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2D miR_HR1_12

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Results for Smad3

Z-value: 0.74

Motif logo

Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
ENSMUSG00000032402.6 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_637119940.491.0e-01Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_100779074 2.24 ENSMUST00000110073.1
ENSMUST00000110070.1
RIKEN cDNA 9030617O03 gene
chr12_+_100779088 2.11 ENSMUST00000110069.1
RIKEN cDNA 9030617O03 gene
chr12_+_100779055 2.11 ENSMUST00000069782.4
RIKEN cDNA 9030617O03 gene
chr2_-_152831112 1.16 ENSMUST00000128172.1
BCL2-like 1
chr2_-_152831665 1.09 ENSMUST00000156688.1
ENSMUST00000007803.5
BCL2-like 1
chr3_-_96263311 0.62 ENSMUST00000171473.1
histone cluster 2, H4
chr11_+_58954675 0.56 ENSMUST00000108817.3
ENSMUST00000047697.5
histone cluster 3, H2a
tripartite motif-containing 17
chr7_+_104857009 0.51 ENSMUST00000067695.7
ubiquitin specific peptidase 17-like A
chr13_-_21832194 0.50 ENSMUST00000102979.1
histone cluster 1, H4n
chr13_-_23551648 0.45 ENSMUST00000102971.1
histone cluster 1, H4f
chr11_-_99986593 0.41 ENSMUST00000105050.2
keratin associated protein 16-1
chr10_+_33905015 0.40 ENSMUST00000169670.1
radial spoke head 4 homolog A (Chlamydomonas)
chr13_+_23581563 0.39 ENSMUST00000102968.1
histone cluster 1, H4d
chr6_-_129275360 0.36 ENSMUST00000032259.3
CD69 antigen
chr13_+_23531044 0.35 ENSMUST00000102972.3
histone cluster 1, H4h
chr17_+_56628118 0.33 ENSMUST00000112979.2
catsper channel auxiliary subunit delta
chr13_+_21735055 0.30 ENSMUST00000087714.4
histone cluster 1, H4j
chr7_-_44236098 0.29 ENSMUST00000037220.4
RIKEN cDNA 1700028J19 gene
chr16_-_45158183 0.28 ENSMUST00000114600.1
solute carrier family 35, member A5
chr13_+_22043189 0.23 ENSMUST00000110452.1
histone cluster 1, H2bj
chr6_-_129533267 0.22 ENSMUST00000181594.1
RIKEN cDNA 1700101I11 gene
chr7_-_100964371 0.21 ENSMUST00000060174.4
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr13_-_22035589 0.20 ENSMUST00000091742.4
histone cluster 1, H2ah
chr6_+_136808248 0.19 ENSMUST00000074556.4
H2A histone family, member J
chr4_+_57782153 0.18 ENSMUST00000124581.1
A kinase (PRKA) anchor protein 2
chr13_-_22042949 0.16 ENSMUST00000091741.4
histone cluster 1, H2ag
chr5_+_34543365 0.16 ENSMUST00000101316.3
SH3-domain binding protein 2
chr1_+_131688766 0.16 ENSMUST00000129905.1
RIKEN cDNA 5430435G22 gene
chr9_+_54286479 0.16 ENSMUST00000056740.5
gliomedin
chrX_-_20291728 0.15 ENSMUST00000115393.2
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chrX_+_143664365 0.15 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_+_140986873 0.14 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
ATPase type 13A2
chrX_-_20291776 0.14 ENSMUST00000072451.4
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr14_+_119138415 0.13 ENSMUST00000065904.3
heparan sulfate 6-O-sulfotransferase 3
chr13_+_21833736 0.13 ENSMUST00000180288.1
ENSMUST00000110467.1
histone cluster 1 H2br
chrX_+_143664290 0.12 ENSMUST00000112868.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr2_-_26640230 0.12 ENSMUST00000181621.1
ENSMUST00000180659.1
small nucleolar RNA host gene (non-protein coding) 7
chr7_+_137437591 0.11 ENSMUST00000064404.6
glutaredoxin 3
chr9_-_66592993 0.10 ENSMUST00000174387.1
ubiquitin specific peptidase 3
chr1_+_171250416 0.10 ENSMUST00000111315.1
ENSMUST00000006570.5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
chr13_-_21787218 0.10 ENSMUST00000091751.2
histone cluster 1, H2an
chr13_-_21810190 0.10 ENSMUST00000110469.1
ENSMUST00000091749.2
histone cluster 1, H2bq
chr6_+_129533183 0.10 ENSMUST00000032264.6
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr11_+_73240310 0.10 ENSMUST00000138853.1
transient receptor potential cation channel, subfamily V, member 1
chr2_+_178193075 0.10 ENSMUST00000103065.1
phosphatase and actin regulator 3
chr13_+_23684192 0.10 ENSMUST00000018246.4
histone cluster 1, H2bc
chr13_+_22035821 0.09 ENSMUST00000110455.2
histone cluster 1, H2bk
chr14_-_49783327 0.09 ENSMUST00000118129.1
ENSMUST00000036972.6
RIKEN cDNA 3632451O06 gene
chr13_-_23683941 0.09 ENSMUST00000171127.1
histone cluster 1, H2ac
chr12_-_110845184 0.09 ENSMUST00000180988.1
predicted gene, 26912
chr13_-_21750505 0.09 ENSMUST00000102983.1
histone cluster 1, H4k
chr19_-_23448322 0.08 ENSMUST00000036069.6
MAM domain containing 2
chrX_-_150814265 0.08 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
melanoma antigen, family D, 2
chr2_-_127143410 0.08 ENSMUST00000132773.1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr10_-_118868903 0.08 ENSMUST00000004281.8
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr15_-_76209056 0.07 ENSMUST00000071869.5
ENSMUST00000170915.1
plectin
chr1_+_131688670 0.07 ENSMUST00000064679.2
ENSMUST00000064664.3
ENSMUST00000136247.1
RIKEN cDNA 5430435G22 gene
chr13_+_21810428 0.07 ENSMUST00000091745.5
histone cluster 1, H2ao
chr13_+_21787461 0.07 ENSMUST00000110473.2
ENSMUST00000102982.1
histone cluster 1, H2bp
chr7_-_127588595 0.07 ENSMUST00000072155.3
predicted gene 166
chr9_-_45936049 0.07 ENSMUST00000034590.2
transgelin
chr9_+_109038565 0.07 ENSMUST00000112059.3
ENSMUST00000026737.5
shisa homolog 5 (Xenopus laevis)
chr3_+_100426405 0.07 ENSMUST00000147951.1
ENSMUST00000152827.1
RIKEN cDNA 4930406D18 gene
chr13_+_23533869 0.06 ENSMUST00000073261.2
histone cluster 1, H2af
chr13_-_23571151 0.06 ENSMUST00000102969.3
histone cluster 1, H2ae
chr5_-_72504202 0.06 ENSMUST00000005352.3
corin
chr6_-_36811361 0.06 ENSMUST00000101534.1
pleiotrophin
chr7_+_25221417 0.06 ENSMUST00000055604.4
zinc finger protein 526
chr12_-_76795489 0.06 ENSMUST00000082431.3
glutathione peroxidase 2
chr14_+_32028989 0.06 ENSMUST00000022460.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr10_-_119240006 0.06 ENSMUST00000020315.6
cullin associated and neddylation disassociated 1
chr15_-_101562889 0.05 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr17_-_31277327 0.05 ENSMUST00000024832.7
radial spoke head 1 homolog (Chlamydomonas)
chr4_+_95557494 0.05 ENSMUST00000079223.4
ENSMUST00000177394.1
FGGY carbohydrate kinase domain containing
chr2_-_30194112 0.04 ENSMUST00000113659.1
ENSMUST00000113660.1
cysteine conjugate-beta lyase 1
chr13_-_21833575 0.04 ENSMUST00000081342.5
histone cluster 1, H2ap
chr13_+_23571382 0.04 ENSMUST00000079251.5
histone cluster 1, H2bg
chr14_+_57424054 0.04 ENSMUST00000122063.1
intraflagellar transport 88
chr1_-_134235420 0.04 ENSMUST00000038191.6
ENSMUST00000086465.4
adenosine A1 receptor
chr13_+_23746734 0.03 ENSMUST00000099703.2
histone cluster 1, H2bb
chr16_-_15594472 0.03 ENSMUST00000118236.1
ENSMUST00000096234.3
ubiquitin-conjugating enzyme E2 variant 2
chr7_-_24316590 0.03 ENSMUST00000108436.1
ENSMUST00000032673.8
zinc finger protein 94
chr7_+_44384803 0.03 ENSMUST00000120262.1
synaptotagmin III
chr9_+_108490676 0.03 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
ubiquitin specific peptidase 19
chr11_+_46436925 0.03 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
mediator complex subunit 7
chr7_+_82867327 0.03 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr5_+_145204523 0.03 ENSMUST00000085671.3
ENSMUST00000031601.7
zinc finger with KRAB and SCAN domains 5
chr5_+_92392585 0.03 ENSMUST00000126281.1
ADP-ribosyltransferase 3
chr1_-_75210732 0.02 ENSMUST00000113623.1
galactosidase, beta 1-like
chr9_+_53771499 0.02 ENSMUST00000048670.8
solute carrier family 35, member F2
chr9_+_21196705 0.02 ENSMUST00000003395.9
phosphodiesterase 4A, cAMP specific
chr9_+_13621646 0.02 ENSMUST00000034401.8
mastermind like 2 (Drosophila)
chr9_-_66593029 0.02 ENSMUST00000098613.2
ubiquitin specific peptidase 3
chr11_+_73240046 0.01 ENSMUST00000108470.1
transient receptor potential cation channel, subfamily V, member 1
chr3_-_107760221 0.01 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
colony stimulating factor 1 (macrophage)
chr6_+_90128424 0.01 ENSMUST00000072859.5
vomeronasal 1 receptor 51
chr4_+_150281573 0.01 ENSMUST00000105682.2
arginine glutamic acid dipeptide (RE) repeats
chr11_+_69156989 0.01 ENSMUST00000036424.2
arachidonate 12-lipoxygenase, 12R type
chr9_-_66593106 0.01 ENSMUST00000127569.1
ubiquitin specific peptidase 3
chr14_+_20348159 0.01 ENSMUST00000090503.4
ENSMUST00000090499.5
ENSMUST00000037698.5
ENSMUST00000051915.6
family with sequence similarity 149, member B
chr19_+_5740885 0.01 ENSMUST00000081496.5
latent transforming growth factor beta binding protein 3
chr18_+_60526194 0.01 ENSMUST00000025505.5
dynactin 4
chr1_+_172341197 0.00 ENSMUST00000056136.3
potassium inwardly-rectifying channel, subfamily J, member 10
chr9_+_44072196 0.00 ENSMUST00000176671.1
ubiquitin specific peptidase 2
chr4_+_45018583 0.00 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
polymerase (RNA) I polypeptide E
chr7_+_127588698 0.00 ENSMUST00000033088.6
ring finger protein 40

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0046898 response to cycloheximide(GO:0046898)
0.1 2.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.0 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.0 0.0 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.3 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 2.8 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors