ISMARA results: Max

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avrg: 2D miR_HR1_12

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Results for Max_Mycn

Z-value: 11.52

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Transcription factors associated with Max_Mycn

Gene Symbol	Gene ID	Gene Info
Max Ensembl NCBI MGI UniProt	ENSMUSG00000059436.6	Max protein
Mycn Ensembl NCBI MGI UniProt	ENSMUSG00000037169.8	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Max	mm10_v2_chr12_-_76962178_76962248	0.91	5.1e-05	Click!
Mycn	mm10_v2_chr12_-_12940600_12940616	-0.58	5.0e-02	Click!

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_104638658 Show fit	45.57	ENSMUST00000046212.1	Slc16a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 16 (monocarboxylic acid transporters), member 1
chr4_-_130574150 Show fit	31.28	ENSMUST00000105993.3	Nkain1 Ensembl NCBI MGI UniProt Show fit	Na+/K+ transporting ATPase interacting 1
chr8_+_48109949 Show fit	30.98	ENSMUST00000170263.2 ENSMUST00000033966.6	Dctd Ensembl NCBI MGI UniProt Show fit	dCMP deaminase
chr8_+_48110156 Show fit	25.60	ENSMUST00000174379.1	Dctd Ensembl NCBI MGI UniProt Show fit	dCMP deaminase
chr5_-_135251209 Show fit	23.71	ENSMUST00000062572.2	Fzd9 Ensembl NCBI MGI UniProt Show fit	frizzled homolog 9 (Drosophila)
chr4_-_116821501 Show fit	23.14	ENSMUST00000055436.3	Hpdl Ensembl NCBI MGI UniProt Show fit	4-hydroxyphenylpyruvate dioxygenase-like
chr11_-_60811228 Show fit	20.09	ENSMUST00000018744.8	Shmt1 Ensembl NCBI MGI UniProt Show fit	serine hydroxymethyltransferase 1 (soluble)
chr9_-_22389113 Show fit	17.81	ENSMUST00000040912.7	Anln Ensembl NCBI MGI UniProt Show fit	anillin, actin binding protein
chr9_+_107587711 Show fit	17.27	ENSMUST00000010192.5	Ifrd2 Ensembl NCBI MGI UniProt Show fit	interferon-related developmental regulator 2
chr15_-_78773452 Show fit	17.22	ENSMUST00000018313.5	Mfng Ensembl NCBI MGI UniProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
19.7	78.8	GO:0006231	dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
1.9	47.1	GO:0000154	rRNA modification(GO:0000154)
0.7	46.1	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
4.6	45.6	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
8.3	41.5	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
2.0	36.4	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
2.2	33.4	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.7	30.9	GO:0006414	translational elongation(GO:0006414)
4.3	30.2	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
1.1	29.3	GO:0009303	rRNA transcription(GO:0009303)

Showing 1 to 10 of 635 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	127.1	GO:0005739	mitochondrion(GO:0005739)
0.2	105.1	GO:0005730	nucleolus(GO:0005730)
0.5	78.6	GO:0001650	fibrillar center(GO:0001650)
1.2	60.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.8	56.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.8	50.0	GO:0005657	replication fork(GO:0005657)
0.2	43.5	GO:0031965	nuclear membrane(GO:0031965)
6.0	42.0	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.3	41.2	GO:0005840	ribosome(GO:0005840)
0.4	39.9	GO:0005759	mitochondrial matrix(GO:0005759)

Showing 1 to 10 of 279 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	221.6	GO:0003723	RNA binding(GO:0003723)
0.7	99.5	GO:0003735	structural constituent of ribosome(GO:0003735)
1.1	46.6	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
7.6	45.6	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
1.9	45.4	GO:0003746	translation elongation factor activity(GO:0003746)
1.0	39.8	GO:0008536	Ran GTPase binding(GO:0008536)
1.5	37.8	GO:0017056	structural constituent of nuclear pore(GO:0017056)
6.2	37.3	GO:0031493	nucleosomal histone binding(GO:0031493)
0.8	35.4	GO:0030332	cyclin binding(GO:0030332)
0.3	34.0	GO:0051117	ATPase binding(GO:0051117)

Showing 1 to 10 of 422 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	145.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.0	44.3	PID AURORA B PATHWAY	Aurora B signaling
0.5	41.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
2.2	35.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	24.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.8	23.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	20.4	PID INSULIN PATHWAY	Insulin Pathway
0.5	20.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.5	18.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.6	17.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	101.0	REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.9	90.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.4	71.8	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.9	65.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.0	61.0	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
1.5	50.6	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
1.0	48.3	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
4.1	45.6	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
1.5	44.5	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.6	39.0	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors

Showing 1 to 10 of 128 entries

Results for Max_Mycn

Z-value: 11.52

Motif logo

Transcription factors associated with Max_Mycn

Activity-expression correlation:

Activity profile of Max_Mycn motif

Sorted Z-values of Max_Mycn motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Max_Mycn

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: