Project

2D miR_HR1_12

Navigation
Downloads

Results for E2f4

Z-value: 3.30

Motif logo

Transcription factors associated with E2f4

Gene Symbol Gene ID Gene Info
ENSMUSG00000014859.8 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.922.9e-05Click!

Activity profile of E2f4 motif

Sorted Z-values of E2f4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_134510999 14.68 ENSMUST00000105866.2
aurora kinase A and ninein interacting protein
chr18_-_34751502 13.12 ENSMUST00000060710.7
cell division cycle 25C
chr1_-_169531343 13.08 ENSMUST00000028000.7
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr19_+_6084983 12.74 ENSMUST00000025704.2
cell division cycle associated 5
chr1_-_169531447 12.28 ENSMUST00000111368.1
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_189688074 12.02 ENSMUST00000171929.1
ENSMUST00000165962.1
centromere protein F
chr14_-_47418407 11.86 ENSMUST00000043296.3
discs, large (Drosophila) homolog-associated protein 5
chr6_+_124830217 11.81 ENSMUST00000131847.1
ENSMUST00000151674.1
cell division cycle associated 3
chr8_-_53638945 10.83 ENSMUST00000047768.4
nei like 3 (E. coli)
chrX_+_164980592 10.42 ENSMUST00000101082.4
ENSMUST00000167446.1
ENSMUST00000057150.6
Fanconi anemia, complementation group B
chr4_-_132345715 10.39 ENSMUST00000084250.4
regulator of chromosome condensation 1
chr4_-_132345686 10.34 ENSMUST00000030726.6
regulator of chromosome condensation 1
chr13_-_73937761 9.83 ENSMUST00000022053.8
thyroid hormone receptor interactor 13
chr11_-_101551837 9.49 ENSMUST00000017290.4
breast cancer 1
chr10_-_88146867 9.29 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
PARP1 binding protein
chr17_-_25727364 8.89 ENSMUST00000170070.1
ENSMUST00000048054.7
CTF18, chromosome transmission fidelity factor 18
chr17_-_24251382 8.48 ENSMUST00000115390.3
cyclin F
chr4_-_116123618 7.96 ENSMUST00000102704.3
ENSMUST00000102705.3
RAD54 like (S. cerevisiae)
chr7_-_92874196 7.49 ENSMUST00000032877.9
RIKEN cDNA 4632434I11 gene
chr14_-_87141206 7.02 ENSMUST00000022599.7
diaphanous homolog 3 (Drosophila)
chr14_-_87141114 6.94 ENSMUST00000168889.1
diaphanous homolog 3 (Drosophila)
chr18_+_34751803 6.74 ENSMUST00000181453.1
ENSMUST00000181641.1
RIKEN cDNA 2010110K18 gene
chr12_+_117843873 6.68 ENSMUST00000176735.1
ENSMUST00000177339.1
cell division cycle associated 7 like
chr16_-_90727329 6.45 ENSMUST00000099554.4
MIS18 kinetochore protein homolog A (S. pombe)
chr9_+_107950952 5.95 ENSMUST00000049348.3
TRAF-interacting protein
chr9_+_106477269 5.84 ENSMUST00000047721.8
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr1_-_57377476 5.57 ENSMUST00000181949.1
RIKEN cDNA 4930558J18 gene
chr1_-_33669745 5.47 ENSMUST00000027312.9
DNA primase, p58 subunit
chr2_+_163054682 5.05 ENSMUST00000018005.3
myeloblastosis oncogene-like 2
chr4_+_11558914 5.05 ENSMUST00000178703.1
ENSMUST00000095145.5
ENSMUST00000108306.2
ENSMUST00000070755.6
RAD54 homolog B (S. cerevisiae)
chr7_-_38107490 4.68 ENSMUST00000108023.3
cyclin E1
chr6_+_113531675 4.66 ENSMUST00000036340.5
ENSMUST00000101051.2
Fanconi anemia, complementation group D2
chr11_+_16951371 4.59 ENSMUST00000109635.1
ENSMUST00000061327.1
F-box protein 48
chr11_+_98907801 4.51 ENSMUST00000092706.6
cell division cycle 6
chr7_-_127260677 4.35 ENSMUST00000035276.4
dCTP pyrophosphatase 1
chr4_-_133967235 4.20 ENSMUST00000123234.1
high mobility group nucleosomal binding domain 2
chr4_-_133967296 3.86 ENSMUST00000105893.1
high mobility group nucleosomal binding domain 2
chr10_+_88147061 3.79 ENSMUST00000169309.1
nucleoporin 37
chr13_+_23535411 3.72 ENSMUST00000080859.5
histone cluster 1, H3g
chr8_+_18595526 3.69 ENSMUST00000146819.1
microcephaly, primary autosomal recessive 1
chr10_+_88146992 3.67 ENSMUST00000052355.7
nucleoporin 37
chr2_+_30286406 3.51 ENSMUST00000138666.1
ENSMUST00000113634.2
nucleoporin 188
chr18_+_56707725 3.50 ENSMUST00000025486.8
lamin B1
chr15_-_76639840 3.49 ENSMUST00000166974.1
ENSMUST00000168185.1
tonsoku-like, DNA repair protein
chr4_-_59783800 3.33 ENSMUST00000107526.1
ENSMUST00000095063.4
INTS3 and NABP interacting protein
chr1_+_157412352 3.11 ENSMUST00000061537.5
RIKEN cDNA 2810025M15 gene
chr6_-_56704673 3.04 ENSMUST00000170382.2
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr8_+_124023394 3.00 ENSMUST00000034457.8
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr17_+_87975044 2.96 ENSMUST00000005503.3
mutS homolog 6 (E. coli)
chr5_-_138171813 2.94 ENSMUST00000155902.1
ENSMUST00000148879.1
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_-_138172383 2.93 ENSMUST00000000505.9
minichromosome maintenance deficient 7 (S. cerevisiae)
chr4_-_133967893 2.90 ENSMUST00000100472.3
ENSMUST00000136327.1
high mobility group nucleosomal binding domain 2
chr10_-_117792663 2.78 ENSMUST00000167943.1
ENSMUST00000064848.5
nucleoporin 107
chr5_+_88764983 2.71 ENSMUST00000031311.9
deoxycytidine kinase
chrX_-_8074720 2.69 ENSMUST00000115636.3
ENSMUST00000115638.3
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr8_+_18595131 2.68 ENSMUST00000039412.8
microcephaly, primary autosomal recessive 1
chr1_+_179803376 2.52 ENSMUST00000097454.2
predicted gene 10518
chr3_+_88553716 2.42 ENSMUST00000008748.6
ubiquilin 4
chr19_+_46075842 2.41 ENSMUST00000165017.1
nucleolar and coiled-body phosphoprotein 1
chr7_+_97371604 2.34 ENSMUST00000098300.4
asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase)
chr17_+_88440711 2.31 ENSMUST00000112238.2
ENSMUST00000155640.1
forkhead box N2
chr5_+_130257029 2.20 ENSMUST00000100662.3
ENSMUST00000040213.6
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
chr2_+_181319714 2.19 ENSMUST00000098971.4
ENSMUST00000054622.8
ENSMUST00000108814.1
ENSMUST00000048608.9
ENSMUST00000108815.1
regulator of telomere elongation helicase 1
chr14_-_54517353 2.19 ENSMUST00000023873.5
protein arginine N-methyltransferase 5
chr7_-_4789541 2.16 ENSMUST00000168578.1
transmembrane protein 238
chr5_-_25705791 2.13 ENSMUST00000030773.7
X-ray repair complementing defective repair in Chinese hamster cells 2
chr19_+_8735808 2.12 ENSMUST00000049424.9
WD repeat domain 74
chr1_-_179803625 2.12 ENSMUST00000027768.7
AT hook containing transcription factor 1
chr4_-_3835595 2.03 ENSMUST00000138502.1
ribosomal protein S20
chr9_+_72438519 2.01 ENSMUST00000184604.1
meiosis-specific nuclear structural protein 1
chr13_-_23745511 1.97 ENSMUST00000091752.2
histone cluster 1, H3c
chr12_+_99884498 1.92 ENSMUST00000153627.1
tyrosyl-DNA phosphodiesterase 1
chr4_-_133967953 1.90 ENSMUST00000102553.4
high mobility group nucleosomal binding domain 2
chr10_+_127677064 1.90 ENSMUST00000118612.1
ENSMUST00000048099.4
transmembrane protein 194
chr2_+_181319806 1.86 ENSMUST00000153112.1
regulator of telomere elongation helicase 1
chr2_-_3512746 1.86 ENSMUST00000056700.7
ENSMUST00000027961.5
heat shock protein 14
heat shock protein 14
chr19_-_5366626 1.84 ENSMUST00000025762.8
barrier to autointegration factor 1
chrX_+_36112110 1.80 ENSMUST00000033418.7
interleukin 13 receptor, alpha 1
chr15_+_57912199 1.79 ENSMUST00000022992.6
TBC1 domain family, member 31
chr5_-_33652339 1.71 ENSMUST00000075670.6
stem-loop binding protein
chr7_-_16286010 1.69 ENSMUST00000145519.2
coiled-coil domain containing 9
chr18_-_60848911 1.57 ENSMUST00000177172.1
ENSMUST00000175934.1
ENSMUST00000176630.1
Treacher Collins Franceschetti syndrome 1, homolog
chr17_-_66101466 1.55 ENSMUST00000024909.8
ENSMUST00000147484.1
ENSMUST00000143987.1
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr2_+_126152141 1.54 ENSMUST00000170908.1
DTW domain containing 1
chr9_-_123678782 1.43 ENSMUST00000170591.1
ENSMUST00000171647.1
solute carrier family 6 (neurotransmitter transporter), member 20A
chr6_-_148831395 1.42 ENSMUST00000145960.1
importin 8
chr17_+_50698525 1.39 ENSMUST00000061681.7
predicted gene 7334
chr17_+_34982099 1.39 ENSMUST00000007266.7
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_140395446 1.36 ENSMUST00000110061.1
MACRO domain containing 2
chr14_-_33447142 1.34 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
mitogen-activated protein kinase 8
chrX_+_105079735 1.34 ENSMUST00000033577.4
polysaccharide biosynthesis domain containing 1
chr13_-_69533839 1.32 ENSMUST00000044081.7
PAP associated domain containing 7
chr17_+_34982154 1.29 ENSMUST00000173004.1
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_72438534 1.26 ENSMUST00000034746.8
meiosis-specific nuclear structural protein 1
chr4_+_108834601 1.24 ENSMUST00000030296.8
thioredoxin domain containing 12 (endoplasmic reticulum)
chr12_+_106010263 1.18 ENSMUST00000021539.8
ENSMUST00000085026.4
ENSMUST00000072040.5
vaccinia related kinase 1
chr1_+_57377593 1.17 ENSMUST00000042734.2
RIKEN cDNA 1700066M21 gene
chr5_+_30232581 1.17 ENSMUST00000145167.1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr17_-_87025353 1.14 ENSMUST00000024957.6
phosphatidylinositol glycan anchor biosynthesis, class F
chrY_+_90784738 1.09 ENSMUST00000179483.1
erythroid differentiation regulator 1
chr2_+_174076296 1.07 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
syntaxin 16
chr14_+_55578123 1.06 ENSMUST00000174484.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_87405049 1.03 ENSMUST00000060835.5
testis expressed gene 14
chr7_+_24884651 1.03 ENSMUST00000153451.2
ENSMUST00000108429.1
ribosomal protein S19
chr11_-_106999369 1.03 ENSMUST00000106768.1
ENSMUST00000144834.1
karyopherin (importin) alpha 2
chrX_+_105079761 1.01 ENSMUST00000119477.1
polysaccharide biosynthesis domain containing 1
chr1_+_132007606 1.01 ENSMUST00000086556.5
ELK4, member of ETS oncogene family
chr4_-_132463873 1.00 ENSMUST00000102567.3
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr17_+_34981847 0.93 ENSMUST00000114011.4
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chrX_+_38600626 0.92 ENSMUST00000000365.2
malignant T cell amplified sequence 1
chr7_+_24884611 0.91 ENSMUST00000108428.1
ribosomal protein S19
chr14_+_8002890 0.91 ENSMUST00000166497.1
abhydrolase domain containing 6
chr10_-_81427114 0.89 ENSMUST00000078185.7
ENSMUST00000020461.8
ENSMUST00000105321.3
nuclear factor I/C
chr9_+_44334685 0.87 ENSMUST00000052686.2
H2A histone family, member X
chr15_+_102406143 0.86 ENSMUST00000170884.1
ENSMUST00000165924.1
ENSMUST00000163709.1
ENSMUST00000001326.6
trans-acting transcription factor 1
chr18_-_39490649 0.85 ENSMUST00000115567.1
nuclear receptor subfamily 3, group C, member 1
chr9_-_103365769 0.83 ENSMUST00000035484.4
ENSMUST00000072249.6
carnitine deficiency-associated gene expressed in ventricle 3
chr6_+_70726430 0.83 ENSMUST00000103410.1
immunoglobulin kappa constant
chr14_+_8002949 0.81 ENSMUST00000026313.3
abhydrolase domain containing 6
chr12_-_118198917 0.79 ENSMUST00000084806.6
dynein, axonemal, heavy chain 11
chrX_-_12762069 0.79 ENSMUST00000096495.4
ENSMUST00000076016.5
mediator complex subunit 14
chr11_-_106999482 0.78 ENSMUST00000018506.6
karyopherin (importin) alpha 2
chr11_+_101552188 0.77 ENSMUST00000147239.1
neighbor of Brca1 gene 1
chr5_-_33652296 0.77 ENSMUST00000151081.1
ENSMUST00000101354.3
stem-loop binding protein
chr3_-_107969162 0.74 ENSMUST00000004136.8
ENSMUST00000106678.1
glutathione S-transferase, mu 3
chr8_-_123158268 0.71 ENSMUST00000000755.7
sulfotransferase family 5A, member 1
chr19_+_4214238 0.70 ENSMUST00000046506.6
cardiotrophin-like cytokine factor 1
chr2_+_101678403 0.68 ENSMUST00000004949.7
TNF receptor-associated factor 6
chr9_+_99456243 0.67 ENSMUST00000163199.2
RIKEN cDNA 1600029I14 gene
chr9_+_44134562 0.67 ENSMUST00000034650.8
ENSMUST00000098852.2
melanoma cell adhesion molecule
chr7_-_16285454 0.66 ENSMUST00000174270.1
coiled-coil domain containing 9
chr11_-_88864534 0.64 ENSMUST00000018572.4
A kinase (PRKA) anchor protein 1
chr3_-_142881942 0.63 ENSMUST00000043812.8
protein kinase N2
chr15_-_38078842 0.63 ENSMUST00000110336.2
ubiquitin protein ligase E3 component n-recognin 5
chr9_+_57708534 0.58 ENSMUST00000043990.7
ENSMUST00000142807.1
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr3_+_121953213 0.56 ENSMUST00000037958.7
ENSMUST00000128366.1
Rho GTPase activating protein 29
chr2_-_26503814 0.53 ENSMUST00000028288.4
notch 1
chr1_+_9798123 0.50 ENSMUST00000168907.1
ENSMUST00000166384.1
serum/glucocorticoid regulated kinase 3
chr11_-_6606053 0.43 ENSMUST00000045713.3
NAC alpha domain containing
chrX_+_162901226 0.36 ENSMUST00000101095.2
cytidine 5'-triphosphate synthase 2
chr2_+_153649617 0.32 ENSMUST00000109771.1
DNA methyltransferase 3B
chr12_-_4233958 0.32 ENSMUST00000111169.3
ENSMUST00000020981.5
centromere protein O
chr14_+_31019159 0.30 ENSMUST00000112094.1
ENSMUST00000144009.1
polybromo 1
chr10_-_91123955 0.29 ENSMUST00000164505.1
ENSMUST00000170810.1
ENSMUST00000076694.6
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
chr2_-_145935014 0.29 ENSMUST00000001818.4
Crn, crooked neck-like 1 (Drosophila)
chrX_+_162901567 0.29 ENSMUST00000112303.1
ENSMUST00000033727.7
cytidine 5'-triphosphate synthase 2
chr9_-_82975475 0.28 ENSMUST00000034787.5
pleckstrin homology domain interacting protein
chr2_-_166713758 0.25 ENSMUST00000036719.5
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chrX_+_162901762 0.24 ENSMUST00000112302.1
ENSMUST00000112301.1
cytidine 5'-triphosphate synthase 2
chr8_-_64205970 0.23 ENSMUST00000066166.4
tolloid-like
chr4_+_44004438 0.22 ENSMUST00000107846.3
clathrin, light polypeptide (Lca)
chr1_-_9748376 0.22 ENSMUST00000057438.6
valosin containing protein (p97)/p47 complex interacting protein 1
chr15_+_12824841 0.21 ENSMUST00000090292.5
drosha, ribonuclease type III
chr17_-_17624458 0.20 ENSMUST00000041047.2
leucyl/cystinyl aminopeptidase
chr1_+_52630692 0.15 ENSMUST00000165859.1
transmembrane protein 194B
chr5_-_66080971 0.14 ENSMUST00000127275.1
ENSMUST00000113724.1
RNA binding motif protein 47
chr9_-_44134481 0.11 ENSMUST00000180670.1
predicted gene 10687
chr11_+_119602981 0.11 ENSMUST00000026671.6
regulatory associated protein of MTOR, complex 1
chr15_+_12824815 0.09 ENSMUST00000169061.1
drosha, ribonuclease type III
chr5_+_144100387 0.08 ENSMUST00000041804.7
lemur tyrosine kinase 2
chr8_-_69974367 0.07 ENSMUST00000116463.2
GATA zinc finger domain containing 2A
chr7_+_97579868 0.05 ENSMUST00000042399.7
ENSMUST00000107153.1
remodeling and spacing factor 1
chr8_-_64849818 0.05 ENSMUST00000034017.7
kelch-like 2, Mayven
chr9_-_65580040 0.04 ENSMUST00000068944.7
pleckstrin homology domain containing, family O member 2
chr15_-_39943963 0.03 ENSMUST00000110305.2
low density lipoprotein-related protein 12
chr1_+_136052750 0.01 ENSMUST00000160641.1
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr17_+_25727726 0.00 ENSMUST00000047273.1
RNA pseudouridylate synthase domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
3.2 9.5 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
2.6 10.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
1.4 5.5 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.2 9.8 GO:0007144 female meiosis I(GO:0007144)
1.2 8.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.2 3.5 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.1 4.3 GO:0009223 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
1.1 6.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.1 6.4 GO:0060623 regulation of chromosome condensation(GO:0060623)
1.0 4.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
1.0 8.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.9 2.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.8 9.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.7 26.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.7 3.5 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.7 2.7 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.7 5.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 16.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 2.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.5 2.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.5 1.9 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.5 4.7 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.4 1.8 GO:0035962 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.4 2.2 GO:0043985 histone H4-R3 methylation(GO:0043985) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.4 13.1 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 13.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.4 24.4 GO:0051290 protein heterotetramerization(GO:0051290)
0.4 2.4 GO:0007000 nucleolus organization(GO:0007000)
0.4 6.0 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.4 1.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.3 9.2 GO:0006270 DNA replication initiation(GO:0006270)
0.3 1.3 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.3 12.0 GO:0051310 metaphase plate congression(GO:0051310)
0.3 3.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 1.2 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.3 2.7 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.2 2.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.2 1.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.7 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.2 10.8 GO:0006284 base-excision repair(GO:0006284)
0.2 1.8 GO:0015074 DNA integration(GO:0015074)
0.2 0.9 GO:0002188 translation reinitiation(GO:0002188)
0.2 3.0 GO:0070986 left/right axis specification(GO:0070986)
0.2 0.6 GO:1900045 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) negative regulation of interleukin-17 secretion(GO:1905077)
0.2 1.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.2 2.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.2 3.5 GO:0031297 replication fork processing(GO:0031297)
0.2 1.6 GO:0014029 neural crest formation(GO:0014029)
0.1 1.9 GO:0000012 single strand break repair(GO:0000012)
0.1 2.3 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 1.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.9 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 0.9 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.1 17.3 GO:0007051 spindle organization(GO:0007051)
0.1 0.3 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.1 0.6 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.7 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.1 1.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.8 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.1 1.0 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.9 GO:0006241 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.1 0.3 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.7 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 2.1 GO:0001825 blastocyst formation(GO:0001825)
0.0 1.1 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 4.2 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 2.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0034508 centromere complex assembly(GO:0034508)
0.0 1.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.6 GO:0051028 mRNA transport(GO:0051028)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.4 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 0.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.8 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 4.6 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.1 GO:0021995 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 0.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.5 GO:1901099 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 1.1 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0 0.7 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.0 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.0 0.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 25.4 GO:0031262 Ndc80 complex(GO:0031262)
1.6 9.5 GO:0070531 BRCA1-A complex(GO:0070531)
1.4 12.7 GO:0008278 cohesin complex(GO:0008278)
1.2 3.5 GO:0035101 FACT complex(GO:0035101)
1.1 12.4 GO:0031080 nuclear pore outer ring(GO:0031080)
1.1 5.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.1 12.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.0 5.0 GO:0031523 Myb complex(GO:0031523)
1.0 8.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.9 6.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.9 10.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.8 5.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.7 3.5 GO:0044611 nuclear pore inner ring(GO:0044611)
0.7 10.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.7 3.3 GO:0070876 SOSS complex(GO:0070876)
0.6 11.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 2.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 3.5 GO:0005638 lamin filament(GO:0005638)
0.5 5.9 GO:0042555 MCM complex(GO:0042555)
0.4 2.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.4 3.0 GO:0032300 mismatch repair complex(GO:0032300)
0.4 2.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.3 1.8 GO:0070847 core mediator complex(GO:0070847)
0.3 1.1 GO:0008537 proteasome activator complex(GO:0008537)
0.2 2.2 GO:0034709 methylosome(GO:0034709)
0.2 2.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.2 0.7 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 19.2 GO:0000922 spindle pole(GO:0000922)
0.2 13.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 6.5 GO:0000793 condensed chromosome(GO:0000793)
0.1 3.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 8.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.3 GO:0070877 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 4.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 4.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.2 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 2.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 3.0 GO:0016235 aggresome(GO:0016235)
0.1 2.4 GO:0015030 Cajal body(GO:0015030)
0.1 2.0 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.0 7.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 7.6 GO:0001650 fibrillar center(GO:0001650)
0.0 3.3 GO:0005882 intermediate filament(GO:0005882)
0.0 6.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 3.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.3 GO:0005795 Golgi stack(GO:0005795)
0.0 12.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.8 GO:0030286 dynein complex(GO:0030286)
0.0 0.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 20.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
2.2 10.8 GO:0000405 bubble DNA binding(GO:0000405)
1.0 3.0 GO:0032142 guanine/thymine mispair binding(GO:0032137) single guanine insertion binding(GO:0032142)
0.8 2.5 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.8 8.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.8 8.0 GO:0036310 annealing helicase activity(GO:0036310)
0.8 2.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.7 5.8 GO:0034511 U3 snoRNA binding(GO:0034511)
0.7 5.0 GO:0015616 DNA translocase activity(GO:0015616)
0.7 2.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.5 2.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.5 1.6 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.5 5.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 4.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 1.2 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.3 1.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 2.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.3 12.0 GO:0070840 dynein complex binding(GO:0070840)
0.3 2.1 GO:0000150 recombinase activity(GO:0000150)
0.3 9.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.3 13.1 GO:0050699 WW domain binding(GO:0050699)
0.3 6.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 0.9 GO:0003883 CTP synthase activity(GO:0003883)
0.2 5.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 1.2 GO:0031493 nucleosomal histone binding(GO:0031493) histone threonine kinase activity(GO:0035184)
0.2 10.4 GO:0003684 damaged DNA binding(GO:0003684)
0.2 1.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 4.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 0.9 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 2.2 GO:0010181 FMN binding(GO:0010181)
0.1 3.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 1.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 3.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 5.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 4.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.3 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 1.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.7 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 2.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.9 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 8.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.4 GO:0019213 deacetylase activity(GO:0019213)
0.0 13.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 1.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 10.3 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.0 GO:0042393 histone binding(GO:0042393)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.8 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 28.1 PID ATM PATHWAY ATM pathway
0.5 10.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 17.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.3 11.9 PID AURORA A PATHWAY Aurora A signaling
0.3 1.8 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.3 10.4 PID ATR PATHWAY ATR signaling pathway
0.2 19.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 7.2 PID E2F PATHWAY E2F transcription factor network
0.1 3.5 ST GAQ PATHWAY G alpha q Pathway
0.1 2.0 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 3.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 13.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.1 24.6 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.6 5.5 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.6 14.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 7.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4 13.8 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.4 5.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 5.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 20.7 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.2 2.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 22.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 1.8 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 7.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 2.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.0 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.1 2.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 3.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 4.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation