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2D miR_HR1_12

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Results for Lhx3

Z-value: 0.45

Motif logo

Transcription factors associated with Lhx3

Gene Symbol Gene ID Gene Info
ENSMUSG00000026934.9 LIM homeobox protein 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lhx3mm10_v2_chr2_-_26206535_26206580-0.471.2e-01Click!

Activity profile of Lhx3 motif

Sorted Z-values of Lhx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_98571004 0.59 ENSMUST00000023728.6
RIKEN cDNA 4930415O20 gene
chr19_-_34166037 0.52 ENSMUST00000025686.7
ankyrin repeat domain 22
chr7_+_45621805 0.50 ENSMUST00000033100.4
izumo sperm-egg fusion 1
chr15_-_58364148 0.37 ENSMUST00000068515.7
annexin A13
chr1_+_21240581 0.36 ENSMUST00000027067.8
glutathione S-transferase, alpha 3
chr4_+_136143497 0.36 ENSMUST00000008016.2
inhibitor of DNA binding 3
chr10_+_75037291 0.35 ENSMUST00000139384.1
RAB36, member RAS oncogene family
chr13_+_49608030 0.34 ENSMUST00000021822.5
osteoglycin
chr14_-_108914237 0.30 ENSMUST00000100322.2
SLIT and NTRK-like family, member 1
chr10_-_24101951 0.30 ENSMUST00000170267.1
trace amine-associated receptor 8C
chr7_-_119459266 0.30 ENSMUST00000033255.5
glycoprotein 2 (zymogen granule membrane)
chr1_+_21240597 0.29 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr6_+_96115249 0.28 ENSMUST00000075080.5
family with sequence similarity 19, member A1
chr3_+_60081861 0.27 ENSMUST00000029326.5
succinate receptor 1
chr15_+_16778101 0.26 ENSMUST00000026432.6
cadherin 9
chr7_-_103827922 0.23 ENSMUST00000023934.6
ENSMUST00000153218.1
hemoglobin, beta adult s chain
chr10_-_53647080 0.22 ENSMUST00000169866.1
family with sequence similarity 184, member A
chr19_+_20601958 0.20 ENSMUST00000087638.3
aldehyde dehydrogenase family 1, subfamily A1
chr15_-_36879816 0.19 ENSMUST00000100713.2
predicted gene 10384
chr1_+_88055377 0.18 ENSMUST00000138182.1
ENSMUST00000113142.3
UDP glycosyltransferase 1 family, polypeptide A10
chr4_+_102589687 0.18 ENSMUST00000097949.4
ENSMUST00000106901.1
phosphodiesterase 4B, cAMP specific
chr18_-_38866702 0.17 ENSMUST00000115582.1
fibroblast growth factor 1
chr3_+_122419772 0.17 ENSMUST00000029766.4
breast cancer anti-estrogen resistance 3
chr6_-_115592571 0.17 ENSMUST00000112957.1
RIKEN cDNA 2510049J12 gene
chr17_+_45734506 0.16 ENSMUST00000180558.1
RIKEN cDNA F630040K05 gene
chr10_+_75037066 0.15 ENSMUST00000147802.1
ENSMUST00000020391.5
RAB36, member RAS oncogene family
chr10_+_116966274 0.15 ENSMUST00000033651.3
RIKEN cDNA D630029K05 gene
chr6_+_34780412 0.15 ENSMUST00000115016.1
ENSMUST00000115017.1
ATP/GTP binding protein-like 3
chr5_-_51553896 0.14 ENSMUST00000132734.1
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_+_59306920 0.14 ENSMUST00000000128.3
ENSMUST00000108783.3
wingless-type MMTV integration site 9A
chr6_-_3399545 0.14 ENSMUST00000120087.3
sterile alpha motif domain containing 9-like
chr2_+_125136692 0.13 ENSMUST00000099452.2
cortexin 2
chr11_-_49113757 0.13 ENSMUST00000060398.1
olfactory receptor 1396
chr17_-_34862473 0.13 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
complement factor B
chr5_+_66968961 0.13 ENSMUST00000132991.1
LIM and calponin homology domains 1
chr4_-_58499398 0.13 ENSMUST00000107570.1
lysophosphatidic acid receptor 1
chr3_+_151437887 0.13 ENSMUST00000046977.7
EGF, latrophilin seven transmembrane domain containing 1
chr17_-_36032682 0.12 ENSMUST00000102678.4
histocompatibility 2, T region locus 23
chr10_+_5593718 0.11 ENSMUST00000051809.8
myc target 1
chr4_+_134930898 0.11 ENSMUST00000030622.2
SYF2 homolog, RNA splicing factor (S. cerevisiae)
chr10_-_64090265 0.11 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr17_+_69439326 0.11 ENSMUST00000169935.1
RIKEN cDNA A330050F15 gene
chr7_-_37772868 0.11 ENSMUST00000176205.1
zinc finger protein 536
chr1_+_88306731 0.10 ENSMUST00000040210.7
transient receptor potential cation channel, subfamily M, member 8
chr2_+_23069210 0.10 ENSMUST00000155602.1
acyl-Coenzyme A binding domain containing 5
chr3_-_67515487 0.10 ENSMUST00000178314.1
ENSMUST00000054825.4
retinoic acid receptor responder (tazarotene induced) 1
chr13_-_101692624 0.10 ENSMUST00000035532.6
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr10_+_116964707 0.09 ENSMUST00000176050.1
ENSMUST00000176455.1
RIKEN cDNA D630029K05 gene
chr17_-_34862122 0.09 ENSMUST00000154526.1
complement factor B
chr17_-_56036546 0.09 ENSMUST00000003268.9
SH3-domain GRB2-like 1
chr4_-_147702553 0.09 ENSMUST00000117638.1
zinc finger protein 534
chr10_-_33624587 0.08 ENSMUST00000160299.1
ENSMUST00000019920.6
clavesin 2
chr2_+_82053222 0.08 ENSMUST00000047527.7
zinc finger protein 804A
chr4_-_14621805 0.08 ENSMUST00000042221.7
solute carrier family 26, member 7
chr11_-_84069179 0.08 ENSMUST00000138208.1
dual specificity phosphatase 14
chr4_-_14621494 0.08 ENSMUST00000149633.1
solute carrier family 26, member 7
chr16_-_64771146 0.08 ENSMUST00000076991.6
RIKEN cDNA 4930453N24 gene
chrX_+_66653003 0.07 ENSMUST00000036043.4
SLIT and NTRK-like family, member 2
chr5_-_118244861 0.07 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
ring finger protein, transmembrane 2
chr8_-_3624989 0.07 ENSMUST00000142431.1
Purkinje cell protein 2 (L7)
chr1_+_88055467 0.07 ENSMUST00000173325.1
UDP glycosyltransferase 1 family, polypeptide A10
chr2_+_78051155 0.07 ENSMUST00000145972.1
RIKEN cDNA 4930440I19 gene
chr6_+_37870786 0.07 ENSMUST00000120428.1
ENSMUST00000031859.7
tripartite motif-containing 24
chr3_-_57294880 0.07 ENSMUST00000171384.1
transmembrane 4 superfamily member 1
chr18_+_37477768 0.06 ENSMUST00000051442.5
protocadherin beta 16
chrX_-_100625901 0.06 ENSMUST00000059099.6
PDZ domain containing 11
chr11_+_62847111 0.06 ENSMUST00000150989.1
ENSMUST00000176577.1
F-box and WD-40 domain protein 10
chr1_+_177444653 0.06 ENSMUST00000094276.3
zinc finger and BTB domain containing 18
chr6_+_124304646 0.06 ENSMUST00000112541.2
ENSMUST00000032234.2
CD163 antigen
chr15_-_103565069 0.06 ENSMUST00000023134.3
glycosylation dependent cell adhesion molecule 1
chr19_+_26623419 0.06 ENSMUST00000176584.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_142530041 0.06 ENSMUST00000099400.2
poly (A) polymerase beta (testis specific)
chr19_+_46397009 0.06 ENSMUST00000118440.1
suppressor of fused homolog (Drosophila)
chr11_+_76902152 0.05 ENSMUST00000102495.1
transmembrane and immunoglobulin domain containing 1
chr7_+_24636566 0.05 ENSMUST00000080718.4
Ly6/Plaur domain containing 3
chr2_+_152626932 0.05 ENSMUST00000000369.3
ENSMUST00000150913.1
rad and gem related GTP binding protein 1
chr5_-_70842617 0.05 ENSMUST00000031119.1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr10_-_62507737 0.04 ENSMUST00000020271.6
serglycin
chr10_+_102159000 0.04 ENSMUST00000020039.6
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_+_102158858 0.04 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_+_145585166 0.04 ENSMUST00000105739.1
ENSMUST00000119718.1
predicted gene 13212
chr10_+_116143881 0.04 ENSMUST00000105271.2
protein tyrosine phosphatase, receptor type, R
chr11_+_62847062 0.04 ENSMUST00000036085.4
F-box and WD-40 domain protein 10
chr3_-_96452306 0.03 ENSMUST00000093126.4
ENSMUST00000098841.3
cDNA sequence BC107364
chr3_+_41742615 0.03 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
DNA segment, Chr 3, ERATO Doi 751, expressed
chr6_-_128275577 0.03 ENSMUST00000130454.1
TEA domain family member 4
chr5_-_3647806 0.03 ENSMUST00000119783.1
ENSMUST00000007559.8
GATA zinc finger domain containing 1
chr1_-_37916485 0.03 ENSMUST00000078307.5
lysozyme G-like 2
chr7_-_126976092 0.03 ENSMUST00000181859.1
RIKEN cDNA D830044I16 gene
chr1_+_153665666 0.03 ENSMUST00000111814.1
ENSMUST00000111810.1
regulator of G-protein signaling 8
chr4_+_145670685 0.03 ENSMUST00000105738.2
predicted gene 13242
chr10_-_37138863 0.03 ENSMUST00000092584.5
myristoylated alanine rich protein kinase C substrate
chr14_+_80000292 0.03 ENSMUST00000088735.3
olfactomedin 4
chrX_-_139871637 0.03 ENSMUST00000033811.7
ENSMUST00000087401.5
microrchidia 4
chr10_+_36506814 0.02 ENSMUST00000167191.1
ENSMUST00000058738.4
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr3_+_135348029 0.02 ENSMUST00000159658.1
ENSMUST00000078568.5
ENSMUST00000160460.1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr6_-_129876659 0.02 ENSMUST00000014687.4
ENSMUST00000122219.1
killer cell lectin-like receptor, subfamily A, member 17
chr2_-_84425258 0.02 ENSMUST00000074262.2
calcitonin receptor-like
chr2_+_36230426 0.02 ENSMUST00000062069.5
prostaglandin-endoperoxide synthase 1
chr2_+_163658370 0.02 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
protein kinase inhibitor, gamma
chr16_-_55934845 0.02 ENSMUST00000121129.1
ENSMUST00000023270.7
centrosomal protein 97
chr4_-_147809788 0.02 ENSMUST00000105734.3
ENSMUST00000176201.1
predicted gene 13157
predicted gene 20707
chr3_-_116712644 0.01 ENSMUST00000029569.2
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr11_+_6560183 0.01 ENSMUST00000109722.2
cerebral cavernous malformation 2
chrX_+_166344692 0.01 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
glycoprotein m6b
chr3_+_142620596 0.01 ENSMUST00000165774.1
guanylate binding protein 2
chr4_+_118961578 0.01 ENSMUST00000058651.4
L-amino acid oxidase 1
chr7_-_101581161 0.01 ENSMUST00000063920.2
ADP-ribosyltransferase 2b
chr4_+_145514884 0.01 ENSMUST00000105741.1
predicted gene 13225
chr12_-_56536895 0.01 ENSMUST00000001536.8
NK2 homeobox 1
chr12_-_84617326 0.01 ENSMUST00000021666.4
ATP-binding cassette, sub-family D (ALD), member 4
chr4_+_145510759 0.01 ENSMUST00000105742.1
ENSMUST00000136309.1
predicted gene 13225
chr3_+_95318782 0.01 ENSMUST00000139866.1
ceramide synthase 2
chr14_-_96519067 0.00 ENSMUST00000022666.7
kelch-like 1
chr9_+_113812547 0.00 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
CLIP associating protein 2
chr1_+_153665587 0.00 ENSMUST00000147700.1
regulator of G-protein signaling 8
chr2_+_92185467 0.00 ENSMUST00000111291.2
PHD finger protein 21A

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043385 mycotoxin metabolic process(GO:0043385) mycotoxin catabolic process(GO:0043387) aflatoxin metabolic process(GO:0046222) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound metabolic process(GO:1901376) organic heteropentacyclic compound catabolic process(GO:1901377)
0.1 0.3 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.1 GO:2000566 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.0 GO:0033374 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.0 0.4 GO:0030903 notochord development(GO:0030903) negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0050955 thermoception(GO:0050955)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.5 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.4 GO:1901611 phosphatidylglycerol binding(GO:1901611)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation