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2D miR_HR1_12

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Results for Nkx2-6

Z-value: 0.43

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Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
ENSMUSG00000044186.9 NK2 homeobox 6

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_78773452 0.94 ENSMUST00000018313.5
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_+_110330697 0.88 ENSMUST00000112481.1
polymerase (DNA directed), epsilon
chr6_+_70726430 0.82 ENSMUST00000103410.1
immunoglobulin kappa constant
chr4_-_91399984 0.75 ENSMUST00000102799.3
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr4_-_109665249 0.56 ENSMUST00000063531.4
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr7_-_116237767 0.29 ENSMUST00000182834.1
pleckstrin homology domain containing, family A member 7
chr2_+_3114220 0.24 ENSMUST00000072955.5
family with sequence similarity 171, member A1
chr6_-_41704339 0.22 ENSMUST00000031899.8
Kell blood group
chr14_-_20269162 0.21 ENSMUST00000024155.7
potassium channel, subfamily K, member 16
chr17_-_45599603 0.20 ENSMUST00000171847.1
ENSMUST00000166633.1
ENSMUST00000169729.1
solute carrier family 29 (nucleoside transporters), member 1
chrX_-_92016183 0.20 ENSMUST00000099471.2
ENSMUST00000072269.1
melanoma antigen, family B, 1
chr2_-_119229885 0.19 ENSMUST00000076084.5
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chrX_+_91331755 0.17 ENSMUST00000101397.1
melanoma antigen, family B, 2
chr7_-_116031047 0.14 ENSMUST00000106612.1
SRY-box containing gene 6
chr15_+_73723131 0.14 ENSMUST00000165541.1
ENSMUST00000167582.1
protein tyrosine phosphatase 4a3
chr5_-_90223923 0.13 ENSMUST00000118816.1
ENSMUST00000048363.7
cytochrome c oxidase assembly protein 18
chrX_+_107149580 0.08 ENSMUST00000137107.1
ENSMUST00000067249.2
RIKEN cDNA A630033H20 gene
chr19_+_8802486 0.08 ENSMUST00000172175.1
zinc finger and BTB domain containing 3
chr2_-_119229849 0.08 ENSMUST00000110820.2
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr14_+_54360826 0.07 ENSMUST00000000985.5
oxidase assembly 1-like
chr3_+_62419668 0.05 ENSMUST00000161057.1
Rho guanine nucleotide exchange factor (GEF) 26
chr10_+_100488289 0.04 ENSMUST00000164751.1
centrosomal protein 290
chr3_+_87525572 0.03 ENSMUST00000170036.1
ENSMUST00000117293.1
ets variant gene 3
chrX_+_107149454 0.02 ENSMUST00000125676.1
ENSMUST00000180182.1
RIKEN cDNA A630033H20 gene
chr2_-_147186389 0.00 ENSMUST00000109970.3
ENSMUST00000067075.5
NK2 homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.6 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0043117 positive regulation of vascular permeability(GO:0043117)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.9 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME G1 PHASE Genes involved in G1 Phase