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2D miR_HR1_12

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Results for Irf3

Z-value: 0.93

Motif logo

Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
ENSMUSG00000003184.8 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_44997700-0.461.3e-01Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_120812506 2.04 ENSMUST00000117193.1
ENSMUST00000130045.1
2'-5' oligoadenylate synthetase 1C
chr5_-_120812484 1.83 ENSMUST00000125547.1
2'-5' oligoadenylate synthetase 1C
chr8_+_61928081 1.82 ENSMUST00000154398.1
ENSMUST00000093485.2
ENSMUST00000156980.1
ENSMUST00000070631.7
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr7_+_104244449 1.58 ENSMUST00000106849.2
ENSMUST00000060315.5
tripartite motif-containing 34A
chr2_+_93187542 1.32 ENSMUST00000111266.1
ENSMUST00000150462.1
transformation related protein 53 inducible protein 11
chr7_-_104315455 1.14 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
tripartite motif-containing 12A
chr7_-_104353328 1.11 ENSMUST00000130139.1
ENSMUST00000059037.8
tripartite motif-containing 12C
chr10_+_128270546 1.07 ENSMUST00000105238.3
ENSMUST00000085708.2
signal transducer and activator of transcription 2
chr16_-_35871544 1.05 ENSMUST00000042665.8
poly (ADP-ribose) polymerase family, member 14
chr7_+_104244465 1.05 ENSMUST00000106848.1
tripartite motif-containing 34A
chr5_-_120907510 1.02 ENSMUST00000080322.7
2'-5' oligoadenylate synthetase 1A
chr2_+_93187574 0.99 ENSMUST00000090554.4
transformation related protein 53 inducible protein 11
chr5_+_114896936 0.98 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
2'-5' oligoadenylate synthetase-like 2
chr11_-_83530505 0.96 ENSMUST00000035938.2
chemokine (C-C motif) ligand 5
chr7_+_104244496 0.89 ENSMUST00000106854.1
ENSMUST00000143414.1
tripartite motif-containing 34A
chr6_-_3399545 0.86 ENSMUST00000120087.3
sterile alpha motif domain containing 9-like
chr7_-_45136056 0.79 ENSMUST00000130628.1
FMS-like tyrosine kinase 3 ligand
chr16_-_10785525 0.79 ENSMUST00000038099.4
suppressor of cytokine signaling 1
chr7_-_102565425 0.78 ENSMUST00000106913.1
ENSMUST00000033264.4
tripartite motif-containing 21
chr5_-_120887582 0.75 ENSMUST00000086368.5
2'-5' oligoadenylate synthetase 1G
chr3_+_142530329 0.73 ENSMUST00000171263.1
ENSMUST00000045097.9
guanylate binding protein 7
chr4_-_40239700 0.71 ENSMUST00000142055.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_167062981 0.71 ENSMUST00000048988.7
zinc finger, NFX1-type containing 1
chr7_-_45136102 0.71 ENSMUST00000125500.1
FMS-like tyrosine kinase 3 ligand
chr11_+_58199556 0.66 ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
ENSMUST00000058704.8
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr17_-_36020525 0.64 ENSMUST00000174063.1
ENSMUST00000113760.3
histocompatibility 2, T region locus 24
chr17_+_23660477 0.61 ENSMUST00000062967.8
coiled-coil domain containing 64B
chr4_-_40239779 0.60 ENSMUST00000037907.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr11_+_58215028 0.59 ENSMUST00000108836.1
immunity-related GTPase family M member 2
chr2_+_145934800 0.55 ENSMUST00000138774.1
ENSMUST00000152515.1
ENSMUST00000130168.1
ENSMUST00000133433.1
ENSMUST00000118002.1
RIKEN cDNA 4930529M08 gene
chr11_-_48992226 0.53 ENSMUST00000059930.2
ENSMUST00000068063.3
predicted gene 12185
T cell specific GTPase 1
chr6_-_125231772 0.52 ENSMUST00000043422.7
TAP binding protein-like
chr11_-_49064202 0.52 ENSMUST00000046745.6
T cell specific GTPase 2
chr17_+_36837123 0.52 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
tripartite motif-containing 26
chr18_-_32559914 0.50 ENSMUST00000174000.1
ENSMUST00000174459.1
glycophorin C
chr2_-_62646146 0.49 ENSMUST00000112459.3
ENSMUST00000028259.5
interferon induced with helicase C domain 1
chr2_+_38998302 0.47 ENSMUST00000112872.1
WD repeat domain 38
chr17_-_34187219 0.44 ENSMUST00000173831.1
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr3_+_81932601 0.44 ENSMUST00000029649.2
cathepsin O
chr2_-_173276144 0.44 ENSMUST00000139306.1
prostate transmembrane protein, androgen induced 1
chr5_-_137116177 0.42 ENSMUST00000054384.5
ENSMUST00000152207.1
tripartite motif-containing 56
chr16_+_23609895 0.41 ENSMUST00000038423.5
receptor transporter protein 4
chr11_+_83852920 0.39 ENSMUST00000108113.1
HNF1 homeobox B
chr17_+_75178797 0.38 ENSMUST00000112516.1
ENSMUST00000135447.1
latent transforming growth factor beta binding protein 1
chr17_+_75178911 0.38 ENSMUST00000112514.1
latent transforming growth factor beta binding protein 1
chr2_-_51934644 0.38 ENSMUST00000165313.1
RNA binding motif protein 43
chr6_-_54972603 0.37 ENSMUST00000060655.8
nucleotide-binding oligomerization domain containing 1
chr7_-_100514800 0.37 ENSMUST00000054923.7
DnaJ (Hsp40) related, subfamily B, member 13
chr13_-_23710714 0.36 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
hemochromatosis
chr1_+_85600672 0.36 ENSMUST00000080204.4
Sp140 nuclear body protein
chr7_-_141266415 0.32 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
interferon regulatory factor 7
chr6_-_39118211 0.32 ENSMUST00000038398.6
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938470 0.32 ENSMUST00000114878.1
poly (ADP-ribose) polymerase family, member 9
chr19_+_34583528 0.31 ENSMUST00000102825.3
interferon-induced protein with tetratricopeptide repeats 3
chr11_+_109362771 0.31 ENSMUST00000020930.7
ENSMUST00000106702.3
guanine nucleotide binding protein, alpha 13
chr3_-_151749877 0.30 ENSMUST00000029671.7
interferon-induced protein 44
chr17_+_34187545 0.29 ENSMUST00000170086.1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_167062607 0.29 ENSMUST00000128676.1
zinc finger, NFX1-type containing 1
chr13_+_40859768 0.28 ENSMUST00000110191.2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_+_77729091 0.27 ENSMUST00000109775.2
apolipoprotein L 9b
chr15_-_77411034 0.27 ENSMUST00000089452.5
ENSMUST00000081776.3
apolipoprotein L 9a
chr2_+_145934776 0.27 ENSMUST00000126415.1
ENSMUST00000116398.1
RIKEN cDNA 4930529M08 gene
chr11_-_100704217 0.25 ENSMUST00000017974.6
DEXH (Asp-Glu-X-His) box polypeptide 58
chr4_+_44012638 0.24 ENSMUST00000107847.3
ENSMUST00000170241.1
clathrin, light polypeptide (Lca)
chr7_+_78913436 0.24 ENSMUST00000121645.1
interferon-stimulated protein
chr2_-_51934943 0.24 ENSMUST00000102767.1
ENSMUST00000102768.1
RNA binding motif protein 43
chr17_+_34187789 0.24 ENSMUST00000041633.8
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_48871344 0.24 ENSMUST00000049519.3
immunity-related GTPase family M member 1
chr2_+_122147680 0.23 ENSMUST00000102476.4
beta-2 microglobulin
chr15_+_32920723 0.23 ENSMUST00000022871.5
syndecan 2
chr7_-_104288094 0.23 ENSMUST00000098179.2
tripartite motif-containing 5
chr16_+_35938972 0.22 ENSMUST00000023622.6
ENSMUST00000114877.1
poly (ADP-ribose) polymerase family, member 9
chr4_+_44012661 0.21 ENSMUST00000107849.3
ENSMUST00000107851.3
ENSMUST00000107845.3
clathrin, light polypeptide (Lca)
chr11_-_121229293 0.20 ENSMUST00000106115.1
ENSMUST00000038709.7
ENSMUST00000147490.1
cDNA sequence BC017643
chr16_-_38341812 0.20 ENSMUST00000114740.2
ENSMUST00000023501.8
MYCBP-associated, testis expressed 1
chr17_+_57358682 0.18 ENSMUST00000086763.5
ENSMUST00000004850.7
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
chr6_-_56797761 0.18 ENSMUST00000114321.1
kelch repeat and BTB (POZ) domain containing 2
chr13_+_74639866 0.15 ENSMUST00000169114.1
endoplasmic reticulum aminopeptidase 1
chr6_-_56797637 0.15 ENSMUST00000114323.1
kelch repeat and BTB (POZ) domain containing 2
chr3_+_142560108 0.14 ENSMUST00000128609.1
ENSMUST00000029935.7
guanylate binding protein 3
chr1_-_85598796 0.14 ENSMUST00000093508.6
Sp110 nuclear body protein
chr11_-_48871408 0.14 ENSMUST00000097271.2
immunity-related GTPase family M member 1
chr6_+_34863130 0.13 ENSMUST00000074949.3
transmembrane protein 140
chr16_+_38346986 0.13 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
cytochrome c oxidase assembly protein 17
predicted gene 21987
chr3_+_142560351 0.13 ENSMUST00000106221.1
guanylate binding protein 3
chr7_+_78913765 0.09 ENSMUST00000038142.8
interferon-stimulated protein
chr3_+_142560052 0.09 ENSMUST00000106222.2
guanylate binding protein 3
chr7_+_78914216 0.05 ENSMUST00000120331.2
interferon-stimulated protein
chr9_-_15045378 0.04 ENSMUST00000164273.1
pannexin 1
chr19_+_43752996 0.04 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
cutC copper transporter homolog (E.coli)
chr17_+_21008921 0.03 ENSMUST00000088811.5
zinc finger protein 160
chr14_+_14012491 0.03 ENSMUST00000022257.2
ataxin 7
chr3_-_69127098 0.03 ENSMUST00000029353.2
karyopherin (importin) alpha 4
chr7_-_3502465 0.02 ENSMUST00000065703.7
T cell-interacting, activating receptor on myeloid cells 1
chr6_-_38354243 0.01 ENSMUST00000114900.1
zinc finger CCCH type, antiviral 1
chr11_+_72301613 0.00 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
XIAP associated factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 1.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.3 1.8 GO:0035549 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.3 0.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.3 1.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 1.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 0.9 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.2 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.1 1.7 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.8 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.9 GO:0035726 endosomal vesicle fusion(GO:0034058) common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0035565 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.1 0.4 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 0.4 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.9 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.1 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:1904732 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.0 8.8 GO:0051607 defense response to virus(GO:0051607)
0.0 0.3 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 1.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 1.0 GO:0048525 negative regulation of viral process(GO:0048525)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.0 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 1.3 GO:1990462 omegasome(GO:1990462)
0.2 2.3 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.2 0.5 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.1 0.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0044754 autolysosome(GO:0044754)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.3 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 1.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 0.8 GO:0050436 microfibril binding(GO:0050436)
0.1 1.2 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.5 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 1.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.1 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 2.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.9 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.7 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation