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2D miR_HR1_12

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Results for Relb

Z-value: 0.45

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Transcription factors associated with Relb

Gene Symbol Gene ID Gene Info
ENSMUSG00000002983.10 avian reticuloendotheliosis viral (v-rel) oncogene related B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.088.1e-01Click!

Activity profile of Relb motif

Sorted Z-values of Relb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_148500449 0.86 ENSMUST00000030840.3
angiopoietin-like 7
chr5_+_90891234 0.53 ENSMUST00000031327.8
chemokine (C-X-C motif) ligand 1
chr1_-_170589791 0.50 ENSMUST00000161966.1
ENSMUST00000160456.1
nitric oxide synthase 1 (neuronal) adaptor protein
chr7_+_99535439 0.46 ENSMUST00000098266.2
ENSMUST00000179755.1
arrestin, beta 1
chr4_+_100776664 0.46 ENSMUST00000030257.8
ENSMUST00000097955.2
cache domain containing 1
chr4_-_117133953 0.45 ENSMUST00000076859.5
polo-like kinase 3
chr4_+_150927918 0.43 ENSMUST00000139826.1
ENSMUST00000116257.1
tumor necrosis factor receptor superfamily, member 9
chr11_+_90030295 0.32 ENSMUST00000092788.3
transmembrane protein 100
chr17_+_35194502 0.31 ENSMUST00000173600.1
lymphotoxin B
chr1_+_193301953 0.31 ENSMUST00000016315.9
laminin, beta 3
chr11_-_54956047 0.29 ENSMUST00000155316.1
ENSMUST00000108889.3
ENSMUST00000126703.1
TNFAIP3 interacting protein 1
chr7_+_99535652 0.28 ENSMUST00000032995.8
ENSMUST00000162404.1
arrestin, beta 1
chr2_-_5063996 0.27 ENSMUST00000114996.1
optineurin
chr14_+_55560480 0.27 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
DDB1 and CUL4 associated factor 11
chr10_-_93311073 0.26 ENSMUST00000008542.5
ELK3, member of ETS oncogene family
chr17_+_37193889 0.26 ENSMUST00000038844.6
ubiquitin D
chr10_-_93310963 0.26 ENSMUST00000151153.1
ELK3, member of ETS oncogene family
chr10_+_79664553 0.25 ENSMUST00000020554.6
mucosal vascular addressin cell adhesion molecule 1
chr18_+_37484955 0.24 ENSMUST00000053856.4
protocadherin beta 17
chr2_-_5063932 0.24 ENSMUST00000027986.4
optineurin
chr15_-_31367527 0.23 ENSMUST00000076942.4
ENSMUST00000123325.1
ENSMUST00000110410.2
ankyrin repeat domain 33B
chr15_-_79164477 0.23 ENSMUST00000040019.4
SRY-box containing gene 10
chr7_-_19629355 0.22 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr7_+_28766747 0.21 ENSMUST00000170068.1
ENSMUST00000072965.4
sirtuin 2
chr7_-_45920830 0.21 ENSMUST00000164119.1
epithelial membrane protein 3
chr8_+_72319033 0.21 ENSMUST00000067912.7
Kruppel-like factor 2 (lung)
chr10_-_77902467 0.20 ENSMUST00000057608.4
leucine rich repeat containing 3
chr10_-_19015347 0.20 ENSMUST00000019997.4
tumor necrosis factor, alpha-induced protein 3
chr2_+_10153563 0.18 ENSMUST00000026886.7
inter-alpha (globulin) inhibitor H5
chr18_+_36560581 0.18 ENSMUST00000155329.2
ankyrin repeat and KH domain containing 1
chr12_-_55492587 0.17 ENSMUST00000021413.7
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr4_+_99656299 0.17 ENSMUST00000087285.3
forkhead box D3
chr19_+_46304709 0.16 ENSMUST00000073116.5
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chrX_+_163909132 0.16 ENSMUST00000033734.7
ENSMUST00000112294.2
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_122989086 0.15 ENSMUST00000046073.9
lysine (K)-specific demethylase 2B
chrX_+_163908982 0.15 ENSMUST00000069041.8
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_122989260 0.15 ENSMUST00000118027.1
lysine (K)-specific demethylase 2B
chr4_+_43631935 0.15 ENSMUST00000030191.8
natriuretic peptide receptor 2
chr4_+_129985098 0.14 ENSMUST00000106017.1
ENSMUST00000121049.1
brain-specific angiogenesis inhibitor 2
chr1_-_135258449 0.14 ENSMUST00000003135.7
E74-like factor 3
chr5_-_33657889 0.14 ENSMUST00000019439.7
transmembrane protein 129
chr7_+_75455534 0.13 ENSMUST00000147005.1
ENSMUST00000166315.1
A kinase (PRKA) anchor protein 13
chr2_-_34958129 0.13 ENSMUST00000172159.1
TNF receptor-associated factor 1
chr14_+_120478443 0.13 ENSMUST00000062117.6
RAS related protein 2a
chr2_+_143546144 0.11 ENSMUST00000028905.9
proprotein convertase subtilisin/kexin type 2
chr17_+_35194405 0.11 ENSMUST00000025262.5
lymphotoxin B
chr12_+_85686648 0.10 ENSMUST00000040536.5
basic leucine zipper transcription factor, ATF-like
chr7_-_70360593 0.10 ENSMUST00000032768.7
nuclear receptor subfamily 2, group F, member 2
chr12_+_111538101 0.10 ENSMUST00000166123.1
eukaryotic translation initiation factor 5
chr7_-_99626936 0.10 ENSMUST00000178124.1
predicted gene 4980
chr12_-_76369586 0.10 ENSMUST00000176278.1
zinc finger and BTB domain containing 25
chr10_+_96616998 0.10 ENSMUST00000038377.7
B cell translocation gene 1, anti-proliferative
chr4_+_130915949 0.09 ENSMUST00000030316.6
lysosomal-associated protein transmembrane 5
chr1_+_152399824 0.09 ENSMUST00000044311.8
collagen beta(1-O)galactosyltransferase 2
chrX_+_141475385 0.09 ENSMUST00000112931.1
ENSMUST00000112930.1
collagen, type IV, alpha 5
chrX_+_103321398 0.09 ENSMUST00000033689.2
caudal type homeobox 4
chr12_-_76369385 0.08 ENSMUST00000176187.1
ENSMUST00000167011.1
ENSMUST00000176967.1
zinc finger and BTB domain containing 25
chr7_-_28766469 0.07 ENSMUST00000085851.5
ENSMUST00000032815.4
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
chr1_+_135133272 0.07 ENSMUST00000167080.1
protein tyrosine phosphatase, non-receptor type 7
chr5_+_90759299 0.07 ENSMUST00000031318.4
chemokine (C-X-C motif) ligand 5
chr4_-_40239779 0.06 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr14_+_60732906 0.06 ENSMUST00000162945.1
spermatogenesis associated 13
chr18_+_36559972 0.06 ENSMUST00000134146.1
ankyrin repeat and KH domain containing 1
chr7_+_43463145 0.06 ENSMUST00000107977.1
ZV-set and immunoglobulin domain containing 10 like
chr4_-_152131865 0.06 ENSMUST00000105653.1
espin
chr1_+_135132693 0.06 ENSMUST00000049449.4
protein tyrosine phosphatase, non-receptor type 7
chr4_+_129984833 0.06 ENSMUST00000120204.1
brain-specific angiogenesis inhibitor 2
chr2_+_59612034 0.06 ENSMUST00000112568.1
ENSMUST00000037526.4
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr4_-_40239700 0.05 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr15_-_89429093 0.05 ENSMUST00000170460.1
choline kinase beta
chr15_-_98677451 0.04 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
Rho family GTPase 1
chr12_+_111417430 0.04 ENSMUST00000072646.6
exocyst complex component 3-like 4
chr10_+_102512216 0.04 ENSMUST00000055355.4
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr16_+_97997313 0.04 ENSMUST00000122450.1
RIKEN cDNA B230307C23 gene
chr7_-_102250086 0.04 ENSMUST00000106923.1
ENSMUST00000098230.4
ras homolog gene family, member G
chr3_-_9610074 0.02 ENSMUST00000041124.7
zinc finger protein 704
chr2_+_119972699 0.01 ENSMUST00000066058.7
mitogen-activated protein kinase binding protein 1
chr4_-_101265236 0.01 ENSMUST00000149297.1
ENSMUST00000102781.3
Janus kinase 1
chr3_+_7612702 0.01 ENSMUST00000181286.1
predicted gene, 16685
chr12_+_111166413 0.00 ENSMUST00000021706.4
TNF receptor-associated factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.2 0.5 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.1 0.7 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.4 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.2 GO:0002632 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.1 0.2 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.1 0.2 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.0 0.4 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.2 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.2 GO:0010624 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.2 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.1 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0032060 bleb assembly(GO:0032060)
0.0 0.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0033010 paranodal junction(GO:0033010)
0.0 0.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.0 0.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines