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2D miR_HR1_12

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Results for Hoxd8

Z-value: 0.57

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Transcription factors associated with Hoxd8

Gene Symbol Gene ID Gene Info
ENSMUSG00000027102.4 homeobox D8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxd8mm10_v2_chr2_+_74704615_747046480.205.2e-01Click!

Activity profile of Hoxd8 motif

Sorted Z-values of Hoxd8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_103367748 1.52 ENSMUST00000074204.4
ENSMUST00000179636.1
solute carrier family 6 (neurotransmitter transporter), member 15
chr7_+_30493622 1.21 ENSMUST00000058280.6
ENSMUST00000133318.1
ENSMUST00000142575.1
ENSMUST00000131040.1
proline dehydrogenase (oxidase) 2
chr17_-_48432723 1.14 ENSMUST00000046549.3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr9_+_53771499 0.99 ENSMUST00000048670.8
solute carrier family 35, member F2
chr1_+_9547948 0.99 ENSMUST00000144177.1
alcohol dehydrogenase, iron containing, 1
chr3_+_94372794 0.64 ENSMUST00000029795.3
RAR-related orphan receptor gamma
chr19_+_23723279 0.62 ENSMUST00000067077.1
predicted gene 9938
chr18_+_11633276 0.52 ENSMUST00000115861.2
retinoblastoma binding protein 8
chr17_-_23835743 0.46 ENSMUST00000059906.6
protease, serine, 33
chr8_+_46010596 0.41 ENSMUST00000110381.2
Lrp2 binding protein
chr7_+_140763739 0.38 ENSMUST00000026552.7
cytochrome P450, family 2, subfamily e, polypeptide 1
chr2_+_163472545 0.36 ENSMUST00000065731.4
RIKEN cDNA 2310001K24 gene
chr2_-_140671462 0.35 ENSMUST00000110057.2
fibronectin leucine rich transmembrane protein 3
chr3_+_76075583 0.35 ENSMUST00000160261.1
follistatin-like 5
chr5_-_90640464 0.34 ENSMUST00000031317.6
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_10088173 0.33 ENSMUST00000061419.7
predicted gene 9833
chr13_-_54399246 0.33 ENSMUST00000124238.1
predicted gene 16248
chr13_-_58354862 0.32 ENSMUST00000043605.5
kinesin family member 27
chr19_+_29925107 0.31 ENSMUST00000120388.2
ENSMUST00000144528.1
ENSMUST00000177518.1
interleukin 33
chr9_+_72806874 0.27 ENSMUST00000055535.8
protogenin homolog (Gallus gallus)
chr11_+_117809653 0.26 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
synaptogyrin 2
predicted gene 20708
chr3_-_96452306 0.26 ENSMUST00000093126.4
ENSMUST00000098841.3
cDNA sequence BC107364
chr2_-_73580288 0.26 ENSMUST00000028515.3
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr10_-_127030813 0.26 ENSMUST00000040560.4
Ts translation elongation factor, mitochondrial
chr18_+_60774675 0.25 ENSMUST00000118551.1
ribosomal protein S14
chrX_+_56786527 0.25 ENSMUST00000144600.1
four and a half LIM domains 1
chr3_-_19265007 0.24 ENSMUST00000091314.4
phosphodiesterase 7A
chr10_-_127030789 0.24 ENSMUST00000120547.1
ENSMUST00000152054.1
Ts translation elongation factor, mitochondrial
chr2_-_163472561 0.24 ENSMUST00000109418.1
fat storage-inducing transmembrane protein 2
chr3_-_72967854 0.23 ENSMUST00000167334.1
sucrase isomaltase (alpha-glucosidase)
chr4_+_148901128 0.22 ENSMUST00000147270.1
castor zinc finger 1
chr2_-_140671400 0.22 ENSMUST00000056760.3
fibronectin leucine rich transmembrane protein 3
chr5_-_123666682 0.22 ENSMUST00000149410.1
CAP-GLY domain containing linker protein 1
chr10_-_80918212 0.22 ENSMUST00000057623.7
ENSMUST00000179022.1
lamin B2
chr5_-_103629279 0.20 ENSMUST00000031263.1
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr2_-_151668533 0.20 ENSMUST00000180195.1
ENSMUST00000096439.3
RAD21-like (S. pombe)
chr4_-_132398199 0.20 ENSMUST00000136711.1
ENSMUST00000084249.4
phosphatase and actin regulator 4
chr2_+_152687137 0.19 ENSMUST00000062148.6
malignant T cell amplified sequence 2
chr12_-_87444017 0.19 ENSMUST00000091090.4
RIKEN cDNA 2700073G19 gene
chr18_+_56562443 0.18 ENSMUST00000130163.1
ENSMUST00000132628.1
phosphorylated adaptor for RNA export
chr4_+_13743424 0.17 ENSMUST00000006761.3
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr10_-_103236280 0.17 ENSMUST00000123364.1
ENSMUST00000166240.1
ENSMUST00000020043.5
leucine-rich repeats and IQ motif containing 1
chr9_+_75051977 0.17 ENSMUST00000170310.1
ENSMUST00000166549.1
cAMP-regulated phosphoprotein 19
chr11_+_117809687 0.17 ENSMUST00000120928.1
ENSMUST00000175737.1
synaptogyrin 2
chr12_+_72536342 0.16 ENSMUST00000044352.6
pecanex-like 4 (Drosophila)
chr2_-_66410064 0.15 ENSMUST00000112366.1
sodium channel, voltage-gated, type I, alpha
chr10_+_58394361 0.15 ENSMUST00000020077.4
LIM and senescent cell antigen-like domains 1
chr11_+_16257706 0.14 ENSMUST00000109645.2
ENSMUST00000109647.2
V-set and transmembrane domain containing 2A
chr6_-_60829826 0.14 ENSMUST00000163779.1
synuclein, alpha
chr12_-_87443800 0.14 ENSMUST00000162961.1
alkB, alkylation repair homolog 1 (E. coli)
chrX_-_160138375 0.13 ENSMUST00000033662.8
pyruvate dehydrogenase E1 alpha 1
chr14_+_47298260 0.13 ENSMUST00000166743.1
mitogen-activated protein kinase 1 interacting protein 1-like
chr5_-_62766153 0.12 ENSMUST00000076623.4
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_57158288 0.12 ENSMUST00000065358.7
COMM domain containing 4
chr1_-_187215454 0.11 ENSMUST00000183819.1
spermatogenesis associated 17
chr13_-_85127514 0.11 ENSMUST00000179230.1
predicted gene 4076
chr12_+_87443896 0.11 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
SRA stem-loop interacting RNA binding protein
chr3_-_14778452 0.11 ENSMUST00000094365.4
carbonic anhydrase 1
chr10_-_63927434 0.11 ENSMUST00000079279.3
predicted gene 10118
chr6_-_30958990 0.10 ENSMUST00000101589.3
Kruppel-like factor 14
chrM_+_7759 0.10 ENSMUST00000082407.1
ENSMUST00000082408.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr1_+_174172738 0.09 ENSMUST00000027817.7
spectrin alpha, erythrocytic 1
chr1_-_172027269 0.09 ENSMUST00000027837.6
ENSMUST00000111264.1
vang-like 2 (van gogh, Drosophila)
chr4_-_108301045 0.09 ENSMUST00000043616.6
zyg-ll family member B, cell cycle regulator
chr14_+_69347587 0.08 ENSMUST00000064831.5
ectonucleoside triphosphate diphosphohydrolase 4
chr10_+_23797052 0.08 ENSMUST00000133289.1
solute carrier family 18, subfamily B, member 1
chr5_+_92809372 0.08 ENSMUST00000113054.2
shroom family member 3
chr6_+_134640940 0.08 ENSMUST00000062755.8
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr2_+_110721340 0.08 ENSMUST00000111016.2
mucin 15
chr2_+_110721587 0.08 ENSMUST00000111017.2
mucin 15
chr4_+_118961578 0.08 ENSMUST00000058651.4
L-amino acid oxidase 1
chr7_-_4397705 0.07 ENSMUST00000108590.2
glycoprotein 6 (platelet)
chr7_-_80405425 0.07 ENSMUST00000107362.3
ENSMUST00000135306.1
furin (paired basic amino acid cleaving enzyme)
chr3_+_95871519 0.07 ENSMUST00000120398.1
RIKEN cDNA C920021L13 gene
chr6_-_106745109 0.07 ENSMUST00000167925.2
interleukin 5 receptor, alpha
chr5_-_31295862 0.06 ENSMUST00000041266.7
ENSMUST00000172435.1
fibronectin type III domain containing 4
chr5_-_87337165 0.06 ENSMUST00000031195.2
UDP glucuronosyltransferase 2 family, polypeptide A3
chr17_-_34862473 0.06 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr14_+_27000362 0.06 ENSMUST00000035433.8
homeobox gene expressed in ES cells
chr8_-_106573461 0.06 ENSMUST00000073722.5
predicted pseudogene 10073
chr3_-_69859875 0.06 ENSMUST00000051239.7
ENSMUST00000171529.1
serine palmitoyltransferase, small subunit B
chr19_-_11856001 0.06 ENSMUST00000079875.3
olfactory receptor 1418
chr3_+_127633134 0.05 ENSMUST00000029587.7
neurogenin 2
chr7_+_103979176 0.05 ENSMUST00000098185.1
olfactory receptor 635
chr15_-_35155750 0.05 ENSMUST00000067033.7
ENSMUST00000018476.7
serine/threonine kinase 3
chr13_+_23839401 0.05 ENSMUST00000039721.7
ENSMUST00000166467.1
solute carrier family 17 (sodium phosphate), member 3
chr1_-_126830786 0.04 ENSMUST00000162646.1
NCK-associated protein 5
chr6_-_129100903 0.04 ENSMUST00000032258.6
C-type lectin domain family 2, member e
chr13_+_23839445 0.04 ENSMUST00000091698.4
ENSMUST00000110422.1
solute carrier family 17 (sodium phosphate), member 3
chr11_-_106973090 0.04 ENSMUST00000150366.1
predicted gene 11707
chr2_+_128862947 0.03 ENSMUST00000110324.1
fibulin 7
chr15_+_99295087 0.03 ENSMUST00000128352.1
ENSMUST00000145482.1
PRP40 pre-mRNA processing factor 40 homolog B (yeast)
chr15_+_81744848 0.03 ENSMUST00000109554.1
zinc finger CCCH type containing 7B
chr3_-_95871367 0.03 ENSMUST00000142437.1
ENSMUST00000067298.4
mitochondrial ribosomal protein S21
chr3_-_144849301 0.03 ENSMUST00000159989.1
chloride channel calcium activated 4
chr11_+_109543694 0.02 ENSMUST00000106696.1
arylsulfatase G
chr17_-_32822200 0.02 ENSMUST00000179695.1
zinc finger protein 799
chr1_+_178798438 0.02 ENSMUST00000160789.1
kinesin family member 26B
chr7_+_45621805 0.02 ENSMUST00000033100.4
izumo sperm-egg fusion 1
chrX_-_106840572 0.02 ENSMUST00000062010.9
zinc finger, CCHC domain containing 5
chr2_-_126500631 0.02 ENSMUST00000129187.1
ATPase, class I, type 8B, member 4
chr19_-_19001099 0.02 ENSMUST00000040153.8
ENSMUST00000112828.1
RAR-related orphan receptor beta
chr8_+_40354303 0.02 ENSMUST00000136835.1
mitochondrial calcium uptake family, member 3
chr3_-_96197580 0.01 ENSMUST00000016087.3
bolA-like 1 (E. coli)
chrX_+_20662898 0.01 ENSMUST00000001989.8
ubiquitin-like modifier activating enzyme 1
chr2_+_150190393 0.01 ENSMUST00000109929.2
predicted gene 14139
chr7_+_126976338 0.01 ENSMUST00000032920.3
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr9_-_55512156 0.01 ENSMUST00000034866.8
electron transferring flavoprotein, alpha polypeptide

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 1.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2 0.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.3 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 0.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 0.2 GO:0051030 snRNA transport(GO:0051030)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0070350 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.1 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.0 0.2 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.0 0.2 GO:0097240 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.4 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.1 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.3 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:0090520 sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.2 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0097636 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0032437 spectrin(GO:0008091) cuticular plate(GO:0032437)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 1.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 1.2 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.4 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0043734 DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0042166 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 0.1 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle