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2D miR_HR1_12

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Results for Nkx1-1_Nkx1-2

Z-value: 0.32

Motif logo

Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
ENSMUSG00000029112.5 NK1 homeobox 1
ENSMUSG00000048528.7 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-1mm10_v2_chr5_-_33433976_33433976-0.117.3e-01Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_3694167 0.40 ENSMUST00000005678.4
Fc receptor, IgE, low affinity II, alpha polypeptide
chr1_-_91459254 0.30 ENSMUST00000069620.8
period circadian clock 2
chr19_+_11965817 0.30 ENSMUST00000025590.9
oxysterol binding protein
chr6_+_78380700 0.29 ENSMUST00000101272.1
regenerating islet-derived 3 alpha
chr7_-_73537621 0.28 ENSMUST00000172704.1
chromodomain helicase DNA binding protein 2
chr7_-_143460989 0.24 ENSMUST00000167912.1
ENSMUST00000037287.6
cyclin-dependent kinase inhibitor 1C (P57)
chrX_+_170009892 0.22 ENSMUST00000180251.1
predicted gene, 21887
chr1_-_150466165 0.21 ENSMUST00000162367.1
ENSMUST00000161611.1
ENSMUST00000161320.1
ENSMUST00000159035.1
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr5_+_140607334 0.21 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_+_9436028 0.17 ENSMUST00000042360.3
calcyphosine-like
chr3_+_55782500 0.16 ENSMUST00000075422.4
mab-21-like 1 (C. elegans)
chr1_+_174501796 0.16 ENSMUST00000030039.7
formin 2
chr14_-_70429072 0.14 ENSMUST00000048129.4
piwi-like RNA-mediated gene silencing 2
chr3_-_116423930 0.13 ENSMUST00000106491.2
CDC14 cell division cycle 14A
chr7_-_100964371 0.13 ENSMUST00000060174.4
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_27195781 0.12 ENSMUST00000108379.1
ENSMUST00000179391.1
cDNA sequence BC024978
chr7_-_44929410 0.11 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
adaptor-related protein complex 2, alpha 1 subunit
chr17_-_57031468 0.11 ENSMUST00000007814.8
KH-type splicing regulatory protein
chr3_-_116424007 0.11 ENSMUST00000090464.4
CDC14 cell division cycle 14A
chr11_+_121237216 0.11 ENSMUST00000103015.3
nuclear prelamin A recognition factor
chr4_+_102570065 0.11 ENSMUST00000097950.2
phosphodiesterase 4B, cAMP specific
chr13_-_102906046 0.10 ENSMUST00000171791.1
microtubule associated serine/threonine kinase family member 4
chr5_+_138187485 0.10 ENSMUST00000110934.2
canopy 4 homolog (zebrafish)
chr17_+_34931253 0.10 ENSMUST00000007253.5
neuraminidase 1
chr2_+_36230426 0.10 ENSMUST00000062069.5
prostaglandin-endoperoxide synthase 1
chr9_-_107872403 0.10 ENSMUST00000183035.1
RNA binding motif protein 6
chrX_+_20364481 0.09 ENSMUST00000033372.6
ENSMUST00000115391.1
ENSMUST00000115387.1
retinitis pigmentosa 2 homolog (human)
chr8_+_113635550 0.09 ENSMUST00000179926.1
MON1 homolog b (yeast)
chr17_-_63863791 0.09 ENSMUST00000050753.3
RIKEN cDNA A930002H24 gene
chr6_-_3399545 0.09 ENSMUST00000120087.3
sterile alpha motif domain containing 9-like
chr14_-_59365410 0.09 ENSMUST00000161031.1
ENSMUST00000160425.1
PHD finger protein 11D
chr8_+_113635787 0.09 ENSMUST00000035777.8
MON1 homolog b (yeast)
chr17_+_7170101 0.09 ENSMUST00000024575.6
ribosomal protein S6 kinase, polypeptide 2
chr4_-_140774196 0.09 ENSMUST00000026381.6
peptidyl arginine deiminase, type IV
chr6_-_124779686 0.08 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
leucine rich repeat containing 23
chr11_-_99244058 0.08 ENSMUST00000103132.3
ENSMUST00000038214.6
keratin 222
chr13_-_105054895 0.07 ENSMUST00000063551.5
regulator of G-protein signalling 7 binding protein
chr10_+_116966274 0.07 ENSMUST00000033651.3
RIKEN cDNA D630029K05 gene
chr13_-_102905740 0.07 ENSMUST00000167462.1
microtubule associated serine/threonine kinase family member 4
chr7_+_3645267 0.07 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr19_+_8802486 0.07 ENSMUST00000172175.1
zinc finger and BTB domain containing 3
chr13_+_94083490 0.07 ENSMUST00000156071.1
lipoma HMGIC fusion partner-like 2
chr7_-_19629355 0.06 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr11_+_21572221 0.06 ENSMUST00000020568.3
ENSMUST00000131135.1
WD repeat containing planar cell polarity effector
chrX_+_103356464 0.06 ENSMUST00000116547.2
cysteine-rich hydrophobic domain 1
chr6_-_57535422 0.06 ENSMUST00000042766.3
protein phosphatase 1K (PP2C domain containing)
chrY_+_90784738 0.06 ENSMUST00000179483.1
erythroid differentiation regulator 1
chr5_-_74531619 0.06 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Sec1 family domain containing 2
chr2_+_154548888 0.05 ENSMUST00000045116.4
ENSMUST00000109709.3
RIKEN cDNA 1700003F12 gene
chr6_+_37870786 0.05 ENSMUST00000120428.1
ENSMUST00000031859.7
tripartite motif-containing 24
chr5_+_90561102 0.05 ENSMUST00000094615.4
RIKEN cDNA 5830473C10 gene
chr19_-_7966000 0.05 ENSMUST00000182102.1
ENSMUST00000075619.4
solute carrier family 22, member 27
chr10_-_41587753 0.05 ENSMUST00000160751.1
coiled-coil domain containing 162
chr16_+_52031549 0.05 ENSMUST00000114471.1
Casitas B-lineage lymphoma b
chr12_+_4769278 0.05 ENSMUST00000020967.4
profilin family, member 4
chr14_+_54464141 0.05 ENSMUST00000022782.8
low-density lipoprotein receptor-related protein 10
chr8_-_86580664 0.05 ENSMUST00000131423.1
ENSMUST00000152438.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr14_+_118854695 0.05 ENSMUST00000100314.3
claudin 10
chr5_-_137072254 0.05 ENSMUST00000077523.3
ENSMUST00000041388.4
serine (or cysteine) peptidase inhibitor, clade E, member 1
chrY_+_90785442 0.05 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
erythroid differentiation regulator 1
chr3_-_90389884 0.04 ENSMUST00000029541.5
solute carrier family 27 (fatty acid transporter), member 3
chr1_+_107535508 0.04 ENSMUST00000182198.1
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
chr15_+_75993756 0.04 ENSMUST00000089669.4
mitogen-activated protein kinase 15
chr10_+_127898515 0.04 ENSMUST00000047134.7
4short chain dehydrogenase/reductase family 9C, member 7
chr7_+_128744870 0.04 ENSMUST00000042942.8
Sec23 interacting protein
chr5_-_150518164 0.04 ENSMUST00000118769.1
zygote arrest 1-like
chr12_+_52699297 0.04 ENSMUST00000095737.3
A kinase (PRKA) anchor protein 6
chrX_-_74085586 0.03 ENSMUST00000123362.1
ENSMUST00000140399.1
ENSMUST00000100750.3
methyl CpG binding protein 2
chr8_-_34965631 0.03 ENSMUST00000033929.4
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr12_-_112802646 0.03 ENSMUST00000124526.1
AHNAK nucleoprotein 2
chrX_+_160768179 0.03 ENSMUST00000112368.2
retinoschisis (X-linked, juvenile) 1 (human)
chr5_-_140702241 0.03 ENSMUST00000077890.5
ENSMUST00000041783.7
ENSMUST00000142081.1
IQ motif containing E
chr2_+_91265252 0.03 ENSMUST00000028691.6
ADP-ribosylation factor GTPase activating protein 2
chrX_+_107255878 0.03 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
G protein-coupled receptor 174
chr12_+_31438209 0.03 ENSMUST00000001254.5
solute carrier family 26, member 3
chr13_+_75967704 0.03 ENSMUST00000022081.1
spermatogenesis associated 9
chr9_-_66126559 0.03 ENSMUST00000137542.1
sorting nexin 1
chr11_+_104576965 0.02 ENSMUST00000106957.1
myosin, light polypeptide 4
chr8_+_83972951 0.02 ENSMUST00000005606.6
protein kinase, cAMP dependent, catalytic, alpha
chr5_+_103425181 0.02 ENSMUST00000048957.9
protein tyrosine phosphatase, non-receptor type 13
chr10_+_116301374 0.02 ENSMUST00000092167.5
protein tyrosine phosphatase, receptor type, B
chr1_-_37916485 0.02 ENSMUST00000078307.5
lysozyme G-like 2
chr4_-_132075250 0.02 ENSMUST00000105970.1
ENSMUST00000105975.1
erythrocyte protein band 4.1
chr17_-_34000257 0.02 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
histocompatibility 2, K1, K region
chr4_-_14621494 0.02 ENSMUST00000149633.1
solute carrier family 26, member 7
chr11_-_21371143 0.01 ENSMUST00000060895.5
UDP-glucose pyrophosphorylase 2
chr5_-_143909782 0.01 ENSMUST00000031613.4
ENSMUST00000100483.2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr19_+_29367447 0.01 ENSMUST00000016640.7
CD274 antigen
chr2_-_132247747 0.01 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
transmembrane protein 230
chr2_-_165388245 0.01 ENSMUST00000103084.3
zinc finger protein 334
chr18_+_77332394 0.01 ENSMUST00000148341.1
lipoxygenase homology domains 1
chr5_-_118244861 0.01 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
ring finger protein, transmembrane 2
chr12_-_25096080 0.01 ENSMUST00000020974.6
inhibitor of DNA binding 2
chr18_+_4993795 0.01 ENSMUST00000153016.1
supervillin
chr8_-_104534630 0.01 ENSMUST00000162466.1
ENSMUST00000034349.9
NEDD8 activating enzyme E1 subunit 1
chr5_+_118245226 0.01 ENSMUST00000049138.7
RIKEN cDNA 2410131K14 gene
chr11_-_100762928 0.01 ENSMUST00000107360.2
ENSMUST00000055083.3
hypocretin
chr9_-_85749308 0.01 ENSMUST00000039213.8
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr18_-_24603791 0.01 ENSMUST00000070726.3
solute carrier family 39 (metal ion transporter), member 6
chrX_-_74085656 0.01 ENSMUST00000033770.6
methyl CpG binding protein 2
chr9_+_66126611 0.01 ENSMUST00000034945.5
family with sequence similarity 96, member A
chr1_+_190928492 0.01 ENSMUST00000066632.7
ENSMUST00000110899.1
angel homolog 2 (Drosophila)
chr15_+_98092569 0.00 ENSMUST00000163507.1
phosphofructokinase, muscle
chr5_+_134932351 0.00 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Williams Beuren syndrome chromosome region 27 (human)
chr16_+_44765732 0.00 ENSMUST00000057488.8
CD200 receptor 1
chr4_+_99030946 0.00 ENSMUST00000030280.6
angiopoietin-like 3
chr11_+_104577281 0.00 ENSMUST00000106956.3
myosin, light polypeptide 4
chr1_+_54250673 0.00 ENSMUST00000027128.4
coiled-coil domain containing 150
chr12_+_111039334 0.00 ENSMUST00000084968.7
REST corepressor 1
chr10_+_81137953 0.00 ENSMUST00000117956.1
zinc finger and BTB domain containing 7a
chr8_+_40354303 0.00 ENSMUST00000136835.1
mitochondrial calcium uptake family, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.2 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.4 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.3 GO:0044126 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.1 GO:0035633 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:1901950 dense core granule localization(GO:0032253) regulation of vesicle transport along microtubule(GO:1901608) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
0.0 0.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.1 GO:0035726 endosomal vesicle fusion(GO:0034058) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.0 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019863 IgE binding(GO:0019863)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0052795 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0019103 pyrimidine nucleotide binding(GO:0019103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors