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avrg: 2D miR_HR1_12
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Results for Sp1
Z-value: 4.27
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Transcription factors associated with Sp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp1 | mm10_v2_chr15_+_102407144_102407269 | -0.84 | 6.4e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_29170204 Show fit | 8.64 |
ENSMUST00000098609.2
|
gametogenetin |
|
| chr19_-_10457447 Show fit | 8.27 |
ENSMUST00000171400.2
|
leucine rich repeat containing 10B |
|
| chr15_-_75566608 Show fit | 7.47 |
ENSMUST00000163116.1
ENSMUST00000023241.5 |
lymphocyte antigen 6 complex, locus H |
|
| chr4_+_43046014 Show fit | 7.33 |
ENSMUST00000180426.1
|
predicted gene, 26881 |
|
| chr4_-_43045686 Show fit | 7.28 |
ENSMUST00000107956.1
ENSMUST00000107957.1 |
family with sequence similarity 214, member B |
|
| chr4_-_43046196 Show fit | 7.07 |
ENSMUST00000036462.5
|
family with sequence similarity 214, member B |
|
| chr7_+_29170345 Show fit | 6.79 |
ENSMUST00000033886.7
|
gametogenetin |
|
| chr12_+_24651346 Show fit | 6.66 |
ENSMUST00000020982.5
|
Kruppel-like factor 11 |
|
| chr17_+_26933070 Show fit | 6.65 |
ENSMUST00000073724.5
|
PHD finger protein 1 |
|
| chr15_-_32244632 Show fit | 6.40 |
ENSMUST00000181536.1
|
RIKEN cDNA 0610007N19 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.4 | GO:1903831 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.2 | 12.5 | GO:0007566 | embryo implantation(GO:0007566) |
| 2.9 | 11.6 | GO:0097494 | regulation of vesicle size(GO:0097494) |
| 1.0 | 11.6 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.6 | 11.1 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 1.6 | 10.9 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 2.1 | 10.6 | GO:0051012 | microtubule sliding(GO:0051012) |
| 1.8 | 10.6 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 1.2 | 10.6 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.2 | 10.2 | GO:0009247 | glycolipid biosynthetic process(GO:0009247) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 94.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 55.4 | GO:0005768 | endosome(GO:0005768) |
| 0.1 | 46.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 40.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 31.8 | GO:0034704 | calcium channel complex(GO:0034704) |
| 0.2 | 26.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 23.3 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.6 | 22.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.4 | 20.9 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 19.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 19.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 19.3 | GO:0019003 | GDP binding(GO:0019003) |
| 2.3 | 18.7 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 18.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 17.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 17.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.3 | 13.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 1.8 | 12.9 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.3 | 12.3 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 10.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 19.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.4 | 18.0 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 18.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 14.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 13.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 13.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 11.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 11.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.6 | 11.3 | ST STAT3 PATHWAY | STAT3 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.9 | 21.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 18.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 17.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 14.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.7 | 13.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 13.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 11.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 11.2 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 0.1 | 11.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |