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2D miR_HR1_12

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Results for Pax4

Z-value: 0.41

Motif logo

Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
ENSMUSG00000029706.9 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm10_v2_chr6_-_28447180_28447180-0.691.4e-02Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_149006948 0.37 ENSMUST00000124198.1
predicted gene 15408
chr5_-_103100054 0.34 ENSMUST00000112848.1
mitogen-activated protein kinase 10
chr6_+_113483297 0.29 ENSMUST00000032422.5
cysteine-rich with EGF-like domains 1
chr17_+_17402672 0.28 ENSMUST00000115576.2
limb expression 1 homolog (chicken)
chr1_-_156034800 0.28 ENSMUST00000169241.1
torsin A interacting protein 1
chr2_-_65238573 0.27 ENSMUST00000090896.3
ENSMUST00000155082.1
Cobl-like 1
chr2_-_65238625 0.26 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobl-like 1
chr19_-_6015152 0.23 ENSMUST00000025891.8
calpain 1
chr8_-_22476809 0.23 ENSMUST00000163774.1
ENSMUST00000033935.8
small integral membrane protein 19
chr4_+_136357423 0.23 ENSMUST00000182167.1
predicted gene, 17388
chr10_+_119992916 0.23 ENSMUST00000105261.2
glutamate receptor interacting protein 1
chr4_+_150087365 0.22 ENSMUST00000094451.3
G protein-coupled receptor 157
chrX_-_73097017 0.22 ENSMUST00000114524.2
ENSMUST00000074619.5
X-linked lymphocyte-regulated 3A
chr11_+_117484368 0.21 ENSMUST00000092394.3
predicted gene 11733
chr19_-_6015769 0.21 ENSMUST00000164843.1
calpain 1
chr10_+_26822560 0.20 ENSMUST00000135866.1
Rho GTPase activating protein 18
chr2_-_168741898 0.19 ENSMUST00000109176.1
ENSMUST00000178504.1
ATPase, class II, type 9A
chr16_-_45844228 0.19 ENSMUST00000076333.5
pleckstrin homology-like domain, family B, member 2
chrX_+_73192222 0.19 ENSMUST00000101486.4
X-linked lymphocyte-regulated 3B
chr7_+_58658181 0.19 ENSMUST00000168747.1
ATPase, class V, type 10A
chr13_+_23738804 0.18 ENSMUST00000040914.1
histone cluster 1, H1c
chr9_-_101198999 0.18 ENSMUST00000066773.7
protein phosphatase 2, regulatory subunit B'', alpha
chr1_+_88087802 0.17 ENSMUST00000113139.1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr5_+_135674572 0.17 ENSMUST00000153515.1
P450 (cytochrome) oxidoreductase
chr5_-_116591811 0.17 ENSMUST00000076124.5
serine/arginine repetitive matrix 4
chr16_-_45844303 0.17 ENSMUST00000036355.6
pleckstrin homology-like domain, family B, member 2
chrX_+_143518576 0.16 ENSMUST00000033640.7
p21 protein (Cdc42/Rac)-activated kinase 3
chr14_-_12823031 0.15 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Ca2+-dependent secretion activator
chr2_-_168741752 0.15 ENSMUST00000029060.4
ATPase, class II, type 9A
chr3_-_59635733 0.15 ENSMUST00000177879.1
predicted gene 5709
chr15_+_80977765 0.14 ENSMUST00000139517.1
ENSMUST00000042506.8
ENSMUST00000137255.1
small G protein signaling modulator 3
chr15_-_79164477 0.14 ENSMUST00000040019.4
SRY-box containing gene 10
chrX_+_143518671 0.14 ENSMUST00000134402.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr7_-_45366714 0.13 ENSMUST00000107779.1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr7_+_78913436 0.13 ENSMUST00000121645.1
interferon-stimulated protein
chr16_-_14291355 0.13 ENSMUST00000090287.3
myosin, heavy polypeptide 11, smooth muscle
chr2_-_160313616 0.12 ENSMUST00000109475.2
predicted gene 826
chr5_-_116288978 0.12 ENSMUST00000050178.6
coiled-coil domain containing 60
chr7_+_78913401 0.12 ENSMUST00000118867.1
interferon-stimulated protein
chr13_+_75089826 0.12 ENSMUST00000022075.4
proprotein convertase subtilisin/kexin type 1
chr18_-_22171392 0.12 ENSMUST00000025160.2
coiled coil domain containing 178
chr10_-_64090265 0.11 ENSMUST00000105439.1
leucine rich repeat transmembrane neuronal 3
chr16_+_15637844 0.11 ENSMUST00000023352.8
protein kinase, DNA activated, catalytic polypeptide
chr2_-_131328982 0.10 ENSMUST00000110194.1
ring finger protein 24
chr9_+_32696005 0.10 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
E26 avian leukemia oncogene 1, 5' domain
chrX_-_75875101 0.10 ENSMUST00000114059.3
plastin 3 (T-isoform)
chr3_+_20057802 0.09 ENSMUST00000002502.5
helicase-like transcription factor
chrX_-_8206475 0.09 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
porcupine homolog (Drosophila)
chr9_+_92275746 0.08 ENSMUST00000126911.1
phospholipid scramblase 2
chr11_+_78499087 0.08 ENSMUST00000017488.4
vitronectin
chr2_+_43555321 0.08 ENSMUST00000028223.2
kynureninase (L-kynurenine hydrolase)
chr12_+_33314277 0.08 ENSMUST00000133549.1
ataxin 7-like 1
chr11_+_43587040 0.07 ENSMUST00000056256.2
RIKEN cDNA 4933415A04 gene
chr7_-_64925560 0.07 ENSMUST00000149851.1
family with sequence similarity 189, member A1
chr10_+_19935223 0.07 ENSMUST00000129437.1
mitogen-activated protein kinase kinase kinase 5
chr7_-_144738520 0.07 ENSMUST00000118556.2
ENSMUST00000033393.8
anoctamin 1, calcium activated chloride channel
chr19_-_11081088 0.07 ENSMUST00000025636.6
membrane-spanning 4-domains, subfamily A, member 8A
chr17_+_69383024 0.07 ENSMUST00000112674.1
zinc finger and BTB domain containing 14
chr7_+_78913765 0.06 ENSMUST00000038142.8
interferon-stimulated protein
chrX_+_9199865 0.06 ENSMUST00000069763.2
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr15_-_89149557 0.06 ENSMUST00000088823.3
mitogen-activated protein kinase 11
chr4_+_150281573 0.06 ENSMUST00000105682.2
arginine glutamic acid dipeptide (RE) repeats
chr7_-_144738478 0.06 ENSMUST00000121758.1
anoctamin 1, calcium activated chloride channel
chr7_+_7171330 0.05 ENSMUST00000051435.7
zinc finger protein 418
chr10_+_127739516 0.05 ENSMUST00000054287.7
zinc finger and BTB domain containing 39
chr6_-_130337502 0.05 ENSMUST00000088017.4
ENSMUST00000111998.2
killer cell lectin-like receptor, subfamily A, member 3
chr5_-_121502980 0.05 ENSMUST00000079368.3
a disintegrin and metallopeptidase domain 1b
chr7_+_81114799 0.04 ENSMUST00000026820.4
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr1_-_74935549 0.04 ENSMUST00000094844.3
coiled-coil domain containing 108
chr12_-_90738438 0.04 ENSMUST00000082432.3
deiodinase, iodothyronine, type II
chr15_-_59374149 0.04 ENSMUST00000022976.4
RIKEN cDNA E430025E21 gene
chr10_+_127421124 0.04 ENSMUST00000170336.1
R3H domain containing 2
chr13_-_101768154 0.04 ENSMUST00000055518.6
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr12_-_98577940 0.03 ENSMUST00000110113.1
potassium channel, subfamily K, member 10
chr2_+_43555342 0.03 ENSMUST00000112826.1
ENSMUST00000050511.6
kynureninase (L-kynurenine hydrolase)
chr6_+_136518820 0.03 ENSMUST00000032335.6
activating transcription factor 7 interacting protein
chr17_-_23645264 0.03 ENSMUST00000024696.7
matrix metallopeptidase 25
chr4_+_6365650 0.02 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
syndecan binding protein
chr18_+_76930017 0.02 ENSMUST00000026487.4
immediate early response 3 interacting protein 1
chr6_+_47877204 0.02 ENSMUST00000061890.7
zinc finger protein 282
chr2_-_105904484 0.02 ENSMUST00000122965.1
elongation protein 4 homolog (S. cerevisiae)
chrX_+_142227923 0.02 ENSMUST00000042329.5
nuclear transport factor 2-like export factor 2
chr8_-_4217261 0.02 ENSMUST00000168386.2
cDNA sequence BC068157
chr2_+_105904629 0.02 ENSMUST00000037499.5
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr4_-_58987095 0.02 ENSMUST00000030069.6
prostaglandin reductase 1
chr19_+_53140430 0.02 ENSMUST00000111741.2
adducin 3 (gamma)
chrX_-_53209724 0.02 ENSMUST00000174390.1
placental specific protein 1
chr19_+_3972322 0.01 ENSMUST00000143380.1
aldehyde dehydrogenase 3 family, member B2
chr9_-_103222063 0.01 ENSMUST00000170904.1
transferrin
chr1_-_4360256 0.01 ENSMUST00000027032.4
retinitis pigmentosa 1 (human)
chr4_+_155831272 0.01 ENSMUST00000139651.1
ENSMUST00000084097.5
aurora kinase A interacting protein 1
chr1_-_88008520 0.01 ENSMUST00000040783.4
ubiquitin specific peptidase 40
chr5_-_116288944 0.00 ENSMUST00000086483.3
coiled-coil domain containing 60
chr2_+_105126505 0.00 ENSMUST00000143043.1
Wilms tumor 1 homolog
chrX_-_9662950 0.00 ENSMUST00000033519.2
dynein light chain Tctex-type 3
chr4_+_155831630 0.00 ENSMUST00000105592.1
ENSMUST00000105591.1
aurora kinase A interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0090345 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.2 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.0 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 0.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:1904996 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.0 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.4 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.0 0.2 GO:0047726 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.1 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases