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avrg: 2D miR_HR1_12
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Results for Zfx_Zfp711
Z-value: 2.55
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Transcription factors associated with Zfx_Zfp711
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfx | mm10_v2_chrX_-_94123359_94123412 | 0.77 | 3.3e-03 | Click! |
| Zfp711 | mm10_v2_chrX_+_112604274_112604274 | 0.70 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zfx_Zfp711
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.6 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.3 | 8.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.5 | 8.2 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
| 0.2 | 7.1 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.1 | 6.7 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 6.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.2 | 6.4 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.3 | 6.2 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.2 | 5.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.5 | 5.4 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 17.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 15.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 15.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 13.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 12.7 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.3 | 12.5 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 11.7 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.1 | 10.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 9.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 44.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 29.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 11.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 10.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 8.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.1 | 6.6 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.3 | 6.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 6.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.1 | 5.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 5.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 13.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 12.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 10.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 8.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 7.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.4 | 6.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 6.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 6.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 5.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 26.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 15.0 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.6 | 12.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 11.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.4 | 10.6 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 8.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.1 | 7.5 | REACTOME ORC1 REMOVAL FROM CHROMATIN | Genes involved in Orc1 removal from chromatin |
| 0.1 | 7.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 7.0 | REACTOME CHROMOSOME MAINTENANCE | Genes involved in Chromosome Maintenance |