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2D miR_HR1_12

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Results for Rfx5

Z-value: 0.58

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
ENSMUSG00000005774.6 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm10_v2_chr3_+_94954075_949542260.547.0e-02Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_37376359 1.22 ENSMUST00000012587.3
kinesin family member 11
chr17_+_35861343 1.03 ENSMUST00000172931.1
nurim (nuclear envelope membrane protein)
chr17_+_34145231 0.79 ENSMUST00000171231.1
histocompatibility 2, class II, locus Mb2
chr17_+_34145311 0.78 ENSMUST00000041982.7
histocompatibility 2, class II, locus Mb2
chr17_+_34325658 0.73 ENSMUST00000050325.8
histocompatibility 2, class II antigen E beta2
chr11_+_106276715 0.67 ENSMUST00000044462.3
testicular cell adhesion molecule 1
chr17_+_35861318 0.64 ENSMUST00000074259.8
ENSMUST00000174873.1
nurim (nuclear envelope membrane protein)
chr17_+_34238896 0.62 ENSMUST00000095342.3
histocompatibility 2, O region beta locus
chr17_+_34238914 0.53 ENSMUST00000167280.1
histocompatibility 2, O region beta locus
chr17_+_34153072 0.47 ENSMUST00000114232.2
histocompatibility 2, class II, locus Mb1
chr9_+_44773191 0.47 ENSMUST00000147559.1
intraflagellar transport 46
chr7_-_30664986 0.42 ENSMUST00000019697.8
HAUS augmin-like complex, subunit 5
chr6_-_29165003 0.42 ENSMUST00000007993.9
RNA binding motif protein 28
chr7_-_101921186 0.35 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
leucine rich repeat containing 51
chr8_-_85067982 0.35 ENSMUST00000177563.1
predicted gene 5741
chr5_+_139150211 0.35 ENSMUST00000026975.6
HEAT repeat containing 2
chr6_-_8259098 0.34 ENSMUST00000012627.4
replication protein A3
chr4_-_116627921 0.33 ENSMUST00000030456.7
nuclear autoantigenic sperm protein (histone-binding)
chr14_+_55618023 0.32 ENSMUST00000002395.7
REC8 homolog (yeast)
chr10_-_123196916 0.25 ENSMUST00000020334.7
ubiquitin specific peptidase 15
chr2_-_152398046 0.23 ENSMUST00000063332.8
ENSMUST00000182625.1
SRY-box containing gene 12
chr17_+_35439155 0.23 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
histocompatibility 2, Q region locus 7
chr2_+_163438455 0.22 ENSMUST00000109420.3
ENSMUST00000109421.3
ENSMUST00000018087.6
ENSMUST00000137070.1
ganglioside-induced differentiation-associated protein 1-like 1
chr7_+_28180272 0.22 ENSMUST00000173223.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28179469 0.21 ENSMUST00000085901.6
ENSMUST00000172761.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr13_+_24831661 0.20 ENSMUST00000038039.2
tyrosyl-DNA phosphodiesterase 2
chr7_+_28180226 0.19 ENSMUST00000172467.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr5_-_125294107 0.19 ENSMUST00000127148.1
scavenger receptor class B, member 1
chr9_-_21291124 0.17 ENSMUST00000086374.6
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr8_+_84969587 0.16 ENSMUST00000109734.1
ENSMUST00000005292.8
peroxiredoxin 2
chr7_+_127091426 0.16 ENSMUST00000056288.5
expressed sequence AI467606
chr1_+_134405984 0.16 ENSMUST00000173908.1
cytochrome b5 reductase 1
chr7_-_101921175 0.15 ENSMUST00000098236.2
leucine rich repeat containing 51
chr10_-_19011948 0.14 ENSMUST00000105527.1
tumor necrosis factor, alpha-induced protein 3
chr11_+_72441341 0.14 ENSMUST00000045633.5
MYB binding protein (P160) 1a
chr13_-_23488840 0.14 ENSMUST00000041541.4
ENSMUST00000110432.1
ENSMUST00000110433.3
butyrophilin, subfamily 2, member A2
chr7_+_101378183 0.13 ENSMUST00000084895.5
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_-_160138375 0.13 ENSMUST00000033662.8
pyruvate dehydrogenase E1 alpha 1
chr11_+_98682554 0.13 ENSMUST00000017365.8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr17_-_34305715 0.12 ENSMUST00000174074.1
predicted gene 20513
chr10_-_7663245 0.12 ENSMUST00000163085.1
ENSMUST00000159917.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr11_+_61505138 0.11 ENSMUST00000102657.3
B9 protein domain 1
chr4_+_66827545 0.11 ENSMUST00000048096.5
ENSMUST00000107365.2
toll-like receptor 4
chr7_-_45694369 0.10 ENSMUST00000040636.6
secretory blood group 1
chr9_+_44773027 0.09 ENSMUST00000125877.1
intraflagellar transport 46
chr1_+_136676413 0.08 ENSMUST00000181491.1
predicted gene, 19705
chr17_+_34135182 0.08 ENSMUST00000042121.9
histocompatibility 2, class II, locus DMa
chr8_+_40793272 0.08 ENSMUST00000056331.7
a disintegrin and metallopeptidase domain 20
chr4_-_35845204 0.08 ENSMUST00000164772.1
ENSMUST00000065173.2
leucine rich repeat and Ig domain containing 2
chr17_-_24886304 0.08 ENSMUST00000044252.5
nucleotide binding protein 2
chr19_-_8819314 0.07 ENSMUST00000096751.4
tetratricopeptide repeat domain 9C
chr18_+_60803838 0.07 ENSMUST00000050487.8
ENSMUST00000097563.2
ENSMUST00000167610.1
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr17_+_34263209 0.07 ENSMUST00000040828.5
histocompatibility 2, class II antigen A, beta 1
chr10_-_127263346 0.07 ENSMUST00000099172.3
kinesin family member 5A
chr19_-_8819278 0.07 ENSMUST00000088092.5
tetratricopeptide repeat domain 9C
chr1_-_183147461 0.06 ENSMUST00000171366.1
dispatched homolog 1 (Drosophila)
chr7_+_46841475 0.06 ENSMUST00000147535.1
lactate dehydrogenase A
chr8_+_94214567 0.06 ENSMUST00000079961.6
nucleoporin 93
chr8_+_27042555 0.06 ENSMUST00000033875.8
ENSMUST00000098851.4
proline synthetase co-transcribed
chr19_+_34217588 0.06 ENSMUST00000119603.1
STAM binding protein like 1
chr2_-_128687354 0.06 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
anaphase promoting complex subunit 1
chr7_+_41032719 0.06 ENSMUST00000164422.1
predicted gene 4884
chr17_+_34305883 0.05 ENSMUST00000074557.8
histocompatibility 2, class II antigen E beta
chr7_+_100537192 0.05 ENSMUST00000120454.1
cytochrome c oxidase assembly factor 4
chr8_+_81856324 0.04 ENSMUST00000109851.2
inositol polyphosphate-4-phosphatase, type II
chrX_+_45090882 0.03 ENSMUST00000040002.3
RIKEN cDNA 1110059M19 gene
chr6_-_83831736 0.03 ENSMUST00000058383.8
poly(A) binding protein interacting protein 2B
chr19_+_32757497 0.02 ENSMUST00000013807.7
phosphatase and tensin homolog
chr3_+_16183177 0.01 ENSMUST00000108345.2
ENSMUST00000108346.2
YTH domain family 3
chrX_+_42526585 0.01 ENSMUST00000101619.3
predicted gene 10483
chr7_-_105752193 0.01 ENSMUST00000033184.4
tripeptidyl peptidase I
chr3_-_95882031 0.01 ENSMUST00000161994.1
predicted gene 129
chr11_-_3539228 0.00 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
smoothelin
chr9_-_51102062 0.00 ENSMUST00000170947.1
RIKEN cDNA 4833427G06 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.2 2.3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 1.2 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 0.2 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.0 0.2 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.0 0.2 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.3 GO:0007141 male meiosis I(GO:0007141)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
0.0 0.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.6 GO:0007520 myoblast fusion(GO:0007520)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.3 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.3 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex