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2D miR_HR1_12

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Results for Smad2

Z-value: 0.51

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
ENSMUSG00000024563.9 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_762421740.556.3e-02Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_62178175 0.95 ENSMUST00000182476.1
plasmacytoma variant translocation 1
chr4_+_11191726 0.79 ENSMUST00000029866.9
ENSMUST00000108324.3
cyclin E2
chr9_+_53771499 0.61 ENSMUST00000048670.8
solute carrier family 35, member F2
chr15_-_101562889 0.49 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr4_+_11191354 0.44 ENSMUST00000170901.1
cyclin E2
chr16_-_36642742 0.40 ENSMUST00000135280.1
CD86 antigen
chr2_-_91950386 0.39 ENSMUST00000111303.1
diacylglycerol kinase zeta
chr12_-_103338314 0.38 ENSMUST00000149431.1
ankyrin repeat and SOCS box-containing 2
chr1_-_179803625 0.34 ENSMUST00000027768.7
AT hook containing transcription factor 1
chr17_+_7925990 0.33 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr9_-_44713196 0.32 ENSMUST00000144251.1
ENSMUST00000156918.1
pleckstrin homology-like domain, family B, member 1
chr4_+_115884384 0.31 ENSMUST00000097918.2
kinocilin
chr15_-_103251465 0.30 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
nuclear factor, erythroid derived 2
chr2_+_156863110 0.29 ENSMUST00000029165.3
RIKEN cDNA 1110008F13 gene
chrX_-_7947553 0.26 ENSMUST00000133349.1
histone deacetylase 6
chr15_+_82252397 0.26 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr10_-_49788743 0.25 ENSMUST00000105483.1
ENSMUST00000105487.1
glutamate receptor, ionotropic, kainate 2 (beta 2)
chr7_-_116237767 0.24 ENSMUST00000182834.1
pleckstrin homology domain containing, family A member 7
chrX_-_7947848 0.24 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
histone deacetylase 6
chr10_-_42583628 0.24 ENSMUST00000019938.4
nuclear receptor subfamily 2, group E, member 1
chr19_+_47228804 0.22 ENSMUST00000111807.3
neuralized homolog 1A (Drosophila)
chrX_-_7947763 0.22 ENSMUST00000154244.1
histone deacetylase 6
chrX_-_94123087 0.22 ENSMUST00000113925.1
zinc finger protein X-linked
chr15_-_84123174 0.21 ENSMUST00000019012.3
patatin-like phospholipase domain containing 5
chr18_+_40258361 0.20 ENSMUST00000091927.4
potassium channel tetramerisation domain containing 16
chrX_+_99821021 0.19 ENSMUST00000096363.2
transmembrane protein 28
chr17_-_34615776 0.19 ENSMUST00000168353.2
EGF-like domain 8
chr16_+_64851991 0.18 ENSMUST00000067744.7
CGG triplet repeat binding protein 1
chr8_-_105637403 0.18 ENSMUST00000182046.1
predicted gene 5914
chr17_-_34615965 0.16 ENSMUST00000097345.3
ENSMUST00000015611.7
EGF-like domain 8
chr16_+_32914094 0.16 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
leucine-rich repeats and calponin homology (CH) domain containing 3
chr7_+_101321703 0.15 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
START domain containing 10
chr10_+_80150448 0.15 ENSMUST00000153477.1
midnolin
chr10_-_118868903 0.15 ENSMUST00000004281.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr13_-_100104064 0.15 ENSMUST00000038104.5
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chrX_-_136741155 0.14 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
mortality factor 4 like 2
chr4_+_148591482 0.13 ENSMUST00000006611.8
spermidine synthase
chr8_+_66386292 0.12 ENSMUST00000039540.5
ENSMUST00000110253.2
membrane-associated ring finger (C3HC4) 1
chr6_+_83137089 0.12 ENSMUST00000121093.1
ENSMUST00000087938.4
rhotekin
chr18_-_42579652 0.12 ENSMUST00000054738.3
G protein-coupled receptor 151
chr11_+_4135233 0.11 ENSMUST00000124670.1
ring finger protein 215
chr13_+_23752267 0.11 ENSMUST00000091703.2
histone cluster 1, H3b
chr11_+_101119938 0.11 ENSMUST00000043680.8
tubulin, gamma 1
chr7_+_82867327 0.10 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr6_-_142702259 0.10 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr2_-_148443543 0.10 ENSMUST00000099269.3
CD93 antigen
chr9_+_44107286 0.09 ENSMUST00000152956.1
ENSMUST00000114815.1
C1q and tumor necrosis factor related protein 5
chr4_-_129261394 0.08 ENSMUST00000145261.1
expressed sequence C77080
chr10_+_80151154 0.08 ENSMUST00000146516.1
ENSMUST00000144526.1
midnolin
chr8_-_87959560 0.08 ENSMUST00000109655.2
zinc finger protein 423
chr10_+_80300997 0.07 ENSMUST00000140828.1
ENSMUST00000138909.1
adenomatosis polyposis coli 2
chr14_-_31168587 0.07 ENSMUST00000036618.7
stabilin 1
chr7_-_29180454 0.07 ENSMUST00000182328.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr14_-_18331855 0.07 ENSMUST00000022296.6
ubiquitin-conjugating enzyme E2E 1
chr17_+_3397189 0.06 ENSMUST00000072156.6
T cell lymphoma invasion and metastasis 2
chr11_-_116654245 0.06 ENSMUST00000021166.5
cytoglobin
chr4_+_117849193 0.06 ENSMUST00000132043.2
ENSMUST00000169990.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_-_20496780 0.05 ENSMUST00000022353.3
MSS51 mitochondrial translational activator
chr7_-_29180699 0.05 ENSMUST00000059642.10
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr12_+_33147693 0.05 ENSMUST00000077456.6
ENSMUST00000110824.2
ataxin 7-like 1
chr13_+_104817171 0.04 ENSMUST00000022230.8
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chrX_-_94123359 0.04 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
zinc finger protein X-linked
chr11_-_33147400 0.04 ENSMUST00000020507.7
fibroblast growth factor 18
chr8_-_105637350 0.04 ENSMUST00000182863.1
predicted gene 5914
chr8_-_69184177 0.03 ENSMUST00000185176.1
leucine zipper, putative tumor suppressor 1
chr10_-_37138863 0.03 ENSMUST00000092584.5
myristoylated alanine rich protein kinase C substrate
chr11_+_69846665 0.03 ENSMUST00000019605.2
phospholipid scramblase 3
chr7_+_99267428 0.03 ENSMUST00000068973.4
ENSMUST00000122101.1
microtubule-associated protein 6
chr14_+_21500879 0.02 ENSMUST00000182964.1
K(lysine) acetyltransferase 6B
chr3_+_127633134 0.02 ENSMUST00000029587.7
neurogenin 2
chrX_-_20931520 0.02 ENSMUST00000001156.7
complement factor properdin
chr12_+_33147754 0.02 ENSMUST00000146040.1
ENSMUST00000125192.1
ataxin 7-like 1
chr17_-_46032366 0.02 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
vascular endothelial growth factor A
chr11_-_100762928 0.02 ENSMUST00000107360.2
ENSMUST00000055083.3
hypocretin
chr7_-_45052865 0.01 ENSMUST00000057293.6
proline rich 12
chr10_-_119240006 0.01 ENSMUST00000020315.6
cullin associated and neddylation disassociated 1
chr17_-_35980197 0.01 ENSMUST00000055454.7
proline-rich polypeptide 3
chr6_+_125009665 0.01 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
zinc finger protein 384

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070844 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 1.2 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.3 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0005915 zonula adherens(GO:0005915)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.2 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.2 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0005344 catalase activity(GO:0004096) oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes