ISMARA results: Ybx1_Nfya_Nfyb_Nfyc

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avrg: 2D miR_HR1_12

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Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 10.37

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Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Gene Symbol	Gene ID	Gene Info
Ybx1 Ensembl NCBI MGI UniProt	ENSMUSG00000028639.8	Y box protein 1
Nfya Ensembl NCBI MGI UniProt	ENSMUSG00000023994.7	nuclear transcription factor-Y alpha
Nfyb Ensembl NCBI MGI UniProt	ENSMUSG00000020248.12	nuclear transcription factor-Y beta
Nfyc Ensembl NCBI MGI UniProt	ENSMUSG00000032897.11	nuclear transcription factor-Y gamma
Cebpz Ensembl NCBI MGI UniProt	ENSMUSG00000024081.8	CCAAT/enhancer binding protein zeta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ybx1	mm10_v2_chr4_-_119294520_119294604	0.97	9.9e-08	Click!
Nfyc	mm10_v2_chr4_-_120815703_120815761	0.95	3.0e-06	Click!
Cebpz	mm10_v2_chr17_-_78937031_78937074	0.91	3.5e-05	Click!
Nfya	mm10_v2_chr17_-_48409729_48409906	0.87	2.0e-04	Click!
Nfyb	mm10_v2_chr10_-_82764088_82764144	0.83	7.4e-04	Click!

Activity profile of Ybx1_Nfya_Nfyb_Nfyc_Cebpz motif

Sorted Z-values of Ybx1_Nfya_Nfyb_Nfyc_Cebpz motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_99024179 Show fit	42.94	ENSMUST00000068031.7	Top2a Ensembl NCBI MGI UniProt Show fit	topoisomerase (DNA) II alpha
chr11_-_87108656 Show fit	40.41	ENSMUST00000051395.8	Prr11 Ensembl NCBI MGI UniProt Show fit	proline rich 11
chr6_+_124829582 Show fit	34.73	ENSMUST00000024270.7	Cdca3 Ensembl NCBI MGI UniProt Show fit	cell division cycle associated 3
chr1_+_139454747 Show fit	33.40	ENSMUST00000053364.8 ENSMUST00000097554.3	Aspm Ensembl NCBI MGI UniProt Show fit	asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr3_-_27153861 Show fit	31.69	ENSMUST00000108300.1 ENSMUST00000108298.2	Ect2 Ensembl NCBI MGI UniProt Show fit	ect2 oncogene
chr8_+_83955507 Show fit	31.07	ENSMUST00000005607.8	Asf1b Ensembl NCBI MGI UniProt Show fit	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153844 Show fit	29.79	ENSMUST00000176242.2 ENSMUST00000176780.1	Ect2 Ensembl NCBI MGI UniProt Show fit	ect2 oncogene
chr14_+_46760526 Show fit	29.25	ENSMUST00000067426.4	Cdkn3 Ensembl NCBI MGI UniProt Show fit	cyclin-dependent kinase inhibitor 3
chr8_+_57511833 Show fit	29.21	ENSMUST00000067925.6	Hmgb2 Ensembl NCBI MGI UniProt Show fit	high mobility group box 2
chr3_-_27153782 Show fit	28.83	ENSMUST00000175857.1 ENSMUST00000177055.1 ENSMUST00000176535.1	Ect2 Ensembl NCBI MGI UniProt Show fit	ect2 oncogene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.5	134.7	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
10.9	87.5	GO:0016321	female meiosis chromosome segregation(GO:0016321)
2.0	72.8	GO:0051310	metaphase plate congression(GO:0051310)
0.5	62.1	GO:0007050	cell cycle arrest(GO:0007050)
7.2	50.4	GO:0090306	spindle assembly involved in meiosis(GO:0090306)
15.5	46.6	GO:0032877	positive regulation of DNA endoreduplication(GO:0032877)
2.5	43.2	GO:0030953	astral microtubule organization(GO:0030953)
0.8	41.5	GO:0007019	microtubule depolymerization(GO:0007019)
2.2	41.2	GO:0006270	DNA replication initiation(GO:0006270)
3.4	40.7	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)

Showing 1 to 10 of 548 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	123.4	GO:0000776	kinetochore(GO:0000776)
0.7	100.1	GO:0005913	cell-cell adherens junction(GO:0005913)
19.9	99.4	GO:0097149	centralspindlin complex(GO:0097149)
0.9	95.9	GO:0005814	centriole(GO:0005814)
1.3	83.3	GO:0005657	replication fork(GO:0005657)
0.1	80.3	GO:0005730	nucleolus(GO:0005730)
1.6	65.2	GO:0005876	spindle microtubule(GO:0005876)
1.2	57.9	GO:0005871	kinesin complex(GO:0005871)
9.4	56.7	GO:0032133	chromosome passenger complex(GO:0032133)
3.3	50.2	GO:0042555	MCM complex(GO:0042555)

Showing 1 to 10 of 234 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	120.6	GO:0003777	microtubule motor activity(GO:0003777)
0.8	108.5	GO:0017048	Rho GTPase binding(GO:0017048)
0.3	74.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.3	64.6	GO:0042393	histone binding(GO:0042393)
0.1	54.7	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.3	54.3	GO:0008017	microtubule binding(GO:0008017)
1.0	51.0	GO:0031492	nucleosomal DNA binding(GO:0031492)
11.5	46.0	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
9.0	44.9	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.8	44.8	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)

Showing 1 to 10 of 352 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	298.5	PID PLK1 PATHWAY	PLK1 signaling events
2.8	124.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
2.0	74.9	PID AURORA B PATHWAY	Aurora B signaling
1.4	67.0	PID FANCONI PATHWAY	Fanconi anemia pathway
0.6	39.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.8	36.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.6	34.6	PID ATR PATHWAY	ATR signaling pathway
1.2	32.9	PID AURORA A PATHWAY	Aurora A signaling
0.3	28.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.9	25.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	200.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.1	96.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
2.9	77.2	REACTOME KINESINS	Genes involved in Kinesins
4.6	73.4	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
7.2	72.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
2.7	67.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
2.6	64.7	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
4.3	55.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
2.6	41.3	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4	39.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Showing 1 to 10 of 121 entries

Results for Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 10.37

Motif logo

Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Activity-expression correlation:

Activity profile of Ybx1_Nfya_Nfyb_Nfyc_Cebpz motif

Sorted Z-values of Ybx1_Nfya_Nfyb_Nfyc_Cebpz motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: