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avrg: 2D miR_HR1_12
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Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 4.59
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Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000031386.8 | host cell factor C1 | |
| ENSMUSG00000040841.5 | sine oculis-related homeobox 5 | |
| ENSMUSG00000025369.8 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | |
| ENSMUSG00000061079.7 | zinc finger protein 143 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hcfc1 | mm10_v2_chrX_-_73966329_73966376 | 0.92 | 2.8e-05 | Click! |
| Zfp143 | mm10_v2_chr7_+_110061702_110061732 | 0.86 | 3.1e-04 | Click! |
| Six5 | mm10_v2_chr7_+_19094594_19094633 | -0.79 | 2.2e-03 | Click! |
| Smarcc2 | mm10_v2_chr10_+_128459236_128459248 | 0.59 | 4.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_118598209 Show fit | 20.95 |
ENSMUST00000038341.7
|
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) |
|
| chr6_+_124829540 Show fit | 16.49 |
ENSMUST00000150120.1
|
cell division cycle associated 3 |
|
| chr2_+_152847961 Show fit | 14.72 |
ENSMUST00000164120.1
ENSMUST00000178997.1 ENSMUST00000109816.1 |
TPX2, microtubule-associated protein homolog (Xenopus laevis) |
|
| chr5_+_33658123 Show fit | 13.86 |
ENSMUST00000074849.6
ENSMUST00000079534.4 |
transforming, acidic coiled-coil containing protein 3 |
|
| chr1_+_178187721 Show fit | 13.73 |
ENSMUST00000159284.1
|
desumoylating isopeptidase 2 |
|
| chr2_+_152847993 Show fit | 13.66 |
ENSMUST00000028969.8
|
TPX2, microtubule-associated protein homolog (Xenopus laevis) |
|
| chr11_+_117849223 Show fit | 12.55 |
ENSMUST00000081387.4
|
baculoviral IAP repeat-containing 5 |
|
| chr11_+_117849286 Show fit | 11.84 |
ENSMUST00000093906.4
|
baculoviral IAP repeat-containing 5 |
|
| chr6_+_124829582 Show fit | 11.32 |
ENSMUST00000024270.7
|
cell division cycle associated 3 |
|
| chr11_-_101551837 Show fit | 11.22 |
ENSMUST00000017290.4
|
breast cancer 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 53.1 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 4.1 | 24.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 1.6 | 22.7 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 3.2 | 22.4 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 1.8 | 22.1 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.0 | 21.3 | GO:0051301 | cell division(GO:0051301) |
| 7.0 | 21.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 3.1 | 18.4 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
| 0.1 | 17.4 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 1.3 | 17.0 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 37.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 5.7 | 34.0 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 3.5 | 28.4 | GO:0005818 | aster(GO:0005818) |
| 0.2 | 28.4 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.4 | 25.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.8 | 23.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 1.0 | 23.0 | GO:0010369 | chromocenter(GO:0010369) |
| 0.3 | 21.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.0 | 20.9 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.8 | GO:0003723 | RNA binding(GO:0003723) |
| 1.0 | 44.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.3 | 40.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.0 | 26.7 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 1.9 | 20.8 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.8 | 18.6 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 3.1 | 18.4 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 2.4 | 16.5 | GO:0048256 | flap endonuclease activity(GO:0048256) |
| 0.0 | 14.9 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 0.6 | 14.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 88.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 1.0 | 41.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 27.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.5 | 27.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 10.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 10.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 7.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.3 | 7.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 6.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 6.5 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 70.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 33.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.8 | 27.4 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 1.2 | 25.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.9 | 22.2 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.8 | 20.4 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 1.3 | 18.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.9 | 15.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 14.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 11.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |