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avrg: 2D miR_HR1_12
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Results for Myb
Z-value: 5.05
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Transcription factors associated with Myb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Myb | mm10_v2_chr10_-_21160925_21160984 | 0.88 | 1.6e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_118437331 Show fit | 11.13 |
ENSMUST00000006565.6
|
cell division cycle 20 |
|
| chr2_+_118814195 Show fit | 9.92 |
ENSMUST00000110842.1
|
kinetochore-localized astrin/SPAG5 binding |
|
| chr2_+_118814237 Show fit | 8.94 |
ENSMUST00000028803.7
ENSMUST00000126045.1 |
kinetochore-localized astrin/SPAG5 binding |
|
| chr2_-_127831817 Show fit | 7.98 |
ENSMUST00000028858.7
|
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) |
|
| chr5_+_123749696 Show fit | 7.97 |
ENSMUST00000031366.7
|
kinetochore associated 1 |
|
| chr2_+_118813995 Show fit | 7.80 |
ENSMUST00000134661.1
|
kinetochore-localized astrin/SPAG5 binding |
|
| chr1_-_191575534 Show fit | 7.45 |
ENSMUST00000027933.5
|
denticleless homolog (Drosophila) |
|
| chr17_-_33890584 Show fit | 6.51 |
ENSMUST00000114361.2
ENSMUST00000173492.1 |
kinesin family member C1 |
|
| chr6_+_124829540 Show fit | 6.40 |
ENSMUST00000150120.1
|
cell division cycle associated 3 |
|
| chr9_+_106281061 Show fit | 6.21 |
ENSMUST00000072206.6
|
POC1 centriolar protein homolog A (Chlamydomonas) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Myb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 31.1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 13.8 | GO:0051301 | cell division(GO:0051301) |
| 4.2 | 12.5 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
| 2.0 | 11.8 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 2.8 | 11.1 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
| 0.8 | 10.1 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.5 | 8.3 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 1.6 | 8.2 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 1.2 | 8.2 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 2.7 | 8.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 26.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 1.2 | 13.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 12.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 12.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.7 | 12.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 11.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.4 | 10.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 9.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 8.3 | GO:0005730 | nucleolus(GO:0005730) |
| 2.7 | 8.0 | GO:1990423 | RZZ complex(GO:1990423) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 12.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.7 | 11.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.4 | 11.8 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 11.7 | GO:0042393 | histone binding(GO:0042393) |
| 1.9 | 11.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.1 | 9.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 7.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 5.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 37.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 8.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 6.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.1 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 4.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 3.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 19.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 14.7 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.4 | 11.8 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 8.2 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 4.9 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.5 | 4.0 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 3.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 3.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.2 | 3.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |