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2D miR_HR1_12

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Results for Hsf1

Z-value: 0.43

Motif logo

Transcription factors associated with Hsf1

Gene Symbol Gene ID Gene Info
ENSMUSG00000022556.9 heat shock factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_764774610.556.5e-02Click!

Activity profile of Hsf1 motif

Sorted Z-values of Hsf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_80844025 0.62 ENSMUST00000053986.7
leucine rich repeat and Ig domain containing 3
chr2_+_157560078 0.59 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
neuronatin
chr14_-_65833963 0.51 ENSMUST00000022613.9
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr4_+_17853451 0.49 ENSMUST00000029881.3
matrix metallopeptidase 16
chr5_-_149636164 0.42 ENSMUST00000076410.4
heat shock 105kDa/110kDa protein 1
chr15_+_62039216 0.41 ENSMUST00000183297.1
plasmacytoma variant translocation 1
chr10_+_86302854 0.38 ENSMUST00000132307.1
tissue inhibitor of metalloproteinase 3
chr12_-_110695860 0.38 ENSMUST00000149189.1
heat shock protein 90, alpha (cytosolic), class A member 1
chr6_+_128438757 0.37 ENSMUST00000144745.1
predicted gene 10069
chr6_-_128438673 0.34 ENSMUST00000032508.4
FK506 binding protein 4
chr7_-_19310035 0.34 ENSMUST00000003640.2
FBJ osteosarcoma oncogene B
chr1_+_66322102 0.33 ENSMUST00000123647.1
microtubule-associated protein 2
chr12_-_110696248 0.33 ENSMUST00000124156.1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_+_117843873 0.33 ENSMUST00000176735.1
ENSMUST00000177339.1
cell division cycle associated 7 like
chr5_-_139484420 0.31 ENSMUST00000150992.1
zinc finger, AN1-type domain 2A
chr15_-_31601506 0.30 ENSMUST00000161266.1
chaperonin containing Tcp1, subunit 5 (epsilon)
chr19_-_7039987 0.29 ENSMUST00000025918.7
stress-induced phosphoprotein 1
chr12_-_110696289 0.29 ENSMUST00000021698.6
heat shock protein 90, alpha (cytosolic), class A member 1
chr5_+_129787390 0.29 ENSMUST00000031402.8
chaperonin containing Tcp1, subunit 6a (zeta)
chr8_-_48555846 0.28 ENSMUST00000110345.1
ENSMUST00000110343.1
teneurin transmembrane protein 3
chr9_+_40801235 0.28 ENSMUST00000117870.1
ENSMUST00000117557.1
heat shock protein 8
chrX_+_42149534 0.28 ENSMUST00000127618.1
stromal antigen 2
chr6_-_72439549 0.28 ENSMUST00000059472.8
methionine adenosyltransferase II, alpha
chr7_-_89941084 0.27 ENSMUST00000075010.4
ENSMUST00000153470.1
lethal, Chr 7, Rinchik 6
chr12_-_110696332 0.27 ENSMUST00000094361.4
heat shock protein 90, alpha (cytosolic), class A member 1
chr1_-_55088156 0.26 ENSMUST00000127861.1
ENSMUST00000144077.1
heat shock protein 1 (chaperonin)
chr3_+_79591356 0.26 ENSMUST00000029382.7
peptidylprolyl isomerase D (cyclophilin D)
chr5_-_143895025 0.26 ENSMUST00000079624.5
ENSMUST00000110717.2
ankyrin repeat domain 61
chr1_+_66321708 0.25 ENSMUST00000114013.1
microtubule-associated protein 2
chr6_+_51470339 0.24 ENSMUST00000094623.3
chromobox 3
chr15_-_31601786 0.23 ENSMUST00000022842.8
chaperonin containing Tcp1, subunit 5 (epsilon)
chr5_-_149184063 0.22 ENSMUST00000180733.1
RIKEN cDNA 5730422E09 gene
chr12_-_103355967 0.22 ENSMUST00000021617.7
ankyrin repeat and SOCS box-containing 2
chr11_+_22990519 0.22 ENSMUST00000173867.1
ENSMUST00000020562.4
chaperonin containing Tcp1, subunit 4 (delta)
chr4_-_136892867 0.21 ENSMUST00000046332.5
complement component 1, q subcomponent, C chain
chr7_-_89941196 0.20 ENSMUST00000117354.1
lethal, Chr 7, Rinchik 6
chr11_-_116843449 0.20 ENSMUST00000047616.3
jumonji domain containing 6
chr16_-_87495704 0.19 ENSMUST00000176750.1
ENSMUST00000175977.1
chaperonin containing Tcp1, subunit 8 (theta)
chr5_+_66676098 0.18 ENSMUST00000031131.9
ubiquitin carboxy-terminal hydrolase L1
chr5_+_115908644 0.18 ENSMUST00000141101.1
citron
chr11_-_106579111 0.18 ENSMUST00000103070.2
testis expressed gene 2
chr6_-_51469836 0.18 ENSMUST00000090002.7
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_-_48946148 0.17 ENSMUST00000104958.1
protease (prosome, macropain) activator subunit 2B
chr16_-_87495823 0.17 ENSMUST00000176041.1
ENSMUST00000026704.7
chaperonin containing Tcp1, subunit 8 (theta)
chr1_-_55088024 0.16 ENSMUST00000027123.8
heat shock protein 1 (chaperonin)
chr17_-_45572495 0.16 ENSMUST00000130406.1
heat shock protein 90 alpha (cytosolic), class B member 1
chr5_-_129787175 0.15 ENSMUST00000031399.6
phosphoserine phosphatase
chr16_-_94856682 0.15 ENSMUST00000165538.1
potassium inwardly-rectifying channel, subfamily J, member 6
chr6_-_51469869 0.15 ENSMUST00000114459.1
ENSMUST00000069949.6
heterogeneous nuclear ribonucleoprotein A2/B1
chr17_+_31564749 0.15 ENSMUST00000175806.1
ENSMUST00000097352.3
Pbx/knotted 1 homeobox
chrX_-_150657366 0.14 ENSMUST00000148604.1
trophinin
chr2_+_29124106 0.14 ENSMUST00000129544.1
senataxin
chr11_+_83662579 0.14 ENSMUST00000019074.3
chemokine (C-C motif) ligand 4
chr17_+_48299952 0.13 ENSMUST00000170941.1
triggering receptor expressed on myeloid cells-like 2
chr7_+_35586232 0.12 ENSMUST00000040844.9
ankyrin repeat domain 27 (VPS9 domain)
chr17_+_34417347 0.12 ENSMUST00000142317.1
cDNA sequence BC051142
chr5_-_149636331 0.11 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
heat shock 105kDa/110kDa protein 1
chr7_+_111028951 0.10 ENSMUST00000005749.5
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr16_-_22265950 0.09 ENSMUST00000161286.1
transformer 2 beta homolog (Drosophila)
chr4_+_155601854 0.09 ENSMUST00000118607.1
solute carrier family 35, member E2
chr9_+_18292267 0.09 ENSMUST00000001825.7
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr13_+_44729535 0.08 ENSMUST00000174068.1
jumonji, AT rich interactive domain 2
chr4_+_155601414 0.08 ENSMUST00000105608.2
solute carrier family 35, member E2
chr2_+_119897212 0.08 ENSMUST00000046717.6
ENSMUST00000110774.1
ENSMUST00000110773.2
ENSMUST00000079934.5
ENSMUST00000156510.1
MAX gene associated
chr2_+_19344317 0.07 ENSMUST00000141289.1
RIKEN cDNA 4930447M23 gene
chr15_+_28203726 0.07 ENSMUST00000067048.6
dynein, axonemal, heavy chain 5
chr4_+_148140699 0.07 ENSMUST00000140049.1
ENSMUST00000105707.1
MAD2 mitotic arrest deficient-like 2
chr11_+_116843278 0.07 ENSMUST00000106370.3
methyltransferase like 23
chr7_+_49759100 0.07 ENSMUST00000085272.5
HIV-1 tat interactive protein 2, homolog (human)
chrX_-_150657392 0.06 ENSMUST00000151403.2
ENSMUST00000087253.4
ENSMUST00000112709.1
ENSMUST00000163969.1
ENSMUST00000087258.3
trophinin
chr6_+_58831748 0.06 ENSMUST00000126292.1
ENSMUST00000031823.5
hect domain and RLD 3
chr15_-_81399594 0.06 ENSMUST00000023039.8
suppression of tumorigenicity 13
chr6_-_136941887 0.06 ENSMUST00000111891.1
Rho, GDP dissociation inhibitor (GDI) beta
chr2_-_92460449 0.06 ENSMUST00000125276.1
solute carrier family 35, member C1
chr2_-_146511992 0.06 ENSMUST00000109986.2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr18_+_77065195 0.05 ENSMUST00000114777.2
protein inhibitor of activated STAT 2
chr6_+_24528144 0.05 ENSMUST00000031696.3
ankyrin repeat and SOCS box-containing 15
chr11_+_83437678 0.05 ENSMUST00000037378.4
RIKEN cDNA 1700020L24 gene
chr4_+_40722912 0.05 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr9_+_120110349 0.05 ENSMUST00000035106.5
solute carrier family 25, member 38
chr4_-_133545906 0.05 ENSMUST00000030665.6
nuclear distribution gene C homolog (Aspergillus)
chrX_-_73659724 0.05 ENSMUST00000114473.1
ENSMUST00000002087.7
pregnancy upregulated non-ubiquitously expressed CaM kinase
chrX_-_140956675 0.05 ENSMUST00000033805.8
ENSMUST00000112978.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr15_+_81400132 0.05 ENSMUST00000163754.1
ENSMUST00000041609.4
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr7_+_44012672 0.04 ENSMUST00000048945.4
kallikrein 1-related petidase b26
chr17_-_56874421 0.04 ENSMUST00000043062.4
acyl-CoA synthetase bubblegum family member 2
chr15_-_81400043 0.04 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
suppression of tumorigenicity 13
chr7_+_119895836 0.04 ENSMUST00000106518.1
ENSMUST00000054440.3
LYR motif containing 1
chr13_-_111490111 0.03 ENSMUST00000047627.7
GC-rich promoter binding protein 1
chr11_+_100619217 0.03 ENSMUST00000107376.1
NFKB inhibitor interacting Ras-like protein 2
chrX_-_73660047 0.03 ENSMUST00000114472.1
pregnancy upregulated non-ubiquitously expressed CaM kinase
chr3_-_106547564 0.03 ENSMUST00000121231.1
ENSMUST00000141525.1
choline/ethanolaminephosphotransferase 1
chr5_+_29735940 0.03 ENSMUST00000114839.1
DnaJ (Hsp40) homolog, subfamily B, member 6
chr7_+_92561141 0.03 ENSMUST00000032842.6
ENSMUST00000085017.4
coiled-coil domain containing 90B
chr13_+_41655697 0.03 ENSMUST00000067176.8
predicted gene 5082
chr1_+_153874335 0.02 ENSMUST00000055314.3
predicted gene 5531
chr5_+_149184678 0.02 ENSMUST00000139474.1
ENSMUST00000117878.1
ubiquitin specific peptidase like 1
chr2_+_72297895 0.02 ENSMUST00000144111.1
sterile alpha motif and leucine zipper containing kinase AZK
chr2_+_25180737 0.02 ENSMUST00000104999.2
Notch-regulated ankyrin repeat protein
chr8_-_109693235 0.02 ENSMUST00000034164.4
increased sodium tolerance 1 homolog (yeast)
chr4_-_141538434 0.02 ENSMUST00000078886.3
SPEN homolog, transcriptional regulator (Drosophila)
chr10_-_61383523 0.02 ENSMUST00000020289.8
phosphatase domain containing, paladin 1
chr5_+_29735991 0.01 ENSMUST00000012734.5
DnaJ (Hsp40) homolog, subfamily B, member 6
chr19_-_29812952 0.01 ENSMUST00000099525.3
RAN binding protein 6
chr5_+_129020069 0.01 ENSMUST00000031383.7
ENSMUST00000111343.1
RAN, member RAS oncogene family
chr5_+_149184555 0.01 ENSMUST00000050472.9
ubiquitin specific peptidase like 1
chr11_-_5099084 0.01 ENSMUST00000063232.6
Ewing sarcoma breakpoint region 1
chr12_-_54695829 0.01 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
E2F-associated phosphoprotein
chr17_+_28530834 0.01 ENSMUST00000025060.2
armadillo repeat containing 12
chr17_+_47593516 0.01 ENSMUST00000182874.1
cyclin D3
chr12_-_54695813 0.01 ENSMUST00000110713.3
E2F-associated phosphoprotein
chr7_-_70366735 0.00 ENSMUST00000089565.5
nuclear receptor subfamily 2, group F, member 2
chr5_-_28055440 0.00 ENSMUST00000181503.1
predicted gene, 26608

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 0.4 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 1.4 GO:1904871 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.3 GO:0097212 protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) positive regulation of protein folding(GO:1903334)
0.1 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.5 GO:1903750 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 0.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.2 GO:1903660 transforming growth factor beta activation(GO:0036363) regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.0 0.3 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.1 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.5 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.2 GO:0043654 peptidyl-lysine hydroxylation(GO:0017185) recognition of apoptotic cell(GO:0043654)
0.0 0.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.6 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.1 GO:0035542 negative regulation of vesicle fusion(GO:0031339) regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.1 GO:0061083 regulation of protein refolding(GO:0061083)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.3 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.3 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0002135 CTP binding(GO:0002135)
0.1 0.3 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.2 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0032564 dATP binding(GO:0032564)
0.0 1.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.0 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation