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2D miR_HR1_12

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Results for E2f7

Z-value: 1.60

Motif logo

Transcription factors associated with E2f7

Gene Symbol Gene ID Gene Info
ENSMUSG00000020185.10 E2F transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.952.1e-06Click!

Activity profile of E2f7 motif

Sorted Z-values of E2f7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_69352886 6.74 ENSMUST00000119827.1
ENSMUST00000020099.5
cyclin-dependent kinase 1
chr15_+_102296256 4.38 ENSMUST00000064924.4
extra spindle poles-like 1 (S. cerevisiae)
chr8_+_75109528 4.21 ENSMUST00000164309.1
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr13_-_100775844 4.20 ENSMUST00000075550.3
centromere protein H
chr3_+_108383829 3.98 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
proline/serine-rich coiled-coil 1
chr2_+_72476159 3.78 ENSMUST00000102691.4
cell division cycle associated 7
chr2_+_72476225 3.66 ENSMUST00000157019.1
cell division cycle associated 7
chr11_+_102248842 3.63 ENSMUST00000100392.4
cDNA sequence BC030867
chr13_-_55329723 3.38 ENSMUST00000021941.7
Max dimerization protein 3
chr12_+_24708984 3.33 ENSMUST00000154588.1
ribonucleotide reductase M2
chr12_-_11265768 3.10 ENSMUST00000166117.1
Gen homolog 1, endonuclease (Drosophila)
chr4_+_108579445 3.04 ENSMUST00000102744.3
origin recognition complex, subunit 1
chr12_+_24708241 3.00 ENSMUST00000020980.5
ribonucleotide reductase M2
chr17_-_35516780 2.98 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
transcription factor 19
chr4_+_126556935 2.82 ENSMUST00000048391.8
claspin
chr1_-_128359610 2.81 ENSMUST00000027601.4
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr7_-_44548733 2.55 ENSMUST00000145956.1
ENSMUST00000049343.8
polymerase (DNA directed), delta 1, catalytic subunit
chr2_+_112261926 2.55 ENSMUST00000028553.3
NOP10 ribonucleoprotein
chr13_+_23581563 2.32 ENSMUST00000102968.1
histone cluster 1, H4d
chr14_+_4334763 2.15 ENSMUST00000165466.1
RIKEN cDNA 2610042L04 gene
chr14_+_4855576 2.04 ENSMUST00000166776.1
predicted gene 3264
chr4_+_126556994 2.02 ENSMUST00000147675.1
claspin
chr9_+_81863744 2.01 ENSMUST00000057067.3
meiosis-specific, MEI4 homolog (S. cerevisiae)
chr18_+_56707725 1.97 ENSMUST00000025486.8
lamin B1
chr6_-_88898664 1.96 ENSMUST00000058011.6
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_116308241 1.93 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
pleckstrin homology domain containing, family A member 7
chr9_+_44084944 1.92 ENSMUST00000176416.1
ENSMUST00000065461.7
ubiquitin specific peptidase 2
chr14_-_7027449 1.86 ENSMUST00000170738.2
predicted gene 10406
chr7_+_28169744 1.84 ENSMUST00000042405.6
fibrillarin
chr7_-_120202104 1.78 ENSMUST00000033198.5
crystallin, mu
chr14_+_3412614 1.70 ENSMUST00000170123.1
predicted gene 10409
chr4_+_136172367 1.49 ENSMUST00000061721.5
E2F transcription factor 2
chr3_+_88532314 1.41 ENSMUST00000172699.1
mex3 homolog A (C. elegans)
chr4_+_132768325 1.40 ENSMUST00000102561.4
replication protein A2
chr10_+_3973086 1.26 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr14_-_54641347 1.21 ENSMUST00000067784.6
cadherin-like 24
chr3_+_126363827 1.20 ENSMUST00000093976.2
arylsulfatase J
chr1_+_180568913 1.15 ENSMUST00000027777.6
poly (ADP-ribose) polymerase family, member 1
chr11_-_70410010 1.09 ENSMUST00000019065.3
ENSMUST00000135148.1
proline, glutamic acid and leucine rich protein 1
chr16_-_37384940 1.04 ENSMUST00000114781.1
ENSMUST00000114780.1
syntaxin binding protein 5-like
chr9_+_64281575 1.03 ENSMUST00000034964.6
timeless interacting protein
chr17_+_12916329 1.03 ENSMUST00000089024.6
ENSMUST00000151287.1
ENSMUST00000143961.1
t-complex protein 1
chrX_-_37085402 1.02 ENSMUST00000115231.3
ribosomal protein L39
chrX_+_153006461 0.96 ENSMUST00000095755.3
ubiquitin specific protease 51
chr12_-_73286698 0.95 ENSMUST00000116420.2
TRM5 tRNA methyltransferase 5
chr6_-_30509706 0.95 ENSMUST00000064330.6
ENSMUST00000102991.2
ENSMUST00000115157.1
ENSMUST00000148638.1
transmembrane protein 209
chr15_+_79030874 0.94 ENSMUST00000171999.1
ENSMUST00000006544.7
glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)
chr19_-_10881677 0.81 ENSMUST00000128835.1
transmembrane protein 109
chr10_+_11281583 0.71 ENSMUST00000070300.4
F-box protein 30
chr19_+_8723478 0.71 ENSMUST00000180819.1
ENSMUST00000181422.1
small nucleolar RNA host gene (non-protein coding) 1
chr7_+_44816088 0.69 ENSMUST00000057195.9
ENSMUST00000107891.1
nucleoporin 62
chr12_+_73286868 0.69 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
solute carrier family 38, member 6
chr12_+_11265867 0.66 ENSMUST00000020931.5
structural maintenance of chromosomes 6
chr11_+_87127267 0.63 ENSMUST00000139532.1
tripartite motif-containing 37
chr4_+_124714776 0.63 ENSMUST00000030734.4
splicing factor 3a, subunit 3
chr10_+_11281304 0.63 ENSMUST00000129456.1
F-box protein 30
chrX_+_68678541 0.62 ENSMUST00000088546.5
fragile X mental retardation syndrome 1
chr6_-_67037399 0.61 ENSMUST00000043098.6
growth arrest and DNA-damage-inducible 45 alpha
chr7_+_66109474 0.61 ENSMUST00000036372.6
chondroitin sulfate synthase 1
chr1_+_86526688 0.59 ENSMUST00000045897.8
prothymosin alpha
chr1_-_156474249 0.58 ENSMUST00000051396.6
sterol O-acyltransferase 1
chr14_-_20388822 0.55 ENSMUST00000022345.6
DnaJ (Hsp40) homolog, subfamily C, member 9
chr4_-_108579330 0.53 ENSMUST00000079213.5
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr15_-_98093245 0.52 ENSMUST00000180657.1
SUMO1/sentrin specific peptidase 1
chr10_-_117376922 0.50 ENSMUST00000177145.1
ENSMUST00000176670.1
cleavage and polyadenylation specific factor 6
chr9_-_58741543 0.49 ENSMUST00000098674.4
RIKEN cDNA 2410076I21 gene
chr11_+_43682038 0.48 ENSMUST00000094294.4
PWWP domain containing 2A
chrX_-_73966329 0.47 ENSMUST00000114372.2
ENSMUST00000033761.6
host cell factor C1
chrX_+_68678624 0.46 ENSMUST00000114656.1
fragile X mental retardation syndrome 1
chr3_-_144202300 0.46 ENSMUST00000121796.1
ENSMUST00000121112.1
LIM domain only 4
chr1_-_180813591 0.45 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3 histone, family 3A
chr19_-_10881723 0.44 ENSMUST00000144681.1
transmembrane protein 109
chr10_-_128409632 0.44 ENSMUST00000172348.1
ENSMUST00000166608.1
ENSMUST00000164199.1
ENSMUST00000171370.1
ENSMUST00000026439.7
nucleic acid binding protein 2
chr13_+_109685994 0.43 ENSMUST00000074103.5
phosphodiesterase 4D, cAMP specific
chr4_+_108459389 0.41 ENSMUST00000106673.1
ENSMUST00000043368.5
zinc finger, CCHC domain containing 11
chr14_-_24486994 0.40 ENSMUST00000026322.7
polymerase (RNA) III (DNA directed) polypeptide A
chr17_-_12916345 0.40 ENSMUST00000079121.3
mitochondrial ribosomal protein L18
chr11_+_88047302 0.38 ENSMUST00000139129.2
serine/arginine-rich splicing factor 1
chr11_-_87404380 0.36 ENSMUST00000067692.6
RAD51 homolog C
chr13_-_21783391 0.35 ENSMUST00000099704.3
histone cluster 1, H3i
chr7_-_45896656 0.32 ENSMUST00000120299.1
synaptogyrin 4
chr10_-_117376955 0.30 ENSMUST00000069168.6
ENSMUST00000176686.1
cleavage and polyadenylation specific factor 6
chr2_+_18672384 0.28 ENSMUST00000171845.1
ENSMUST00000061158.4
COMM domain containing 3
chr11_+_43681998 0.28 ENSMUST00000061070.5
PWWP domain containing 2A
chr17_+_34238914 0.27 ENSMUST00000167280.1
histocompatibility 2, O region beta locus
chr13_-_21833575 0.27 ENSMUST00000081342.5
histone cluster 1, H2ap
chr5_+_43662373 0.27 ENSMUST00000048150.8
coiled-coil and C2 domain containing 2A
chr2_+_130667610 0.27 ENSMUST00000103193.4
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr11_-_95842409 0.27 ENSMUST00000059026.3
ABI gene family, member 3
chr5_+_129020069 0.25 ENSMUST00000031383.7
ENSMUST00000111343.1
RAN, member RAS oncogene family
chr15_-_81871883 0.25 ENSMUST00000023117.8
PHD finger protein 5A
chr11_-_77513335 0.24 ENSMUST00000060417.4
transformation related protein 53 inducible protein 13
chr7_+_110122299 0.24 ENSMUST00000033326.8
WEE 1 homolog 1 (S. pombe)
chr5_-_65697856 0.24 ENSMUST00000031104.6
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr5_+_135187251 0.23 ENSMUST00000002825.5
bromodomain adjacent to zinc finger domain, 1B
chr5_-_137533170 0.23 ENSMUST00000168746.1
ENSMUST00000170293.1
guanine nucleotide binding protein (G protein), beta 2
chr11_+_88047693 0.22 ENSMUST00000079866.4
serine/arginine-rich splicing factor 1
chr9_+_44334685 0.21 ENSMUST00000052686.2
H2A histone family, member X
chr3_+_14533788 0.21 ENSMUST00000108370.2
leucine rich repeat and coiled-coil domain containing 1
chr3_+_14533867 0.21 ENSMUST00000163660.1
leucine rich repeat and coiled-coil domain containing 1
chr11_+_95842283 0.20 ENSMUST00000107714.2
ENSMUST00000107711.1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr7_-_28598140 0.20 ENSMUST00000040531.8
ENSMUST00000108283.1
sterile alpha motif domain containing 4B
p21 protein (Cdc42/Rac)-activated kinase 4
chr7_-_45694369 0.19 ENSMUST00000040636.6
secretory blood group 1
chr1_+_74506044 0.18 ENSMUST00000087215.5
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr17_+_35517100 0.17 ENSMUST00000164242.2
ENSMUST00000045956.7
coiled-coil alpha-helical rod protein 1
chr4_+_108619925 0.17 ENSMUST00000030320.6
coiled-coil and C2 domain containing 1B
chr11_-_6444352 0.17 ENSMUST00000093346.5
ENSMUST00000109737.2
H2A histone family, member V
chr2_-_180920925 0.17 ENSMUST00000037299.8
ENSMUST00000108876.2
YTH domain family 1
chr2_-_26208281 0.16 ENSMUST00000054099.9
LIM homeobox protein 3
chr5_+_130448801 0.13 ENSMUST00000111288.2
calneuron 1
chr19_-_7217549 0.12 ENSMUST00000039758.4
cytochrome c oxidase subunit VIIIa
chr11_+_88047788 0.08 ENSMUST00000107920.3
serine/arginine-rich splicing factor 1
chr18_+_35562158 0.08 ENSMUST00000166793.1
matrin 3
chr7_-_35802968 0.07 ENSMUST00000061586.4
zinc finger protein 507
chr7_-_128740471 0.06 ENSMUST00000119081.1
ENSMUST00000057557.7
MCM (minichromosome maintenance deficient) binding protein
chr3_+_60501252 0.06 ENSMUST00000099087.2
muscleblind-like 1 (Drosophila)
chr17_+_25773769 0.03 ENSMUST00000134108.1
ENSMUST00000002350.4
nuclear prelamin A recognition factor-like
chr1_+_118389058 0.03 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
CLIP associating protein 1
chr19_-_11856001 0.03 ENSMUST00000079875.3
olfactory receptor 1418
chr2_-_36104060 0.03 ENSMUST00000112961.3
ENSMUST00000112966.3
LIM homeobox protein 6
chr14_-_6889962 0.02 ENSMUST00000171906.1
predicted gene 3667
chr7_-_142578139 0.01 ENSMUST00000136359.1
H19 fetal liver mRNA
chr6_-_30509738 0.00 ENSMUST00000115160.3
transmembrane protein 209
chr14_-_7174533 0.00 ENSMUST00000172431.1
predicted gene 3512

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0045004 DNA replication proofreading(GO:0045004)
0.8 3.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.7 6.1 GO:0090166 Golgi disassembly(GO:0090166)
0.7 2.0 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.5 2.1 GO:0060025 regulation of synaptic activity(GO:0060025)
0.5 2.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.5 4.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 4.8 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.4 1.1 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.4 1.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.4 1.1 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.4 6.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 3.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 1.7 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.3 1.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 4.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.2 4.0 GO:0051382 kinetochore assembly(GO:0051382)
0.2 1.0 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 0.7 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 1.8 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 1.5 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 1.3 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
0.2 1.0 GO:0000076 DNA replication checkpoint(GO:0000076)
0.2 1.0 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.2 0.5 GO:0019046 release from viral latency(GO:0019046)
0.2 4.2 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.4 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.1 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 4.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 2.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 1.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.5 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 3.0 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 1.9 GO:0045475 locomotor rhythm(GO:0045475) negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.3 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.1 1.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.6 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379) amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.0 1.0 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.4 GO:0070200 establishment of protein localization to telomere(GO:0070200)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 1.1 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.6 GO:0043486 histone exchange(GO:0043486)
0.0 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 1.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0006378 mRNA polyadenylation(GO:0006378)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.9 2.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 2.5 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.6 5.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.5 7.1 GO:0042555 MCM complex(GO:0042555)
0.3 1.8 GO:0001651 dense fibrillar component(GO:0001651)
0.3 2.0 GO:0005638 lamin filament(GO:0005638)
0.3 1.1 GO:0019034 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.2 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.2 1.9 GO:0005915 zonula adherens(GO:0005915)
0.2 10.8 GO:0005876 spindle microtubule(GO:0005876)
0.2 1.0 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.8 GO:0042382 paraspeckles(GO:0042382)
0.1 1.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 3.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.4 GO:0070876 SOSS complex(GO:0070876)
0.1 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 1.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.4 GO:0048476 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 2.0 GO:0000800 lateral element(GO:0000800)
0.1 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 4.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.0 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 4.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.8 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8 4.2 GO:0043515 kinetochore binding(GO:0043515)
0.8 4.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 6.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 3.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.4 7.0 GO:0035173 histone kinase activity(GO:0035173)
0.4 2.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 1.3 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.3 3.1 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.2 0.6 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 1.8 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 0.5 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 2.6 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 1.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.1 1.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.7 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.7 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.4 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 1.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.0 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.2 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 4.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.2 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 1.4 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0008097 5S rRNA binding(GO:0008097)
0.0 1.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 4.9 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0023026 MHC class II protein complex binding(GO:0023026)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 9.2 PID ATR PATHWAY ATR signaling pathway
0.1 10.8 PID E2F PATHWAY E2F transcription factor network
0.1 7.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 2.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID AURORA A PATHWAY Aurora A signaling
0.0 1.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 1.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.0 9.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.6 9.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 4.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 6.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 2.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events