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2D miR_HR1_12

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Results for Six4

Z-value: 0.54

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Transcription factors associated with Six4

Gene Symbol Gene ID Gene Info
ENSMUSG00000034460.8 sine oculis-related homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six4mm10_v2_chr12_-_73113407_731134560.594.3e-02Click!

Activity profile of Six4 motif

Sorted Z-values of Six4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_134929118 1.15 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5
chr13_+_51645232 1.10 ENSMUST00000075853.5
CDC28 protein kinase regulatory subunit 2
chr6_+_134929089 1.07 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
RP23-45G16.5
chr3_+_94398517 0.84 ENSMUST00000050975.3
leucine rich repeat and Ig domain containing 4
chr7_+_29307924 0.72 ENSMUST00000108230.1
ENSMUST00000065181.5
D4, zinc and double PHD fingers family 1
chr11_+_85312164 0.58 ENSMUST00000127717.1
protein phosphatase 1D magnesium-dependent, delta isoform
chr6_+_50110186 0.52 ENSMUST00000166318.1
ENSMUST00000036236.8
ENSMUST00000036225.8
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr19_+_8764934 0.51 ENSMUST00000184663.1
nuclear RNA export factor 1
chr14_-_89898466 0.51 ENSMUST00000081204.4
predicted gene 10110
chr17_-_12851893 0.50 ENSMUST00000162389.1
ENSMUST00000162119.1
ENSMUST00000159223.1
MAS1 oncogene
chr3_-_129831374 0.45 ENSMUST00000029643.8
GAR1 ribonucleoprotein homolog (yeast)
chr1_+_37890477 0.45 ENSMUST00000027256.5
mitochondrial ribosomal protein L30
chr13_+_54071815 0.38 ENSMUST00000021930.8
sideroflexin 1
chr7_+_29309429 0.37 ENSMUST00000137848.1
D4, zinc and double PHD fingers family 1
chrX_-_150440887 0.37 ENSMUST00000163233.1
transmembrane protein 29
chr13_+_73626886 0.32 ENSMUST00000022104.7
telomerase reverse transcriptase
chr2_-_103797617 0.30 ENSMUST00000028607.6
cell cycle associated protein 1
chr1_-_180813534 0.29 ENSMUST00000159789.1
ENSMUST00000081026.4
H3 histone, family 3A
chr11_-_45955183 0.27 ENSMUST00000109254.1
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr8_-_85067982 0.27 ENSMUST00000177563.1
predicted gene 5741
chr6_+_115134899 0.23 ENSMUST00000009538.5
ENSMUST00000169345.1
synapsin II
chr10_-_80918212 0.23 ENSMUST00000057623.7
ENSMUST00000179022.1
lamin B2
chr11_-_45955465 0.22 ENSMUST00000011398.6
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr7_+_28180226 0.21 ENSMUST00000172467.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr7_+_28180272 0.20 ENSMUST00000173223.1
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr10_+_75564086 0.20 ENSMUST00000141062.1
ENSMUST00000152657.1
gamma-glutamyltransferase 1
chr5_-_145191511 0.20 ENSMUST00000161845.1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr19_-_38224096 0.19 ENSMUST00000067167.5
FRA10AC1 homolog (human)
chr9_-_57158288 0.18 ENSMUST00000065358.7
COMM domain containing 4
chr10_+_79755103 0.17 ENSMUST00000020577.2
fibroblast growth factor 22
chr1_-_37890333 0.17 ENSMUST00000139725.1
ENSMUST00000027257.8
MIT, microtubule interacting and transport, domain containing 1
chr15_-_66831625 0.16 ENSMUST00000164163.1
src-like adaptor
chr11_-_118342500 0.15 ENSMUST00000103024.3
cDNA sequence BC100451
chr8_+_94214567 0.15 ENSMUST00000079961.6
nucleoporin 93
chr1_-_180813591 0.15 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3 histone, family 3A
chr10_-_76442758 0.14 ENSMUST00000001179.5
pericentrin (kendrin)
chr15_+_92051153 0.14 ENSMUST00000169825.1
contactin 1
chr18_+_60212080 0.14 ENSMUST00000031549.5
predicted gene 4951
chr3_+_145938004 0.14 ENSMUST00000039571.7
RIKEN cDNA 2410004B18 gene
chr6_+_124931378 0.14 ENSMUST00000032214.7
ENSMUST00000180095.1
myeloid leukemia factor 2
chr8_+_94377911 0.13 ENSMUST00000159142.1
predicted gene 15889
chr7_+_18991245 0.13 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
Myb-related transcription factor, partner of profilin
chr4_-_134018829 0.12 ENSMUST00000051674.2
lin-28 homolog A (C. elegans)
chr2_+_31314303 0.11 ENSMUST00000113532.2
hemicentin 2
chr2_+_10047838 0.11 ENSMUST00000181588.1
RIKEN cDNA C630004M23 gene
chr19_+_29410919 0.11 ENSMUST00000112576.2
programmed cell death 1 ligand 2
chr3_+_139205658 0.10 ENSMUST00000106239.1
sperm tail PG rich repeat containing 2
chr2_-_10048580 0.09 ENSMUST00000026888.4
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_-_10974664 0.09 ENSMUST00000072748.6
membrane-spanning 4-domains, subfamily A, member 10
chr9_-_70503718 0.09 ENSMUST00000034739.5
ring finger 111
chr3_+_139205887 0.07 ENSMUST00000062306.6
sperm tail PG rich repeat containing 2
chr15_-_103255433 0.07 ENSMUST00000075192.6
nuclear factor, erythroid derived 2
chr2_-_104493690 0.06 ENSMUST00000111124.1
homeodomain interacting protein kinase 3
chr5_-_41764493 0.06 ENSMUST00000060820.6
NK3 homeobox 2
chr1_-_131200089 0.06 ENSMUST00000068564.8
Ras association (RalGDS/AF-6) domain family member 5
chr3_-_30969399 0.06 ENSMUST00000177992.1
ENSMUST00000129817.2
ENSMUST00000168645.1
ENSMUST00000108255.1
ENSMUST00000064718.5
ENSMUST00000099163.3
polyhomeotic-like 3 (Drosophila)
chr11_+_67078293 0.06 ENSMUST00000108689.1
ENSMUST00000165221.1
ENSMUST00000007301.7
myosin, heavy polypeptide 3, skeletal muscle, embryonic
chr7_+_43825404 0.05 ENSMUST00000107967.1
kallikrein related-peptidase 6
chr2_-_122702615 0.05 ENSMUST00000005952.4
ENSMUST00000099457.3
solute carrier family 30 (zinc transporter), member 4
chr1_+_171839694 0.04 ENSMUST00000155802.1
CD84 antigen
chr17_+_35049966 0.01 ENSMUST00000007257.9
chloride intracellular channel 1
chr11_-_71142366 0.01 ENSMUST00000048514.4
NLR family, pyrin domain containing 1A
chr1_+_54250673 0.01 ENSMUST00000027128.4
coiled-coil domain containing 150
chr9_-_76213657 0.01 ENSMUST00000074880.5
GDNF family receptor alpha like
chr12_+_75818294 0.00 ENSMUST00000143031.1
ENSMUST00000044217.9
ENSMUST00000150317.1
spectrin repeat containing, nuclear envelope 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031509 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.3 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.1 0.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.5 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 1.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.4 GO:0001740 Barr body(GO:0001740)
0.0 1.1 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.5 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.6 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.5 GO:0001595 angiotensin receptor activity(GO:0001595)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0002151 G-quadruplex RNA binding(GO:0002151)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres