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avrg: 2D miR_HR1_12
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Results for Zbtb33_Chd2
Z-value: 6.81
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Transcription factors associated with Zbtb33_Chd2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zbtb33 | mm10_v2_chrX_+_38189780_38189826 | 0.73 | 7.0e-03 | Click! |
| Chd2 | mm10_v2_chr7_-_73541738_73541758 | 0.72 | 8.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_34833631 Show fit | 16.44 |
ENSMUST00000093191.2
|
spindle apparatus coiled-coil protein 1 |
|
| chr5_+_45669907 Show fit | 14.79 |
ENSMUST00000117396.1
|
non-SMC condensin I complex, subunit G |
|
| chr4_-_118437331 Show fit | 13.42 |
ENSMUST00000006565.6
|
cell division cycle 20 |
|
| chrX_+_151803642 Show fit | 12.97 |
ENSMUST00000156616.2
|
HECT, UBA and WWE domain containing 1 |
|
| chr14_-_57826128 Show fit | 12.28 |
ENSMUST00000022536.2
|
spindle and kinetochore associated complex subunit 3 |
|
| chr19_+_38931008 Show fit | 11.73 |
ENSMUST00000145051.1
|
helicase, lymphoid specific |
|
| chr17_+_56040350 Show fit | 11.35 |
ENSMUST00000002914.8
|
chromatin assembly factor 1, subunit A (p150) |
|
| chr4_+_24496434 Show fit | 11.13 |
ENSMUST00000108222.2
ENSMUST00000138567.2 ENSMUST00000050446.6 |
MMS22-like, DNA repair protein |
|
| chr19_+_38930909 Show fit | 10.43 |
ENSMUST00000025965.5
|
helicase, lymphoid specific |
|
| chr5_+_110286306 Show fit | 10.05 |
ENSMUST00000007296.5
ENSMUST00000112482.1 |
polymerase (DNA directed), epsilon |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zbtb33_Chd2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 30.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 1.5 | 25.1 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
| 3.2 | 22.2 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 3.7 | 14.8 | GO:0060265 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) |
| 3.4 | 13.4 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
| 0.1 | 12.3 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.4 | 12.2 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 4.0 | 12.0 | GO:0010705 | meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705) |
| 0.5 | 12.0 | GO:0045005 | replication fork processing(GO:0031297) DNA-dependent DNA replication maintenance of fidelity(GO:0045005) |
| 0.4 | 11.4 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 39.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 3.8 | 37.6 | GO:0000796 | condensin complex(GO:0000796) |
| 2.2 | 28.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.3 | 25.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.7 | 24.6 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.5 | 13.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 3.8 | 11.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 2.3 | 11.3 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 3.7 | 11.1 | GO:0035101 | FACT complex(GO:0035101) |
| 1.2 | 10.5 | GO:0000801 | central element(GO:0000801) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 32.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 28.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 3.3 | 16.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.4 | 14.8 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.2 | 14.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 2.2 | 13.4 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.4 | 11.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 11.3 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.2 | 11.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 45.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.4 | 24.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 17.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 13.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 13.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.3 | 9.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 5.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 5.2 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 4.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 35.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 25.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 19.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 16.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.7 | 13.7 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.3 | 13.3 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 12.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.8 | 11.6 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.5 | 10.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 7.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |