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2D miR_HR1_12

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Results for Foxo6

Z-value: 0.58

Motif logo

Transcription factors associated with Foxo6

Gene Symbol Gene ID Gene Info
ENSMUSG00000052135.8 forkhead box O6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_1202873490.471.2e-01Click!

Activity profile of Foxo6 motif

Sorted Z-values of Foxo6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_110330697 1.67 ENSMUST00000112481.1
polymerase (DNA directed), epsilon
chr4_+_134510999 1.32 ENSMUST00000105866.2
aurora kinase A and ninein interacting protein
chr4_-_89294608 1.09 ENSMUST00000107131.1
cyclin-dependent kinase inhibitor 2A
chr16_+_17146937 0.90 ENSMUST00000115706.1
ENSMUST00000069064.4
YdjC homolog (bacterial)
chr14_-_47418407 0.79 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr12_-_91384403 0.74 ENSMUST00000141429.1
centrosomal protein 128
chr9_+_7272514 0.68 ENSMUST00000015394.8
matrix metallopeptidase 13
chr10_+_39420009 0.56 ENSMUST00000157009.1
Fyn proto-oncogene
chr1_-_38664947 0.54 ENSMUST00000039827.7
ENSMUST00000027250.7
AF4/FMR2 family, member 3
chr17_-_40914350 0.54 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr14_-_49245389 0.50 ENSMUST00000130853.1
ENSMUST00000022398.7
RIKEN cDNA 1700011H14 gene
chrX_+_134585644 0.49 ENSMUST00000113211.1
ribosomal protein L36A
chr5_-_117389029 0.47 ENSMUST00000111953.1
ENSMUST00000086461.6
replication factor C (activator 1) 5
chr12_-_98577940 0.47 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr18_+_5593566 0.42 ENSMUST00000160910.1
zinc finger E-box binding homeobox 1
chr2_-_11603192 0.39 ENSMUST00000040314.5
RNA binding motif protein 17
chr17_+_48346465 0.37 ENSMUST00000113237.3
triggering receptor expressed on myeloid cells 2
chr16_-_88563166 0.37 ENSMUST00000049697.4
claudin 8
chr5_-_99037035 0.36 ENSMUST00000031277.6
protein kinase, cGMP-dependent, type II
chr2_+_78051155 0.34 ENSMUST00000145972.1
RIKEN cDNA 4930440I19 gene
chr11_+_46235460 0.33 ENSMUST00000060185.2
fibronectin type III domain containing 9
chr15_+_52712434 0.32 ENSMUST00000037115.7
mediator complex subunit 30
chr17_-_24696147 0.30 ENSMUST00000046839.8
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr17_-_31129602 0.28 ENSMUST00000024827.4
trefoil factor 3, intestinal
chr7_+_28808795 0.28 ENSMUST00000172529.1
heterogeneous nuclear ribonucleoprotein L
chr11_-_12027958 0.28 ENSMUST00000109654.1
growth factor receptor bound protein 10
chr3_-_27896360 0.27 ENSMUST00000058077.3
transmembrane protein 212
chr19_+_44293676 0.26 ENSMUST00000026221.5
stearoyl-Coenzyme A desaturase 2
chr16_-_38800193 0.26 ENSMUST00000057767.4
uroplakin 1B
chr4_+_48663502 0.26 ENSMUST00000030033.4
muscle-related coiled-coil protein
chr15_+_3270767 0.26 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
selenoprotein P, plasma, 1
chr15_-_74983430 0.25 ENSMUST00000023250.4
ENSMUST00000166694.1
lymphocyte antigen 6 complex, locus I
chrX_+_103493769 0.25 ENSMUST00000182447.1
ENSMUST00000182486.1
Jpx transcript, Xist activator (non-protein coding)
chr9_-_51328898 0.23 ENSMUST00000039959.4
RIKEN cDNA 1810046K07 gene
chr5_-_65391408 0.23 ENSMUST00000057885.6
ribosomal protein L9
chr5_-_65391380 0.21 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
ribosomal protein L9
chr2_+_148395369 0.21 ENSMUST00000109962.2
ENSMUST00000047292.2
somatostatin receptor 4
chr2_-_93046053 0.20 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
PR domain containing 11
chr3_-_51408925 0.20 ENSMUST00000038108.6
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr6_+_56956466 0.19 ENSMUST00000096612.3
vomeronasal 1 receptor 4
chr18_-_12305638 0.19 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
ankyrin repeat domain 29
chr12_-_102423741 0.18 ENSMUST00000110020.1
legumain
chr19_-_4877882 0.17 ENSMUST00000006626.3
actinin alpha 3
chr5_+_115279666 0.16 ENSMUST00000040421.4
coenzyme Q5 homolog, methyltransferase (yeast)
chr3_-_59180085 0.15 ENSMUST00000056898.4
G protein-coupled receptor 87
chr1_-_44061936 0.14 ENSMUST00000168641.1
predicted gene 8251
chr19_+_8892987 0.13 ENSMUST00000096249.5
integrator complex subunit 5
chr11_+_29463735 0.13 ENSMUST00000155854.1
coiled coil domain containing 88A
chr14_+_65605267 0.13 ENSMUST00000079469.6
nuclear GTPase, germinal center associated
chr5_+_115605642 0.12 ENSMUST00000094427.3
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr18_+_60212080 0.12 ENSMUST00000031549.5
predicted gene 4951
chr1_+_51987139 0.12 ENSMUST00000168302.1
signal transducer and activator of transcription 4
chrX_-_79358068 0.12 ENSMUST00000114021.2
predicted gene 8787
chr7_+_143052739 0.12 ENSMUST00000037941.9
CD81 antigen
chr6_-_90224438 0.12 ENSMUST00000076086.2
vomeronasal 1 receptor 53
chr5_+_87000838 0.12 ENSMUST00000031186.7
UDP glucuronosyltransferase 2 family, polypeptide B35
chr4_-_149099802 0.12 ENSMUST00000103217.4
peroxisomal biogenesis factor 14
chr5_-_52190484 0.11 ENSMUST00000031061.7
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr6_+_57702601 0.09 ENSMUST00000072954.1
ENSMUST00000050077.8
LanC (bacterial lantibiotic synthetase component C)-like 2
chr13_+_76579681 0.09 ENSMUST00000109589.2
multiple C2 domains, transmembrane 1
chr7_+_140881898 0.08 ENSMUST00000026560.7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr7_+_44225430 0.07 ENSMUST00000075162.3
kallikrein 1
chrX_-_8193387 0.07 ENSMUST00000143223.1
ENSMUST00000033509.8
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
chr1_+_93928037 0.06 ENSMUST00000177958.1
predicted gene 9994
chr10_+_79879614 0.06 ENSMUST00000006679.8
proteinase 3
chr12_+_108410542 0.06 ENSMUST00000054955.7
echinoderm microtubule associated protein like 1
chr14_+_51162260 0.06 ENSMUST00000075648.3
eosinophil-associated, ribonuclease A family, member 5
chrX_-_74281598 0.05 ENSMUST00000114189.2
ENSMUST00000119361.2
deoxyribonuclease 1-like 1
chr8_+_83566671 0.05 ENSMUST00000036996.5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr3_+_103968110 0.05 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
putative homeodomain transcription factor 1
chr9_-_22071345 0.04 ENSMUST00000179605.1
ENSMUST00000043922.6
zinc finger protein 653
chr1_-_72700558 0.04 ENSMUST00000053499.4
ankyrin and armadillo repeat containing
chr12_+_119443410 0.04 ENSMUST00000048880.6
metastasis associated in colon cancer 1
chr4_-_46196298 0.03 ENSMUST00000142380.1
ENSMUST00000058232.4
ENSMUST00000030013.5
xeroderma pigmentosum, complementation group A
chr17_-_31277327 0.03 ENSMUST00000024832.7
radial spoke head 1 homolog (Chlamydomonas)
chr10_+_39732364 0.03 ENSMUST00000164763.1
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr3_-_146596588 0.03 ENSMUST00000029836.4
deoxyribonuclease II beta
chr4_+_108479081 0.02 ENSMUST00000155068.1
zinc finger, CCHC domain containing 11
chr4_-_139131058 0.02 ENSMUST00000143971.1
mitochondrial inner membrane organizing system 1
chr15_+_75268379 0.02 ENSMUST00000023247.6
lymphocyte antigen 6 complex, locus F
chr10_+_29313164 0.02 ENSMUST00000160399.1
enoyl Coenzyme A hydratase domain containing 1
chr12_+_108410625 0.02 ENSMUST00000109857.1
echinoderm microtubule associated protein like 1
chr3_+_146597077 0.01 ENSMUST00000029837.7
ENSMUST00000121133.1
urate oxidase
chr12_-_113260217 0.01 ENSMUST00000178282.1
immunoglobulin heavy constant alpha
chr5_-_87092546 0.01 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
UDP glucuronosyltransferase 2 family, polypeptide B36
chr15_+_100154379 0.01 ENSMUST00000023768.6
ENSMUST00000108971.2
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr13_-_4279420 0.01 ENSMUST00000021632.3
aldo-keto reductase family 1, member C12
chr16_+_44943737 0.00 ENSMUST00000114622.3
ENSMUST00000166731.1
CD200 receptor 3
chr18_-_84589491 0.00 ENSMUST00000125763.1
zinc finger protein 407
chr7_-_123369870 0.00 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
Rho GTPase activating protein 17

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0045004 DNA replication proofreading(GO:0045004)
0.2 1.1 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.2 0.7 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.1 0.6 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 0.4 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.4 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.3 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.2 GO:1904023 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) regulation of fermentation(GO:0043465) positive regulation of skeletal muscle fiber development(GO:0048743) regulation of bone mineralization involved in bone maturation(GO:1900157) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.1 0.5 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.2 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.0 0.4 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.3 GO:0097421 liver regeneration(GO:0097421)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.3 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.3 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.1 GO:0001652 granular component(GO:0001652)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 2.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.2 1.7 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.6 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.2 GO:0005550 pheromone binding(GO:0005550)
0.0 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.4 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.3 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation