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avrg: 2D miR_HR1_12
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Results for Nfic_Nfib
Z-value: 4.67
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Transcription factors associated with Nfic_Nfib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfic | mm10_v2_chr10_-_81430966_81431039 | -0.91 | 5.0e-05 | Click! |
| Nfib | mm10_v2_chr4_-_82505749_82505802 | -0.79 | 2.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_42752710 Show fit | 8.41 |
ENSMUST00000076505.3
|
pyridine nucleotide-disulphide oxidoreductase domain 2 |
|
| chr4_+_120161206 Show fit | 6.49 |
ENSMUST00000030384.4
|
endothelin 2 |
|
| chr7_-_127890918 Show fit | 5.42 |
ENSMUST00000121394.1
|
protease, serine, 53 |
|
| chr11_+_115154139 Show fit | 5.41 |
ENSMUST00000021076.5
|
RAB37, member of RAS oncogene family |
|
| chr2_-_103283760 Show fit | 5.26 |
ENSMUST00000111174.1
|
ets homologous factor |
|
| chr11_-_109722214 Show fit | 5.16 |
ENSMUST00000020938.7
|
family with sequence similarity 20, member A |
|
| chr4_+_41762309 Show fit | 4.65 |
ENSMUST00000108042.2
|
interleukin 11 receptor, alpha chain 1 |
|
| chr11_+_78324200 Show fit | 4.56 |
ENSMUST00000102478.3
|
aldolase C, fructose-bisphosphate |
|
| chr10_-_81291227 Show fit | 4.25 |
ENSMUST00000045744.6
|
tight junction protein 3 |
|
| chr5_+_102768771 Show fit | 4.05 |
ENSMUST00000112852.1
|
Rho GTPase activating protein 24 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfic_Nfib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 7.2 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.2 | 7.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.6 | 6.5 | GO:0001543 | ovarian follicle rupture(GO:0001543) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.1 | 6.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.5 | 6.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.4 | 5.9 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.5 | 5.2 | GO:0070166 | enamel mineralization(GO:0070166) |
| 1.2 | 4.8 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.2 | 4.6 | GO:0046697 | decidualization(GO:0046697) |
| 0.2 | 4.4 | GO:0060134 | prepulse inhibition(GO:0060134) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 13.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 8.8 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 7.9 | GO:0009986 | cell surface(GO:0009986) |
| 0.6 | 7.2 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.2 | 5.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 4.5 | GO:0005811 | lipid particle(GO:0005811) |
| 1.1 | 4.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 4.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 4.2 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.2 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.3 | 7.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.6 | 6.5 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.8 | 6.4 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 5.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 5.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 5.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 4.8 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 4.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 4.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 8.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 7.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.2 | 4.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 4.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.3 | 3.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 3.7 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 3.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 3.1 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |