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avrg: 2D miR_HR1_12
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Results for Xbp1_Creb3l1
Z-value: 5.04
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Transcription factors associated with Xbp1_Creb3l1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3l1 | mm10_v2_chr2_-_92024502_92024529 | 0.92 | 2.6e-05 | Click! |
| Xbp1 | mm10_v2_chr11_+_5520652_5520659 | 0.88 | 1.8e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_45092130 Show fit | 13.91 |
ENSMUST00000148175.1
|
reticulocalbin 3, EF-hand calcium binding domain |
|
| chr7_-_45092198 Show fit | 13.30 |
ENSMUST00000140449.1
ENSMUST00000117546.1 ENSMUST00000019683.3 |
reticulocalbin 3, EF-hand calcium binding domain |
|
| chr7_-_45091713 Show fit | 8.72 |
ENSMUST00000141576.1
|
reticulocalbin 3, EF-hand calcium binding domain |
|
| chr15_+_79516396 Show fit | 6.00 |
ENSMUST00000010974.7
|
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
|
| chr3_+_93520473 Show fit | 5.25 |
ENSMUST00000029515.4
|
S100 calcium binding protein A11 (calgizzarin) |
|
| chr2_+_180725263 Show fit | 5.03 |
ENSMUST00000094218.3
|
solute carrier family 17, member 9 |
|
| chr18_+_57354733 Show fit | 4.97 |
ENSMUST00000025490.8
|
proline-rich coiled-coil 1 |
|
| chr15_-_32244632 Show fit | 4.52 |
ENSMUST00000181536.1
|
RIKEN cDNA 0610007N19 |
|
| chr9_+_72925622 Show fit | 3.77 |
ENSMUST00000038489.5
|
pygopus 1 |
|
| chr19_+_11965817 Show fit | 3.71 |
ENSMUST00000025590.9
|
oxysterol binding protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Xbp1_Creb3l1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 12.6 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 8.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 1.1 | 7.6 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.4 | 7.4 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.5 | 6.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 5.5 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.1 | 5.0 | GO:1903146 | regulation of mitophagy(GO:1903146) |
| 0.5 | 4.9 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.2 | 4.1 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
| 0.2 | 3.8 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 65.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 12.8 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.2 | 9.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.4 | 8.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.4 | 6.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.2 | 3.9 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 3.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.3 | 3.3 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.4 | 3.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 3.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 10.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 10.2 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.2 | 8.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 1.9 | 7.6 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.1 | 4.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.1 | 3.7 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 3.6 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.8 | 3.3 | GO:0004104 | cholinesterase activity(GO:0004104) |
| 0.1 | 3.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 3.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 2.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.1 | 2.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.8 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 8.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.5 | 6.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 4.7 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 3.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 3.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 3.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 2.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |