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2D miR_HR1_12

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Results for Mtf1

Z-value: 0.40

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Transcription factors associated with Mtf1

Gene Symbol Gene ID Gene Info
ENSMUSG00000028890.7 metal response element binding transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_124802678-0.491.0e-01Click!

Activity profile of Mtf1 motif

Sorted Z-values of Mtf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_98490522 0.59 ENSMUST00000035029.2
retinol binding protein 2, cellular
chr8_+_94172618 0.50 ENSMUST00000034214.6
metallothionein 2
chr6_+_90619241 0.41 ENSMUST00000032177.8
solute carrier family 41, member 3
chr8_+_94179089 0.25 ENSMUST00000034215.6
metallothionein 1
chr10_+_77606571 0.24 ENSMUST00000099538.5
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr8_-_54529951 0.23 ENSMUST00000067476.8
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr16_+_22857845 0.21 ENSMUST00000004574.7
ENSMUST00000178320.1
ENSMUST00000166487.2
DnaJ (Hsp40) homolog, subfamily B, member 11
chr9_-_14381242 0.19 ENSMUST00000167549.1
endonuclease domain containing 1
chr4_+_134343181 0.18 ENSMUST00000105873.1
ENSMUST00000105874.2
solute carrier family 30 (zinc transporter), member 2
chr15_-_76616841 0.18 ENSMUST00000073428.5
solute carrier family 39 (zinc transporter), member 4
chr16_-_91597636 0.17 ENSMUST00000023686.8
transmembrane protein 50B
chr4_+_134343466 0.16 ENSMUST00000105872.1
solute carrier family 30 (zinc transporter), member 2
chr14_-_26170283 0.16 ENSMUST00000100809.4
placenta specific 9b
chr11_+_63133068 0.15 ENSMUST00000108700.1
peripheral myelin protein 22
chr11_-_32222233 0.15 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
rhomboid family 1 (Drosophila)
chr19_-_4615453 0.14 ENSMUST00000053597.2
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_63132569 0.14 ENSMUST00000108701.1
peripheral myelin protein 22
chr2_-_91236877 0.14 ENSMUST00000111352.1
damage specific DNA binding protein 2
chr16_-_22857514 0.14 ENSMUST00000004576.6
TBCC domain containing 1
chr12_+_24572276 0.13 ENSMUST00000085553.5
grainyhead-like 1 (Drosophila)
chr19_-_4615647 0.13 ENSMUST00000113822.2
leucine rich repeat and fibronectin type III domain containing 4
chr10_+_77606217 0.13 ENSMUST00000129492.1
ENSMUST00000141228.2
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr8_+_84872105 0.12 ENSMUST00000136026.1
ENSMUST00000170296.1
synaptonemal complex central element protein 2
chr3_-_58692391 0.12 ENSMUST00000070368.7
seven in absentia 2
chr6_+_37870786 0.12 ENSMUST00000120428.1
ENSMUST00000031859.7
tripartite motif-containing 24
chr2_-_91236967 0.11 ENSMUST00000028696.4
damage specific DNA binding protein 2
chr1_+_135729147 0.11 ENSMUST00000027677.7
cysteine and glycine-rich protein 1
chr7_+_119794102 0.10 ENSMUST00000084644.2
RIKEN cDNA 2610020H08 gene
chr2_-_173119402 0.10 ENSMUST00000094287.3
ENSMUST00000179693.1
CCCTC-binding factor (zinc finger protein)-like
chr6_-_39118211 0.10 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr1_+_131867224 0.10 ENSMUST00000112386.1
ENSMUST00000027693.7
RAB7, member RAS oncogene family-like 1
chr8_+_123373778 0.10 ENSMUST00000057934.3
ENSMUST00000108840.2
transcription factor 25 (basic helix-loop-helix)
chr4_-_93335510 0.10 ENSMUST00000066774.4
tumor suppressor candidate 1
chr8_+_92827273 0.09 ENSMUST00000034187.7
matrix metallopeptidase 2
chr8_-_95306585 0.09 ENSMUST00000119870.2
ENSMUST00000093268.4
cyclic nucleotide gated channel beta 1
chr5_-_112356033 0.09 ENSMUST00000051117.2
predicted gene 6583
chr7_+_119793987 0.09 ENSMUST00000033218.8
ENSMUST00000106520.1
RIKEN cDNA 2610020H08 gene
chr2_-_130664565 0.09 ENSMUST00000089559.4
DDRGK domain containing 1
chr9_-_56635624 0.09 ENSMUST00000114256.1
leucine rich repeat and Ig domain containing 1
chr8_+_13159135 0.08 ENSMUST00000033824.6
lysosomal-associated membrane protein 1
chr3_-_121815212 0.08 ENSMUST00000029770.5
ATP-binding cassette, sub-family D (ALD), member 3
chr9_-_66124872 0.08 ENSMUST00000034946.8
sorting nexin 1
chr10_+_70245083 0.08 ENSMUST00000046807.6
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr6_-_145746270 0.07 ENSMUST00000144757.1
predicted gene 15704
chr7_-_109865586 0.07 ENSMUST00000007423.5
ENSMUST00000106728.2
ENSMUST00000106729.1
signal peptide, CUB domain, EGF-like 2
chr9_+_57940104 0.07 ENSMUST00000043059.7
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr1_+_191906743 0.07 ENSMUST00000044954.6
solute carrier family 30 (zinc transporter), member 1
chr9_+_109832998 0.07 ENSMUST00000119376.1
ENSMUST00000122343.1
NME/NM23 nucleoside diphosphate kinase 6
chr2_+_31759993 0.07 ENSMUST00000124089.1
c-abl oncogene 1, non-receptor tyrosine kinase
chr1_-_166002591 0.07 ENSMUST00000111429.4
ENSMUST00000176800.1
POU domain, class 2, transcription factor 1
chr9_+_78175898 0.07 ENSMUST00000180974.1
RIKEN cDNA C920006O11 gene
chr1_-_166002613 0.07 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
POU domain, class 2, transcription factor 1
chr14_+_59201209 0.07 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr11_+_99047311 0.06 ENSMUST00000140772.1
insulin-like growth factor binding protein 4
chr12_+_111758923 0.06 ENSMUST00000118471.1
ENSMUST00000122300.1
kinesin light chain 1
chr9_-_107605295 0.06 ENSMUST00000102529.3
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_167393826 0.06 ENSMUST00000028005.2
microsomal glutathione S-transferase 3
chr12_+_111758848 0.06 ENSMUST00000084941.5
kinesin light chain 1
chr4_-_126163470 0.06 ENSMUST00000097891.3
SH3 domain containing 21
chr10_+_17723220 0.06 ENSMUST00000038107.7
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr3_-_121532271 0.06 ENSMUST00000039197.7
solute carrier family 44, member 3
chr7_-_43313233 0.06 ENSMUST00000012796.7
ENSMUST00000107986.2
zinc finger protein 715
chr4_+_129985098 0.05 ENSMUST00000106017.1
ENSMUST00000121049.1
brain-specific angiogenesis inhibitor 2
chr4_+_133574728 0.05 ENSMUST00000030662.2
G patch domain containing 3
chr4_-_43040279 0.05 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
family with sequence similarity 214, member B
chr4_-_126162619 0.05 ENSMUST00000094760.2
SH3 domain containing 21
chr1_+_167618246 0.05 ENSMUST00000111380.1
retinoid X receptor gamma
chr6_-_23839420 0.04 ENSMUST00000115358.2
ENSMUST00000163871.2
Ca2+-dependent activator protein for secretion 2
chr7_+_43607169 0.04 ENSMUST00000120935.1
ENSMUST00000127765.1
ENSMUST00000032661.7
zinc finger protein 819
chr10_+_77606044 0.04 ENSMUST00000020501.8
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr8_-_70776650 0.04 ENSMUST00000034296.8
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr17_+_71673255 0.04 ENSMUST00000097284.3
family with sequence similarity 179, member A
chr5_+_115506668 0.04 ENSMUST00000067268.8
ENSMUST00000086523.3
paxillin
chr7_+_5056856 0.04 ENSMUST00000131368.1
ENSMUST00000123956.1
coiled-coil domain containing 106
chr6_-_83775767 0.03 ENSMUST00000014892.6
testis expressed gene 261
chr9_-_65391652 0.03 ENSMUST00000068307.3
kelch repeat and BTB (POZ) domain containing 13
chr5_+_30869623 0.03 ENSMUST00000114716.1
transmembrane protein 214
chr4_-_152152207 0.03 ENSMUST00000030785.8
ENSMUST00000105658.1
ENSMUST00000105659.2
espin
chr7_+_140920896 0.03 ENSMUST00000183845.1
ENSMUST00000106045.1
NLR family, pyrin domain containing 6
chr5_+_30869579 0.03 ENSMUST00000046349.7
transmembrane protein 214
chr16_+_18348181 0.03 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
armadillo repeat gene deleted in velo-cardio-facial syndrome
chr2_+_31759932 0.03 ENSMUST00000028190.6
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_-_123749393 0.03 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
arginine/serine-rich coiled-coil 2
chr18_+_11839220 0.02 ENSMUST00000171109.1
ENSMUST00000046948.8
CDK5 and Abl enzyme substrate 1
chr12_+_33957645 0.02 ENSMUST00000049089.5
twist basic helix-loop-helix transcription factor 1
chr11_-_5898771 0.02 ENSMUST00000102921.3
myosin, light polypeptide 7, regulatory
chr10_+_20952547 0.02 ENSMUST00000105525.4
Abelson helper integration site 1
chr4_+_134496996 0.02 ENSMUST00000095074.3
progestin and adipoQ receptor family member VII
chr9_+_108490676 0.02 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
ubiquitin specific peptidase 19
chr15_-_83149307 0.02 ENSMUST00000100375.4
polymerase (DNA-directed), delta interacting protein 3
chr13_-_23934156 0.02 ENSMUST00000052776.2
histone cluster 1, H2ba
chr6_-_56923927 0.02 ENSMUST00000031793.5
5'-nucleotidase, cytosolic III
chr5_+_57718021 0.01 ENSMUST00000094783.3
ENSMUST00000068110.7
protocadherin 7
chr4_+_103619580 0.01 ENSMUST00000106827.1
disabled 1
chr2_+_29889785 0.01 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
outer dense fiber of sperm tails 2
chr3_-_89960562 0.01 ENSMUST00000069805.7
ATPase, class I, type 8B, member 2
chr18_-_84589491 0.01 ENSMUST00000125763.1
zinc finger protein 407
chr1_-_166309585 0.01 ENSMUST00000168347.1
RIKEN cDNA 5330438I03 gene
chr3_-_94412883 0.01 ENSMUST00000181305.1
RIKEN cDNA 1700040D17 gene
chr2_+_29889720 0.01 ENSMUST00000113767.1
outer dense fiber of sperm tails 2
chr19_-_41263931 0.01 ENSMUST00000025989.8
transmembrane 9 superfamily member 3
chrX_+_6873484 0.00 ENSMUST00000145302.1
diacylglycerol kinase kappa
chr12_+_103532435 0.00 ENSMUST00000021631.5
protein phosphatase 4, regulatory subunit 4
chr15_-_93519499 0.00 ENSMUST00000109255.2
prickle homolog 1 (Drosophila)
chr4_+_129984833 0.00 ENSMUST00000120204.1
brain-specific angiogenesis inhibitor 2
chr5_-_123749371 0.00 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
arginine/serine-rich coiled-coil 2
chr7_-_34655500 0.00 ENSMUST00000032709.1
potassium channel tetramerisation domain containing 15

Network of associatons between targets according to the STRING database.

First level regulatory network of Mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061090 positive regulation of sequestering of zinc ion(GO:0061090)
0.1 0.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.1 GO:0097501 stress response to metal ion(GO:0097501)
0.1 0.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.3 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.1 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.1 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0035802 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER