex, locus H |
|
| chr1_+_90915064 Show fit | 3.84 |
ENSMUST00000027528.6
|
melanophilin |
|
| chr11_+_69965396 Show fit | 3.69 |
ENSMUST00000018713.6
|
claudin 7 |
|
| chr5_+_141241490 Show fit | 3.66 |
ENSMUST00000085774.4
|
sidekick homolog 1 (chicken) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 15.0 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.4 | 11.3 | GO:1903831 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.1 | 10.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.4 | 7.9 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 6.3 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 5.8 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.3 | 5.3 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.1 | 5.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 5.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.8 | 4.6 | GO:0002838 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 19.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.8 | 16.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 15.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 13.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 12.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 10.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 8.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 6.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.4 | 5.8 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.0 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 13.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.7 | 13.2 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.3 | 7.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 6.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 6.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.4 | 5.8 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.3 | 5.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 5.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 5.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 6.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 5.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 5.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 5.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.7 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 4.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 4.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 8.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 5.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 5.7 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 5.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 5.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 3.6 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 3.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 3.5 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |