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2D miR_HR1_12

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Results for Onecut1_Cux2

Z-value: 0.54

Motif logo

Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
ENSMUSG00000043013.9 one cut domain, family member 1
ENSMUSG00000042589.12 cut-like homeobox 2
ENSMUSG00000072641.1 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.411.9e-01Click!
Cux2mm10_v2_chr5_-_122049822_1220498820.313.3e-01Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_84698769 1.08 ENSMUST00000095550.2
synapse differentiation inducing 1 like
chr1_-_158958367 1.03 ENSMUST00000159861.2
pappalysin 2
chr6_+_4755327 0.93 ENSMUST00000176551.1
paternally expressed 10
chr4_-_63154130 0.75 ENSMUST00000030041.4
alpha 1 microglobulin/bikunin
chr10_-_64090265 0.70 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr10_-_128401218 0.58 ENSMUST00000042666.5
solute carrier family 39 (metal ion transporter), member 5
chr17_-_54299034 0.44 ENSMUST00000095712.3
solute carrier family 5 (choline transporter), member 7
chr7_+_44207307 0.44 ENSMUST00000077354.4
kallikrein 1-related pepidase b4
chr9_+_59589288 0.42 ENSMUST00000121266.1
ENSMUST00000118164.1
CUGBP, Elav-like family member 6
chr7_+_35802593 0.42 ENSMUST00000052454.2
RIKEN cDNA E130304I02 gene
chr6_+_139843648 0.42 ENSMUST00000087657.6
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr14_+_68083853 0.40 ENSMUST00000022639.7
neurofilament, light polypeptide
chrX_+_41401128 0.39 ENSMUST00000115103.2
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr1_-_13127163 0.38 ENSMUST00000047577.6
PR domain containing 14
chr6_-_136922169 0.37 ENSMUST00000032343.6
endoplasmic reticulum protein 27
chr7_-_127449109 0.37 ENSMUST00000053392.4
zinc finger protein 689
chr11_+_117484368 0.29 ENSMUST00000092394.3
predicted gene 11733
chr3_+_125404072 0.29 ENSMUST00000173932.1
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_+_127064107 0.28 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
par-3 (partitioning defective 3) homolog (C. elegans)
chrX_+_101377267 0.28 ENSMUST00000052130.7
gap junction protein, beta 1
chr14_-_30943275 0.28 ENSMUST00000006704.8
ENSMUST00000163118.1
inter-alpha trypsin inhibitor, heavy chain 1
chr19_-_57197556 0.28 ENSMUST00000099294.2
actin-binding LIM protein 1
chrX_-_7574120 0.26 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr3_+_125404292 0.26 ENSMUST00000144344.1
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_-_129755305 0.26 ENSMUST00000029653.2
epidermal growth factor
chr3_+_8509477 0.25 ENSMUST00000029002.7
stathmin-like 2
chr5_-_5694559 0.24 ENSMUST00000115426.2
six transmembrane epithelial antigen of prostate 2
chr19_-_32061438 0.23 ENSMUST00000096119.4
N-acylsphingosine amidohydrolase 2
chr19_+_56287911 0.20 ENSMUST00000095948.4
hyaluronic acid binding protein 2
chr19_-_37178011 0.19 ENSMUST00000133988.1
cytoplasmic polyadenylation element binding protein 3
chr14_+_17981633 0.19 ENSMUST00000022304.8
thyroid hormone receptor beta
chr19_+_26750939 0.19 ENSMUST00000175953.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_-_42676967 0.18 ENSMUST00000022921.5
angiopoietin 1
chr6_+_29853746 0.18 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
S-adenosylhomocysteine hydrolase-like 2
chr16_+_44765732 0.18 ENSMUST00000057488.8
CD200 receptor 1
chr9_-_114844090 0.18 ENSMUST00000047013.3
CKLF-like MARVEL transmembrane domain containing 8
chr8_+_127064022 0.17 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
par-3 (partitioning defective 3) homolog (C. elegans)
chr11_-_120624973 0.17 ENSMUST00000106183.2
ENSMUST00000080202.5
sirtuin 7
chr6_+_121346618 0.16 ENSMUST00000032200.9
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr12_+_72441933 0.15 ENSMUST00000161284.1
leucine rich repeat containing 9
chr10_-_112928974 0.14 ENSMUST00000099276.2
ataxin 7-like 3B
chr5_+_149678224 0.14 ENSMUST00000100404.3
beta 1,3-galactosyltransferase-like
chrX_+_56454871 0.14 ENSMUST00000039374.2
ENSMUST00000101553.2
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr3_+_28697901 0.14 ENSMUST00000029240.7
solute carrier family 2 (facilitated glucose transporter), member 2
chr5_+_63649335 0.13 ENSMUST00000159584.1
RIKEN cDNA 3110047P20 gene
chr4_+_62965560 0.13 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
zinc finger protein 618
chr4_-_110292719 0.13 ENSMUST00000106601.1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_51880312 0.13 ENSMUST00000145049.1
growth arrest specific 2
chr11_+_101367542 0.12 ENSMUST00000019469.2
glucose-6-phosphatase, catalytic
chr7_+_75848338 0.12 ENSMUST00000092073.5
ENSMUST00000171155.2
kelch-like 25
chrX_+_56609751 0.12 ENSMUST00000144068.1
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr12_+_72441852 0.11 ENSMUST00000162159.1
leucine rich repeat containing 9
chr18_+_57468478 0.11 ENSMUST00000091892.2
cortexin 3
chr5_-_3596071 0.10 ENSMUST00000121877.1
RNA binding motif protein 48
chr2_-_69342600 0.10 ENSMUST00000102709.1
ENSMUST00000102710.3
ENSMUST00000180142.1
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr2_-_84775420 0.10 ENSMUST00000111641.1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr11_+_78499087 0.10 ENSMUST00000017488.4
vitronectin
chr2_-_148046896 0.10 ENSMUST00000172928.1
ENSMUST00000047315.3
forkhead box A2
chr5_-_138272786 0.09 ENSMUST00000161279.1
ENSMUST00000161647.1
galactose-3-O-sulfotransferase 4
chr8_-_8660773 0.09 ENSMUST00000001319.7
ephrin B2
chr2_+_163602294 0.09 ENSMUST00000171696.1
ENSMUST00000109408.3
tocopherol (alpha) transfer protein-like
chrX_+_82948861 0.08 ENSMUST00000114000.1
dystrophin, muscular dystrophy
chr4_+_5724304 0.08 ENSMUST00000108380.1
family with sequence similarity 110, member B
chr19_-_57197435 0.08 ENSMUST00000111550.1
actin-binding LIM protein 1
chr5_-_136567307 0.08 ENSMUST00000004097.9
cut-like homeobox 1
chr5_-_122050102 0.08 ENSMUST00000154139.1
cut-like homeobox 2
chr2_-_84775388 0.07 ENSMUST00000023994.3
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_32451396 0.07 ENSMUST00000028160.8
ENSMUST00000113310.2
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr5_-_138272733 0.07 ENSMUST00000161665.1
ENSMUST00000100530.1
galactose-3-O-sulfotransferase 4
chr16_-_95459245 0.07 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
avian erythroblastosis virus E-26 (v-ets) oncogene related
chr8_-_91801547 0.07 ENSMUST00000093312.4
Iroquois related homeobox 3 (Drosophila)
chrX_-_51205990 0.07 ENSMUST00000114876.2
muscleblind-like 3 (Drosophila)
chr5_-_3596540 0.07 ENSMUST00000042753.7
RNA binding motif protein 48
chr7_-_127448993 0.06 ENSMUST00000106299.1
zinc finger protein 689
chr3_+_102010138 0.06 ENSMUST00000066187.4
nescient helix loop helix 2
chr12_-_80260091 0.06 ENSMUST00000167327.1
actinin, alpha 1
chr1_-_54194048 0.06 ENSMUST00000120904.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr19_+_31082841 0.06 ENSMUST00000066039.6
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr18_+_12972225 0.05 ENSMUST00000025290.5
imprinted and ancient
chr3_+_146597077 0.05 ENSMUST00000029837.7
ENSMUST00000121133.1
urate oxidase
chr9_+_54980880 0.05 ENSMUST00000093844.3
cholinergic receptor, nicotinic, alpha polypeptide 5
chr14_-_55092277 0.05 ENSMUST00000036328.8
zinc finger homeobox 2
chr3_-_146596588 0.04 ENSMUST00000029836.4
deoxyribonuclease II beta
chr5_+_3596066 0.04 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
peroxisomal biogenesis factor 1
chr4_-_46991842 0.04 ENSMUST00000107749.2
gamma-aminobutyric acid (GABA) B receptor, 2
chr2_-_168767136 0.04 ENSMUST00000029061.5
ENSMUST00000103074.1
sal-like 4 (Drosophila)
chr15_-_78468620 0.04 ENSMUST00000017086.3
transmembrane serine protease 6
chr4_+_117849361 0.04 ENSMUST00000163288.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_+_32430895 0.03 ENSMUST00000115137.1
ENSMUST00000079791.4
phosphate cytidylyltransferase 1, choline, alpha isoform
chr3_+_5218546 0.03 ENSMUST00000026284.6
zinc finger homeodomain 4
chr7_+_45627482 0.03 ENSMUST00000057927.7
Ras interacting protein 1
chr8_-_79399513 0.03 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
SMAD family member 1
chr18_+_35965088 0.03 ENSMUST00000175734.1
pleckstrin and Sec7 domain containing 2
chr13_-_54688246 0.02 ENSMUST00000122935.1
ENSMUST00000128257.1
ring finger protein 44
chr19_+_59219648 0.02 ENSMUST00000065204.6
potassium channel, subfamily K, member 18
chr1_-_89933290 0.02 ENSMUST00000036954.7
gastrulation brain homeobox 2
chr6_-_143100028 0.02 ENSMUST00000111758.2
ENSMUST00000171349.1
ENSMUST00000087485.4
C2 calcium-dependent domain containing 5
chr19_-_57197377 0.02 ENSMUST00000111546.1
actin-binding LIM protein 1
chr19_+_55894508 0.02 ENSMUST00000142291.1
transcription factor 7 like 2, T cell specific, HMG box
chr8_+_56294552 0.02 ENSMUST00000034026.8
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr2_-_168767029 0.02 ENSMUST00000075044.3
sal-like 4 (Drosophila)
chr5_+_144100387 0.01 ENSMUST00000041804.7
lemur tyrosine kinase 2
chr12_-_46818749 0.01 ENSMUST00000021438.6
neuro-oncological ventral antigen 1
chr18_+_35965036 0.01 ENSMUST00000176873.1
ENSMUST00000177432.1
pleckstrin and Sec7 domain containing 2
chr18_-_84589491 0.01 ENSMUST00000125763.1
zinc finger protein 407
chrX_+_134404543 0.01 ENSMUST00000113228.1
ENSMUST00000153424.1
dystrophin related protein 2
chr8_+_113643206 0.01 ENSMUST00000034219.4
ENSMUST00000095173.1
synaptonemal complex central element protein 1 like
chr17_-_24479034 0.00 ENSMUST00000179163.1
ENSMUST00000070888.6
MTOR associated protein, LST8 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 0.4 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.1 0.4 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.4 GO:1902093 inner cell mass cell fate commitment(GO:0001827) positive regulation of sperm motility(GO:1902093)
0.1 0.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.5 GO:0003383 apical constriction(GO:0003383)
0.1 0.7 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.2 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.1 0.2 GO:0009992 cellular water homeostasis(GO:0009992)
0.1 0.3 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.2 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0 0.1 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.3 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.2 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.3 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.4 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.4 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.1 GO:1903849 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.0 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0033269 internode region of axon(GO:0033269)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:2001069 glycogen binding(GO:2001069)
0.1 0.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220) choline binding(GO:0033265)
0.1 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0 0.2 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0055056 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.4 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.0 GO:0004531 deoxyribonuclease II activity(GO:0004531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling