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2D miR_HR1_12

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Results for Hmx3

Z-value: 0.61

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Transcription factors associated with Hmx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000040148.5 H6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_131542867-0.481.2e-01Click!

Activity profile of Hmx3 motif

Sorted Z-values of Hmx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_9436028 1.62 ENSMUST00000042360.3
calcyphosine-like
chr1_-_158814469 1.13 ENSMUST00000161589.2
pappalysin 2
chr9_+_21955747 1.01 ENSMUST00000053583.5
SWIM type zinc finger 7 associated protein 1
chr13_-_92131494 0.84 ENSMUST00000099326.3
ENSMUST00000146492.1
RAS protein-specific guanine nucleotide-releasing factor 2
chr14_-_55560340 0.68 ENSMUST00000066106.3
RIKEN cDNA A730061H03 gene
chr11_+_103133303 0.58 ENSMUST00000107037.1
hexamethylene bis-acetamide inducible 2
chr2_-_103283760 0.55 ENSMUST00000111174.1
ets homologous factor
chr11_+_103133333 0.47 ENSMUST00000124928.1
ENSMUST00000062530.4
hexamethylene bis-acetamide inducible 2
chr17_-_35046539 0.45 ENSMUST00000007250.7
mutS homolog 5 (E. coli)
chr14_+_54464141 0.42 ENSMUST00000022782.8
low-density lipoprotein receptor-related protein 10
chr12_-_83921899 0.40 ENSMUST00000117217.1
numb gene homolog (Drosophila)
chr5_-_53707532 0.39 ENSMUST00000031093.3
cholecystokinin A receptor
chr15_+_101473472 0.39 ENSMUST00000088049.3
keratin 86
chr17_-_57247632 0.39 ENSMUST00000005975.6
G protein-coupled receptor 108
chr19_-_56822161 0.38 ENSMUST00000118592.1
RIKEN cDNA A630007B06 gene
chr5_-_137684665 0.38 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
ArfGAP with FG repeats 2
chr3_+_3634145 0.37 ENSMUST00000108394.1
hepatocyte nuclear factor 4, gamma
chr14_-_73049107 0.31 ENSMUST00000044664.4
ENSMUST00000169168.1
cysteinyl leukotriene receptor 2
chr7_+_3645267 0.30 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr19_+_11965817 0.30 ENSMUST00000025590.9
oxysterol binding protein
chr4_+_134397380 0.27 ENSMUST00000105870.1
platelet-activating factor acetylhydrolase 2
chr7_+_43690418 0.27 ENSMUST00000056329.6
kallikrein related-peptidase 14
chr7_-_45510400 0.27 ENSMUST00000033096.7
nucleobindin 1
chr2_-_84715160 0.25 ENSMUST00000035840.5
zinc finger, DHHC domain containing 5
chrX_+_159708593 0.24 ENSMUST00000080394.6
SH3-domain kinase binding protein 1
chr7_-_121035096 0.24 ENSMUST00000065740.2
predicted gene 9905
chrX_+_139563316 0.23 ENSMUST00000113027.1
ring finger protein 128
chr11_+_69838514 0.23 ENSMUST00000133967.1
ENSMUST00000094065.4
transmembrane protein 256
chr12_-_83921809 0.22 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
numb gene homolog (Drosophila)
chr1_+_110099295 0.22 ENSMUST00000134301.1
cadherin 7, type 2
chr4_-_45532470 0.18 ENSMUST00000147448.1
src homology 2 domain-containing transforming protein B
chr2_+_74697663 0.17 ENSMUST00000059272.8
homeobox D9
chr12_-_108179237 0.17 ENSMUST00000071095.7
SET domain containing 3
chr2_-_130424242 0.16 ENSMUST00000089581.4
PC-esterase domain containing 1A
chr4_+_144893127 0.16 ENSMUST00000142808.1
dehydrogenase/reductase (SDR family) member 3
chr7_-_127208423 0.15 ENSMUST00000120705.1
TBC1 domain family, member 10b
chr7_+_25267669 0.15 ENSMUST00000169266.1
capicua homolog (Drosophila)
chr3_-_49757257 0.12 ENSMUST00000035931.7
protocadherin 18
chr15_-_13173607 0.12 ENSMUST00000036439.4
cadherin 6
chr13_+_23746734 0.11 ENSMUST00000099703.2
histone cluster 1, H2bb
chr7_-_126897424 0.11 ENSMUST00000120007.1
transmembrane protein 219
chr12_+_52699297 0.10 ENSMUST00000095737.3
A kinase (PRKA) anchor protein 6
chr10_+_99263224 0.08 ENSMUST00000020118.4
dual specificity phosphatase 6
chr7_-_30559600 0.05 ENSMUST00000043975.4
ENSMUST00000156241.1
lin-37 homolog (C. elegans)
chr3_+_109573907 0.05 ENSMUST00000106576.2
vav 3 oncogene
chr7_-_30559828 0.04 ENSMUST00000108164.1
lin-37 homolog (C. elegans)
chr6_-_129622685 0.04 ENSMUST00000032252.5
killer cell lectin-like receptor subfamily K, member 1
chr2_+_27165233 0.03 ENSMUST00000000910.6
dopamine beta hydroxylase
chr12_+_72441852 0.03 ENSMUST00000162159.1
leucine rich repeat containing 9
chr4_+_19818722 0.02 ENSMUST00000035890.7
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chr2_-_130424673 0.01 ENSMUST00000110277.1
PC-esterase domain containing 1A
chr15_-_101892916 0.00 ENSMUST00000100179.1
keratin 76
chr3_-_155055341 0.00 ENSMUST00000064076.3
TNNI3 interacting kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0021849 neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.4 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.5 GO:0051026 chiasma assembly(GO:0051026)
0.0 1.0 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.8 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.3 GO:0007320 insemination(GO:0007320)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.3 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 0.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.0 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.0 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.5 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells