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2D miR_HR1_12

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Results for Irf5_Irf6

Z-value: 0.56

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Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
ENSMUSG00000029771.6 interferon regulatory factor 5
ENSMUSG00000026638.9 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf6mm10_v2_chr1_+_193153107_193153116-0.215.2e-01Click!
Irf5mm10_v2_chr6_+_29529277_29529296-0.136.9e-01Click!

Activity profile of Irf5_Irf6 motif

Sorted Z-values of Irf5_Irf6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_35826435 1.79 ENSMUST00000060128.5
claudin 23
chr11_+_69966896 1.71 ENSMUST00000151515.1
claudin 7
chr3_+_138065052 0.84 ENSMUST00000163080.2
RIKEN cDNA 1110002E22 gene
chr4_-_40239779 0.66 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr15_+_9436028 0.65 ENSMUST00000042360.3
calcyphosine-like
chr17_+_23679363 0.54 ENSMUST00000024699.2
claudin 6
chr4_-_40239700 0.52 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr8_+_72189613 0.45 ENSMUST00000072097.6
hematopoietic SH2 domain containing
chr16_-_35871544 0.37 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr9_-_14381242 0.37 ENSMUST00000167549.1
endonuclease domain containing 1
chr3_-_32616479 0.34 ENSMUST00000108234.1
ENSMUST00000155737.1
guanine nucleotide binding protein (G protein), beta 4
chr12_+_26469204 0.33 ENSMUST00000020969.3
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr8_+_61928081 0.33 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_+_101582236 0.31 ENSMUST00000039581.7
ENSMUST00000100403.2
ENSMUST00000107194.1
ENSMUST00000128614.1
transmembrane protein 106A
chr19_+_5568002 0.30 ENSMUST00000096318.3
adaptor-related protein complex 5, beta 1 subunit
chr1_-_184732616 0.30 ENSMUST00000048572.6
H2.0-like homeobox
chr9_-_123851855 0.30 ENSMUST00000184082.1
ENSMUST00000167595.2
FYVE and coiled-coil domain containing 1
chr16_+_23609895 0.29 ENSMUST00000038423.5
receptor transporter protein 4
chr1_-_184732444 0.29 ENSMUST00000174257.1
H2.0-like homeobox
chr19_+_55741810 0.29 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
transcription factor 7 like 2, T cell specific, HMG box
chr9_+_45042425 0.28 ENSMUST00000034600.4
myelin protein zero-like 2
chr5_-_24447587 0.27 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
transmembrane and ubiquitin-like domain containing 1
chr4_-_46536134 0.26 ENSMUST00000046897.6
tripartite motif-containing 14
chr6_-_39118211 0.25 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr17_-_6782775 0.25 ENSMUST00000064234.6
ezrin
chr12_-_26456423 0.24 ENSMUST00000020970.7
radical S-adenosyl methionine domain containing 2
chr17_-_32189457 0.24 ENSMUST00000087721.3
ENSMUST00000162117.1
epoxide hydrolase 3
chr12_-_78980758 0.23 ENSMUST00000174072.1
transmembrane protein 229B
chr19_-_5560570 0.19 ENSMUST00000025861.1
OVO homolog-like 1 (Drosophila)
chr17_+_34203527 0.19 ENSMUST00000025197.5
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_77170592 0.19 ENSMUST00000164114.2
ENSMUST00000049544.7
coiled-coil domain containing 141
chr7_-_141010759 0.18 ENSMUST00000026565.6
interferon induced transmembrane protein 3
chr2_-_51934644 0.18 ENSMUST00000165313.1
RNA binding motif protein 43
chr1_+_52119438 0.17 ENSMUST00000070968.7
signal transducer and activator of transcription 1
chr4_-_46536096 0.17 ENSMUST00000102924.2
tripartite motif-containing 14
chr11_+_72301613 0.16 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
XIAP associated factor 1
chr19_+_47937648 0.15 ENSMUST00000066308.7
coiled-coil domain containing 147
chr12_-_31950535 0.15 ENSMUST00000172314.2
high mobility group box transcription factor 1
chr1_+_130826676 0.15 ENSMUST00000027675.7
polymeric immunoglobulin receptor
chr16_+_35938972 0.14 ENSMUST00000023622.6
ENSMUST00000114877.1
poly (ADP-ribose) polymerase family, member 9
chr16_-_67620805 0.13 ENSMUST00000120594.1
cell adhesion molecule 2
chr11_-_78984946 0.12 ENSMUST00000108268.3
lectin, galactose binding, soluble 9
chrX_-_101222426 0.12 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
sorting nexin 12
chr11_-_78984831 0.12 ENSMUST00000073001.4
ENSMUST00000108269.3
lectin, galactose binding, soluble 9
chr6_+_113471427 0.11 ENSMUST00000058300.7
interleukin 17 receptor C
chr17_+_34644805 0.11 ENSMUST00000174796.1
FK506 binding protein-like
chr16_+_35938470 0.11 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr2_-_69586021 0.10 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
low density lipoprotein receptor-related protein 2
chr16_-_67620880 0.09 ENSMUST00000114292.1
ENSMUST00000120898.1
cell adhesion molecule 2
chr12_-_31950210 0.09 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
high mobility group box transcription factor 1
chr1_-_163313661 0.09 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
paired related homeobox 1
chr17_-_34862473 0.09 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr3_+_142496924 0.08 ENSMUST00000090127.2
guanylate binding protein 5
chr7_-_141266415 0.08 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
interferon regulatory factor 7
chr1_+_130826762 0.07 ENSMUST00000133792.1
polymeric immunoglobulin receptor
chr5_-_45857473 0.07 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
ligand dependent nuclear receptor corepressor-like
chr10_-_43174521 0.07 ENSMUST00000040275.7
sine oculis-binding protein homolog (Drosophila)
chr2_-_77170534 0.06 ENSMUST00000111833.2
coiled-coil domain containing 141
chr2_-_77519565 0.06 ENSMUST00000111830.2
zinc finger protein 385B
chr17_+_34644764 0.05 ENSMUST00000036720.8
FK506 binding protein-like
chr7_+_49246131 0.05 ENSMUST00000064395.6
neuron navigator 2
chr11_-_120348513 0.05 ENSMUST00000071555.6
actin, gamma, cytoplasmic 1
chr6_-_38354243 0.05 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr12_-_31950170 0.05 ENSMUST00000176520.1
high mobility group box transcription factor 1
chr9_-_111057235 0.04 ENSMUST00000111888.1
chemokine (C-C motif) receptor-like 2
chrX_+_77511002 0.03 ENSMUST00000088217.5
transducin (beta)-like 1 X-linked
chr7_-_126396715 0.02 ENSMUST00000075671.4
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr7_+_128523576 0.02 ENSMUST00000033136.7
BCL2-associated athanogene 3
chr3_+_135438722 0.02 ENSMUST00000166033.1
ubiquitin-conjugating enzyme E2D 3
chr1_-_105356658 0.01 ENSMUST00000058688.5
ENSMUST00000172299.1
ring finger protein 152
chr4_-_116651644 0.00 ENSMUST00000030455.8
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr7_-_44375006 0.00 ENSMUST00000107933.1
RIKEN cDNA 1700008O03 gene
chr7_-_126594941 0.00 ENSMUST00000058429.5
interleukin 27

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0009597 detection of virus(GO:0009597)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.3 GO:0009138 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 1.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 0.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.2 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.2 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.2 GO:0046968 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591) peptide antigen transport(GO:0046968)
0.1 0.3 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:2000562 regulation of natural killer cell degranulation(GO:0043321) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.2 GO:0034239 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239)
0.0 0.3 GO:0048625 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) embryonic hindgut morphogenesis(GO:0048619) myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.3 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 0.1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 3.0 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.2 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 1.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling