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avrg: 2D miR_HR1_12
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Results for Smad1
Z-value: 3.21
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Transcription factors associated with Smad1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad1 | mm10_v2_chr8_-_79399513_79399532 | -0.90 | 5.4e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_4082473 Show fit | 6.46 |
ENSMUST00000159148.1
|
calcium binding protein 2 |
|
| chr6_-_55175019 Show fit | 6.07 |
ENSMUST00000003569.5
|
indolethylamine N-methyltransferase |
|
| chr7_+_24777172 Show fit | 5.64 |
ENSMUST00000038069.7
|
carcinoembryonic antigen-related cell adhesion molecule 10 |
|
| chr12_-_24680890 Show fit | 4.76 |
ENSMUST00000156453.2
|
cystin 1 |
|
| chr2_-_93452679 Show fit | 4.28 |
ENSMUST00000111257.1
ENSMUST00000145553.1 |
CD82 antigen |
|
| chr10_+_127866457 Show fit | 4.23 |
ENSMUST00000092058.3
|
cDNA sequence BC089597 |
|
| chr19_+_4081565 Show fit | 4.13 |
ENSMUST00000159593.1
|
calcium binding protein 2 |
|
| chr8_-_111691002 Show fit | 4.10 |
ENSMUST00000034435.5
|
chymotrypsinogen B1 |
|
| chr13_-_3945349 Show fit | 3.90 |
ENSMUST00000058610.7
|
urocortin 3 |
|
| chr1_+_93006328 Show fit | 3.65 |
ENSMUST00000059676.4
|
aquaporin 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.1 | GO:0046466 | membrane lipid catabolic process(GO:0046466) |
| 0.6 | 7.6 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.7 | 6.3 | GO:0061713 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231) |
| 0.8 | 5.8 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.5 | 5.7 | GO:2000252 | negative regulation of feeding behavior(GO:2000252) |
| 0.5 | 5.6 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 5.6 | GO:0007586 | digestion(GO:0007586) |
| 0.4 | 5.5 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.9 | 5.3 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.9 | 5.3 | GO:0002835 | negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 66.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 22.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 12.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.4 | 11.2 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.2 | 9.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 7.3 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.3 | 7.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 6.4 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.1 | 6.4 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 6.1 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 9.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 9.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.2 | 7.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 7.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 6.6 | GO:0017022 | myosin binding(GO:0017022) |
| 1.6 | 6.2 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.5 | 6.2 | GO:0016918 | retinal binding(GO:0016918) |
| 0.9 | 6.0 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.2 | 5.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 16.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 14.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 13.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.1 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 5.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 4.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 4.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 10.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 7.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.4 | 6.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.4 | 6.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 6.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 5.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.3 | 5.1 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 4.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |