Project

2D miR_HR1_12

Navigation
Downloads

Results for Egr4

Z-value: 0.65

Motif logo

Transcription factors associated with Egr4

Gene Symbol Gene ID Gene Info
ENSMUSG00000071341.3 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr4mm10_v2_chr6_-_85513586_85513591-0.745.7e-03Click!

Activity profile of Egr4 motif

Sorted Z-values of Egr4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_137288273 1.22 ENSMUST00000024099.4
ENSMUST00000085934.3
acetylcholinesterase
chrX_+_36195968 1.20 ENSMUST00000115256.1
zinc finger, CCHC domain containing 12
chrX_+_36195938 1.01 ENSMUST00000048067.3
zinc finger, CCHC domain containing 12
chrX_+_36195904 0.99 ENSMUST00000115258.2
zinc finger, CCHC domain containing 12
chrX_+_36195950 0.99 ENSMUST00000115257.1
zinc finger, CCHC domain containing 12
chr11_+_114851814 0.81 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
G protein-coupled receptor, family C, group 5, member C
chrX_+_49470450 0.77 ENSMUST00000114904.3
Rho GTPase activating protein 36
chr3_-_89089955 0.76 ENSMUST00000166687.1
RUN and SH3 domain containing 1
chrX_+_49470555 0.63 ENSMUST00000042444.6
Rho GTPase activating protein 36
chr10_-_116473875 0.62 ENSMUST00000068233.4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr6_-_4747157 0.58 ENSMUST00000090686.4
ENSMUST00000115579.1
ENSMUST00000115577.2
ENSMUST00000101677.3
ENSMUST00000004750.8
sarcoglycan, epsilon
chr6_+_4747306 0.55 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
paternally expressed 10
chr11_+_114851507 0.53 ENSMUST00000177952.1
G protein-coupled receptor, family C, group 5, member C
chr11_+_4186789 0.51 ENSMUST00000041042.6
ENSMUST00000180088.1
TBC1 domain family, member 10a
chr6_-_4747019 0.48 ENSMUST00000126151.1
ENSMUST00000133306.1
ENSMUST00000123907.1
sarcoglycan, epsilon
chr7_+_102267795 0.46 ENSMUST00000033289.4
stromal interaction molecule 1
chr4_-_43046196 0.45 ENSMUST00000036462.5
family with sequence similarity 214, member B
chrX_-_153037549 0.44 ENSMUST00000051484.3
melanoma antigen, family H, 1
chr11_+_45980309 0.39 ENSMUST00000049038.3
SRY-box containing gene 30
chr4_+_86748526 0.39 ENSMUST00000082026.7
ENSMUST00000045512.8
DENN/MADD domain containing 4C
chr12_-_91849081 0.35 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
sel-1 suppressor of lin-12-like (C. elegans)
chr10_-_116473418 0.34 ENSMUST00000087965.4
ENSMUST00000164271.1
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr4_-_151996113 0.34 ENSMUST00000055688.9
PHD finger protein 13
chr11_+_103116228 0.34 ENSMUST00000053063.5
hexamethylene bis-acetamide inducible 1
chr2_+_119237531 0.33 ENSMUST00000110817.2
serine protease inhibitor, Kunitz type 1
chr2_-_66634952 0.32 ENSMUST00000100064.2
ENSMUST00000100063.2
sodium channel, voltage-gated, type IX, alpha
chr10_-_81350305 0.31 ENSMUST00000167481.1
high mobility group 20B
chr10_-_81350389 0.30 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
high mobility group 20B
chrX_-_20291728 0.30 ENSMUST00000115393.2
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr2_+_156008045 0.30 ENSMUST00000006035.6
ERGIC and golgi 3
chr9_+_65630552 0.29 ENSMUST00000055844.8
RNA binding protein with multiple splicing 2
chr2_+_156008088 0.29 ENSMUST00000088650.4
ERGIC and golgi 3
chr10_-_81350191 0.29 ENSMUST00000122993.1
high mobility group 20B
chr2_+_119237351 0.28 ENSMUST00000028783.7
serine protease inhibitor, Kunitz type 1
chr2_+_119237453 0.28 ENSMUST00000110816.1
serine protease inhibitor, Kunitz type 1
chr11_-_86993682 0.27 ENSMUST00000018571.4
yippee-like 2 (Drosophila)
chr9_+_108306205 0.26 ENSMUST00000007959.8
ras homolog gene family, member A
chr19_-_21652714 0.26 ENSMUST00000177577.1
RIKEN cDNA 1110059E24 gene
chr11_-_51688614 0.25 ENSMUST00000007921.2
RIKEN cDNA 0610009B22 gene
chr19_+_6363671 0.23 ENSMUST00000131252.1
splicing factor 1
chr8_+_69088646 0.22 ENSMUST00000006435.7
ATPase, H+ transporting, lysosomal V1 subunit B2
chrX_-_20291776 0.21 ENSMUST00000072451.4
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr13_+_48261427 0.21 ENSMUST00000021810.1
inhibitor of DNA binding 4
chr4_+_128883549 0.20 ENSMUST00000035667.8
tripartite motif-containing 62
chr19_-_5085483 0.19 ENSMUST00000140389.1
ENSMUST00000151413.1
ENSMUST00000077066.7
transmembrane protein 151A
chr9_+_21165714 0.18 ENSMUST00000039413.8
phosphodiesterase 4A, cAMP specific
chr16_+_8830093 0.18 ENSMUST00000023150.5
RIKEN cDNA 1810013L24 gene
chr19_+_38264761 0.18 ENSMUST00000087252.5
leucine-rich repeat LGI family, member 1
chr2_-_121355284 0.18 ENSMUST00000134796.1
ENSMUST00000110628.1
ENSMUST00000110627.1
ENSMUST00000110625.1
diphosphoinositol pentakisphosphate kinase 1
chr17_+_34647187 0.17 ENSMUST00000173984.1
activating transcription factor 6 beta
chr12_+_17690793 0.17 ENSMUST00000071858.3
hippocalcin-like 1
chr19_+_6363719 0.17 ENSMUST00000113489.1
ENSMUST00000113488.1
splicing factor 1
chr19_-_50678642 0.17 ENSMUST00000072685.6
ENSMUST00000164039.2
VPS10 domain receptor protein SORCS 1
chr15_+_58141397 0.17 ENSMUST00000067563.7
WDYHV motif containing 1
chr9_-_102354685 0.17 ENSMUST00000035129.7
ENSMUST00000085169.5
Eph receptor B1
chr9_+_118926453 0.16 ENSMUST00000073109.5
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr8_-_92356103 0.16 ENSMUST00000034183.3
RIKEN cDNA 4933436C20 gene
chr17_+_34647128 0.16 ENSMUST00000015605.8
ENSMUST00000182587.1
activating transcription factor 6 beta
chr11_-_96777492 0.16 ENSMUST00000127375.1
ENSMUST00000021246.2
ENSMUST00000107661.3
sorting nexin 11
chrX_+_7842056 0.15 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
OTU domain containing 5
chr5_+_145084100 0.14 ENSMUST00000124379.1
actin related protein 2/3 complex, subunit 1A
chr1_+_167001457 0.14 ENSMUST00000126198.1
family with sequence similarity 78, member B
chr17_+_69383024 0.14 ENSMUST00000112674.1
zinc finger and BTB domain containing 14
chr17_+_24470393 0.14 ENSMUST00000053024.6
phosphoglycolate phosphatase
chr11_+_70000578 0.13 ENSMUST00000019362.8
dishevelled 2, dsh homolog (Drosophila)
chr7_+_35119285 0.11 ENSMUST00000042985.9
CCAAT/enhancer binding protein (C/EBP), alpha
chr9_+_108347827 0.11 ENSMUST00000035237.6
ubiquitin specific peptidase 4 (proto-oncogene)
chr10_+_19591949 0.10 ENSMUST00000020188.6
interferon gamma receptor 1
chr19_+_6363896 0.10 ENSMUST00000113487.1
splicing factor 1
chr9_-_44440868 0.09 ENSMUST00000098837.1
forkhead box R1
chr18_+_35829798 0.09 ENSMUST00000060722.6
CXXC finger 5
chr6_+_127149389 0.09 ENSMUST00000180811.1
RIKEN cDNA 9330179D12 gene
chr9_+_59750876 0.08 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
myosin IXa
chr19_-_5273080 0.08 ENSMUST00000025786.7
phosphofurin acidic cluster sorting protein 1
chr1_-_36939521 0.08 ENSMUST00000027290.5
transmembrane protein 131
chr2_+_32535315 0.08 ENSMUST00000133512.1
ENSMUST00000048375.5
family with sequence similarity 102, member A
chr5_-_31295862 0.08 ENSMUST00000041266.7
ENSMUST00000172435.1
fibronectin type III domain containing 4
chr4_+_99955715 0.07 ENSMUST00000102783.4
phosphoglucomutase 2
chr11_-_86757483 0.07 ENSMUST00000060766.9
ENSMUST00000103186.4
clathrin, heavy polypeptide (Hc)
chrX_+_152144240 0.06 ENSMUST00000168786.1
ENSMUST00000112605.1
ENSMUST00000112604.1
IQ motif and Sec7 domain 2
chr8_-_11312731 0.05 ENSMUST00000033898.9
collagen, type IV, alpha 1
chr8_+_11312805 0.05 ENSMUST00000033899.7
collagen, type IV, alpha 2
chr19_-_50678485 0.05 ENSMUST00000111756.3
VPS10 domain receptor protein SORCS 1
chr9_-_59750616 0.04 ENSMUST00000163586.1
ENSMUST00000177963.1
ENSMUST00000051039.4
SUMO/sentrin specific peptidase 8
chr2_+_105127200 0.04 ENSMUST00000139585.1
Wilms tumor 1 homolog
chr4_+_99656299 0.04 ENSMUST00000087285.3
forkhead box D3
chr2_+_124610278 0.03 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr3_+_135438722 0.03 ENSMUST00000166033.1
ubiquitin-conjugating enzyme E2D 3
chrX_-_12762069 0.03 ENSMUST00000096495.4
ENSMUST00000076016.5
mediator complex subunit 14
chr14_+_79481164 0.03 ENSMUST00000040131.5
E74-like factor 1
chrX_+_7762652 0.03 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
transcription factor E3
chr6_-_3968357 0.03 ENSMUST00000031674.8
tissue factor pathway inhibitor 2
chr3_+_144570687 0.03 ENSMUST00000106211.1
selenoprotein
chr11_+_3649494 0.02 ENSMUST00000093389.2
microrchidia 2A
chr16_+_44173271 0.02 ENSMUST00000088356.4
ENSMUST00000169582.1
predicted gene 608
chrX_-_145505175 0.02 ENSMUST00000143610.1
angiomotin
chr6_-_85451248 0.00 ENSMUST00000113770.1
ENSMUST00000032080.2
protease-associated domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.2 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 1.4 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:1990868 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 0.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 0.2 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.0 0.5 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.5 GO:0033327 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.0 0.3 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.3 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.0 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.0 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0071285 cellular response to lithium ion(GO:0071285)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.2 1.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005118 sevenless binding(GO:0005118)
0.3 1.2 GO:0004104 cholinesterase activity(GO:0004104)
0.1 4.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.5 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 1.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0052724 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.1 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.0 0.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)