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2D miR_HR1_12

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Results for Six3_Six1_Six2

Z-value: 0.37

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
ENSMUSG00000038805.9 sine oculis-related homeobox 3
ENSMUSG00000051367.8 sine oculis-related homeobox 1
ENSMUSG00000024134.10 sine oculis-related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_85688275-0.264.2e-01Click!
Six1mm10_v2_chr12_-_73047179_73047179-0.205.3e-01Click!
Six3mm10_v2_chr17_+_85621017_85621031-0.166.1e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_98571004 0.93 ENSMUST00000023728.6
RIKEN cDNA 4930415O20 gene
chr1_+_139454747 0.31 ENSMUST00000053364.8
ENSMUST00000097554.3
asp (abnormal spindle)-like, microcephaly associated (Drosophila)
chr2_+_31245801 0.21 ENSMUST00000000199.7
neuronal calcium sensor 1
chr17_-_40914350 0.21 ENSMUST00000166343.1
glycine-N-acyltransferase-like 3
chr14_+_75242287 0.17 ENSMUST00000022576.8
carboxypeptidase B2 (plasma)
chr2_+_127336152 0.16 ENSMUST00000028846.6
dual specificity phosphatase 2
chr7_+_30232310 0.16 ENSMUST00000108193.1
ENSMUST00000108192.1
polymerase (RNA) II (DNA directed) polypeptide I
chr3_-_37724321 0.15 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
predicted gene 5148
chr7_+_30231884 0.15 ENSMUST00000019882.9
polymerase (RNA) II (DNA directed) polypeptide I
chr19_-_44135816 0.14 ENSMUST00000026218.5
CWF19-like 1, cell cycle control (S. pombe)
chr14_+_57798182 0.13 ENSMUST00000111269.1
Sin3-associated polypeptide 18
chr6_+_123123313 0.13 ENSMUST00000041779.6
C-type lectin domain family 4, member a2
chrX_-_142966709 0.13 ENSMUST00000041317.2
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_65123108 0.11 ENSMUST00000050047.3
ENSMUST00000148020.1
RIKEN cDNA D630023F18 gene
chr10_+_23949516 0.11 ENSMUST00000045152.4
trace amine-associated receptor 3
chr5_+_138820080 0.11 ENSMUST00000179205.1
predicted gene 5294
chr7_+_43690418 0.11 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr6_+_123123423 0.10 ENSMUST00000032248.7
C-type lectin domain family 4, member a2
chr15_-_82244716 0.09 ENSMUST00000089155.4
ENSMUST00000089157.3
centromere protein M
chr13_+_104229366 0.09 ENSMUST00000022227.6
centromere protein K
chr7_-_101903783 0.08 ENSMUST00000106969.1
transmembrane O-methyltransferase
chr1_+_136467958 0.07 ENSMUST00000047817.6
kinesin family member 14
chr7_-_30232186 0.07 ENSMUST00000006254.5
tubulin folding cofactor B
chr7_-_80115294 0.07 ENSMUST00000107384.3
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr14_+_55765956 0.07 ENSMUST00000057569.3
leukotriene B4 receptor 1
chr9_+_65141154 0.06 ENSMUST00000034961.4
immunoglobulin superfamily, DCC subclass, member 3
chr19_-_23075853 0.06 ENSMUST00000181623.1
RIKEN cDNA C330002G04 gene
chr6_-_52218686 0.06 ENSMUST00000134367.2
homeobox A7
chr15_+_82252397 0.06 ENSMUST00000136948.1
RIKEN cDNA 1500009C09 gene
chr8_-_4275886 0.06 ENSMUST00000003029.7
translocase of inner mitochondrial membrane 44
chr8_+_69832633 0.06 ENSMUST00000131637.2
ENSMUST00000081503.6
pre B cell leukemia homeobox 4
chr17_-_53539411 0.05 ENSMUST00000056198.3
protein phosphatase 2C-like domain containing 1
chr10_-_128180265 0.05 ENSMUST00000099139.1
RNA binding motif, single stranded interacting protein 2
chr15_-_75894474 0.05 ENSMUST00000023237.6
nicotinate phosphoribosyltransferase domain containing 1
chr7_-_119459266 0.05 ENSMUST00000033255.5
glycoprotein 2 (zymogen granule membrane)
chr2_+_131491764 0.05 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
spermine oxidase
chr6_+_38534823 0.05 ENSMUST00000019833.4
RIKEN cDNA 1110001J03 gene
chr5_+_21543525 0.04 ENSMUST00000035651.4
leucine rich repeat containing 17
chr9_+_32393963 0.04 ENSMUST00000172015.1
potassium inwardly-rectifying channel, subfamily J, member 1
chr11_-_9039585 0.04 ENSMUST00000043377.5
Sad1 and UNC84 domain containing 3
chr6_-_115675871 0.04 ENSMUST00000112949.1
v-raf-leukemia viral oncogene 1
chr3_-_85722474 0.04 ENSMUST00000119077.1
family with sequence similarity 160, member A1
chr8_+_84831522 0.04 ENSMUST00000036734.5
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_+_131032061 0.04 ENSMUST00000084509.3
deleted in malignant brain tumors 1
chr17_+_35241838 0.04 ENSMUST00000173731.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr17_+_56717759 0.04 ENSMUST00000002452.6
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr13_-_74292297 0.04 ENSMUST00000109640.1
ENSMUST00000022059.7
aryl-hydrocarbon receptor repressor
chr7_-_126676428 0.04 ENSMUST00000106373.1
sulfotransferase family 1A, phenol-preferring, member 1
chr8_-_106573461 0.03 ENSMUST00000073722.5
predicted pseudogene 10073
chr11_-_69695521 0.03 ENSMUST00000181261.1
tumor necrosis factor (ligand) superfamily, member 12
chr12_+_84773262 0.03 ENSMUST00000021667.5
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr10_-_78487842 0.03 ENSMUST00000069431.4
predicted gene 9978
chr11_-_99230998 0.03 ENSMUST00000103133.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr7_+_30977043 0.03 ENSMUST00000058093.4
family with sequence similarity 187, member B
chr14_+_57798156 0.03 ENSMUST00000128764.1
Sin3-associated polypeptide 18
chr10_+_24595623 0.03 ENSMUST00000176228.1
ENSMUST00000129142.1
connective tissue growth factor
chr1_-_59094885 0.03 ENSMUST00000097080.3
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (human)
chr16_-_11203259 0.03 ENSMUST00000119953.1
ribosomal L1 domain containing 1
chr4_-_43030440 0.03 ENSMUST00000135660.1
stomatin (Epb7.2)-like 2
chr5_+_104046869 0.02 ENSMUST00000031250.7
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr19_+_8764934 0.02 ENSMUST00000184663.1
nuclear RNA export factor 1
chr7_-_100855403 0.02 ENSMUST00000156855.1
RELT tumor necrosis factor receptor
chr17_-_36951636 0.02 ENSMUST00000040402.7
ENSMUST00000174711.1
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr3_+_94398517 0.02 ENSMUST00000050975.3
leucine rich repeat and Ig domain containing 4
chr19_+_46341118 0.02 ENSMUST00000128041.1
transmembrane protein 180
chr4_-_116651644 0.02 ENSMUST00000030455.8
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr5_+_140607334 0.02 ENSMUST00000031555.1
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_-_55315980 0.01 ENSMUST00000076891.5
zinc finger, DHHC domain containing 6
chrX_-_167102059 0.01 ENSMUST00000146929.1
predicted gene 15232
chr16_+_22920222 0.01 ENSMUST00000023587.4
ENSMUST00000116625.2
fetuin beta
chr17_+_35241746 0.01 ENSMUST00000068056.5
ENSMUST00000174757.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr16_-_45724600 0.01 ENSMUST00000096057.4
transgelin 3
chr5_-_106926245 0.01 ENSMUST00000117588.1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr2_+_117249725 0.01 ENSMUST00000028825.4
family with sequence similarity 98, member B
chr9_+_106222598 0.01 ENSMUST00000062241.9
toll-like receptor 9
chr19_+_55316313 0.01 ENSMUST00000095950.2
vesicle transport through interaction with t-SNAREs 1A
chr4_-_32950813 0.01 ENSMUST00000084750.1
ENSMUST00000084748.2
ankyrin repeat domain 6
chr7_-_141168671 0.01 ENSMUST00000106033.3
ribonuclease/angiogenin inhibitor 1
chr1_-_119504736 0.01 ENSMUST00000004565.8
v-ral simian leukemia viral oncogene homolog B (ras related)
chr1_+_165485168 0.01 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
adenylate cyclase 10
chr1_-_153851189 0.01 ENSMUST00000059607.6
RIKEN cDNA 5830403L16 gene
chr9_+_119341487 0.00 ENSMUST00000175743.1
ENSMUST00000176397.1
acetyl-Coenzyme A acyltransferase 1A
chr15_+_38661904 0.00 ENSMUST00000022904.6
ATPase, H+ transporting, lysosomal V1 subunit C1
chr7_+_87803815 0.00 ENSMUST00000125009.1
ENSMUST00000155358.1
glutamate receptor, metabotropic 5
chr6_+_48537560 0.00 ENSMUST00000040361.5
ATPase, H+ transporting, lysosomal V0 subunit E2
chr1_+_60746358 0.00 ENSMUST00000027165.2
CD28 antigen
chr8_-_22653406 0.00 ENSMUST00000033938.5
polymerase (DNA directed), beta
chr2_-_119029359 0.00 ENSMUST00000110833.1
coiled-coil domain containing 32

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.1 GO:1990773 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.2 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.1 GO:0033624 negative regulation of integrin activation(GO:0033624)
0.0 0.0 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis