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2D miR_HR1_12

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Results for Pknox2_Pknox1

Z-value: 0.37

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Transcription factors associated with Pknox2_Pknox1

Gene Symbol Gene ID Gene Info
ENSMUSG00000035934.9 Pbx/knotted 1 homeobox 2
ENSMUSG00000006705.6 Pbx/knotted 1 homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_315648540.773.6e-03Click!
Pknox2mm10_v2_chr9_-_37147257_371473230.528.2e-02Click!

Activity profile of Pknox2_Pknox1 motif

Sorted Z-values of Pknox2_Pknox1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_31913462 1.78 ENSMUST00000116615.3
BarH-like homeobox 2
chr7_-_48881032 0.49 ENSMUST00000058745.8
E2F transcription factor 8
chr19_-_9899450 0.49 ENSMUST00000025562.7
inner centromere protein
chr10_-_123196916 0.36 ENSMUST00000020334.7
ubiquitin specific peptidase 15
chr10_+_41810528 0.35 ENSMUST00000099931.3
sestrin 1
chr11_+_78826575 0.34 ENSMUST00000147875.2
ENSMUST00000141321.1
LYR motif containing 9
chr8_+_20136455 0.30 ENSMUST00000179299.1
ENSMUST00000096485.4
predicted gene, 21811
chr17_-_48432723 0.29 ENSMUST00000046549.3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr13_+_63815240 0.29 ENSMUST00000021926.5
ENSMUST00000095724.3
ENSMUST00000143449.1
ENSMUST00000067821.5
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
chr5_-_138619653 0.29 ENSMUST00000129832.1
zinc finger protein 68
chr11_+_23256001 0.27 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
exportin 1, CRM1 homolog (yeast)
chr7_-_48881596 0.23 ENSMUST00000119223.1
E2F transcription factor 8
chr9_-_62980874 0.22 ENSMUST00000098651.4
protein inhibitor of activated STAT 1
chr7_-_131410325 0.22 ENSMUST00000154602.1
IKAROS family zinc finger 5
chr2_-_31141802 0.22 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
formin binding protein 1
chr3_-_51560816 0.21 ENSMUST00000037141.7
SET domain containing (lysine methyltransferase) 7
chr2_-_34913976 0.21 ENSMUST00000028232.3
PHD finger protein 19
chr5_+_138820080 0.20 ENSMUST00000179205.1
predicted gene 5294
chr11_+_3202908 0.18 ENSMUST00000179770.1
ENSMUST00000110048.1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr16_-_43979050 0.17 ENSMUST00000165648.1
ENSMUST00000036321.7
zinc finger, DHHC domain containing 23
chrX_-_48034842 0.17 ENSMUST00000039026.7
apelin
chr3_+_95232287 0.17 ENSMUST00000107200.1
ENSMUST00000107199.1
CDC42 small effector 1
chr1_+_156558759 0.16 ENSMUST00000173929.1
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr7_-_127273919 0.16 ENSMUST00000082428.3
selenophosphate synthetase 2
chr11_+_117986292 0.15 ENSMUST00000132676.1
phosphatidylglycerophosphate synthase 1
chr6_+_54039558 0.15 ENSMUST00000046856.7
chimerin (chimaerin) 2
chr17_-_70851189 0.15 ENSMUST00000059775.8
TGFB-induced factor homeobox 1
chr5_-_100500592 0.15 ENSMUST00000149714.1
ENSMUST00000046154.5
lin-54 homolog (C. elegans)
chr8_+_19682268 0.15 ENSMUST00000153710.1
ENSMUST00000127799.1
predicted gene 6483
chr10_+_50592669 0.14 ENSMUST00000035606.8
activating signal cointegrator 1 complex subunit 3
chr8_-_111522073 0.14 ENSMUST00000034437.6
ENSMUST00000038193.7
WD repeat domain 59
chr1_+_74588347 0.14 ENSMUST00000113732.1
BCS1-like (yeast)
chr3_+_116594959 0.14 ENSMUST00000029571.8
spindle assembly 6 homolog (C. elegans)
chr2_-_160872829 0.14 ENSMUST00000176141.1
zinc fingers and homeoboxes 3
chr7_-_45434590 0.14 ENSMUST00000107771.3
ENSMUST00000141761.1
RuvB-like protein 2
chr6_-_106800051 0.13 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
cereblon
chr9_-_29963112 0.13 ENSMUST00000075069.4
neurotrimin
chr1_-_179546261 0.13 ENSMUST00000027769.5
transcription factor B2, mitochondrial
chr5_+_150673739 0.13 ENSMUST00000016569.4
ENSMUST00000038900.8
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr13_-_24206281 0.13 ENSMUST00000123076.1
leucine rich repeat containing 16A
chr7_+_89404356 0.12 ENSMUST00000058755.3
frizzled homolog 4 (Drosophila)
chr1_+_74588289 0.12 ENSMUST00000113733.3
ENSMUST00000027358.4
BCS1-like (yeast)
chr3_+_51415986 0.12 ENSMUST00000029303.7
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr6_+_54039935 0.12 ENSMUST00000114403.1
chimerin (chimaerin) 2
chr10_-_41072279 0.12 ENSMUST00000061796.6
G protein-coupled receptor 6
chr15_-_76723814 0.12 ENSMUST00000036247.8
RIKEN cDNA C030006K11 gene
chr9_+_113930934 0.11 ENSMUST00000084885.5
ENSMUST00000009885.7
upstream binding protein 1
chr11_-_49712674 0.11 ENSMUST00000020624.6
ENSMUST00000145353.1
CCR4-NOT transcription complex, subunit 6
chr2_+_146855861 0.11 ENSMUST00000099278.2
ENSMUST00000156232.1
polo-like kinase 1 substrate 1
chr17_-_24141542 0.11 ENSMUST00000115411.1
ENSMUST00000115409.2
ENSMUST00000115407.2
ENSMUST00000102927.3
3-phosphoinositide dependent protein kinase 1
chr3_+_85574109 0.10 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
PET112 homolog (S. cerevisiae)
chr2_+_162987330 0.10 ENSMUST00000018012.7
serum/glucocorticoid regulated kinase 2
chr5_-_25498702 0.09 ENSMUST00000173073.1
ENSMUST00000045291.7
lysine (K)-specific methyltransferase 2C
chrX_-_109013389 0.09 ENSMUST00000033597.8
high-mobility group nucleosome binding domain 5
chr13_+_109685994 0.09 ENSMUST00000074103.5
phosphodiesterase 4D, cAMP specific
chr2_+_162987502 0.09 ENSMUST00000117123.1
serum/glucocorticoid regulated kinase 2
chr9_+_67840386 0.09 ENSMUST00000077879.5
vacuolar protein sorting 13C (yeast)
chr15_+_59374198 0.09 ENSMUST00000079703.3
ENSMUST00000168722.1
non-SMC element 2 homolog (MMS21, S. cerevisiae)
chr17_+_35533194 0.09 ENSMUST00000025273.8
psoriasis susceptibility 1 candidate 2 (human)
chr18_+_49832622 0.09 ENSMUST00000180611.1
Dmx-like 1
chr7_-_131410495 0.08 ENSMUST00000121033.1
ENSMUST00000046306.8
IKAROS family zinc finger 5
chr3_+_137864487 0.08 ENSMUST00000041045.7
H2A histone family, member Z
chr10_-_42276688 0.08 ENSMUST00000175881.1
ENSMUST00000056974.3
forkhead box O3
chr2_-_160872985 0.08 ENSMUST00000109460.1
ENSMUST00000127201.1
zinc fingers and homeoboxes 3
chr5_-_71548190 0.07 ENSMUST00000050129.5
cytochrome c oxidase subunit VIIb2
chr1_+_75549581 0.07 ENSMUST00000154101.1
solute carrier family 4 (anion exchanger), member 3
chr17_-_70851710 0.07 ENSMUST00000166395.2
TGFB-induced factor homeobox 1
chr1_+_156558844 0.07 ENSMUST00000166172.2
ENSMUST00000027888.6
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr1_-_87101590 0.07 ENSMUST00000113270.2
alkaline phosphatase, intestinal
chr2_-_113758638 0.07 ENSMUST00000099575.3
gremlin 1
chr9_-_86880414 0.07 ENSMUST00000074501.5
ENSMUST00000098495.3
ENSMUST00000074468.6
ENSMUST00000036347.6
synaptosomal-associated protein 91
chr11_-_80080928 0.07 ENSMUST00000103233.3
ENSMUST00000061283.8
cytokine receptor-like factor 3
chr2_-_31142002 0.07 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
formin binding protein 1
chr4_+_127021311 0.07 ENSMUST00000030623.7
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr1_-_52817503 0.06 ENSMUST00000162576.1
inositol polyphosphate-1-phosphatase
chr9_+_44134562 0.06 ENSMUST00000034650.8
ENSMUST00000098852.2
melanoma cell adhesion molecule
chr14_-_30923547 0.06 ENSMUST00000170415.1
inter-alpha trypsin inhibitor, heavy chain 3
chr16_-_96127604 0.06 ENSMUST00000133885.1
ENSMUST00000050884.7
high mobility group nucleosomal binding domain 1
chr19_-_44069736 0.06 ENSMUST00000172041.1
ENSMUST00000071698.6
ENSMUST00000112028.3
ER lipid raft associated 1
chr13_+_91461050 0.06 ENSMUST00000004094.8
ENSMUST00000042122.8
single-stranded DNA binding protein 2
chr4_+_11758147 0.05 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr16_-_11909398 0.05 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
calcineurin-like phosphoesterase domain containing 1
chr9_-_44134481 0.05 ENSMUST00000180670.1
predicted gene 10687
chr2_-_132578128 0.05 ENSMUST00000028822.7
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr9_-_122294361 0.05 ENSMUST00000042546.2
anoctamin 10
chr19_-_44069526 0.05 ENSMUST00000170801.1
ER lipid raft associated 1
chr10_-_86541334 0.05 ENSMUST00000165173.1
predicted gene 6729
chr7_+_112225856 0.05 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr8_+_25601591 0.05 ENSMUST00000155861.1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr7_+_98703091 0.04 ENSMUST00000033009.9
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr2_+_130012336 0.04 ENSMUST00000110299.2
transglutaminase 3, E polypeptide
chr11_+_83964419 0.04 ENSMUST00000049714.8
ENSMUST00000092834.5
ENSMUST00000183714.1
ENSMUST00000183456.1
synergin, gamma
chr11_-_46312220 0.04 ENSMUST00000129474.1
ENSMUST00000093166.4
ENSMUST00000165599.2
cytoplasmic FMR1 interacting protein 2
chr1_+_87124946 0.04 ENSMUST00000044878.3
alkaline phosphatase 3, intestine, not Mn requiring
chr9_-_82975475 0.04 ENSMUST00000034787.5
pleckstrin homology domain interacting protein
chr5_+_34761734 0.04 ENSMUST00000080036.2
huntingtin
chr18_-_79109391 0.03 ENSMUST00000025430.8
ENSMUST00000161465.2
SET binding protein 1
chr14_+_55575617 0.03 ENSMUST00000022826.5
fat storage-inducing transmembrane protein 1
chr13_-_58274121 0.03 ENSMUST00000091579.4
G kinase anchoring protein 1
chr18_+_40256960 0.03 ENSMUST00000096572.1
RIKEN cDNA 2900055J20 gene
chr7_+_45434876 0.03 ENSMUST00000107766.1
glycogen synthase 1, muscle
chr7_-_126584578 0.03 ENSMUST00000150311.1
ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr16_+_91391721 0.03 ENSMUST00000160764.1
predicted gene 21970
chr1_-_74588117 0.03 ENSMUST00000066986.6
zinc finger protein 142
chr1_-_58973421 0.03 ENSMUST00000173590.1
ENSMUST00000027186.5
trafficking protein, kinesin binding 2
chr8_-_61902669 0.03 ENSMUST00000121785.1
ENSMUST00000034057.7
palladin, cytoskeletal associated protein
chr16_+_55973881 0.03 ENSMUST00000050248.8
ribosomal protein L24
chr1_+_58973521 0.03 ENSMUST00000114296.1
ENSMUST00000027185.4
STE20-related kinase adaptor beta
chr5_-_138619702 0.03 ENSMUST00000063262.4
zinc finger protein 68
chr1_+_74236479 0.02 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
actin related protein 2/3 complex, subunit 2
chr15_-_59374149 0.02 ENSMUST00000022976.4
RIKEN cDNA E430025E21 gene
chrX_-_102505359 0.02 ENSMUST00000087916.4
histone deacetylase 8
chr5_-_29478470 0.02 ENSMUST00000001608.7
ENSMUST00000165512.2
motor neuron and pancreas homeobox 1
chr8_-_69184177 0.02 ENSMUST00000185176.1
leucine zipper, putative tumor suppressor 1
chr4_-_3938354 0.02 ENSMUST00000003369.3
pleiomorphic adenoma gene 1
chr16_-_11176056 0.01 ENSMUST00000142389.1
ENSMUST00000138185.1
zinc finger CCCH type containing 7 A
chrX_+_49463926 0.01 ENSMUST00000130558.1
Rho GTPase activating protein 36
chr1_+_134182404 0.01 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
chitinase 3-like 1
chr12_-_24493656 0.01 ENSMUST00000073088.2
predicted pseudogene 16372
chr10_-_42276744 0.01 ENSMUST00000105502.1
ENSMUST00000105501.1
forkhead box O3
chr10_+_7792891 0.00 ENSMUST00000015901.4
peptidylprolyl isomerase (cyclophilin)-like 4
chr6_+_95117740 0.00 ENSMUST00000032107.7
ENSMUST00000119582.1
kelch repeat and BTB (POZ) domain containing 8
chr10_+_82699007 0.00 ENSMUST00000020478.7
host cell factor C2
chr17_+_30624354 0.00 ENSMUST00000170651.1
dynein, axonemal, heavy chain 8
chr1_+_134182150 0.00 ENSMUST00000156873.1
chitinase 3-like 1
chr2_-_132578244 0.00 ENSMUST00000110142.1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr2_-_30415509 0.00 ENSMUST00000134120.1
ENSMUST00000102854.3
carnitine acetyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 1.8 GO:0042637 catagen(GO:0042637)
0.1 0.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.2 GO:1904020 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466) regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0016259 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.0 0.1 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0 0.1 GO:0071898 regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:0034093 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.3 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:2000327 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.0 0.1 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.0 0.0 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0000801 central element(GO:0000801)
0.0 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0098830 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.0 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling