Project
avrg: 2D miR_HR1_12
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Results for Esr2
Z-value: 3.57
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Transcription factors associated with Esr2
Network of associatons between targets according to the STRING database.
First level regulatory network of Esr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 11.8 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 1.9 | 5.7 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.4 | 5.6 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.5 | 5.5 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.4 | 5.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 5.2 | GO:0032096 | negative regulation of response to food(GO:0032096) |
| 0.3 | 5.2 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.1 | 5.1 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
| 0.4 | 4.8 | GO:0060586 | multicellular organismal iron ion homeostasis(GO:0060586) |
| 0.8 | 4.6 | GO:0003100 | regulation of systemic arterial blood pressure by endothelin(GO:0003100) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 51.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 11.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 10.3 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 8.4 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.0 | 8.2 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 6.4 | GO:0005930 | axoneme(GO:0005930) |
| 0.1 | 5.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 5.5 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 5.5 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.6 | 5.2 | GO:0097427 | microtubule bundle(GO:0097427) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 12.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 8.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 7.2 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.5 | 5.9 | GO:0019841 | retinol binding(GO:0019841) |
| 0.2 | 5.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.8 | 5.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 4.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 4.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.1 | 4.8 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.6 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 6.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 6.1 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 5.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 4.8 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 3.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 3.7 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 17.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 7.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 6.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 5.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 4.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 4.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 4.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 3.9 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 3.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |