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avrg: 2D miR_HR1_12
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Results for Rfx3_Rfx1_Rfx4
Z-value: 3.93
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Transcription factors associated with Rfx3_Rfx1_Rfx4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000040929.10 | regulatory factor X, 3 (influences HLA class II expression) | |
| ENSMUSG00000031706.6 | regulatory factor X, 1 (influences HLA class II expression) | |
| ENSMUSG00000020037.9 | regulatory factor X, 4 (influences HLA class II expression) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx4 | mm10_v2_chr10_+_84756055_84756084 | -0.71 | 9.6e-03 | Click! |
| Rfx3 | mm10_v2_chr19_-_28011138_28011181 | -0.55 | 6.2e-02 | Click! |
| Rfx1 | mm10_v2_chr8_+_84066824_84066882 | -0.47 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_10457447 Show fit | 9.02 |
ENSMUST00000171400.2
|
leucine rich repeat containing 10B |
|
| chr17_+_24696234 Show fit | 5.72 |
ENSMUST00000019464.7
|
NADPH oxidase organizer 1 |
|
| chr9_+_59589288 Show fit | 5.57 |
ENSMUST00000121266.1
ENSMUST00000118164.1 |
CUGBP, Elav-like family member 6 |
|
| chr1_+_172521044 Show fit | 5.54 |
ENSMUST00000085894.5
ENSMUST00000161140.1 ENSMUST00000162988.1 |
coiled-coil domain containing 19 |
|
| chr8_+_123235086 Show fit | 5.51 |
ENSMUST00000181432.1
|
RIKEN cDNA 4933417D19 gene |
|
| chr10_+_75037066 Show fit | 5.00 |
ENSMUST00000147802.1
ENSMUST00000020391.5 |
RAB36, member RAS oncogene family |
|
| chrX_-_74645635 Show fit | 4.97 |
ENSMUST00000114119.1
|
predicted gene 5640 |
|
| chr8_-_22125030 Show fit | 4.82 |
ENSMUST00000169834.1
|
NIMA (never in mitosis gene a)-related expressed kinase 5 |
|
| chr13_+_24845122 Show fit | 4.81 |
ENSMUST00000006893.8
|
RIKEN cDNA D130043K22 gene |
|
| chrX_+_73123068 Show fit | 4.80 |
ENSMUST00000179117.1
|
predicted gene 14685 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rfx3_Rfx1_Rfx4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 13.0 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.3 | 9.8 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 1.7 | 8.6 | GO:2000327 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.1 | 7.9 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.2 | 6.5 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 1.5 | 6.1 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.9 | 5.6 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.3 | 5.4 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.2 | 4.9 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.1 | 4.9 | GO:2000171 | negative regulation of dendrite development(GO:2000171) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.8 | GO:0097223 | sperm part(GO:0097223) |
| 0.0 | 8.1 | GO:0005768 | endosome(GO:0005768) |
| 0.5 | 8.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 7.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 6.9 | GO:0005769 | early endosome(GO:0005769) |
| 1.3 | 6.3 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.1 | 6.2 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.6 | 5.7 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 5.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 4.1 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | GO:0032183 | SUMO binding(GO:0032183) |
| 1.0 | 8.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.3 | 7.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.6 | 5.7 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 4.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 4.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 4.0 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.0 | 3.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.9 | 3.6 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.7 | 3.6 | GO:0031849 | olfactory receptor binding(GO:0031849) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 5.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.2 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.2 | 3.4 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 3.3 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.2 | 3.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 2.3 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 2.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.2 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.2 | 2.1 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 2.1 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |