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avrg: 2D miR_HR1_12
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Results for Yy1_Yy2
Z-value: 5.26
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Transcription factors associated with Yy1_Yy2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Yy1 | mm10_v2_chr12_+_108792946_108792988 | 0.84 | 5.6e-04 | Click! |
| Yy2 | mm10_v2_chrX_-_157568983_157568991 | 0.84 | 5.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Yy1_Yy2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 40.3 | GO:0006412 | translation(GO:0006412) |
| 0.3 | 31.1 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.6 | 25.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 3.7 | 22.4 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.7 | 22.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 1.3 | 17.1 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.7 | 16.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.6 | 15.0 | GO:0006336 | DNA replication-independent nucleosome assembly(GO:0006336) |
| 0.8 | 14.1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 14.0 | GO:0006413 | translational initiation(GO:0006413) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 80.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.9 | 41.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.6 | 38.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.1 | 35.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 22.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 3.5 | 20.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.3 | 19.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 19.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 3.7 | 18.6 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.3 | 17.1 | GO:0005840 | ribosome(GO:0005840) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 144.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 64.8 | GO:0003723 | RNA binding(GO:0003723) |
| 1.2 | 30.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.4 | 24.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.5 | 23.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.1 | 15.3 | GO:0042393 | histone binding(GO:0042393) |
| 1.0 | 12.5 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.2 | 12.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.9 | 12.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.2 | 12.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 40.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 31.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 24.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 24.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 13.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 13.4 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 11.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 10.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 8.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.3 | 8.2 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 123.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.7 | 67.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 32.3 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.8 | 30.9 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 0.4 | 27.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.3 | 21.9 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 21.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 19.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 14.4 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.8 | 14.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |