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2D miR_HR1_12

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Results for Zkscan3

Z-value: 0.56

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Transcription factors associated with Zkscan3

Gene Symbol Gene ID Gene Info
ENSMUSG00000021327.12 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_214027550.342.9e-01Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_100786402 1.83 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
cyclin B1
chr5_-_100572192 0.90 ENSMUST00000031264.5
placenta-specific 8
chr5_+_120649188 0.82 ENSMUST00000156722.1
RAS protein activator like 1 (GAP1 like)
chr7_+_19518731 0.73 ENSMUST00000078908.4
NTPase, KAP family P-loop domain containing 1
chr3_+_79629074 0.60 ENSMUST00000029388.8
RIKEN cDNA 4930579G24 gene
chr2_+_118772766 0.56 ENSMUST00000130293.1
ENSMUST00000061360.3
proline/histidine/glycine-rich 1
chr8_+_106893616 0.51 ENSMUST00000047629.5
cirrhosis, autosomal recessive 1A (human)
chr12_-_69724830 0.46 ENSMUST00000021370.8
L-2-hydroxyglutarate dehydrogenase
chr6_+_71199827 0.42 ENSMUST00000067492.7
fatty acid binding protein 1, liver
chr7_+_101896340 0.40 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
anaphase prompoting complex C subunit 15
chr13_-_38658991 0.38 ENSMUST00000001757.7
eukaryotic translation elongation factor 1 epsilon 1
chr1_-_65123108 0.35 ENSMUST00000050047.3
ENSMUST00000148020.1
RIKEN cDNA D630023F18 gene
chr2_+_31670714 0.34 ENSMUST00000038474.7
ENSMUST00000137156.1
exosome component 2
chr19_-_10869757 0.34 ENSMUST00000120524.1
ENSMUST00000025645.7
transmembrane protein 132A
chr10_+_75568641 0.31 ENSMUST00000131565.1
gamma-glutamyltransferase 1
chr11_+_87405049 0.30 ENSMUST00000060835.5
testis expressed gene 14
chr10_+_75568630 0.29 ENSMUST00000145928.1
gamma-glutamyltransferase 1
chr11_-_75422524 0.29 ENSMUST00000125982.1
ENSMUST00000137103.1
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr7_-_81345189 0.28 ENSMUST00000080813.4
ribosomal protein S17
chr10_+_75568648 0.26 ENSMUST00000134503.1
ENSMUST00000125770.1
ENSMUST00000128886.1
ENSMUST00000151212.1
gamma-glutamyltransferase 1
chr13_-_104109576 0.26 ENSMUST00000109315.3
neurolysin (metallopeptidase M3 family)
chr17_-_24150910 0.26 ENSMUST00000052462.6
3-phosphoinositide dependent protein kinase 1
chr11_-_100650693 0.25 ENSMUST00000103119.3
zinc finger protein 385C
chr11_-_88851462 0.24 ENSMUST00000107903.1
A kinase (PRKA) anchor protein 1
chr11_-_102218923 0.24 ENSMUST00000131254.1
histone deacetylase 5
chr17_-_34517352 0.23 ENSMUST00000075483.4
butyrophilin-like 6
chr13_+_104109752 0.23 ENSMUST00000160322.1
ENSMUST00000159574.1
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr8_+_124897877 0.22 ENSMUST00000034467.5
SprT-like N-terminal domain
chr8_+_70616816 0.22 ENSMUST00000052437.3
leucine rich repeat containing 25
chr7_+_126759601 0.21 ENSMUST00000050201.4
ENSMUST00000057669.9
mitogen-activated protein kinase 3
chr1_+_37997975 0.18 ENSMUST00000027252.7
eukaryotic translation initiation factor 5B
chr18_+_67800101 0.18 ENSMUST00000025425.5
centrosomal protein 192
chr17_-_35673517 0.17 ENSMUST00000162266.1
ENSMUST00000160734.1
ENSMUST00000159852.1
ENSMUST00000160039.1
general transcription factor II H, polypeptide 4
chr9_+_114688782 0.17 ENSMUST00000047404.6
dynein cytoplasmic 1 light intermediate chain 1
chr6_-_122856151 0.16 ENSMUST00000042081.8
complement component 3a receptor 1
chr7_-_98178254 0.16 ENSMUST00000040971.7
calpain 5
chr17_-_34475937 0.15 ENSMUST00000065841.4
butyrophilin-like 4
chr8_-_106893581 0.15 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
CTF8, chromosome transmission fidelity factor 8
chr14_-_32685246 0.15 ENSMUST00000096038.3
RIKEN cDNA 3425401B19 gene
chr1_+_135232045 0.13 ENSMUST00000110798.3
predicted gene 4204
chr8_+_33732237 0.12 ENSMUST00000171010.1
general transcription factor II E, polypeptide 2 (beta subunit)
chr5_-_88675613 0.12 ENSMUST00000113234.1
ENSMUST00000153565.1
G-rich RNA sequence binding factor 1
chr2_+_121171204 0.11 ENSMUST00000039541.5
ENSMUST00000110657.1
tubulin, gamma complex associated protein 4
chr1_-_39651165 0.11 ENSMUST00000053355.4
cellular repressor of E1A-stimulated genes 2
chr2_+_121295437 0.11 ENSMUST00000110639.1
microtubule-associated protein 1 A
chr8_+_31091593 0.11 ENSMUST00000161713.1
dual specificity phosphatase 26 (putative)
chr8_-_106893515 0.11 ENSMUST00000176090.1
CTF8, chromosome transmission fidelity factor 8
chr13_+_104109737 0.11 ENSMUST00000044385.7
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr11_+_116918844 0.11 ENSMUST00000103027.3
mannoside acetylglucosaminyltransferase 5, isoenzyme B
chr11_-_75422586 0.10 ENSMUST00000138661.1
ENSMUST00000000769.7
serine (or cysteine) peptidase inhibitor, clade F, member 1
chr17_+_46110982 0.10 ENSMUST00000024763.3
ENSMUST00000123646.1
mitochondrial ribosomal protein S18A
chr7_+_43609907 0.10 ENSMUST00000116324.2
zinc finger protein 819
chr10_+_89744988 0.10 ENSMUST00000020112.5
UHRF1 (ICBP90) binding protein 1-like
chr1_-_92902883 0.10 ENSMUST00000160548.1
ENSMUST00000112998.1
ankyrin repeat and MYND domain containing 1
chr2_+_156613664 0.10 ENSMUST00000169464.2
ENSMUST00000109567.3
discs, large homolog-associated protein 4 (Drosophila)
chr11_-_102365111 0.10 ENSMUST00000006749.9
solute carrier family 4 (anion exchanger), member 1
chr4_+_139192899 0.09 ENSMUST00000102508.3
ENSMUST00000131912.1
ENSMUST00000102507.3
capping protein (actin filament) muscle Z-line, beta
chr16_-_16359016 0.09 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
dynamin 1-like
chr13_+_44730726 0.09 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
jumonji, AT rich interactive domain 2
chr8_-_13200576 0.09 ENSMUST00000165605.2
GH regulated TBC protein 1
chr17_-_35673738 0.08 ENSMUST00000001565.8
general transcription factor II H, polypeptide 4
chr2_+_121171155 0.08 ENSMUST00000110658.1
tubulin, gamma complex associated protein 4
chr6_-_43309554 0.07 ENSMUST00000031749.9
NOBOX oogenesis homeobox
chr8_-_72009619 0.07 ENSMUST00000003574.4
cytochrome P450, family 4, subfamily f, polypeptide 18
chr18_-_77713978 0.06 ENSMUST00000074653.4
RIKEN cDNA 8030462N17 gene
chr16_-_38433145 0.06 ENSMUST00000002926.6
phospholipase A1 member A
chr10_+_80629646 0.05 ENSMUST00000085435.5
casein kinase 1, gamma 2
chr18_+_61105844 0.05 ENSMUST00000115268.3
colony stimulating factor 1 receptor
chr12_+_84641019 0.04 ENSMUST00000166772.2
vertebrae development associated
chr11_-_33578933 0.04 ENSMUST00000020366.1
ENSMUST00000135350.1
gamma-aminobutyric acid (GABA) A receptor, pi
chr18_-_34651703 0.04 ENSMUST00000025228.5
ENSMUST00000133181.1
CDC23 cell division cycle 23
chr1_+_132298606 0.04 ENSMUST00000046071.4
kelch domain containing 8A
chr17_-_29519790 0.03 ENSMUST00000168877.1
predicted gene, 17657
chr1_+_160978576 0.03 ENSMUST00000064725.5
serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
chr6_-_142473075 0.02 ENSMUST00000032371.7
glycogen synthase 2
chr8_-_70760889 0.02 ENSMUST00000038626.8
MPV17 mitochondrial membrane protein-like 2
chr1_+_131638485 0.02 ENSMUST00000112411.1
cathepsin E
chr5_-_88675190 0.02 ENSMUST00000133532.1
ENSMUST00000150438.1
G-rich RNA sequence binding factor 1
chr13_+_73467197 0.02 ENSMUST00000022099.8
lysophosphatidylcholine acyltransferase 1
chr19_+_45998131 0.01 ENSMUST00000181820.1
RIKEN cDNA 4930505N22 gene
chr1_+_131638306 0.01 ENSMUST00000073350.6
cathepsin E
chr11_+_115912001 0.01 ENSMUST00000132961.1
small integral membrane protein 6
chr2_+_155775333 0.00 ENSMUST00000029141.5
matrix metallopeptidase 24
chr8_-_124897685 0.00 ENSMUST00000098312.2
exocyst complex component 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 0.9 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.3 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 0.3 GO:0071051 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.2 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.2 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.3 GO:0032466 negative regulation of cytokinesis(GO:0032466)
0.0 0.6 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.2 GO:0002461 tolerance induction dependent upon immune response(GO:0002461)
0.0 0.1 GO:1904579 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0042374 menaquinone metabolic process(GO:0009233) phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.2 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.3 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.3 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.4 GO:0043203 axon hillock(GO:0043203)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.2 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.9 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0052871 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
0.0 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0060229 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.8 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER