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2D miR_HR1_12

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Results for Pax6

Z-value: 0.75

Motif logo

Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
ENSMUSG00000027168.15 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105682463_105682547-0.501.0e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_61022560 2.07 ENSMUST00000089184.4
potassium inwardly-rectifying channel, subfamily J, member 12
chr7_-_101869012 1.78 ENSMUST00000123321.1
folate receptor 1 (adult)
chr8_-_24948771 1.75 ENSMUST00000119720.1
ENSMUST00000121438.2
a disintegrin and metallopeptidase domain 32
chr7_-_101868667 1.65 ENSMUST00000150184.1
folate receptor 1 (adult)
chr18_-_32139570 1.16 ENSMUST00000171765.1
protein C
chr1_+_43092588 1.13 ENSMUST00000039080.3
RIKEN cDNA 8430432A02 gene
chr18_+_37447641 0.94 ENSMUST00000052387.3
protocadherin beta 14
chr17_+_43016536 0.89 ENSMUST00000024708.4
tumor necrosis factor receptor superfamily, member 21
chr15_-_101850778 0.87 ENSMUST00000023790.3
keratin 1
chr3_+_65109343 0.85 ENSMUST00000159525.1
ENSMUST00000049230.8
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_+_92250039 0.82 ENSMUST00000093801.3
phospholipid scramblase 1
chr19_-_57118981 0.72 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
actin-binding LIM protein 1
chrX_+_73214333 0.72 ENSMUST00000156188.1
ENSMUST00000069077.3
ENSMUST00000069103.4
ENSMUST00000114506.1
ENSMUST00000081827.3
X-linked lymphocyte-regulated 4B
chr8_-_80880479 0.67 ENSMUST00000034150.8
growth factor receptor bound protein 2-associated protein 1
chrX_+_103422010 0.65 ENSMUST00000182089.1
predicted gene, 26992
chr4_-_34050077 0.59 ENSMUST00000029927.5
sperm acrosome associated 1
chr9_+_64179289 0.58 ENSMUST00000034965.6
small nuclear RNA activating complex, polypeptide 5
chr17_-_6827990 0.58 ENSMUST00000181895.1
predicted gene 2885
chr9_+_15239045 0.57 ENSMUST00000034413.6
V-set and transmembrane domain containing 5
chr6_+_48395586 0.56 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
KRAB-A domain containing 1
chr13_-_23914998 0.55 ENSMUST00000021769.8
ENSMUST00000110407.2
solute carrier family 17 (sodium phosphate), member 4
chr17_-_51832666 0.53 ENSMUST00000144331.1
special AT-rich sequence binding protein 1
chr19_-_57118897 0.50 ENSMUST00000111526.1
actin-binding LIM protein 1
chr7_+_97453204 0.50 ENSMUST00000050732.7
ENSMUST00000121987.1
potassium channel tetramerisation domain containing 14
chr16_-_22857514 0.48 ENSMUST00000004576.6
TBCC domain containing 1
chr6_+_48395652 0.43 ENSMUST00000077093.4
KRAB-A domain containing 1
chr17_-_51831884 0.42 ENSMUST00000124222.1
special AT-rich sequence binding protein 1
chr3_+_31902507 0.40 ENSMUST00000119310.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr16_+_4968936 0.38 ENSMUST00000090457.5
RIKEN cDNA 4930451G09 gene
chr16_-_52452654 0.36 ENSMUST00000168071.1
activated leukocyte cell adhesion molecule
chr15_+_103272893 0.36 ENSMUST00000100162.3
coatomer protein complex, subunit zeta 1
chr3_-_89245005 0.36 ENSMUST00000107464.1
tripartite motif-containing 46
chr3_-_89245159 0.36 ENSMUST00000090924.6
tripartite motif-containing 46
chr5_-_38480131 0.35 ENSMUST00000143758.1
ENSMUST00000067886.5
solute carrier family 2 (facilitated glucose transporter), member 9
chr10_-_53694823 0.35 ENSMUST00000171807.1
family with sequence similarity 184, member A
chr13_-_43480973 0.33 ENSMUST00000144326.2
RAN binding protein 9
chr1_+_21240581 0.32 ENSMUST00000027067.8
glutathione S-transferase, alpha 3
chr14_-_43819639 0.32 ENSMUST00000100691.3
eosinophil-associated, ribonuclease A family, member 1
chr7_+_123462274 0.30 ENSMUST00000033023.3
aquaporin 8
chr9_-_22307638 0.30 ENSMUST00000086278.6
zinc finger protein 810
chr13_+_64432479 0.28 ENSMUST00000021939.6
cyclin-dependent kinase 20
chr5_+_149265035 0.27 ENSMUST00000130144.1
ENSMUST00000071130.3
arachidonate 5-lipoxygenase activating protein
chr18_-_34373313 0.27 ENSMUST00000006027.5
receptor accessory protein 5
chr2_-_75981967 0.25 ENSMUST00000099994.3
tetratricopeptide repeat domain 30A1
chrX_+_23693043 0.25 ENSMUST00000035766.6
ENSMUST00000101670.2
WD repeat domain 44
chr2_+_163602294 0.25 ENSMUST00000171696.1
ENSMUST00000109408.3
tocopherol (alpha) transfer protein-like
chr8_-_72475212 0.25 ENSMUST00000079510.4
calcium homeostasis endoplasmic reticulum protein
chr5_-_74677792 0.22 ENSMUST00000117525.1
ENSMUST00000153543.1
ENSMUST00000039744.6
ENSMUST00000113531.2
ENSMUST00000121690.1
ligand of numb-protein X 1
chr1_+_156040884 0.20 ENSMUST00000060404.4
torsin A interacting protein 2
chr2_-_162661075 0.20 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
protein tyrosine phosphatase, receptor type, T
chr14_-_57890242 0.19 ENSMUST00000089473.3
zinc finger, DHHC domain containing 20
chr11_-_6200411 0.19 ENSMUST00000066496.3
NudC domain containing 3
chr2_+_105904629 0.18 ENSMUST00000037499.5
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr13_-_53377355 0.18 ENSMUST00000021920.6
serine palmitoyltransferase, long chain base subunit 1
chr13_+_66905415 0.17 ENSMUST00000099412.2
predicted gene 10767
chr6_-_113377376 0.17 ENSMUST00000043333.2
transcriptional adaptor 3
chr8_-_57962564 0.17 ENSMUST00000098757.3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr7_-_86775860 0.17 ENSMUST00000001824.5
folate hydrolase 1
chr7_+_12897800 0.17 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
zinc finger and SCAN domain containing 22
chr17_+_34604262 0.16 ENSMUST00000174041.1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr1_+_131638306 0.15 ENSMUST00000073350.6
cathepsin E
chr5_+_90903864 0.14 ENSMUST00000075433.6
chemokine (C-X-C motif) ligand 2
chr12_+_112976471 0.14 ENSMUST00000165079.1
ENSMUST00000002880.6
BTB (POZ) domain containing 6
chr11_-_95587691 0.14 ENSMUST00000000122.6
nerve growth factor receptor (TNFR superfamily, member 16)
chr1_+_21240597 0.14 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr11_+_45852031 0.13 ENSMUST00000109261.3
ENSMUST00000109260.1
clathrin interactor 1
chr11_-_67965631 0.13 ENSMUST00000021287.5
ENSMUST00000126766.1
WD repeat domain 16
chr7_-_86775808 0.12 ENSMUST00000107271.3
folate hydrolase 1
chr11_+_78328415 0.10 ENSMUST00000048073.8
phosphatidylinositol glycan anchor biosynthesis, class S
chr7_-_12775658 0.10 ENSMUST00000046245.5
zinc finger and SCAN domain containing 18
chr11_+_104550663 0.10 ENSMUST00000018800.2
myosin, light polypeptide 4
chr2_-_105904484 0.09 ENSMUST00000122965.1
elongation protein 4 homolog (S. cerevisiae)
chr1_-_195131536 0.09 ENSMUST00000075451.6
complement component (3b/4b) receptor 1-like
chr9_+_105642957 0.08 ENSMUST00000065778.6
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr17_-_33718591 0.07 ENSMUST00000174040.1
ENSMUST00000173015.1
ENSMUST00000066121.6
ENSMUST00000172767.1
ENSMUST00000173329.1
membrane-associated ring finger (C3HC4) 2
chr13_-_66905322 0.07 ENSMUST00000021993.4
ubiquinol-cytochrome c reductase binding protein
chr12_-_51829525 0.06 ENSMUST00000179265.1
ENSMUST00000042052.8
HECT domain containing 1
chr19_+_6400611 0.06 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr11_-_115612491 0.05 ENSMUST00000106507.2
MIF4G domain containing
chr19_+_34290653 0.04 ENSMUST00000025691.5
ENSMUST00000112472.2
Fas (TNF receptor superfamily member 6)
chr17_-_43543639 0.04 ENSMUST00000178772.1
ankyrin repeat domain 66
chr5_-_18360384 0.03 ENSMUST00000074694.5
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr19_+_34583528 0.03 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_138619687 0.02 ENSMUST00000027642.2
NIMA (never in mitosis gene a)-related expressed kinase 7
chr6_-_88045190 0.02 ENSMUST00000113596.1
ENSMUST00000113600.3
RAB7, member RAS oncogene family
chr6_+_60944472 0.02 ENSMUST00000129603.1
multimerin 1
chr13_-_113618549 0.01 ENSMUST00000109241.3
sorting nexin 18
chr15_-_35938009 0.01 ENSMUST00000156915.1
cytochrome c oxidase subunit VIc
chr6_+_56956466 0.00 ENSMUST00000096612.3
vomeronasal 1 receptor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.3 0.9 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.3 0.8 GO:2000371 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 1.2 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 0.5 GO:0043385 mycotoxin metabolic process(GO:0043385) mycotoxin catabolic process(GO:0043387) aflatoxin metabolic process(GO:0046222) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound metabolic process(GO:1901376) organic heteropentacyclic compound catabolic process(GO:1901377)
0.1 0.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.5 GO:0051684 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 0.7 GO:0099612 protein localization to axon(GO:0099612)
0.1 0.3 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 2.1 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.9 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.7 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.4 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.0 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.3 GO:0006760 folic acid-containing compound metabolic process(GO:0006760)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.7 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.3 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 0.9 GO:0001533 cornified envelope(GO:0001533)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0000800 lateral element(GO:0000800)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0051870 methotrexate binding(GO:0051870)
0.3 0.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 1.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.3 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.1 0.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 2.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.6 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.9 GO:0070402 NADPH binding(GO:0070402)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.4 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 1.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0015250 water channel activity(GO:0015250)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival