Project

2D miR_HR1_12

Navigation
Downloads

Results for Nkx2-4

Z-value: 0.65

Motif logo

Transcription factors associated with Nkx2-4

Gene Symbol Gene ID Gene Info
ENSMUSG00000054160.2 NK2 homeobox 4

Activity profile of Nkx2-4 motif

Sorted Z-values of Nkx2-4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_4611971 2.93 ENSMUST00000105590.1
ENSMUST00000067086.7
estrogen receptor 1 (alpha)
chr14_-_47418407 1.74 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr9_+_108560422 1.46 ENSMUST00000081111.8
inosine 5'-phosphate dehydrogenase 2
chr10_+_88091070 1.26 ENSMUST00000048621.7
pro-melanin-concentrating hormone
chr6_+_134929089 1.07 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5
chr6_+_134929118 1.04 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5
chr6_-_29165003 0.97 ENSMUST00000007993.9
RNA binding motif protein 28
chr13_+_3478226 0.89 ENSMUST00000181708.1
ENSMUST00000180836.1
ENSMUST00000180567.1
RIKEN cDNA 2810429I04 gene
chr7_-_34812677 0.87 ENSMUST00000078686.6
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr13_+_108316395 0.86 ENSMUST00000171178.1
DEP domain containing 1B
chr10_+_128232065 0.82 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
timeless circadian clock 1
chr10_+_20347788 0.72 ENSMUST00000169712.1
mitochondrial fission regulator 2
chr8_+_66860215 0.69 ENSMUST00000118009.1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr6_+_21986887 0.66 ENSMUST00000151315.1
cadherin-like and PC-esterase domain containing 1
chr2_+_30061754 0.64 ENSMUST00000149578.1
ENSMUST00000102866.3
SET nuclear oncogene
chr12_-_91746020 0.59 ENSMUST00000166967.1
stonin 2
chrX_+_37265338 0.59 ENSMUST00000115194.3
reproductive homeobox 4A
chrX_+_107089234 0.57 ENSMUST00000118666.1
ENSMUST00000053375.3
purinergic receptor P2Y, G-protein coupled 10
chr6_+_21986438 0.52 ENSMUST00000115382.1
cadherin-like and PC-esterase domain containing 1
chr17_-_40914350 0.49 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chrX_+_37390848 0.47 ENSMUST00000179915.2
predicted gene, 21098
chr2_+_140170641 0.47 ENSMUST00000044825.4
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr2_-_93046053 0.47 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr4_-_108848619 0.46 ENSMUST00000164855.1
RIKEN cDNA A730015C16 gene
chr9_-_71896047 0.46 ENSMUST00000184448.1
transcription factor 12
chr4_+_48663502 0.46 ENSMUST00000030033.4
muscle-related coiled-coil protein
chr7_-_80905060 0.45 ENSMUST00000119428.1
ENSMUST00000026817.4
neuromedin B
chrX_+_37557412 0.41 ENSMUST00000089075.4
reproductive homeobox 4E
chr2_-_27507656 0.40 ENSMUST00000154316.1
bromodomain containing 3
chr1_+_34439851 0.40 ENSMUST00000027303.7
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr11_+_53720790 0.34 ENSMUST00000048605.2
interleukin 5
chr11_+_70026815 0.30 ENSMUST00000135916.2
discs, large homolog 4 (Drosophila)
chr2_-_34755229 0.27 ENSMUST00000102800.1
GTPase activating protein and VPS9 domains 1
chr3_-_110250963 0.27 ENSMUST00000106567.1
protein arginine N-methyltransferase 6
chr3_+_76593550 0.25 ENSMUST00000162471.1
follistatin-like 5
chr1_-_118311132 0.24 ENSMUST00000027623.7
translin
chr8_+_31091593 0.24 ENSMUST00000161713.1
dual specificity phosphatase 26 (putative)
chr11_+_87592897 0.23 ENSMUST00000119628.1
myotubularin related protein 4
chr8_+_46490968 0.22 ENSMUST00000110372.1
ENSMUST00000130563.1
acyl-CoA synthetase long-chain family member 1
chr5_+_89028035 0.22 ENSMUST00000113216.2
ENSMUST00000134303.1
solute carrier family 4 (anion exchanger), member 4
chr4_-_40279389 0.21 ENSMUST00000108108.2
ENSMUST00000095128.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6
chr12_+_38780817 0.21 ENSMUST00000160856.1
ets variant gene 1
chr16_+_32419696 0.17 ENSMUST00000014220.8
ENSMUST00000080316.7
Tctex1 domain containing 2
chr4_-_136892867 0.16 ENSMUST00000046332.5
complement component 1, q subcomponent, C chain
chr3_-_59180085 0.15 ENSMUST00000056898.4
G protein-coupled receptor 87
chr6_+_142413441 0.13 ENSMUST00000088263.4
RIKEN cDNA B230216G23 gene
chr9_-_14903932 0.13 ENSMUST00000034409.7
ENSMUST00000117620.1
folate receptor 4 (delta)
chr2_+_131950855 0.12 ENSMUST00000110170.1
ENSMUST00000110172.2
ENSMUST00000110171.2
prion protein dublet
chr17_+_16972910 0.12 ENSMUST00000071374.5
cDNA sequence BC002059
chr7_+_82867327 0.12 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr19_-_5457397 0.12 ENSMUST00000179549.1
coiled-coil domain containing 85B
chr2_+_174643534 0.11 ENSMUST00000059452.5
zinc finger protein 831
chr11_+_101733011 0.10 ENSMUST00000129741.1
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr8_+_88199194 0.09 ENSMUST00000119033.1
ENSMUST00000066748.3
ENSMUST00000118952.1
PAP associated domain containing 5
chr2_+_25180737 0.09 ENSMUST00000104999.2
Notch-regulated ankyrin repeat protein
chr5_+_32136458 0.09 ENSMUST00000031017.9
fos-like antigen 2
chr11_+_101732950 0.09 ENSMUST00000039152.7
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr8_+_45628176 0.09 ENSMUST00000130850.1
sorbin and SH3 domain containing 2
chr13_+_108860072 0.09 ENSMUST00000177907.1
phosphodiesterase 4D, cAMP specific
chr12_+_38781093 0.09 ENSMUST00000161513.1
ets variant gene 1
chr3_+_121291725 0.07 ENSMUST00000039442.7
asparagine-linked glycosylation 14
chr1_+_16105774 0.07 ENSMUST00000027053.7
retinol dehydrogenase 10 (all-trans)
chr5_+_89027959 0.06 ENSMUST00000130041.1
solute carrier family 4 (anion exchanger), member 4
chr2_-_85196697 0.06 ENSMUST00000099930.2
ENSMUST00000111601.1
leucine rich repeat containing 55
chr5_-_137533170 0.06 ENSMUST00000168746.1
ENSMUST00000170293.1
guanine nucleotide binding protein (G protein), beta 2
chr14_+_55672235 0.05 ENSMUST00000002397.5
guanosine monophosphate reductase 2
chr5_-_137533212 0.05 ENSMUST00000143495.1
ENSMUST00000111038.1
guanine nucleotide binding protein (G protein), beta 2
erythropoietin
chrX_-_143933089 0.05 ENSMUST00000087313.3
doublecortin
chr5_+_94339749 0.05 ENSMUST00000097477.3
expressed sequence AA792892
chr1_+_85649988 0.05 ENSMUST00000155094.1
nuclear antigen Sp100
chr7_-_132813095 0.04 ENSMUST00000106165.1
family with sequence similarity 53, member B
chr2_-_85035487 0.04 ENSMUST00000028465.7
purinergic receptor P2X, ligand-gated ion channel, 3
chr13_+_47193942 0.04 ENSMUST00000110111.2
ring finger protein 144B
chrX_+_13661354 0.04 ENSMUST00000053659.1
G protein-coupled receptor 82
chr8_+_77549393 0.03 ENSMUST00000056237.8
ENSMUST00000118622.1
protein arginine methyltransferase 10 (putative)
chr5_-_137533297 0.03 ENSMUST00000111020.1
ENSMUST00000111023.1
guanine nucleotide binding protein (G protein), beta 2
chr6_-_122609964 0.03 ENSMUST00000032211.4
growth differentiation factor 3
chr19_-_8131982 0.02 ENSMUST00000065651.4
solute carrier family 22, member 28
chr5_-_64932761 0.02 ENSMUST00000059349.4
toll-like receptor 1
chr14_-_55671873 0.02 ENSMUST00000163750.1
ENSMUST00000010520.8
neural precursor cell expressed, developmentally down-regulated gene 8
chr9_+_122572493 0.02 ENSMUST00000181682.1
ENSMUST00000181107.1
ENSMUST00000181719.1
RIKEN cDNA 9530059O14 gene
chr5_+_34999111 0.02 ENSMUST00000114283.1
regulator of G-protein signaling 12
chr1_-_37536232 0.01 ENSMUST00000042161.8
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr6_+_123229843 0.01 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
C-type lectin domain family 4, member n
chr1_+_178798438 0.01 ENSMUST00000160789.1
kinesin family member 26B
chr15_+_99670574 0.01 ENSMUST00000023758.7
acid-sensing (proton-gated) ion channel 1
chr14_+_48446128 0.01 ENSMUST00000124720.1
transmembrane protein 260
chr2_+_61804453 0.01 ENSMUST00000048934.8
T-box brain gene 1
chr6_+_94500313 0.00 ENSMUST00000061118.8
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chrX_-_140956675 0.00 ENSMUST00000033805.8
ENSMUST00000112978.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr7_-_44670820 0.00 ENSMUST00000048102.7
myosin, heavy polypeptide 14
chr1_+_85650008 0.00 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
nuclear antigen Sp100
chr7_-_115824699 0.00 ENSMUST00000169129.1
SRY-box containing gene 6
chr17_-_25844514 0.00 ENSMUST00000176709.1
ras homolog gene family, member T2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0060523 Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523)
0.4 1.3 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.3 1.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 0.8 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 0.7 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.1 0.3 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.3 GO:0098970 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.0 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.1 GO:0043634 polyadenylation-dependent ncRNA catabolic process(GO:0043634)
0.0 0.4 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.7 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0060431 primary lung bud formation(GO:0060431)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.4 GO:0034457 Mpp10 complex(GO:0034457)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.7 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 1.7 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.4 1.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 0.9 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.4 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.4 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.7 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.7 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism