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2D miR_HR1_12

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Results for E2f8

Z-value: 1.72

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
ENSMUSG00000046179.11 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.944.2e-06Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_75109528 7.29 ENSMUST00000164309.1
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_+_56303321 5.48 ENSMUST00000001258.8
ubiquitin-like, containing PHD and RING finger domains, 1
chr5_+_123749696 5.15 ENSMUST00000031366.7
kinetochore associated 1
chr1_-_128359610 5.12 ENSMUST00000027601.4
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr17_+_56040350 4.99 ENSMUST00000002914.8
chromatin assembly factor 1, subunit A (p150)
chr17_+_56303396 4.51 ENSMUST00000113038.1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_48881596 4.22 ENSMUST00000119223.1
E2F transcription factor 8
chr7_-_48881032 4.06 ENSMUST00000058745.8
E2F transcription factor 8
chr16_-_18811615 4.03 ENSMUST00000096990.3
cell division cycle 45
chr19_+_38931008 3.89 ENSMUST00000145051.1
helicase, lymphoid specific
chr12_+_24708984 3.66 ENSMUST00000154588.1
ribonucleotide reductase M2
chr16_+_10835046 3.60 ENSMUST00000037913.8
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr19_+_38930909 3.54 ENSMUST00000025965.5
helicase, lymphoid specific
chr11_+_98907801 3.50 ENSMUST00000092706.6
cell division cycle 6
chr6_+_35177610 3.40 ENSMUST00000170234.1
nucleoporin 205
chr6_-_88898664 3.31 ENSMUST00000058011.6
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr12_+_24708241 3.31 ENSMUST00000020980.5
ribonucleotide reductase M2
chr9_-_36726374 3.07 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
checkpoint kinase 1
chr10_+_128015157 3.05 ENSMUST00000178041.1
ENSMUST00000026461.7
DNA primase, p49 subunit
chr7_-_44548733 3.02 ENSMUST00000145956.1
ENSMUST00000049343.8
polymerase (DNA directed), delta 1, catalytic subunit
chr6_+_35177386 2.95 ENSMUST00000043815.9
nucleoporin 205
chr9_+_103305156 2.44 ENSMUST00000035164.3
topoisomerase (DNA) II binding protein 1
chr2_+_163054682 2.16 ENSMUST00000018005.3
myeloblastosis oncogene-like 2
chr16_-_15637277 1.81 ENSMUST00000023353.3
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr15_+_55557399 1.80 ENSMUST00000022998.7
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr3_+_126363827 1.67 ENSMUST00000093976.2
arylsulfatase J
chr4_+_132768325 1.67 ENSMUST00000102561.4
replication protein A2
chr6_+_117916981 1.60 ENSMUST00000179478.1
heterogeneous nuclear ribonucleoprotein F
chr15_+_55557575 1.56 ENSMUST00000170046.1
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr9_-_35116804 1.55 ENSMUST00000034537.6
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr2_+_24949747 1.50 ENSMUST00000028350.3
zinc finger, MYND domain containing 19
chr5_-_65335564 1.36 ENSMUST00000172780.1
replication factor C (activator 1) 1
chr6_+_117917281 1.28 ENSMUST00000180020.1
ENSMUST00000177570.1
heterogeneous nuclear ribonucleoprotein F
chr2_-_34913976 1.27 ENSMUST00000028232.3
PHD finger protein 19
chr5_-_33652339 1.26 ENSMUST00000075670.6
stem-loop binding protein
chr4_-_129189600 1.13 ENSMUST00000117497.1
ENSMUST00000117350.1
S100P binding protein
chr5_-_65335597 1.10 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
replication factor C (activator 1) 1
chr9_-_50659780 1.10 ENSMUST00000034567.3
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr15_-_55557748 1.01 ENSMUST00000172387.1
mitochondrial ribosomal protein L13
chr1_+_131910458 0.96 ENSMUST00000062264.6
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr15_-_98093245 0.91 ENSMUST00000180657.1
SUMO1/sentrin specific peptidase 1
chr5_-_33652296 0.72 ENSMUST00000151081.1
ENSMUST00000101354.3
stem-loop binding protein
chr6_-_87851011 0.66 ENSMUST00000113617.1
cellular nucleic acid binding protein
chr4_-_129189512 0.66 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100P binding protein
chr10_-_21160925 0.66 ENSMUST00000020158.6
myeloblastosis oncogene
chr13_+_44731281 0.56 ENSMUST00000174086.1
jumonji, AT rich interactive domain 2
chr11_+_79993062 0.56 ENSMUST00000017692.8
ENSMUST00000163272.1
suppressor of zeste 12 homolog (Drosophila)
chr4_+_129189760 0.55 ENSMUST00000106054.2
ENSMUST00000001365.2
tyrosyl-tRNA synthetase
chr10_+_19356558 0.54 ENSMUST00000053225.5
oligodendrocyte transcription factor 3
chr10_+_42860543 0.54 ENSMUST00000157071.1
sex comb on midleg-like 4 (Drosophila)
chr4_-_129189646 0.53 ENSMUST00000106059.1
S100P binding protein
chr2_-_154569845 0.53 ENSMUST00000103145.4
E2F transcription factor 1
chr5_+_150673739 0.52 ENSMUST00000016569.4
ENSMUST00000038900.8
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr7_+_102065485 0.49 ENSMUST00000106950.1
ENSMUST00000146450.1
transient receptor potential cation channel, subfamily C, member 2
chr11_+_88047693 0.48 ENSMUST00000079866.4
serine/arginine-rich splicing factor 1
chr7_+_110122299 0.44 ENSMUST00000033326.8
WEE 1 homolog 1 (S. pombe)
chr11_+_88047302 0.35 ENSMUST00000139129.2
serine/arginine-rich splicing factor 1
chrX_+_49470555 0.34 ENSMUST00000042444.6
Rho GTPase activating protein 36
chr2_-_45112890 0.32 ENSMUST00000076836.6
zinc finger E-box binding homeobox 2
chr3_-_126998408 0.31 ENSMUST00000182764.1
ENSMUST00000044443.8
ankyrin 2, brain
chr5_+_129020069 0.29 ENSMUST00000031383.7
ENSMUST00000111343.1
RAN, member RAS oncogene family
chr2_-_154569720 0.26 ENSMUST00000000894.5
E2F transcription factor 1
chr16_-_18248697 0.26 ENSMUST00000115645.3
RAN binding protein 1
chr10_+_84917616 0.25 ENSMUST00000038523.7
ENSMUST00000095385.3
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chrX_+_49470450 0.24 ENSMUST00000114904.3
Rho GTPase activating protein 36
chr7_+_102065713 0.24 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
transient receptor potential cation channel, subfamily C, member 2
chr12_+_84642896 0.22 ENSMUST00000095551.4
vertebrae development associated
chr17_-_35235755 0.22 ENSMUST00000048994.6
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr14_+_55222005 0.20 ENSMUST00000022820.5
dehydrogenase/reductase member 2
chr3_-_127553233 0.20 ENSMUST00000029588.5
La ribonucleoprotein domain family, member 7
chr5_+_135187251 0.20 ENSMUST00000002825.5
bromodomain adjacent to zinc finger domain, 1B
chr2_-_155945282 0.18 ENSMUST00000040162.2
growth differentiation factor 5
chrX_-_70477170 0.17 ENSMUST00000101506.3
ENSMUST00000114630.2
cDNA sequence BC023829
chr11_+_88047788 0.17 ENSMUST00000107920.3
serine/arginine-rich splicing factor 1
chr7_-_115824699 0.12 ENSMUST00000169129.1
SRY-box containing gene 6
chr13_+_19623163 0.11 ENSMUST00000002883.5
secreted frizzled-related protein 4
chr13_+_44731265 0.10 ENSMUST00000173246.1
jumonji, AT rich interactive domain 2
chrX_+_73716712 0.04 ENSMUST00000114461.2
ATP-binding cassette, sub-family D (ALD), member 1
chr12_+_84642555 0.03 ENSMUST00000167227.1
vertebrae development associated
chrX_+_152016428 0.02 ENSMUST00000045312.5
structural maintenance of chromosomes 1A
chr7_-_128740471 0.01 ENSMUST00000119081.1
ENSMUST00000057557.7
MCM (minichromosome maintenance deficient) binding protein
chr12_+_110279228 0.01 ENSMUST00000097228.4
deiodinase, iodothyronine type III
chr15_+_61985540 0.00 ENSMUST00000159327.1
ENSMUST00000167731.1
myelocytomatosis oncogene

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.3 4.0 GO:0071163 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.2 17.4 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.0 10.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.0 3.0 GO:0045004 DNA replication proofreading(GO:0045004)
0.8 3.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.7 3.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.5 13.2 GO:0006270 DNA replication initiation(GO:0006270)
0.5 6.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.4 7.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 3.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.3 1.0 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.3 0.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.2 0.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 2.0 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 1.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 5.0 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.7 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 1.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 1.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.5 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.1 1.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 1.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 4.4 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 3.6 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 2.2 GO:1902850 mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 0.1 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.3 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 1.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.1 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) positive regulation of mesenchymal stem cell differentiation(GO:2000741)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:1990423 RZZ complex(GO:1990423)
1.7 5.0 GO:0033186 CAF-1 complex(GO:0033186)
1.4 7.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.3 4.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.3 6.3 GO:0044611 nuclear pore inner ring(GO:0044611)
1.2 17.5 GO:0042555 MCM complex(GO:0042555)
1.0 3.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 3.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 2.2 GO:0031523 Myb complex(GO:0031523)
0.4 2.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.4 1.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 2.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.2 14.9 GO:0005657 replication fork(GO:0005657)
0.2 7.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 2.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 0.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 2.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.6 GO:0051233 spindle midzone(GO:0051233)
0.0 3.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 3.4 GO:0000776 kinetochore(GO:0000776)
0.0 0.3 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.7 GO:0032590 dendrite membrane(GO:0032590)
0.0 6.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.0 GO:0031493 nucleosomal histone binding(GO:0031493)
1.4 7.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.0 14.6 GO:0003688 DNA replication origin binding(GO:0003688)
1.0 3.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.7 2.0 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.6 5.0 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 1.6 GO:0047288 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) monosialoganglioside sialyltransferase activity(GO:0047288)
0.3 0.9 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 2.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 6.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.5 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 3.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 1.1 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.2 6.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 1.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.7 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 2.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 3.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 7.4 GO:0004386 helicase activity(GO:0004386)
0.0 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.2 GO:0036122 BMP binding(GO:0036122)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 10.9 PID ATR PATHWAY ATR signaling pathway
0.1 7.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 10.2 PID E2F PATHWAY E2F transcription factor network
0.0 2.5 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 21.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 11.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.6 7.7 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.4 3.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 6.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 1.7 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 2.0 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 3.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase