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2D miR_HR1_12

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Results for Egr3

Z-value: 0.74

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Transcription factors associated with Egr3

Gene Symbol Gene ID Gene Info
ENSMUSG00000033730.3 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.441.6e-01Click!

Activity profile of Egr3 motif

Sorted Z-values of Egr3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_109722214 1.82 ENSMUST00000020938.7
family with sequence similarity 20, member A
chr1_+_120340569 1.13 ENSMUST00000037286.8
complement component 1, q subcomponent-like 2
chr7_+_80246375 1.12 ENSMUST00000058266.6
tubulin tyrosine ligase-like family, member 13
chr7_+_80246529 1.05 ENSMUST00000107381.1
tubulin tyrosine ligase-like family, member 13
chrX_-_7574120 1.05 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr17_-_87282771 1.03 ENSMUST00000161759.1
RIKEN cDNA 4833418N02 gene
chr8_+_62951361 0.97 ENSMUST00000119068.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chrX_+_36195968 0.93 ENSMUST00000115256.1
zinc finger, CCHC domain containing 12
chr17_-_87282793 0.92 ENSMUST00000146560.2
RIKEN cDNA 4833418N02 gene
chr5_+_64970069 0.85 ENSMUST00000031080.8
family with sequence similarity 114, member A1
chr9_+_75410145 0.81 ENSMUST00000180533.1
ENSMUST00000180574.1
RIKEN cDNA 4933433G15 gene
chr19_+_16956110 0.81 ENSMUST00000087689.4
prune homolog 2 (Drosophila)
chr1_+_125676969 0.72 ENSMUST00000027581.6
G protein-coupled receptor 39
chr5_-_134747241 0.63 ENSMUST00000015138.9
elastin
chr9_-_55048544 0.61 ENSMUST00000034854.6
cholinergic receptor, nicotinic, beta polypeptide 4
chr10_-_29144194 0.60 ENSMUST00000070359.2
predicted gene 9996
chrX_-_162159717 0.58 ENSMUST00000087085.3
Nance-Horan syndrome (human)
chr19_-_38124801 0.55 ENSMUST00000112335.2
retinol binding protein 4, plasma
chr6_+_42261957 0.55 ENSMUST00000095987.3
transmembrane protein 139
chr17_-_29078953 0.52 ENSMUST00000133221.1
tumor protein p53 pathway corepressor 1
chr16_-_94370994 0.51 ENSMUST00000113914.1
ENSMUST00000113905.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_3645267 0.46 ENSMUST00000038913.9
CCR4-NOT transcription complex, subunit 3
chr3_+_105452326 0.44 ENSMUST00000098761.3
potassium voltage-gated channel, Shal-related family, member 3
chrX_+_143664365 0.43 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_+_59221945 0.43 ENSMUST00000182161.1
sosondowah ankyrin repeat domain family member C
chrX_+_143664290 0.41 ENSMUST00000112868.1
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_138279960 0.40 ENSMUST00000014089.7
ENSMUST00000161827.1
glypican 2 (cerebroglycan)
chr5_+_102481546 0.39 ENSMUST00000112854.1
Rho GTPase activating protein 24
chr5_+_143403819 0.39 ENSMUST00000110731.2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr3_+_97901190 0.38 ENSMUST00000029476.2
ENSMUST00000122288.1
SEC22 vesicle trafficking protein homolog B (S. cerevisiae)
chr18_+_65698253 0.38 ENSMUST00000115097.1
ENSMUST00000117694.1
O-acyltransferase like
chr7_-_45510400 0.36 ENSMUST00000033096.7
nucleobindin 1
chr1_-_9299238 0.34 ENSMUST00000140295.1
syntrophin, gamma 1
chr7_-_19023538 0.34 ENSMUST00000036018.5
forkhead box A3
chr18_-_37935378 0.33 ENSMUST00000025337.7
diaphanous homolog 1 (Drosophila)
chr17_-_33760306 0.33 ENSMUST00000173860.1
RAB11B, member RAS oncogene family
chr7_+_80860909 0.33 ENSMUST00000132163.1
ENSMUST00000147125.1
zinc finger and SCAN domain containing 2
chr4_-_126968124 0.31 ENSMUST00000106108.2
zinc finger, MYM-type 4
chr7_-_100371889 0.31 ENSMUST00000032963.8
protein phosphatase methylesterase 1
chr18_-_37935403 0.30 ENSMUST00000080033.6
ENSMUST00000115631.1
diaphanous homolog 1 (Drosophila)
chr19_-_4615453 0.29 ENSMUST00000053597.2
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_125067913 0.29 ENSMUST00000088292.5
lysophosphatidic acid receptor 5
chr18_-_37935429 0.29 ENSMUST00000115634.1
diaphanous homolog 1 (Drosophila)
chr4_+_40948401 0.28 ENSMUST00000030128.5
charged multivesicular body protein 5
chr1_-_157412576 0.25 ENSMUST00000078308.6
ENSMUST00000139470.1
RAS protein activator like 2
chr18_+_59062462 0.25 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
RIKEN cDNA A730017C20 gene
chr17_-_46327990 0.24 ENSMUST00000167360.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr17_-_46327949 0.24 ENSMUST00000047970.7
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr13_+_59585259 0.22 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr10_+_83722865 0.22 ENSMUST00000150459.1
RIKEN cDNA 1500009L16 gene
chr5_+_77265454 0.21 ENSMUST00000080359.5
RE1-silencing transcription factor
chr7_-_110061319 0.21 ENSMUST00000098110.2
expressed sequence AA474408
chr17_-_28560704 0.20 ENSMUST00000114785.1
ENSMUST00000025062.3
colipase, pancreatic
chr18_-_41951187 0.20 ENSMUST00000070949.4
PRELI domain containing 2
chr10_+_29143996 0.20 ENSMUST00000092629.2
SOGA family member 3
chr4_+_123183722 0.18 ENSMUST00000152194.1
hippocalcin-like 4
chr11_+_71750980 0.18 ENSMUST00000108511.1
WSC domain containing 1
chr6_+_91684061 0.18 ENSMUST00000032185.7
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chrX_+_101274198 0.17 ENSMUST00000117203.1
ENSMUST00000087948.4
ENSMUST00000087956.5
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr7_+_4740178 0.17 ENSMUST00000108583.2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr9_-_66124872 0.17 ENSMUST00000034946.8
sorting nexin 1
chr11_+_71750680 0.17 ENSMUST00000021168.7
WSC domain containing 1
chr12_-_51971289 0.16 ENSMUST00000040583.5
HEAT repeat containing 5A
chr9_-_75409951 0.16 ENSMUST00000049355.10
mitogen-activated protein kinase 6
chr9_-_58204310 0.15 ENSMUST00000114144.2
immunoglobulin superfamily containing leucine-rich repeat 2
chr18_-_84086379 0.15 ENSMUST00000060303.8
teashirt zinc finger family member 1
chr7_+_4740111 0.14 ENSMUST00000098853.2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr1_-_74600564 0.14 ENSMUST00000127938.1
ENSMUST00000154874.1
ring finger protein 25
chr2_+_105127200 0.14 ENSMUST00000139585.1
Wilms tumor 1 homolog
chr19_-_47157764 0.14 ENSMUST00000178630.1
calcium homeostasis modulator 3
chr10_-_5922385 0.14 ENSMUST00000131996.1
ENSMUST00000064225.7
regulator of G-protein signaling 17
chr19_-_4615647 0.13 ENSMUST00000113822.2
leucine rich repeat and fibronectin type III domain containing 4
chrX_+_101274023 0.13 ENSMUST00000117706.1
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr5_+_138280516 0.13 ENSMUST00000048028.8
stromal antigen 3
chr3_-_81975742 0.12 ENSMUST00000029645.8
tryptophan 2,3-dioxygenase
chr11_-_98775333 0.12 ENSMUST00000064941.6
nuclear receptor subfamily 1, group D, member 1
chr7_+_4740137 0.12 ENSMUST00000130215.1
ENSMUST00000108582.3
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr18_+_32163073 0.11 ENSMUST00000096575.3
mitogen-activated protein kinase kinase kinase 2
chr2_+_121413775 0.11 ENSMUST00000028683.7
protein disulfide isomerase associated 3
chr2_-_63184253 0.11 ENSMUST00000075052.3
ENSMUST00000112454.1
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr2_+_32395896 0.10 ENSMUST00000028162.3
prostaglandin E synthase 2
chr10_+_69534039 0.10 ENSMUST00000182557.1
ankyrin 3, epithelial
chr1_+_36068371 0.10 ENSMUST00000088174.3
heparan sulfate 6-O-sulfotransferase 1
chr7_-_141539784 0.09 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
chitinase domain containing 1
chr9_+_106203108 0.09 ENSMUST00000024047.5
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr10_-_18023229 0.07 ENSMUST00000020002.7
ABRA C-terminal like
chr4_-_129696579 0.07 ENSMUST00000137640.1
transmembrane protein 39b
chr3_+_135438722 0.06 ENSMUST00000166033.1
ubiquitin-conjugating enzyme E2D 3
chr2_-_107059646 0.06 ENSMUST00000028533.6
follicle stimulating hormone beta
chr7_+_100372224 0.06 ENSMUST00000051777.8
ENSMUST00000098259.4
C2 calcium-dependent domain containing 3
chr5_+_138280538 0.05 ENSMUST00000162245.1
ENSMUST00000161691.1
stromal antigen 3
chr10_-_111010001 0.05 ENSMUST00000099285.3
ENSMUST00000041723.7
zinc finger, DHHC domain containing 17
chr16_+_94370618 0.05 ENSMUST00000117648.1
ENSMUST00000147352.1
ENSMUST00000150346.1
ENSMUST00000155692.1
ENSMUST00000153988.1
ENSMUST00000141856.1
ENSMUST00000152117.1
ENSMUST00000150097.1
ENSMUST00000122895.1
ENSMUST00000151770.1
tetratricopeptide repeat domain 3
chr6_-_83572429 0.05 ENSMUST00000068054.7
STAM binding protein
chr1_-_156939387 0.04 ENSMUST00000171292.1
Ral GEF with PH domain and SH3 binding motif 2
chr19_+_6400611 0.04 ENSMUST00000113467.1
RAS, guanyl releasing protein 2
chr2_+_116067213 0.03 ENSMUST00000152412.1
RIKEN cDNA G630016G05 gene
chr2_+_27165233 0.03 ENSMUST00000000910.6
dopamine beta hydroxylase
chr2_+_85136355 0.03 ENSMUST00000057019.7
apelin receptor
chr8_+_104170513 0.03 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
brain expressed, associated with Nedd4, 1
chr7_+_128523576 0.02 ENSMUST00000033136.7
BCL2-associated athanogene 3
chr10_-_5922341 0.01 ENSMUST00000117676.1
ENSMUST00000019909.7
regulator of G-protein signaling 17
chr4_+_99955715 0.01 ENSMUST00000102783.4
phosphoglucomutase 2
chr15_+_43477213 0.00 ENSMUST00000022962.6
ER membrane protein complex subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0035483 gastric emptying(GO:0035483)
0.2 0.6 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.2 0.9 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.8 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.6 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.3 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.0 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 0.3 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.1 0.3 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.3 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.1 GO:0072278 metanephric comma-shaped body morphogenesis(GO:0072278) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.0 0.2 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.1 GO:1903334 positive regulation of protein folding(GO:1903334)
0.0 0.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.1 GO:0070859 negative regulation of receptor biosynthetic process(GO:0010871) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.4 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0061511 centriole elongation(GO:0061511)
0.0 0.1 GO:0032532 regulation of microvillus length(GO:0032532)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071953 elastic fiber(GO:0071953)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0000802 transverse filament(GO:0000802)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0060205 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:2001069 glycogen binding(GO:2001069)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.2 GO:0030977 taurine binding(GO:0030977)
0.1 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.6 GO:0016918 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.8 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors