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avrg: 2D miR_HR1_12
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Results for Epas1_Bcl3
Z-value: 4.02
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Transcription factors associated with Epas1_Bcl3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Epas1 | mm10_v2_chr17_+_86753900_86753914 | 0.34 | 2.8e-01 | Click! |
| Bcl3 | mm10_v2_chr7_-_19822698_19822776 | -0.09 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_3357012 Show fit | 8.85 |
ENSMUST00000180719.1
|
predicted gene, 26520 |
|
| chr14_-_60177482 Show fit | 6.27 |
ENSMUST00000140924.1
|
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
|
| chr1_-_158958367 Show fit | 5.35 |
ENSMUST00000159861.2
|
pappalysin 2 |
|
| chr6_-_129233969 Show fit | 5.33 |
ENSMUST00000181517.1
|
RIKEN cDNA 2310001H17 gene |
|
| chr1_-_174921813 Show fit | 4.83 |
ENSMUST00000055294.3
|
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) |
|
| chr13_+_89540636 Show fit | 4.57 |
ENSMUST00000022108.7
|
hyaluronan and proteoglycan link protein 1 |
|
| chr19_+_16956110 Show fit | 4.35 |
ENSMUST00000087689.4
|
prune homolog 2 (Drosophila) |
|
| chr11_+_34314757 Show fit | 4.12 |
ENSMUST00000165963.1
ENSMUST00000093192.3 |
family with sequence similarity 196, member B |
|
| chr5_-_134747241 Show fit | 4.11 |
ENSMUST00000015138.9
|
elastin |
|
| chrX_-_38252398 Show fit | 3.64 |
ENSMUST00000089056.3
ENSMUST00000089054.4 ENSMUST00000066498.7 |
transmembrane protein 255A |
Network of associatons between targets according to the STRING database.
First level regulatory network of Epas1_Bcl3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.3 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
| 1.6 | 4.8 | GO:0060300 | regulation of cytokine activity(GO:0060300) |
| 0.5 | 4.2 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.6 | 3.4 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.6 | 3.4 | GO:0014826 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) |
| 0.4 | 3.4 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.1 | 3.2 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.3 | 3.0 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.4 | 2.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 2.6 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.0 | 4.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 3.4 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.9 | 2.6 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.1 | 2.6 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 2.4 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 2.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 2.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 2.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.7 | 2.2 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 5.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 4.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 4.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 4.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 3.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.1 | 3.4 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.8 | 3.4 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 3.1 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 3.0 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 3.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 3.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 2.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 1.7 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 1.4 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 5.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 4.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 4.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.2 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.2 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.3 | 3.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 3.1 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 3.1 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |