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2D miR_HR1_12

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Results for Nkx2-5

Z-value: 0.54

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Transcription factors associated with Nkx2-5

Gene Symbol Gene ID Gene Info
ENSMUSG00000015579.4 NK2 homeobox 5

Activity profile of Nkx2-5 motif

Sorted Z-values of Nkx2-5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_141846277 1.03 ENSMUST00000105781.1
chymotrypsin C (caldecrin)
chr6_+_30639218 0.96 ENSMUST00000031806.9
carboxypeptidase A1, pancreatic
chr6_+_41521782 0.78 ENSMUST00000070380.4
protease, serine, 2
chr6_-_136922169 0.70 ENSMUST00000032343.6
endoplasmic reticulum protein 27
chr6_+_41302265 0.67 ENSMUST00000031913.4
trypsin 4
chr14_+_41131777 0.66 ENSMUST00000022314.3
ENSMUST00000170719.1
surfactant associated protein A1
chr6_+_30541582 0.61 ENSMUST00000096066.4
carboxypeptidase A2, pancreatic
chr4_-_137409777 0.54 ENSMUST00000024200.6
predicted gene 13011
chr15_+_99591028 0.51 ENSMUST00000169082.1
aquaporin 5
chr4_-_4138432 0.47 ENSMUST00000070375.7
preproenkephalin
chrX_-_155623325 0.42 ENSMUST00000038665.5
patched domain containing 1
chr3_+_114904062 0.42 ENSMUST00000081752.6
olfactomedin 3
chr10_+_117045341 0.41 ENSMUST00000073834.4
leucine rich repeat containing 10
chr9_+_54917252 0.39 ENSMUST00000039742.7
hydroxylysine kinase 1
chr3_+_115080965 0.38 ENSMUST00000051309.8
olfactomedin 3
chr11_-_78550777 0.33 ENSMUST00000103242.4
transmembrane protein 97
chr7_+_29170345 0.33 ENSMUST00000033886.7
gametogenetin
chr7_-_4844665 0.30 ENSMUST00000066041.5
ENSMUST00000172377.1
shisa homolog 7 (Xenopus laevis)
chr11_+_115974709 0.29 ENSMUST00000021107.7
ENSMUST00000106461.1
ENSMUST00000169928.1
integrin beta 4
chr2_-_127270032 0.29 ENSMUST00000099407.1
predicted gene 10766
chr5_+_90561102 0.28 ENSMUST00000094615.4
RIKEN cDNA 5830473C10 gene
chr17_-_55915870 0.25 ENSMUST00000074828.4
ribosomal protein L21, pseudogene 6
chr7_+_29170204 0.24 ENSMUST00000098609.2
gametogenetin
chr7_+_128246812 0.24 ENSMUST00000164710.1
ENSMUST00000070656.5
transforming growth factor beta 1 induced transcript 1
chr19_+_16956110 0.22 ENSMUST00000087689.4
prune homolog 2 (Drosophila)
chrX_-_75416533 0.21 ENSMUST00000033542.4
mature T cell proliferation 1
chr6_+_47244359 0.20 ENSMUST00000060839.6
contactin associated protein-like 2
chr14_-_63271682 0.20 ENSMUST00000132122.1
GATA binding protein 4
chr12_+_74297474 0.19 ENSMUST00000072100.3
DNA binding protein with his-thr domain
chr12_+_37880700 0.19 ENSMUST00000040500.7
diacylglycerol kinase, beta
chr6_+_72304592 0.19 ENSMUST00000183018.1
surfactant associated protein B
chr9_-_20976762 0.19 ENSMUST00000054197.5
sphingosine-1-phosphate receptor 2
chr5_-_8997324 0.18 ENSMUST00000003720.4
carnitine O-octanoyltransferase
chr7_+_128246953 0.18 ENSMUST00000167965.1
transforming growth factor beta 1 induced transcript 1
chr7_+_100607660 0.17 ENSMUST00000098252.4
RAB6A, member RAS oncogene family
chr3_+_52268337 0.17 ENSMUST00000053764.5
forkhead box O1
chr9_+_7347374 0.17 ENSMUST00000065079.5
ENSMUST00000005950.5
matrix metallopeptidase 12
chr2_-_173276144 0.17 ENSMUST00000139306.1
prostate transmembrane protein, androgen induced 1
chr12_+_8012359 0.17 ENSMUST00000171239.1
apolipoprotein B
chr6_+_127577963 0.17 ENSMUST00000071563.4
EF-hand calcium binding domain 4B
chr7_+_43690418 0.15 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr9_-_37657189 0.15 ENSMUST00000117654.1
transforming growth factor beta regulated gene 1
chr9_+_57940104 0.15 ENSMUST00000043059.7
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr11_+_117332335 0.15 ENSMUST00000106349.1
septin 9
chr13_+_30136498 0.14 ENSMUST00000047311.8
membrane bound O-acyltransferase domain containing 1
chr6_+_92869357 0.14 ENSMUST00000113434.1
predicted gene 15737
chr4_+_62619515 0.13 ENSMUST00000084521.4
ENSMUST00000107424.1
regulator of G-protein signaling 3
chr9_-_53536608 0.13 ENSMUST00000150244.1
ataxia telangiectasia mutated homolog (human)
chr4_+_137594140 0.13 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
ubiquitin specific peptidase 48
chr2_+_32288317 0.13 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
golgi autoantigen, golgin subfamily a, 2
chr19_-_38124801 0.13 ENSMUST00000112335.2
retinol binding protein 4, plasma
chr4_-_35845204 0.13 ENSMUST00000164772.1
ENSMUST00000065173.2
leucine rich repeat and Ig domain containing 2
chr11_-_96977660 0.12 ENSMUST00000107626.1
ENSMUST00000107624.1
Sp2 transcription factor
chr1_-_75133866 0.11 ENSMUST00000027405.4
solute carrier family 23 (nucleobase transporters), member 3
chrX_-_75416562 0.11 ENSMUST00000033543.7
ENSMUST00000149863.2
ENSMUST00000114081.1
mature T cell proliferation 1
mature T cell proliferation 1
chr17_-_29716969 0.11 ENSMUST00000129091.1
ENSMUST00000128751.1
coiled-coil domain containing 167
chr10_-_42018363 0.10 ENSMUST00000162405.1
ENSMUST00000095729.4
ENSMUST00000161081.1
ENSMUST00000160262.2
armadillo repeat containing 2
chr3_+_3634145 0.10 ENSMUST00000108394.1
hepatocyte nuclear factor 4, gamma
chr11_-_58552237 0.09 ENSMUST00000073933.1
olfactory receptor 328
chr5_-_30907692 0.09 ENSMUST00000132034.2
ENSMUST00000132253.2
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr6_-_115676623 0.09 ENSMUST00000000451.7
v-raf-leukemia viral oncogene 1
chr9_+_98422961 0.09 ENSMUST00000052068.9
retinol binding protein 1, cellular
chr10_-_127311740 0.09 ENSMUST00000037290.5
ENSMUST00000171564.1
methionine-tRNA synthetase
chr5_+_145083830 0.09 ENSMUST00000031625.8
actin related protein 2/3 complex, subunit 1A
chr17_+_47726834 0.09 ENSMUST00000024782.5
ENSMUST00000144955.1
progastricsin (pepsinogen C)
chr5_+_124328083 0.09 ENSMUST00000111477.1
ENSMUST00000077376.2
RIKEN cDNA 2810006K23 gene
chr16_-_85173692 0.09 ENSMUST00000005406.10
amyloid beta (A4) precursor protein
chr19_-_4163285 0.08 ENSMUST00000118483.1
ENSMUST00000025749.7
ribosomal protein S6 kinase, polypeptide 2
chr11_-_58502554 0.08 ENSMUST00000170501.2
ENSMUST00000081743.2
olfactory receptor 331
chr15_-_101743099 0.08 ENSMUST00000023710.4
keratin 71
chr11_-_96916407 0.08 ENSMUST00000130774.1
CDK5 regulatory subunit associated protein 3
chr14_+_20674311 0.08 ENSMUST00000048657.8
Sec24 related gene family, member C (S. cerevisiae)
chr11_-_96916366 0.08 ENSMUST00000144731.1
ENSMUST00000127048.1
CDK5 regulatory subunit associated protein 3
chr5_-_124327883 0.08 ENSMUST00000031344.6
M-phase phosphoprotein 9
chr19_+_26753588 0.08 ENSMUST00000177116.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_113643206 0.07 ENSMUST00000034219.4
ENSMUST00000095173.1
synaptonemal complex central element protein 1 like
chr9_+_123806468 0.07 ENSMUST00000049810.7
chemokine (C-X-C motif) receptor 6
chr2_+_32608704 0.07 ENSMUST00000129165.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_+_114474509 0.07 ENSMUST00000113370.2
kelch-like 4
chrX_-_165327376 0.07 ENSMUST00000058787.8
glycine receptor, alpha 2 subunit
chr4_+_119637704 0.07 ENSMUST00000024015.2
guanylate cyclase activator 2a (guanylin)
chr4_-_45532470 0.06 ENSMUST00000147448.1
src homology 2 domain-containing transforming protein B
chr4_-_126968124 0.06 ENSMUST00000106108.2
zinc finger, MYM-type 4
chr2_+_129800451 0.06 ENSMUST00000165413.2
ENSMUST00000166282.2
serine/threonine kinase 35
chr9_-_120023558 0.06 ENSMUST00000111635.2
xin actin-binding repeat containing 1
chr2_+_52038005 0.06 ENSMUST00000065927.5
tumor necrosis factor alpha induced protein 6
chrX_+_114474312 0.06 ENSMUST00000113371.1
ENSMUST00000040504.5
kelch-like 4
chr1_-_66817536 0.06 ENSMUST00000068168.3
ENSMUST00000113987.1
KAT8 regulatory NSL complex subunit 1-like
chr2_-_73892619 0.06 ENSMUST00000112007.1
ENSMUST00000112016.2
activating transcription factor 2
chr14_+_70530819 0.05 ENSMUST00000047331.6
leucine-rich repeat LGI family, member 3
chr15_+_76351303 0.05 ENSMUST00000023212.8
ENSMUST00000160172.1
MAF1 homolog (S. cerevisiae)
chr11_+_101155884 0.05 ENSMUST00000043654.9
tubulin, gamma 2
chr6_-_29380426 0.05 ENSMUST00000147483.2
opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
chr1_+_74278550 0.05 ENSMUST00000077985.3
G protein-coupled bile acid receptor 1
chr2_-_73892588 0.04 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
activating transcription factor 2
chr17_+_35379608 0.04 ENSMUST00000081435.4
histocompatibility 2, Q region locus 4
chr9_+_44772951 0.04 ENSMUST00000128150.1
intraflagellar transport 46
chrX_+_13071500 0.04 ENSMUST00000089302.4
ubiquitin specific peptidase 9, X chromosome
chrX_-_7898950 0.04 ENSMUST00000115655.1
ENSMUST00000156741.1
polyglutamine binding protein 1
chr2_-_73892530 0.04 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
activating transcription factor 2
chr9_-_50746501 0.03 ENSMUST00000034564.1
RIKEN cDNA 2310030G06 gene
chr12_+_55089202 0.03 ENSMUST00000021407.10
signal recognition particle 54A
chrX_+_114474569 0.02 ENSMUST00000133447.1
kelch-like 4
chr6_+_14901440 0.02 ENSMUST00000128567.1
forkhead box P2
chr15_+_101174096 0.02 ENSMUST00000000544.9
activin A receptor, type 1B
chr15_-_99457712 0.02 ENSMUST00000161948.1
NCK-associated protein 5-like
chr2_-_5942740 0.02 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
dehydrogenase E1 and transketolase domain containing 1
chr3_-_104366613 0.02 ENSMUST00000056145.2
predicted gene 5546
chr4_+_103619580 0.01 ENSMUST00000106827.1
disabled 1
chr6_-_5193817 0.01 ENSMUST00000002663.5
paraoxonase 1
chr5_-_106624390 0.01 ENSMUST00000112694.1
zinc finger protein 644
chr14_+_80000292 0.01 ENSMUST00000088735.3
olfactomedin 4
chr16_+_44943737 0.01 ENSMUST00000114622.3
ENSMUST00000166731.1
CD200 receptor 3
chr11_-_115603866 0.01 ENSMUST00000125097.1
ENSMUST00000106508.3
ENSMUST00000019135.7
golgi associated, gamma adaptin ear containing, ARF binding protein 3
chr18_+_49832622 0.01 ENSMUST00000180611.1
Dmx-like 1
chr8_+_107150621 0.01 ENSMUST00000034400.3
cytochrome b5 type B
chr11_+_73234292 0.01 ENSMUST00000102526.2
transient receptor potential cation channel, subfamily V, member 1
chr19_+_8819401 0.01 ENSMUST00000096753.3
heterogeneous nuclear ribonucleoprotein U-like 2
chr2_-_174853355 0.01 ENSMUST00000149377.1
predicted gene 14618
chr8_-_45382198 0.01 ENSMUST00000093526.6
family with sequence similarity 149, member A
chr8_+_3631109 0.00 ENSMUST00000004745.8
syntaxin binding protein 2
chr16_+_44173271 0.00 ENSMUST00000088356.4
ENSMUST00000169582.1
predicted gene 608
chr6_+_42286709 0.00 ENSMUST00000163936.1
chloride channel 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1903367 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.7 GO:0008228 opsonization(GO:0008228)
0.1 0.2 GO:1905204 cardiac muscle tissue regeneration(GO:0061026) negative regulation of connective tissue replacement(GO:1905204)
0.1 0.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.8 GO:0031000 response to caffeine(GO:0031000)
0.0 0.1 GO:1904868 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.5 GO:0061450 trophoblast cell migration(GO:0061450)
0.0 0.2 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.1 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.2 GO:1901552 sphingosine-1-phosphate signaling pathway(GO:0003376) positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.4 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.0 0.2 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.2 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.2 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.6 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.1 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:0035473 lipase binding(GO:0035473)
0.0 0.2 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 2.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.2 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.2 GO:0004143 NAD+ kinase activity(GO:0003951) diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME DEFENSINS Genes involved in Defensins
0.1 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint