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2D miR_HR1_12

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Results for Nfat5

Z-value: 0.37

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Transcription factors associated with Nfat5

Gene Symbol Gene ID Gene Info
ENSMUSG00000003847.10 nuclear factor of activated T cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293500_1072935590.303.4e-01Click!

Activity profile of Nfat5 motif

Sorted Z-values of Nfat5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_5639210 0.43 ENSMUST00000019906.4
vasoactive intestinal polypeptide
chr7_+_141078188 0.36 ENSMUST00000106039.2
plakophilin 3
chr2_-_30415389 0.34 ENSMUST00000142096.1
carnitine acetyltransferase
chr6_+_123262107 0.33 ENSMUST00000032240.2
C-type lectin domain family 4, member d
chr8_-_25091341 0.29 ENSMUST00000125466.1
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2
chr17_-_34517352 0.27 ENSMUST00000075483.4
butyrophilin-like 6
chr6_+_120773633 0.26 ENSMUST00000112682.2
solute carrier family 25 (mitochondrial carrier), member 18
chr18_+_36559972 0.25 ENSMUST00000134146.1
ankyrin repeat and KH domain containing 1
chr1_+_193301953 0.24 ENSMUST00000016315.9
laminin, beta 3
chr7_+_99535652 0.23 ENSMUST00000032995.8
ENSMUST00000162404.1
arrestin, beta 1
chr1_+_24678536 0.22 ENSMUST00000095062.3
LMBR1 domain containing 1
chr4_+_110397764 0.21 ENSMUST00000097920.2
ENSMUST00000080744.6
ATP/GTP binding protein-like 4
chr11_-_70656467 0.20 ENSMUST00000131642.1
predicted gene 12319
chr7_+_46847128 0.19 ENSMUST00000005051.4
lactate dehydrogenase A
chr10_+_112165676 0.19 ENSMUST00000170013.1
calcyphosphine 2
chr14_-_16575456 0.19 ENSMUST00000063750.6
retinoic acid receptor, beta
chr4_-_82505707 0.18 ENSMUST00000107248.1
ENSMUST00000107247.1
nuclear factor I/B
chr3_-_129755305 0.18 ENSMUST00000029653.2
epidermal growth factor
chr5_+_139423151 0.17 ENSMUST00000066211.4
G protein-coupled estrogen receptor 1
chr7_+_99535439 0.17 ENSMUST00000098266.2
ENSMUST00000179755.1
arrestin, beta 1
chr4_+_134864536 0.17 ENSMUST00000030627.7
Rh blood group, D antigen
chr7_+_110773658 0.17 ENSMUST00000143786.1
adenosine monophosphate deaminase 3
chrX_+_139684980 0.16 ENSMUST00000096313.3
TBC1 domain family, member 8B
chr14_-_23803304 0.16 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr4_+_110397661 0.16 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
ATP/GTP binding protein-like 4
chr7_-_43533171 0.16 ENSMUST00000004728.5
ENSMUST00000039861.5
CD33 antigen
chr1_+_180945898 0.15 ENSMUST00000160508.1
ENSMUST00000160536.1
transmembrane protein 63a
chr3_-_27710413 0.15 ENSMUST00000046157.4
fibronectin type III domain containing 3B
chr2_+_125136692 0.15 ENSMUST00000099452.2
cortexin 2
chr18_+_36560581 0.14 ENSMUST00000155329.2
ankyrin repeat and KH domain containing 1
chr19_-_5845471 0.14 ENSMUST00000174287.1
ENSMUST00000173672.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_+_90772435 0.13 ENSMUST00000031320.6
platelet factor 4
chr17_-_34475937 0.12 ENSMUST00000065841.4
butyrophilin-like 4
chr10_-_109010955 0.12 ENSMUST00000105276.1
ENSMUST00000064054.7
synaptotagmin I
chr8_-_105979413 0.12 ENSMUST00000034371.7
dipeptidase 3
chr12_+_35992900 0.11 ENSMUST00000020898.5
anterior gradient 2
chr1_+_88070765 0.11 ENSMUST00000073772.4
UDP glucuronosyltransferase 1 family, polypeptide A9
chr6_-_142964404 0.11 ENSMUST00000032421.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr10_-_62507737 0.11 ENSMUST00000020271.6
serglycin
chr2_+_68117713 0.10 ENSMUST00000112346.2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_16817339 0.10 ENSMUST00000040820.6
monoamine oxidase B
chr2_+_86007778 0.09 ENSMUST00000062166.1
olfactory receptor 1032
chr16_+_84774123 0.09 ENSMUST00000114195.1
junction adhesion molecule 2
chr3_-_15838643 0.09 ENSMUST00000148194.1
signal-regulatory protein beta 1C
chr12_-_83597140 0.09 ENSMUST00000048319.4
zinc finger, FYVE domain containing 1
chr11_-_58570559 0.09 ENSMUST00000108822.2
olfactory receptor 224
chr16_+_84774361 0.08 ENSMUST00000098407.2
junction adhesion molecule 2
chr5_-_104021799 0.08 ENSMUST00000119025.1
hydroxysteroid (17-beta) dehydrogenase 11
chr7_-_30598863 0.08 ENSMUST00000108150.1
zinc finger and BTB domain containing 32
chr6_-_129275360 0.08 ENSMUST00000032259.3
CD69 antigen
chr6_+_91684061 0.08 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr10_-_29535857 0.08 ENSMUST00000092623.3
R-spondin 3 homolog (Xenopus laevis)
chr5_-_105051047 0.08 ENSMUST00000112718.4
guanylate-binding protein 8
chr1_+_88055377 0.08 ENSMUST00000138182.1
ENSMUST00000113142.3
UDP glycosyltransferase 1 family, polypeptide A10
chr7_+_6371364 0.08 ENSMUST00000086323.4
ENSMUST00000108559.2
zinc finger protein 78
chr19_+_25236959 0.07 ENSMUST00000049400.8
KN motif and ankyrin repeat domains 1
chr18_+_61275002 0.07 ENSMUST00000135688.1
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr9_-_71771535 0.07 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
cingulin-like 1
chr16_+_27389911 0.07 ENSMUST00000143823.1
coiled-coil domain containing 50
chr2_-_30415509 0.07 ENSMUST00000134120.1
ENSMUST00000102854.3
carnitine acetyltransferase
chr19_+_10525244 0.06 ENSMUST00000038379.3
cleavage and polyadenylation specific factor 7
chr16_-_79091078 0.06 ENSMUST00000023566.4
ENSMUST00000060402.5
transmembrane protease, serine 15
chr5_-_104021919 0.06 ENSMUST00000031251.9
hydroxysteroid (17-beta) dehydrogenase 11
chr16_-_16600533 0.06 ENSMUST00000159542.1
FYVE, RhoGEF and PH domain containing 4
chr12_-_86079019 0.06 ENSMUST00000003687.6
transforming growth factor, beta 3
chr7_-_126625676 0.05 ENSMUST00000032961.3
nuclear protein transcription regulator 1
chrX_+_72987339 0.05 ENSMUST00000164800.1
ENSMUST00000114546.2
zinc finger protein 185
chr15_-_75894474 0.05 ENSMUST00000023237.6
nicotinate phosphoribosyltransferase domain containing 1
chr17_+_87107621 0.05 ENSMUST00000041369.6
suppressor of cytokine signaling 5
chr5_+_120511213 0.05 ENSMUST00000111890.2
ENSMUST00000076051.5
ENSMUST00000147496.1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr5_-_27501362 0.05 ENSMUST00000155721.1
ENSMUST00000053257.3
spermatogenesis associated glutamate (E)-rich protein 4b
chr11_-_118401826 0.05 ENSMUST00000106290.3
ENSMUST00000043722.3
lectin, galactoside-binding, soluble, 3 binding protein
chr19_-_10525201 0.05 ENSMUST00000025570.6
succinate dehydrogenase complex assembly factor 2
chr11_-_99493112 0.04 ENSMUST00000006969.7
keratin 23
chr5_+_120511168 0.04 ENSMUST00000068326.7
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr5_-_26089291 0.04 ENSMUST00000094946.4
predicted gene 10471
chr10_-_86541334 0.04 ENSMUST00000165173.1
predicted gene 6729
chr1_+_88055467 0.03 ENSMUST00000173325.1
UDP glycosyltransferase 1 family, polypeptide A10
chr6_-_101377897 0.03 ENSMUST00000075994.6
PDZ domain containing RING finger 3
chrX_-_49797700 0.03 ENSMUST00000033442.7
ENSMUST00000114891.1
immunoglobulin superfamily, member 1
chr14_+_17660956 0.03 ENSMUST00000022303.7
ENSMUST00000091471.4
thyroid hormone receptor beta
chr7_-_141918481 0.03 ENSMUST00000151890.1
toll interacting protein
chr2_-_177925604 0.03 ENSMUST00000108934.2
ENSMUST00000081529.4
RIKEN cDNA C330013J21 gene
chr15_+_5185700 0.03 ENSMUST00000081640.5
tetratricopeptide repeat domain 33
chr3_-_69004565 0.02 ENSMUST00000169064.1
intraflagellar transport 80
chr6_+_121210731 0.02 ENSMUST00000032233.7
tubulin, alpha 8
chr7_-_81493725 0.02 ENSMUST00000119121.1
adaptor-related protein complex 3, beta 2 subunit
chr7_+_20008023 0.02 ENSMUST00000073151.6
ENSMUST00000137183.1
NLR family, pyrin domain containing 9B
chr8_+_86745679 0.02 ENSMUST00000098532.2
predicted gene 10638
chr13_-_113180897 0.02 ENSMUST00000038212.7
granzyme K
chrX_+_74429671 0.02 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
inhibitor of kappaB kinase gamma
chr6_-_58907120 0.02 ENSMUST00000059539.3
nucleosome assembly protein 1-like 5
chr10_+_21994666 0.02 ENSMUST00000020145.5
serum/glucocorticoid regulated kinase 1
chr2_-_30415302 0.01 ENSMUST00000132981.2
ENSMUST00000129494.1
carnitine acetyltransferase
chr5_-_137871739 0.01 ENSMUST00000164886.1
paired immunoglobin-like type 2 receptor beta 2
chr10_-_95415484 0.01 ENSMUST00000172070.1
ENSMUST00000150432.1
suppressor of cytokine signaling 2
chr2_+_172549581 0.01 ENSMUST00000030391.2
transcription factor AP-2, gamma
chr1_+_165485168 0.01 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
adenylate cyclase 10
chr9_-_7835255 0.00 ENSMUST00000074246.6
baculoviral IAP repeat-containing 2
chr9_+_7764041 0.00 ENSMUST00000052865.9
transmembrane protein 123
chr5_-_66618752 0.00 ENSMUST00000162366.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr7_+_110774240 0.00 ENSMUST00000147587.1
adenosine monophosphate deaminase 3
chr11_+_119022962 0.00 ENSMUST00000026662.7
chromobox 2
chr7_-_81493883 0.00 ENSMUST00000082090.7
adaptor-related protein complex 3, beta 2 subunit
chr5_-_66618636 0.00 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
amyloid beta (A4) precursor protein-binding, family B, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfat5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0010579 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.3 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.1 0.4 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.4 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.2 GO:1904305 negative regulation of gastro-intestinal system smooth muscle contraction(GO:1904305) negative regulation of small intestine smooth muscle contraction(GO:1904348)
0.0 0.2 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
0.0 0.2 GO:0007262 STAT protein import into nucleus(GO:0007262) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.1 GO:0033370 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.2 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005914 spot adherens junction(GO:0005914)
0.1 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.2 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation