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2D miR_HR1_12

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Results for Nr4a3

Z-value: 0.59

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Transcription factors associated with Nr4a3

Gene Symbol Gene ID Gene Info
ENSMUSG00000028341.3 nuclear receptor subfamily 4, group A, member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48049080_48049114-0.773.3e-03Click!

Activity profile of Nr4a3 motif

Sorted Z-values of Nr4a3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_128206346 1.63 ENSMUST00000033049.7
cytochrome c oxidase subunit VIa polypeptide 2
chr5_+_66968416 0.80 ENSMUST00000038188.7
LIM and calponin homology domains 1
chr17_-_35909626 0.79 ENSMUST00000141132.1
alpha tubulin acetyltransferase 1
chr8_-_123894736 0.65 ENSMUST00000034453.4
actin, alpha 1, skeletal muscle
chr7_-_79842287 0.64 ENSMUST00000049004.6
alanyl (membrane) aminopeptidase
chr11_+_113619318 0.63 ENSMUST00000146390.2
ENSMUST00000106630.1
somatostatin receptor 2
chr17_-_35910032 0.60 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
alpha tubulin acetyltransferase 1
chr4_+_134396320 0.60 ENSMUST00000105869.2
platelet-activating factor acetylhydrolase 2
chr16_-_20730544 0.55 ENSMUST00000076422.5
thrombopoietin
chr10_-_20725023 0.53 ENSMUST00000020165.7
phosphodiesterase 7B
chr9_-_22002599 0.51 ENSMUST00000115336.2
ENSMUST00000044926.5
coiled-coil domain containing 151
chr9_-_46235260 0.49 ENSMUST00000121916.1
ENSMUST00000034586.2
apolipoprotein C-III
chr18_-_60624304 0.47 ENSMUST00000097566.3
synaptopodin
chr18_-_60624201 0.47 ENSMUST00000155195.2
synaptopodin
chr5_+_66968559 0.45 ENSMUST00000127184.1
LIM and calponin homology domains 1
chr9_-_64341145 0.44 ENSMUST00000120760.1
ENSMUST00000168844.2
DIS3 mitotic control homolog (S. cerevisiae)-like
chr15_-_79804717 0.43 ENSMUST00000023057.8
neuronal pentraxin receptor
chr11_+_70505244 0.40 ENSMUST00000019063.2
transmembrane 4 superfamily member 5
chr7_+_102267795 0.38 ENSMUST00000033289.4
stromal interaction molecule 1
chr11_-_3504766 0.37 ENSMUST00000044507.5
inositol polyphosphate 5-phosphatase J
chr6_-_137571007 0.36 ENSMUST00000100841.2
epidermal growth factor receptor pathway substrate 8
chr11_-_53423123 0.35 ENSMUST00000036045.5
liver-expressed antimicrobial peptide 2
chr6_-_112946754 0.33 ENSMUST00000113169.2
SLIT-ROBO Rho GTPase activating protein 3
chr9_-_110989611 0.33 ENSMUST00000084922.5
receptor transporter protein 3
chr10_+_59403644 0.31 ENSMUST00000009790.7
phospholipase A2, group XIIB
chr8_+_13026024 0.31 ENSMUST00000033820.3
coagulation factor VII
chr12_-_111672290 0.29 ENSMUST00000001304.7
creatine kinase, brain
chr10_-_20724696 0.29 ENSMUST00000170265.1
phosphodiesterase 7B
chr19_-_45998479 0.28 ENSMUST00000045396.7
RIKEN cDNA 9130011E15 gene
chr4_-_43578824 0.28 ENSMUST00000030189.7
glucosidase beta 2
chr2_-_59160644 0.28 ENSMUST00000077687.5
coiled-coil domain containing 148
chr11_-_61494173 0.27 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
mitogen-activated protein kinase 7
chr15_+_54952939 0.26 ENSMUST00000181704.1
predicted gene, 26684
chr4_+_134397380 0.26 ENSMUST00000105870.1
platelet-activating factor acetylhydrolase 2
chr5_-_66151903 0.26 ENSMUST00000167950.1
RNA binding motif protein 47
chr7_+_30712209 0.25 ENSMUST00000005692.6
ENSMUST00000170371.1
ATPase, H+/K+ exchanging, gastric, alpha polypeptide
chr1_+_75435930 0.25 ENSMUST00000037796.7
ENSMUST00000113584.1
ENSMUST00000145166.1
ENSMUST00000143730.1
ENSMUST00000133418.1
ENSMUST00000144874.1
ENSMUST00000140287.1
GDP-mannose pyrophosphorylase A
chr3_-_104818224 0.24 ENSMUST00000002297.5
Moloney leukemia virus 10
chr16_+_10545339 0.24 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
C-type lectin domain family 16, member A
chr2_+_157279026 0.23 ENSMUST00000116380.2
ribophorin II
chr12_-_110978981 0.23 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
ankyrin repeat domain 9
chr9_+_22003035 0.23 ENSMUST00000115331.2
ENSMUST00000003493.7
protein kinase C substrate 80K-H
chr12_-_110978943 0.23 ENSMUST00000142012.1
ankyrin repeat domain 9
chr2_+_157279065 0.23 ENSMUST00000029171.5
ribophorin II
chr4_-_129227883 0.22 ENSMUST00000106051.1
expressed sequence C77080
chr3_-_104818539 0.21 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Moloney leukemia virus 10
chrX_+_101299143 0.21 ENSMUST00000118111.1
ENSMUST00000130555.1
ENSMUST00000151528.1
neuroligin 3
chr11_-_99244058 0.21 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr4_+_116075269 0.21 ENSMUST00000030471.8
leucine rich repeat containing 41
chr15_-_79141197 0.21 ENSMUST00000169604.1
RIKEN cDNA 1700088E04 gene
chr5_+_16553488 0.21 ENSMUST00000030683.3
hepatocyte growth factor
chr19_+_46152505 0.20 ENSMUST00000026254.7
golgi-specific brefeldin A-resistance factor 1
chr12_-_110978618 0.20 ENSMUST00000140788.1
ankyrin repeat domain 9
chr4_+_131873608 0.18 ENSMUST00000053819.3
serine/arginine-rich splicing factor 4
chr5_-_66151323 0.18 ENSMUST00000131838.1
RNA binding motif protein 47
chr18_-_62179948 0.18 ENSMUST00000053640.3
adrenergic receptor, beta 2
chr17_+_17831004 0.18 ENSMUST00000172097.2
RIKEN cDNA 4930546H06 gene
chr11_+_70764209 0.17 ENSMUST00000060444.5
zinc finger protein 3
chrX_-_71492799 0.17 ENSMUST00000037391.5
ENSMUST00000114586.2
ENSMUST00000114587.2
CD99 antigen-like 2
chr19_-_37207293 0.16 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
cytoplasmic polyadenylation element binding protein 3
chr11_+_70657687 0.16 ENSMUST00000134087.1
ENSMUST00000170716.1
enolase 3, beta muscle
chr11_-_100822525 0.15 ENSMUST00000107358.2
signal transducer and activator of transcription 5B
chr6_-_116716888 0.15 ENSMUST00000056623.6
transmembrane protein 72
chr6_-_113531575 0.15 ENSMUST00000032425.5
ER membrane protein complex subunit 3
chr4_+_126058557 0.15 ENSMUST00000035497.4
organic solute carrier partner 1
chrX_+_101299207 0.14 ENSMUST00000065858.2
neuroligin 3
chr10_-_128401218 0.13 ENSMUST00000042666.5
solute carrier family 39 (metal ion transporter), member 5
chr3_-_104818266 0.13 ENSMUST00000168015.1
Moloney leukemia virus 10
chrY_-_1245685 0.13 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr15_+_25773985 0.12 ENSMUST00000125667.1
myosin X
chr11_+_115475645 0.12 ENSMUST00000035240.6
armadillo repeat containing 7
chr8_+_108714644 0.12 ENSMUST00000043896.8
zinc finger homeobox 3
chr4_+_43578921 0.12 ENSMUST00000030190.8
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr9_-_119578981 0.11 ENSMUST00000117911.1
ENSMUST00000120420.1
sodium channel, voltage-gated, type V, alpha
chr15_+_100761741 0.11 ENSMUST00000023776.6
solute carrier family 4 (anion exchanger), member 8
chrY_-_1245753 0.11 ENSMUST00000154004.1
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr11_+_74649462 0.10 ENSMUST00000092915.5
ENSMUST00000117818.1
clustered mitochondria (cluA/CLU1) homolog
chr3_-_89773221 0.10 ENSMUST00000038450.1
RIKEN cDNA 4632404H12 gene
chr2_+_92375306 0.09 ENSMUST00000028650.8
peroxisomal biogenesis factor 16
chr3_-_95133989 0.08 ENSMUST00000172572.2
ENSMUST00000173462.2
sodium channel modifier 1
chr7_-_109616548 0.08 ENSMUST00000077909.1
ENSMUST00000084738.3
suppression of tumorigenicity 5
chr2_+_79707780 0.08 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chrX_+_18162575 0.07 ENSMUST00000044484.6
ENSMUST00000052368.8
lysine (K)-specific demethylase 6A
chr4_-_141623799 0.07 ENSMUST00000038661.7
solute carrier family 25, member 34
chr16_+_10545390 0.07 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
C-type lectin domain family 16, member A
chr4_+_99955715 0.07 ENSMUST00000102783.4
phosphoglucomutase 2
chr9_+_110849507 0.06 ENSMUST00000119427.2
protease, serine, 46
chr7_+_130865835 0.06 ENSMUST00000075181.4
ENSMUST00000048180.5
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_-_4334001 0.05 ENSMUST00000176653.1
lysine (K)-specific demethylase 2A
chr17_+_34605855 0.05 ENSMUST00000037489.8
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr8_-_22060019 0.05 ENSMUST00000110738.2
ATPase, Cu++ transporting, beta polypeptide
chr2_-_180273488 0.05 ENSMUST00000108891.1
CDK5 and Abl enzyme substrate 2
chr4_-_139131058 0.05 ENSMUST00000143971.1
mitochondrial inner membrane organizing system 1
chr19_+_45998131 0.05 ENSMUST00000181820.1
RIKEN cDNA 4930505N22 gene
chr4_+_154960915 0.05 ENSMUST00000049621.6
hairy and enhancer of split 5 (Drosophila)
chr11_+_70657196 0.04 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
enolase 3, beta muscle
chr2_-_13491900 0.04 ENSMUST00000091436.5
cubilin (intrinsic factor-cobalamin receptor)
chr12_+_4082574 0.04 ENSMUST00000020986.7
DnaJ (Hsp40) homolog, subfamily C, member 27
chr7_-_79466167 0.03 ENSMUST00000073889.7
polymerase (DNA directed), gamma
chr1_+_57845534 0.03 ENSMUST00000169772.1
spermatogenesis associated, serine-rich 2-like
chr4_+_150914562 0.03 ENSMUST00000135169.1
tumor necrosis factor receptor superfamily, member 9
chr7_+_100009914 0.02 ENSMUST00000107084.1
chordin-like 2
chr11_-_115536181 0.02 ENSMUST00000118155.1
ENSMUST00000153892.1
SMT3 suppressor of mif two 3 homolog 2 (yeast)
chr7_-_127345314 0.02 ENSMUST00000060783.5
zinc finger protein 768
chr11_+_83850863 0.01 ENSMUST00000108114.2
HNF1 homeobox B
chr11_+_83850832 0.01 ENSMUST00000021016.3
HNF1 homeobox B
chr6_-_138426735 0.01 ENSMUST00000162932.1
LIM domain only 3
chr3_-_101287879 0.00 ENSMUST00000152321.1
CD2 antigen
chr7_-_19715395 0.00 ENSMUST00000032555.9
ENSMUST00000093552.5
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr17_-_73950172 0.00 ENSMUST00000024866.4
xanthine dehydrogenase
chr4_-_126202757 0.00 ENSMUST00000080919.5
thyroid hormone receptor associated protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 0.9 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.6 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.6 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.1 0.4 GO:2000331 regulation of terminal button organization(GO:2000331)
0.1 0.6 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.3 GO:0070375 ERK5 cascade(GO:0070375)
0.1 0.3 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.1 0.4 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 0.2 GO:0003099 positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.1 0.3 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.2 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.6 GO:0030432 peristalsis(GO:0030432)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0 0.4 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.6 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.1 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.0 0.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0046544 development of secondary male sexual characteristics(GO:0046544) response to interleukin-15(GO:0070672)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.2 GO:1902947 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) regulation of tau-protein kinase activity(GO:1902947)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.4 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.0 GO:2000978 negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.0 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.9 GO:0097444 spine apparatus(GO:0097444)
0.1 0.3 GO:0036019 endolysosome(GO:0036019)
0.1 0.6 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.6 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.4 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.4 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 0.3 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 0.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 0.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.2 GO:0051380 norepinephrine binding(GO:0051380)
0.1 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0004623 phospholipase A2 activity(GO:0004623)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis