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2D miR_HR1_12

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Results for Twist1

Z-value: 0.67

Motif logo

Transcription factors associated with Twist1

Gene Symbol Gene ID Gene Info
ENSMUSG00000035799.5 twist basic helix-loop-helix transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_33957671-0.642.5e-02Click!

Activity profile of Twist1 motif

Sorted Z-values of Twist1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_40999479 2.22 ENSMUST00000166306.1
predicted gene 2663
chr6_+_40964760 2.06 ENSMUST00000076638.5
RIKEN cDNA 1810009J06 gene
chr7_-_31115227 1.42 ENSMUST00000168884.1
ENSMUST00000108102.2
hepsin
chr6_+_30639218 0.95 ENSMUST00000031806.9
carboxypeptidase A1, pancreatic
chr6_-_41035501 0.86 ENSMUST00000031931.5
RIKEN cDNA 2210010C04 gene
chr2_-_172940299 0.75 ENSMUST00000009143.7
bone morphogenetic protein 7
chr8_-_105933832 0.73 ENSMUST00000034368.6
chymotrypsin-like
chr17_+_36943025 0.57 ENSMUST00000173072.1
ring finger protein 39
chr1_-_15892657 0.47 ENSMUST00000040695.4
somatomedin B and thrombospondin, type 1 domain containing
chr18_+_60911757 0.40 ENSMUST00000040359.5
arylsulfatase i
chr4_-_130275542 0.36 ENSMUST00000154846.1
ENSMUST00000105996.1
serine incorporator 2
chr18_+_40256960 0.35 ENSMUST00000096572.1
RIKEN cDNA 2900055J20 gene
chr7_-_4844665 0.31 ENSMUST00000066041.5
ENSMUST00000172377.1
shisa homolog 7 (Xenopus laevis)
chr14_-_70176787 0.31 ENSMUST00000153735.1
PDZ and LIM domain 2
chr13_-_58113592 0.29 ENSMUST00000160860.1
kelch-like 3
chr7_-_29232478 0.29 ENSMUST00000085818.4
potassium inwardly-rectifying channel, subfamily K, member 6
chr7_+_35119285 0.28 ENSMUST00000042985.9
CCAAT/enhancer binding protein (C/EBP), alpha
chr17_+_36942910 0.27 ENSMUST00000040498.5
ring finger protein 39
chr16_+_78930940 0.27 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
chondrolectin
chr8_+_122422020 0.27 ENSMUST00000050963.3
interleukin 17C
chr7_+_45216671 0.26 ENSMUST00000134420.1
TEA domain family member 2
chr7_+_27486910 0.22 ENSMUST00000008528.7
SERTA domain containing 1
chr8_-_71381907 0.20 ENSMUST00000002466.8
nuclear receptor subfamily 2, group F, member 6
chr7_+_4119556 0.19 ENSMUST00000079415.5
tweety homolog 1 (Drosophila)
chr7_+_44468020 0.18 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josephin domain containing 2
chr5_+_24364804 0.18 ENSMUST00000030834.4
ENSMUST00000115090.1
nitric oxide synthase 3, endothelial cell
chr3_-_65529355 0.18 ENSMUST00000099076.3
RIKEN cDNA 4931440P22 gene
chr7_+_4119525 0.18 ENSMUST00000119661.1
ENSMUST00000129423.1
tweety homolog 1 (Drosophila)
chr2_+_31887262 0.18 ENSMUST00000138325.1
ENSMUST00000028187.6
laminin gamma 3
chr16_+_37776873 0.18 ENSMUST00000114763.2
follistatin-like 1
chrX_+_71050160 0.17 ENSMUST00000082088.3
ENSMUST00000114629.3
mastermind-like domain containing 1
chr6_-_90716489 0.17 ENSMUST00000101153.3
IQ motif and Sec7 domain 1
chrX_+_100730178 0.16 ENSMUST00000113744.1
glycerophosphodiester phosphodiesterase domain containing 2
chr9_-_114844090 0.16 ENSMUST00000047013.3
CKLF-like MARVEL transmembrane domain containing 8
chr1_+_40681659 0.15 ENSMUST00000027231.7
solute carrier family 9 (sodium/hydrogen exchanger), member 2
chr8_-_70700070 0.15 ENSMUST00000116172.1
predicted gene 11175
chr4_-_148038769 0.15 ENSMUST00000030879.5
ENSMUST00000137724.1
chloride channel 6
chr9_-_54661870 0.15 ENSMUST00000034822.5
acyl-CoA synthetase bubblegum family member 1
chr4_-_119658781 0.14 ENSMUST00000106309.2
ENSMUST00000044426.7
guanylate cyclase activator 2b (retina)
chr7_+_44468051 0.13 ENSMUST00000118493.1
Josephin domain containing 2
chr1_+_74791516 0.13 ENSMUST00000006718.8
wingless related MMTV integration site 10a
chr15_-_79164477 0.12 ENSMUST00000040019.4
SRY-box containing gene 10
chr17_-_65613521 0.12 ENSMUST00000024897.8
vesicle-associated membrane protein, associated protein A
chr6_-_119963733 0.11 ENSMUST00000161512.2
WNK lysine deficient protein kinase 1
chr2_-_85519018 0.11 ENSMUST00000099923.1
RIKEN cDNA 4833423E24 gene
chr8_+_122269569 0.11 ENSMUST00000055537.2
predicted gene 22
chr1_-_172590463 0.11 ENSMUST00000065679.6
SLAM family member 8
chr14_-_50930803 0.10 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
transmembrane protein 55b
chr8_+_105305572 0.10 ENSMUST00000109375.2
engulfment and cell motility 3
chr2_-_180225812 0.10 ENSMUST00000015791.5
laminin, alpha 5
chr9_+_75625707 0.10 ENSMUST00000034702.4
LysM, putative peptidoglycan-binding, domain containing 2
chr9_-_108567336 0.10 ENSMUST00000074208.4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr11_+_69935796 0.10 ENSMUST00000018698.5
Y box protein 2
chr16_+_62814676 0.10 ENSMUST00000055557.5
syntaxin 19
chr11_-_100759942 0.09 ENSMUST00000107363.2
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr7_+_108934405 0.09 ENSMUST00000033342.6
eukaryotic translation initiation factor 3, subunit F
chr7_-_75308373 0.09 ENSMUST00000085164.5
synaptic vesicle glycoprotein 2 b
chr16_+_18811772 0.09 ENSMUST00000168822.1
ENSMUST00000115578.3
ubiquitin fusion degradation 1 like
chr8_-_105413473 0.09 ENSMUST00000167294.1
ENSMUST00000063071.6
potassium channel tetramerisation domain containing 19
chr19_+_25610533 0.09 ENSMUST00000048935.4
doublesex and mab-3 related transcription factor 3
chr8_-_122476036 0.08 ENSMUST00000014614.3
ring finger protein 166
chr11_+_72207537 0.08 ENSMUST00000021158.3
thioredoxin domain containing 17
chr4_+_149518216 0.08 ENSMUST00000030839.6
catenin beta interacting protein 1
chr11_+_53770458 0.08 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
interferon regulatory factor 1
chr5_+_149411749 0.08 ENSMUST00000093110.5
mesenteric estrogen dependent adipogenesis
chr17_+_45563928 0.08 ENSMUST00000041353.6
solute carrier family 35, member B2
chr4_+_125085134 0.08 ENSMUST00000154689.1
ENSMUST00000055213.4
ENSMUST00000106171.2
MYST/Esa1-associated factor 6
chr15_+_100227819 0.07 ENSMUST00000023769.4
activating transcription factor 1
chr5_-_35729276 0.07 ENSMUST00000070203.7
SH3 domain and tetratricopeptide repeats 1
chr10_+_89873497 0.07 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_+_69534039 0.07 ENSMUST00000182557.1
ankyrin 3, epithelial
chr7_+_82867327 0.07 ENSMUST00000082237.5
mex3 homolog B (C. elegans)
chr7_-_70360593 0.07 ENSMUST00000032768.7
nuclear receptor subfamily 2, group F, member 2
chr8_+_119910792 0.07 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
ubiquitin specific peptidase 10
predicted gene 20388
chr2_+_174110340 0.07 ENSMUST00000044415.9
aminopeptidase-like 1
chr6_+_83135812 0.07 ENSMUST00000065512.4
rhotekin
chr11_-_113709520 0.06 ENSMUST00000173655.1
ENSMUST00000100248.4
cleavage and polyadenylation specific factor 4-like
chr4_-_130275523 0.06 ENSMUST00000146478.1
serine incorporator 2
chr4_-_139131058 0.06 ENSMUST00000143971.1
mitochondrial inner membrane organizing system 1
chr15_-_57892358 0.06 ENSMUST00000022993.5
Der1-like domain family, member 1
chr19_+_8664005 0.06 ENSMUST00000035444.3
ENSMUST00000163785.1
cholinergic receptor, muscarinic 1, CNS
chr8_+_72135247 0.06 ENSMUST00000003575.9
tropomyosin 4
chr9_-_45009590 0.06 ENSMUST00000102832.1
CD3 antigen, epsilon polypeptide
chr10_-_75517324 0.06 ENSMUST00000039796.7
guanylyl cyclase domain containing 1
chr18_-_67724560 0.05 ENSMUST00000120934.1
ENSMUST00000025420.7
ENSMUST00000122412.1
protein tyrosine phosphatase, non-receptor type 2
chr10_-_127030813 0.05 ENSMUST00000040560.4
Ts translation elongation factor, mitochondrial
chr9_+_118478851 0.05 ENSMUST00000150633.1
eomesodermin homolog (Xenopus laevis)
chr15_+_100227871 0.05 ENSMUST00000163855.1
activating transcription factor 1
chr11_+_58009064 0.05 ENSMUST00000071487.6
ENSMUST00000178636.1
La ribonucleoprotein domain family, member 1
chr19_-_3686549 0.05 ENSMUST00000025856.10
ENSMUST00000176867.1
low density lipoprotein receptor-related protein 5
chr10_-_127341583 0.05 ENSMUST00000026474.3
GLI-Kruppel family member GLI1
chr2_-_32784424 0.05 ENSMUST00000102813.1
RIKEN cDNA 1700019L03 gene
chr4_-_129558387 0.04 ENSMUST00000067240.4
lymphocyte protein tyrosine kinase
chr2_-_137116624 0.04 ENSMUST00000028735.7
jagged 1
chr9_-_54661666 0.04 ENSMUST00000128624.1
acyl-CoA synthetase bubblegum family member 1
chr7_-_44524642 0.04 ENSMUST00000165208.2
myosin binding protein C, fast-type
chr4_-_129558355 0.04 ENSMUST00000167288.1
ENSMUST00000134336.1
lymphocyte protein tyrosine kinase
chr17_-_70990751 0.04 ENSMUST00000038446.8
myosin, light chain 12B, regulatory
chrX_-_18461371 0.04 ENSMUST00000044188.4
RIKEN cDNA 4930578C19 gene
chr19_+_7417586 0.04 ENSMUST00000159348.1
RIKEN cDNA 2700081O15 gene
chr18_+_77065195 0.04 ENSMUST00000114777.2
protein inhibitor of activated STAT 2
chr11_+_87737530 0.03 ENSMUST00000093955.5
suppressor of Ty 4A
chr6_+_85187438 0.03 ENSMUST00000045942.8
empty spiracles homeobox 1
chr8_-_117082449 0.03 ENSMUST00000098375.4
ENSMUST00000109093.2
polycystic kidney disease 1 like 2
chr11_+_103103051 0.03 ENSMUST00000152971.1
acyl-Coenzyme A binding domain containing 4
chr5_-_38561658 0.03 ENSMUST00000005234.9
WD repeat domain 1
chr1_+_75382114 0.03 ENSMUST00000113590.1
ENSMUST00000148515.1
SPEG complex locus
chr11_+_69935894 0.02 ENSMUST00000149194.1
Y box protein 2
chr18_-_16809233 0.02 ENSMUST00000025166.7
cadherin 2
chr4_-_57143437 0.02 ENSMUST00000095076.3
ENSMUST00000030142.3
erythrocyte protein band 4.1-like 4b
chr11_+_97663366 0.02 ENSMUST00000044730.5
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_-_73775341 0.01 ENSMUST00000112024.3
ENSMUST00000166199.1
ENSMUST00000180045.1
chimerin (chimaerin) 1
chr6_+_83165920 0.01 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
dynactin 1
chr9_+_111118070 0.01 ENSMUST00000035078.6
ENSMUST00000098340.2
leucine rich repeat (in FLII) interacting protein 2
chr7_+_44384803 0.01 ENSMUST00000120262.1
synaptotagmin III
chr11_-_76179499 0.01 ENSMUST00000167114.1
ENSMUST00000094015.4
ENSMUST00000108419.2
ENSMUST00000170730.1
ENSMUST00000129256.1
ENSMUST00000056601.4
vacuolar protein sorting 53 (yeast)
chr13_+_73467197 0.01 ENSMUST00000022099.8
lysophosphatidylcholine acyltransferase 1
chr3_+_90051630 0.01 ENSMUST00000159064.1
RIKEN cDNA 4933434E20 gene
chr4_+_119539652 0.00 ENSMUST00000044564.8
ENSMUST00000162267.1
ENSMUST00000106310.2
ENSMUST00000138845.2
forkhead box J3
chr7_-_141016892 0.00 ENSMUST00000081924.3
interferon induced transmembrane protein 6
chr6_-_124813065 0.00 ENSMUST00000149610.2
triosephosphate isomerase 1
chrX_-_53114530 0.00 ENSMUST00000114843.2
placental specific protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Twist1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0034769 basement membrane disassembly(GO:0034769)
0.2 0.7 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.4 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.3 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0 0.3 GO:0072017 distal tubule development(GO:0072017)
0.0 0.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.1 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.0 0.1 GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0 0.3 GO:0071285 urea cycle(GO:0000050) cellular response to lithium ion(GO:0071285)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.3 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 0.0 GO:1901355 response to rapamycin(GO:1901355)
0.0 0.1 GO:0045590 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.1 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.1 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.7 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway