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2D miR_HR1_12

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Results for Irx5

Z-value: 0.43

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000031737.10 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.352.6e-01Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_88146867 0.53 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
PARP1 binding protein
chr17_+_7925990 0.48 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr8_+_85171322 0.41 ENSMUST00000076896.5
predicted gene 6531
chr6_+_50110837 0.39 ENSMUST00000167628.1
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr2_-_79908428 0.35 ENSMUST00000102652.3
ENSMUST00000102651.3
phosphodiesterase 1A, calmodulin-dependent
chrX_+_20549780 0.34 ENSMUST00000023832.6
regucalcin
chr19_-_16780822 0.34 ENSMUST00000068156.6
vacuolar protein sorting 13A (yeast)
chr14_-_19977151 0.30 ENSMUST00000055100.7
ENSMUST00000162425.1
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977040 0.29 ENSMUST00000159028.1
guanine nucleotide binding protein (G protein), gamma 2
chr10_-_99759658 0.28 ENSMUST00000056085.4
citrate synthase like
chr10_+_88146992 0.27 ENSMUST00000052355.7
nucleoporin 37
chr6_+_56956466 0.26 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr3_+_124321031 0.24 ENSMUST00000058994.4
translocation associated membrane protein 1-like 1
chr2_-_79908389 0.22 ENSMUST00000090756.4
phosphodiesterase 1A, calmodulin-dependent
chr17_-_35643684 0.20 ENSMUST00000095467.3
diffuse panbronchiolitis critical region 1 (human)
chr4_-_59783800 0.19 ENSMUST00000107526.1
ENSMUST00000095063.4
INTS3 and NABP interacting protein
chr13_+_24943144 0.18 ENSMUST00000021773.5
glycosylphosphatidylinositol specific phospholipase D1
chr2_-_5895319 0.17 ENSMUST00000026926.4
ENSMUST00000102981.3
Sec61, alpha subunit 2 (S. cerevisiae)
chr12_+_71048338 0.17 ENSMUST00000135709.1
AT rich interactive domain 4A (RBP1-like)
chr14_+_48120841 0.17 ENSMUST00000073150.4
pellino 2
chr9_-_110624361 0.17 ENSMUST00000035069.9
neurotrophin receptor associated death domain
chr14_-_19977249 0.17 ENSMUST00000160013.1
guanine nucleotide binding protein (G protein), gamma 2
chr19_-_55241236 0.16 ENSMUST00000069183.6
guanylate cyclase 2g
chr2_+_25180737 0.16 ENSMUST00000104999.2
Notch-regulated ankyrin repeat protein
chr11_-_49712674 0.15 ENSMUST00000020624.6
ENSMUST00000145353.1
CCR4-NOT transcription complex, subunit 6
chr2_-_73625731 0.15 ENSMUST00000070579.6
chimerin (chimaerin) 1
chr15_-_77022632 0.15 ENSMUST00000019037.8
ENSMUST00000169226.1
myoglobin
chr2_-_106970391 0.14 ENSMUST00000093883.3
ADP-ribosylation factor-like 14 effector protein
chr6_-_24956106 0.14 ENSMUST00000127247.2
transmembrane protein 229A
chr5_-_100429503 0.13 ENSMUST00000181873.1
ENSMUST00000180779.1
RIKEN cDNA 5430416N02 gene
chr4_-_49521036 0.13 ENSMUST00000057829.3
mitochondrial ribosomal protein L50
chr19_+_26623419 0.13 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_76579670 0.13 ENSMUST00000126960.1
ENSMUST00000109583.2
multiple C2 domains, transmembrane 1
chr2_-_85035487 0.12 ENSMUST00000028465.7
purinergic receptor P2X, ligand-gated ion channel, 3
chr2_-_151009364 0.12 ENSMUST00000109896.1
ninein-like
chr14_+_55510445 0.11 ENSMUST00000165262.1
ENSMUST00000074225.4
copine VI
chr17_-_87025353 0.11 ENSMUST00000024957.6
phosphatidylinositol glycan anchor biosynthesis, class F
chr11_+_78176711 0.11 ENSMUST00000098545.5
TLC domain containing 1
chr17_+_50698525 0.11 ENSMUST00000061681.7
predicted gene 7334
chr1_+_165301863 0.11 ENSMUST00000178700.1
G protein-coupled receptor 161
chr3_-_158031705 0.11 ENSMUST00000072875.8
serine/arginine-rich splicing factor 11
chr3_-_88762244 0.10 ENSMUST00000183267.1
synaptotagmin XI
chr12_-_85288419 0.10 ENSMUST00000121930.1
acylphosphatase 1, erythrocyte (common) type
chr3_-_126998408 0.10 ENSMUST00000182764.1
ENSMUST00000044443.8
ankyrin 2, brain
chr10_+_79960145 0.09 ENSMUST00000045247.7
WD repeat domain 18
chr2_+_152427639 0.09 ENSMUST00000128737.1
RIKEN cDNA 6820408C15 gene
chr7_+_56239743 0.09 ENSMUST00000032633.5
ENSMUST00000156886.1
oculocutaneous albinism II
chr1_-_169969143 0.09 ENSMUST00000027989.6
ENSMUST00000111353.3
hydroxysteroid (17-beta) dehydrogenase 7
chr6_+_121183667 0.09 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
peroxisomal biogenesis factor 26
chr7_+_45785331 0.09 ENSMUST00000120005.1
ENSMUST00000123585.1
lemur tyrosine kinase 3
chr14_+_14820765 0.08 ENSMUST00000112631.2
ENSMUST00000178538.1
ENSMUST00000112630.2
NIMA (never in mitosis gene a)- related kinase 10
chr8_+_4240105 0.08 ENSMUST00000110994.1
ENSMUST00000110995.1
mitogen-activated protein kinase kinase 7
chr16_-_56024628 0.08 ENSMUST00000119981.1
ENSMUST00000096021.3
PEST proteolytic signal containing nuclear protein
chr12_-_108893197 0.07 ENSMUST00000161154.1
ENSMUST00000161410.1
tryptophanyl-tRNA synthetase
chr11_-_69579320 0.06 ENSMUST00000048139.5
WD repeat containing, antisense to Trp53
chr2_+_104027823 0.06 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
F-box protein 3
chr7_-_98112618 0.06 ENSMUST00000153657.1
myosin VIIA
chr13_+_76579681 0.06 ENSMUST00000109589.2
multiple C2 domains, transmembrane 1
chr9_+_78051938 0.06 ENSMUST00000024104.7
glial cells missing homolog 1 (Drosophila)
chr19_-_8713862 0.05 ENSMUST00000010239.4
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr2_+_104027721 0.05 ENSMUST00000028603.3
F-box protein 3
chr10_+_3872667 0.05 ENSMUST00000136671.1
ENSMUST00000042438.6
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr5_+_146948640 0.05 ENSMUST00000146511.1
ENSMUST00000132102.1
general transcription factor III A
chr14_-_14120904 0.04 ENSMUST00000022256.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr3_+_90266507 0.04 ENSMUST00000098914.3
DENN/MADD domain containing 4B
chr10_-_13868779 0.04 ENSMUST00000105534.3
androgen-induced 1
chr3_-_79737794 0.04 ENSMUST00000078527.6
relaxin/insulin-like family peptide receptor 1
chr4_+_148039097 0.03 ENSMUST00000141283.1
5,10-methylenetetrahydrofolate reductase
chr6_-_66559708 0.03 ENSMUST00000079584.1
vomeronasal 1 receptor 32
chr1_+_58278309 0.03 ENSMUST00000114366.1
aldehyde oxidase 2
chr7_+_131174400 0.02 ENSMUST00000050586.5
RIKEN cDNA 5430419D17 gene
chr7_-_142576492 0.02 ENSMUST00000140716.1
H19 fetal liver mRNA
chr17_-_27622785 0.02 ENSMUST00000176458.1
ENSMUST00000114886.1
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr5_-_88675190 0.02 ENSMUST00000133532.1
ENSMUST00000150438.1
G-rich RNA sequence binding factor 1
chr18_+_76944384 0.02 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
haloacid dehalogenase-like hydrolase domain containing 2
chr12_-_99393010 0.02 ENSMUST00000177451.1
forkhead box N3
chr12_-_69892989 0.01 ENSMUST00000110567.1
ENSMUST00000171211.1
mitogen-activated protein kinase kinase kinase kinase 5
chr2_-_101621033 0.01 ENSMUST00000090513.4
RIKEN cDNA B230118H07 gene
chr16_-_55838827 0.01 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
chr2_-_160872552 0.01 ENSMUST00000103111.2
zinc fingers and homeoboxes 3
chr9_-_7835255 0.01 ENSMUST00000074246.6
baculoviral IAP repeat-containing 2
chr12_+_55598917 0.00 ENSMUST00000051857.3
insulinoma-associated 2
chr1_+_13668739 0.00 ENSMUST00000088542.3
X Kell blood group precursor related family member 9 homolog

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1901896 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) positive regulation of calcium-transporting ATPase activity(GO:1901896) negative regulation of bone development(GO:1903011) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.2 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:1990927 calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:2000327 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0 0.1 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005550 pheromone binding(GO:0005550)
0.1 0.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.2 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex