ISMARA results: Hey1_Myc

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avrg: 2D miR_HR1_12

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Results for Hey1_Myc_Mxi1

Z-value: 5.16

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Transcription factors associated with Hey1_Myc_Mxi1

Gene Symbol	Gene ID	Gene Info
Hey1 Ensembl NCBI MGI UniProt	ENSMUSG00000040289.3	hairy/enhancer-of-split related with YRPW motif 1
Myc Ensembl NCBI MGI UniProt	ENSMUSG00000022346.8	myelocytomatosis oncogene
Mxi1 Ensembl NCBI MGI UniProt	ENSMUSG00000025025.7	MAX interactor 1, dimerization protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mxi1	mm10_v2_chr19_+_53329413_53329478	0.93	1.2e-05	Click!
Myc	mm10_v2_chr15_+_61985377_61985397	0.73	7.0e-03	Click!
Hey1	mm10_v2_chr3_-_8667033_8667046	-0.59	4.4e-02	Click!

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_104638658 Show fit	13.38	ENSMUST00000046212.1	Slc16a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 16 (monocarboxylic acid transporters), member 1
chr2_+_164769892 Show fit	10.32	ENSMUST00000088248.6 ENSMUST00000001439.6	Ube2c Ensembl NCBI MGI UniProt Show fit	ubiquitin-conjugating enzyme E2C
chr9_+_107587711 Show fit	10.27	ENSMUST00000010192.5	Ifrd2 Ensembl NCBI MGI UniProt Show fit	interferon-related developmental regulator 2
chr4_+_134468320 Show fit	10.18	ENSMUST00000030636.4 ENSMUST00000127279.1 ENSMUST00000105867.1	Stmn1 Ensembl NCBI MGI UniProt Show fit	stathmin 1
chr7_+_141476374 Show fit	9.25	ENSMUST00000117634.1	Tspan4 Ensembl NCBI MGI UniProt Show fit	tetraspanin 4
chr16_-_57606816 Show fit	8.76	ENSMUST00000114371.3	Cmss1 Ensembl NCBI MGI UniProt Show fit	cms small ribosomal subunit 1
chr12_+_109459843 Show fit	7.68	ENSMUST00000173812.1	Dlk1 Ensembl NCBI MGI UniProt Show fit	delta-like 1 homolog (Drosophila)
chr2_+_127336152 Show fit	7.06	ENSMUST00000028846.6	Dusp2 Ensembl NCBI MGI UniProt Show fit	dual specificity phosphatase 2
chr9_-_22389113 Show fit	6.47	ENSMUST00000040912.7	Anln Ensembl NCBI MGI UniProt Show fit	anillin, actin binding protein
chr2_+_130274424 Show fit	6.40	ENSMUST00000103198.4	Nop56 Ensembl NCBI MGI UniProt Show fit	NOP56 ribonucleoprotein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	17.2	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
0.7	16.5	GO:0000154	rRNA modification(GO:0000154)
0.4	13.5	GO:0006270	DNA replication initiation(GO:0006270)
1.3	13.4	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.5	13.1	GO:0009644	response to high light intensity(GO:0009644)
2.6	12.9	GO:0030920	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.4	11.9	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.9	11.1	GO:0048254	snoRNA localization(GO:0048254)
1.7	10.3	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.4	10.2	GO:0000027	ribosomal large subunit assembly(GO:0000027)

Showing 1 to 10 of 439 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	23.0	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	22.2	GO:0005813	centrosome(GO:0005813)
0.0	21.3	GO:0005730	nucleolus(GO:0005730)
0.1	18.6	GO:0001650	fibrillar center(GO:0001650)
0.3	16.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
2.0	15.6	GO:0031415	NatA complex(GO:0031415)
0.1	14.9	GO:0031965	nuclear membrane(GO:0031965)
0.2	13.0	GO:0022626	cytosolic ribosome(GO:0022626)
0.6	12.7	GO:0030686	90S preribosome(GO:0030686)
2.5	12.4	GO:0044611	nuclear pore inner ring(GO:0044611)

Showing 1 to 10 of 214 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	45.0	GO:0003723	RNA binding(GO:0003723)
0.1	16.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.3	15.2	GO:0030332	cyclin binding(GO:0030332)
0.9	13.9	GO:1990226	histone methyltransferase binding(GO:1990226)
0.3	13.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
2.2	13.4	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
2.6	12.9	GO:1990190	peptide-glutamate-N-acetyltransferase activity(GO:1990190)
1.6	12.6	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.5	12.4	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	11.7	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 309 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.0	16.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	9.9	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	7.5	PID NOTCH PATHWAY	Notch signaling pathway
0.1	7.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	7.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.2	6.6	PID ATR PATHWAY	ATR signaling pathway
0.1	6.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	5.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	5.6	PID MTOR 4PATHWAY	mTOR signaling pathway

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	32.5	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2	16.2	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	15.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.3	13.8	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.4	13.8	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3	12.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.6	10.6	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.5	10.4	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3	10.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3	10.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 105 entries

Results for Hey1_Myc_Mxi1

Z-value: 5.16

Motif logo

Transcription factors associated with Hey1_Myc_Mxi1

Activity-expression correlation:

Activity profile of Hey1_Myc_Mxi1 motif

Sorted Z-values of Hey1_Myc_Mxi1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hey1_Myc_Mxi1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: