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2D miR_HR1_12

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Results for Runx3

Z-value: 0.79

Motif logo

Transcription factors associated with Runx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000070691.4 runt related transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx3mm10_v2_chr4_+_135152496_1351525540.471.3e-01Click!

Activity profile of Runx3 motif

Sorted Z-values of Runx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_51645232 1.74 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr5_+_21424934 1.28 ENSMUST00000056045.4
family with sequence similarity 185, member A
chr13_-_35906324 1.21 ENSMUST00000174230.1
ENSMUST00000171686.2
ribonuclease P 40 subunit
chr18_-_47368446 1.16 ENSMUST00000076043.6
ENSMUST00000135790.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_+_27556641 1.11 ENSMUST00000119486.1
ENSMUST00000118599.1
high mobility group AT-hook 1
chr2_+_72476225 1.08 ENSMUST00000157019.1
cell division cycle associated 7
chr4_-_120570252 1.07 ENSMUST00000030381.7
cytidine 5'-triphosphate synthase
chr2_+_72476159 1.06 ENSMUST00000102691.4
cell division cycle associated 7
chr17_+_27556668 1.05 ENSMUST00000117254.1
ENSMUST00000118570.1
high mobility group AT-hook 1
chr17_+_27556613 1.01 ENSMUST00000117600.1
ENSMUST00000114888.3
high mobility group AT-hook 1
chr10_-_62602261 1.00 ENSMUST00000045866.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr13_-_23551648 0.98 ENSMUST00000102971.1
histone cluster 1, H4f
chr9_+_106429537 0.97 ENSMUST00000059802.6
ribosomal protein L29
chr17_+_28328471 0.96 ENSMUST00000042334.8
ribosomal protein L10A
chr11_-_5878207 0.93 ENSMUST00000102922.3
polymerase (DNA directed), delta 2, regulatory subunit
chr10_-_81001338 0.89 ENSMUST00000099462.1
ENSMUST00000118233.1
guanine nucleotide binding protein (G protein), gamma 7
chr9_+_106429399 0.86 ENSMUST00000150576.1
ribosomal protein L29
chr6_-_100671126 0.83 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
SHQ1 homolog (S. cerevisiae)
chr13_-_22041352 0.71 ENSMUST00000102977.2
histone cluster 1, H4i
chr9_-_78481724 0.70 ENSMUST00000042235.8
eukaryotic translation elongation factor 1 alpha 1
chr10_+_128083273 0.67 ENSMUST00000026459.5
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr17_-_6961156 0.65 ENSMUST00000063683.6
T cell activation GTPase activating protein 1
chr5_+_121397936 0.63 ENSMUST00000042163.8
N(alpha)-acetyltransferase 25, NatB auxiliary subunit
chr8_+_4243264 0.57 ENSMUST00000110996.1
mitogen-activated protein kinase kinase 7
chr9_+_70012540 0.57 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
general transcription factor II A, 2
chr5_+_45493374 0.55 ENSMUST00000046122.6
leucine aminopeptidase 3
chr9_-_20898592 0.54 ENSMUST00000004206.8
eukaryotic translation initiation factor 3, subunit G
chr15_-_95655960 0.48 ENSMUST00000054244.6
developing brain homeobox 2
chr4_-_116627478 0.46 ENSMUST00000081182.4
ENSMUST00000030457.5
nuclear autoantigenic sperm protein (histone-binding)
chr17_+_8165501 0.44 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1 oncogene partner
chr4_-_70410422 0.44 ENSMUST00000144099.1
CDK5 regulatory subunit associated protein 2
chr11_-_70410010 0.42 ENSMUST00000019065.3
ENSMUST00000135148.1
proline, glutamic acid and leucine rich protein 1
chr7_-_78783026 0.42 ENSMUST00000032841.5
mitochondrial ribosomal protein L46
chr7_+_78783119 0.41 ENSMUST00000032840.4
mitochondrial ribosomal protein S11
chr1_+_40465976 0.40 ENSMUST00000108044.2
ENSMUST00000087983.2
interleukin 18 receptor 1
chr11_+_75532127 0.40 ENSMUST00000127226.1
solute carrier family 43, member 2
chr13_-_21832194 0.40 ENSMUST00000102979.1
histone cluster 1, H4n
chr11_-_84916338 0.40 ENSMUST00000103195.4
zinc finger, HIT type 3
chr7_+_28808795 0.38 ENSMUST00000172529.1
heterogeneous nuclear ribonucleoprotein L
chr7_-_141437587 0.37 ENSMUST00000172654.1
ENSMUST00000106006.1
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_+_127091426 0.37 ENSMUST00000056288.5
expressed sequence AI467606
chr1_+_74278550 0.34 ENSMUST00000077985.3
G protein-coupled bile acid receptor 1
chr10_+_79755103 0.34 ENSMUST00000020577.2
fibroblast growth factor 22
chr11_-_100193246 0.34 ENSMUST00000059707.2
keratin 9
chr6_-_99632376 0.33 ENSMUST00000176255.1
predicted gene 20696
chr13_+_37825975 0.33 ENSMUST00000138043.1
ras responsive element binding protein 1
chr13_-_25020289 0.33 ENSMUST00000021772.2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr15_+_40655020 0.31 ENSMUST00000053467.4
zinc finger protein, multitype 2
chr11_-_100207507 0.30 ENSMUST00000007272.7
keratin 14
chr10_+_76531593 0.29 ENSMUST00000048678.6
lanosterol synthase
chr3_+_122245557 0.29 ENSMUST00000029769.7
glutamate-cysteine ligase, modifier subunit
chr9_-_108094459 0.28 ENSMUST00000081309.7
acylpeptide hydrolase
chr11_-_70220969 0.23 ENSMUST00000060010.2
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr18_-_77713978 0.22 ENSMUST00000074653.4
RIKEN cDNA 8030462N17 gene
chr7_-_25816616 0.20 ENSMUST00000043314.3
cytochrome P450, family 2, subfamily s, polypeptide 1
chr2_-_50296680 0.20 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr11_-_87875524 0.18 ENSMUST00000049768.3
eosinophil peroxidase
chr1_+_40465552 0.17 ENSMUST00000167723.1
interleukin 18 receptor 1
chr7_-_102494773 0.17 ENSMUST00000058750.3
olfactory receptor 545
chr13_-_115101909 0.17 ENSMUST00000061673.7
integrin alpha 1
chr11_+_75679259 0.16 ENSMUST00000017920.7
ENSMUST00000108426.1
ENSMUST00000108425.1
ENSMUST00000093115.3
v-crk sarcoma virus CT10 oncogene homolog (avian)
chr3_+_122245625 0.16 ENSMUST00000178826.1
glutamate-cysteine ligase, modifier subunit
chr3_+_121953213 0.14 ENSMUST00000037958.7
ENSMUST00000128366.1
Rho GTPase activating protein 29
chr7_+_141216626 0.14 ENSMUST00000141804.1
ENSMUST00000148975.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chrX_-_147554050 0.13 ENSMUST00000112819.2
ENSMUST00000136789.1
leucine-rich repeats and calponin homology (CH) domain containing 2
chr2_+_155517948 0.12 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
acyl-CoA synthetase short-chain family member 2
chr7_-_142095266 0.11 ENSMUST00000039926.3
dual specificity phosphatase 8
chr19_+_5038826 0.09 ENSMUST00000053705.6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr9_+_121719403 0.08 ENSMUST00000182225.1
natural killer tumor recognition sequence
chr16_+_92301266 0.08 ENSMUST00000063641.4
ENSMUST00000118064.1
small integral membrane protein 11
chr7_+_3617357 0.08 ENSMUST00000076657.4
ENSMUST00000108644.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
chr18_-_34651703 0.07 ENSMUST00000025228.5
ENSMUST00000133181.1
CDC23 cell division cycle 23
chr10_-_116581478 0.07 ENSMUST00000105267.1
ENSMUST00000105265.1
ENSMUST00000167706.1
ENSMUST00000168036.1
ENSMUST00000169921.1
ENSMUST00000020374.5
CCR4-NOT transcription complex, subunit 2
chr13_+_37826018 0.06 ENSMUST00000110238.2
ras responsive element binding protein 1
chr9_+_110532501 0.06 ENSMUST00000153838.2
SET domain containing 2
chr7_-_35802968 0.06 ENSMUST00000061586.4
zinc finger protein 507
chr7_-_44974781 0.05 ENSMUST00000063761.7
carnitine palmitoyltransferase 1c
chr17_+_35879770 0.04 ENSMUST00000025292.8
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr12_+_98628126 0.04 ENSMUST00000048402.5
ENSMUST00000101144.3
ENSMUST00000101146.3
spermatogenesis associated 7
chr11_-_32267547 0.03 ENSMUST00000109389.2
ENSMUST00000129010.1
ENSMUST00000020530.5
nitrogen permease regulator-like 3
chr8_-_115706994 0.03 ENSMUST00000069009.6
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr3_+_95658771 0.03 ENSMUST00000178686.1
myeloid cell leukemia sequence 1
chr11_+_75532099 0.02 ENSMUST00000169547.2
solute carrier family 43, member 2
chr8_-_54724474 0.02 ENSMUST00000175915.1
WD repeat domain 17
chr17_-_23599487 0.02 ENSMUST00000057029.4
zinc finger protein 13
chr5_-_21424664 0.02 ENSMUST00000115245.1
ENSMUST00000030552.5
coiled-coil domain containing 146
chrX_-_73458990 0.01 ENSMUST00000033737.8
ENSMUST00000077243.4
HAUS augmin-like complex, subunit 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.5 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.9 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.1 1.1 GO:0006241 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 0.4 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.6 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.1 3.2 GO:0006284 base-excision repair(GO:0006284)
0.1 1.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.2 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 0.5 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.6 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 1.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.0 1.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441)
0.0 0.7 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083) short-chain fatty acid biosynthetic process(GO:0051790)
0.0 1.0 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.3 GO:2000810 regulation of bicellular tight junction assembly(GO:2000810)
0.0 0.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.3 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.4 GO:0015807 L-amino acid transport(GO:0015807)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.2 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.2 0.5 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.7 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.6 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4 3.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 1.1 GO:0003883 CTP synthase activity(GO:0003883)
0.2 0.5 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 1.0 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.6 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 1.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0038181 bile acid receptor activity(GO:0038181)
0.1 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.1 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.9 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 3.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.9 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type