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avrg: 2D miR_HR1_12
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Results for Gtf2i_Gtf2f1
Z-value: 2.55
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Transcription factors associated with Gtf2i_Gtf2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gtf2f1 | mm10_v2_chr17_-_57011271_57011326 | -0.84 | 5.8e-04 | Click! |
| Gtf2i | mm10_v2_chr5_-_134314678_134314760 | -0.50 | 1.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_76521902 Show fit | 4.06 |
ENSMUST00000164703.1
ENSMUST00000096365.3 |
scratch homolog 1, zinc finger protein (Drosophila) |
|
| chr16_-_42340595 Show fit | 3.42 |
ENSMUST00000102817.4
|
growth associated protein 43 |
|
| chr17_+_26933070 Show fit | 2.48 |
ENSMUST00000073724.5
|
PHD finger protein 1 |
|
| chr4_+_138454305 Show fit | 2.35 |
ENSMUST00000050918.3
|
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
| chr16_+_20733104 Show fit | 2.33 |
ENSMUST00000115423.1
ENSMUST00000007171.6 |
chordin |
|
| chr2_-_94264713 Show fit | 2.26 |
ENSMUST00000129661.1
|
RIKEN cDNA E530001K10 gene |
|
| chr4_+_54947976 Show fit | 2.25 |
ENSMUST00000098070.3
|
zinc finger protein 462 |
|
| chr5_+_30913398 Show fit | 2.14 |
ENSMUST00000031055.5
|
elastin microfibril interfacer 1 |
|
| chr1_-_74885322 Show fit | 2.04 |
ENSMUST00000159232.1
ENSMUST00000068631.3 |
FEV (ETS oncogene family) |
|
| chr17_+_37045980 Show fit | 2.02 |
ENSMUST00000174456.1
|
gamma-aminobutyric acid (GABA) B receptor, 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gtf2i_Gtf2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.4 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.1 | 4.9 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.6 | 4.3 | GO:0014053 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) |
| 0.0 | 4.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.2 | 3.5 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 3.3 | GO:0055078 | sodium ion homeostasis(GO:0055078) |
| 0.3 | 3.0 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 3.0 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 1.0 | 2.9 | GO:0009436 | glyoxylate catabolic process(GO:0009436) L-alanine metabolic process(GO:0042851) |
| 0.7 | 2.9 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 6.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 4.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.9 | 4.3 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 4.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.2 | 3.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 3.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.3 | 3.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 3.1 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.0 | 3.1 | GO:0030141 | secretory granule(GO:0030141) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.7 | 4.3 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 4.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.5 | 3.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 3.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 3.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 3.3 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.4 | 3.1 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 3.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.6 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 4.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.4 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 4.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 4.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 3.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 3.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 3.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 3.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 3.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.9 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 2.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |