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2D miR_HR1_12

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Results for E2f2_E2f5

Z-value: 6.10

Motif logo

Transcription factors associated with E2f2_E2f5

Gene Symbol Gene ID Gene Info
ENSMUSG00000018983.9 E2F transcription factor 2
ENSMUSG00000027552.8 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.931.5e-05Click!
E2f5mm10_v2_chr3_+_14578609_145786870.847.1e-04Click!

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_55329723 38.42 ENSMUST00000021941.7
Max dimerization protein 3
chr10_-_69352886 37.46 ENSMUST00000119827.1
ENSMUST00000020099.5
cyclin-dependent kinase 1
chr8_+_75109528 28.49 ENSMUST00000164309.1
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr4_+_126556935 28.02 ENSMUST00000048391.8
claspin
chr17_+_56304313 25.38 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
ubiquitin-like, containing PHD and RING finger domains, 1
chr10_+_110745433 22.75 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2F transcription factor 7
chr9_+_122951051 22.59 ENSMUST00000040717.5
kinesin family member 15
chr5_-_138171813 22.28 ENSMUST00000155902.1
ENSMUST00000148879.1
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_-_128359610 21.79 ENSMUST00000027601.4
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr2_-_113848655 21.12 ENSMUST00000102545.1
ENSMUST00000110948.1
Rho GTPase activating protein 11A
chr2_-_113848601 20.42 ENSMUST00000110949.2
Rho GTPase activating protein 11A
chr15_-_58135047 20.41 ENSMUST00000038194.3
ATPase family, AAA domain containing 2
chr2_+_72476159 19.67 ENSMUST00000102691.4
cell division cycle associated 7
chr12_+_24708241 18.91 ENSMUST00000020980.5
ribonucleotide reductase M2
chr2_+_72476225 18.57 ENSMUST00000157019.1
cell division cycle associated 7
chr4_+_136172367 18.37 ENSMUST00000061721.5
E2F transcription factor 2
chr12_-_11265768 18.22 ENSMUST00000166117.1
Gen homolog 1, endonuclease (Drosophila)
chr1_-_20820213 18.19 ENSMUST00000053266.9
minichromosome maintenance deficient 3 (S. cerevisiae)
chr4_+_134468320 18.19 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
stathmin 1
chr15_-_55090422 17.96 ENSMUST00000110231.1
ENSMUST00000023059.6
defective in sister chromatid cohesion 1 homolog (S. cerevisiae)
chr4_+_126556994 17.49 ENSMUST00000147675.1
claspin
chr2_+_150909565 16.04 ENSMUST00000028948.4
GINS complex subunit 1 (Psf1 homolog)
chr1_-_86359455 15.63 ENSMUST00000027438.6
nucleolin
chrX_-_93632113 15.58 ENSMUST00000006856.2
polymerase (DNA directed), alpha 1
chr13_-_24761440 14.37 ENSMUST00000176890.1
ENSMUST00000175689.1
geminin
chr4_+_115000156 14.12 ENSMUST00000030490.6
Scl/Tal1 interrupting locus
chr1_-_191575534 13.94 ENSMUST00000027933.5
denticleless homolog (Drosophila)
chr13_-_24761861 13.76 ENSMUST00000006898.3
ENSMUST00000110382.2
geminin
chr11_+_80089385 13.69 ENSMUST00000108239.1
ENSMUST00000017694.5
ATPase family, AAA domain containing 5
chr6_-_88898664 13.52 ENSMUST00000058011.6
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr10_-_5805412 12.88 ENSMUST00000019907.7
F-box protein 5
chr2_+_119112793 12.87 ENSMUST00000140939.1
ENSMUST00000028795.3
RAD51 homolog
chr7_-_48881596 12.53 ENSMUST00000119223.1
E2F transcription factor 8
chr7_-_48881032 12.10 ENSMUST00000058745.8
E2F transcription factor 8
chr12_-_69228167 12.06 ENSMUST00000021359.5
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr5_-_138172383 11.99 ENSMUST00000000505.9
minichromosome maintenance deficient 7 (S. cerevisiae)
chr3_+_98013503 11.75 ENSMUST00000079812.6
notch 2
chr12_+_116405397 11.16 ENSMUST00000084828.3
non-SMC condensin II complex, subunit G2
chr17_+_56303396 10.97 ENSMUST00000113038.1
ubiquitin-like, containing PHD and RING finger domains, 1
chr9_-_20952838 10.86 ENSMUST00000004202.9
DNA methyltransferase (cytosine-5) 1
chr8_+_105348163 10.36 ENSMUST00000073149.5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr5_+_110286306 10.27 ENSMUST00000007296.5
ENSMUST00000112482.1
polymerase (DNA directed), epsilon
chr7_-_44548733 10.11 ENSMUST00000145956.1
ENSMUST00000049343.8
polymerase (DNA directed), delta 1, catalytic subunit
chr2_+_132816141 9.88 ENSMUST00000028831.8
ENSMUST00000066559.5
minichromosome maintenance deficient 8 (S. cerevisiae)
chr9_+_65890237 9.71 ENSMUST00000045802.6
RIKEN cDNA 2810417H13 gene
chr4_+_115000174 9.68 ENSMUST00000129957.1
Scl/Tal1 interrupting locus
chr3_+_104638658 9.56 ENSMUST00000046212.1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr15_+_102296256 9.31 ENSMUST00000064924.4
extra spindle poles-like 1 (S. cerevisiae)
chr13_+_92354783 9.25 ENSMUST00000022218.4
dihydrofolate reductase
chr12_+_24708984 8.64 ENSMUST00000154588.1
ribonucleotide reductase M2
chr15_-_9140374 8.46 ENSMUST00000096482.3
ENSMUST00000110585.2
S-phase kinase-associated protein 2 (p45)
chr14_-_31019055 8.05 ENSMUST00000037739.6
guanine nucleotide binding protein-like 3 (nucleolar)
chr5_+_110839973 7.95 ENSMUST00000066160.1
checkpoint kinase 2
chr8_-_53638945 7.88 ENSMUST00000047768.4
nei like 3 (E. coli)
chr9_+_64281575 7.69 ENSMUST00000034964.6
timeless interacting protein
chr18_+_10617768 7.50 ENSMUST00000002551.3
small nuclear ribonucleoprotein D1
chr16_-_18811615 6.90 ENSMUST00000096990.3
cell division cycle 45
chr6_+_113531675 6.89 ENSMUST00000036340.5
ENSMUST00000101051.2
Fanconi anemia, complementation group D2
chr17_+_56303321 6.65 ENSMUST00000001258.8
ubiquitin-like, containing PHD and RING finger domains, 1
chr3_+_88532314 6.57 ENSMUST00000172699.1
mex3 homolog A (C. elegans)
chr6_+_51470633 6.55 ENSMUST00000114445.1
ENSMUST00000114446.1
ENSMUST00000141711.1
chromobox 3
chr6_-_47594967 6.53 ENSMUST00000081721.6
ENSMUST00000114618.1
ENSMUST00000114616.1
enhancer of zeste homolog 2 (Drosophila)
chr19_+_8723478 6.48 ENSMUST00000180819.1
ENSMUST00000181422.1
small nucleolar RNA host gene (non-protein coding) 1
chr16_-_15637277 6.33 ENSMUST00000023353.3
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr9_+_103305156 6.11 ENSMUST00000035164.3
topoisomerase (DNA) II binding protein 1
chrX_-_8074720 6.10 ENSMUST00000115636.3
ENSMUST00000115638.3
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr5_-_110286159 5.94 ENSMUST00000031472.5
peroxisomal membrane protein 2
chr1_+_175880775 5.79 ENSMUST00000039725.6
exonuclease 1
chr10_+_128232065 5.68 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
timeless circadian clock 1
chr6_+_51470510 5.59 ENSMUST00000031862.7
chromobox 3
chr4_+_132768325 5.46 ENSMUST00000102561.4
replication protein A2
chr6_-_148946146 5.45 ENSMUST00000132696.1
family with sequence similarity 60, member A
chr9_-_97018823 5.41 ENSMUST00000055433.4
splA/ryanodine receptor domain and SOCS box containing 4
chr5_+_88764983 5.34 ENSMUST00000031311.9
deoxycytidine kinase
chr2_-_5012716 5.32 ENSMUST00000027980.7
minichromosome maintenance deficient 10 (S. cerevisiae)
chr2_+_24949747 5.01 ENSMUST00000028350.3
zinc finger, MYND domain containing 19
chr7_-_19359477 4.97 ENSMUST00000047036.8
CD3E antigen, epsilon polypeptide associated protein
chr7_+_102441685 4.90 ENSMUST00000033283.9
ribonucleotide reductase M1
chrX_+_42151002 4.84 ENSMUST00000123245.1
stromal antigen 2
chr17_+_23726336 4.69 ENSMUST00000024701.7
protein kinase, membrane associated tyrosine/threonine 1
chr7_+_13278778 4.67 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
ligase I, DNA, ATP-dependent
chr12_+_11265867 4.56 ENSMUST00000020931.5
structural maintenance of chromosomes 6
chr13_-_64153194 4.54 ENSMUST00000059817.4
ENSMUST00000117241.1
zinc finger protein 367
chr6_-_8259098 4.48 ENSMUST00000012627.4
replication protein A3
chr7_-_38107490 4.40 ENSMUST00000108023.3
cyclin E1
chr2_-_154569845 4.33 ENSMUST00000103145.4
E2F transcription factor 1
chr4_+_11191354 4.29 ENSMUST00000170901.1
cyclin E2
chr3_+_116594959 4.28 ENSMUST00000029571.8
spindle assembly 6 homolog (C. elegans)
chr7_-_4789541 4.07 ENSMUST00000168578.1
transmembrane protein 238
chr1_+_86526688 4.05 ENSMUST00000045897.8
prothymosin alpha
chr11_+_98907801 3.98 ENSMUST00000092706.6
cell division cycle 6
chr19_-_53371766 3.87 ENSMUST00000086887.1
predicted gene 10197
chr4_-_133967953 3.85 ENSMUST00000102553.4
high mobility group nucleosomal binding domain 2
chr19_-_10203880 3.81 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
flap structure specific endonuclease 1
chr18_+_56707725 3.78 ENSMUST00000025486.8
lamin B1
chr9_+_106477269 3.76 ENSMUST00000047721.8
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr9_+_44334685 3.76 ENSMUST00000052686.2
H2A histone family, member X
chr19_+_53600377 3.58 ENSMUST00000025930.9
structural maintenance of chromosomes 3
chr4_-_43010226 3.53 ENSMUST00000030165.4
Fanconi anemia, complementation group G
chr15_+_55557399 3.51 ENSMUST00000022998.7
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr2_-_132253227 3.43 ENSMUST00000028817.6
proliferating cell nuclear antigen
chr9_+_109875541 3.39 ENSMUST00000094324.3
cell division cycle 25A
chr6_+_51470339 3.35 ENSMUST00000094623.3
chromobox 3
chr3_-_30509462 3.34 ENSMUST00000173899.1
MDS1 and EVI1 complex locus
chr10_-_80577285 3.33 ENSMUST00000038558.8
Kruppel-like factor 16
chr8_-_105707933 3.20 ENSMUST00000013299.9
enkurin domain containing 1
chr19_-_5964132 3.20 ENSMUST00000025752.7
ENSMUST00000165143.1
polymerase (DNA directed), alpha 2
chr12_+_112644828 3.18 ENSMUST00000021728.4
ENSMUST00000109755.3
SIVA1, apoptosis-inducing factor
chr10_+_7667503 3.17 ENSMUST00000040135.8
nucleoporin 43
chr16_-_11203259 3.13 ENSMUST00000119953.1
ribosomal L1 domain containing 1
chr15_+_55557575 3.13 ENSMUST00000170046.1
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr1_-_9700209 3.09 ENSMUST00000088658.4
myeloblastosis oncogene-like 1
chr9_-_36726374 3.09 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
checkpoint kinase 1
chr4_-_132843111 3.07 ENSMUST00000105919.1
ENSMUST00000030702.7
protein phosphatase 1, regulatory (inhibitor) subunit 8
chr8_+_95633500 2.96 ENSMUST00000034094.9
GINS complex subunit 3 (Psf3 homolog)
chr14_-_20388822 2.95 ENSMUST00000022345.6
DnaJ (Hsp40) homolog, subfamily C, member 9
chr7_-_127260677 2.92 ENSMUST00000035276.4
dCTP pyrophosphatase 1
chr1_-_156474249 2.90 ENSMUST00000051396.6
sterol O-acyltransferase 1
chr13_-_35906324 2.90 ENSMUST00000174230.1
ENSMUST00000171686.2
ribonuclease P 40 subunit
chr17_-_71475285 2.87 ENSMUST00000127430.1
SMC hinge domain containing 1
chr2_-_157204483 2.87 ENSMUST00000029170.7
retinoblastoma-like 1 (p107)
chr15_+_8109313 2.76 ENSMUST00000163765.1
nucleoporin 155
chr1_+_157412352 2.73 ENSMUST00000061537.5
RIKEN cDNA 2810025M15 gene
chr11_-_35980473 2.68 ENSMUST00000018993.6
WW, C2 and coiled-coil domain containing 1
chr15_+_9140527 2.66 ENSMUST00000090380.4
LMBR1 domain containing 2
chr17_+_87975044 2.62 ENSMUST00000005503.3
mutS homolog 6 (E. coli)
chr5_+_114130386 2.59 ENSMUST00000031587.6
uracil DNA glycosylase
chr7_+_79392305 2.58 ENSMUST00000117227.1
ENSMUST00000118959.1
ENSMUST00000036865.6
Fanconi anemia, complementation group I
chr7_+_29309429 2.58 ENSMUST00000137848.1
D4, zinc and double PHD fingers family 1
chr15_-_98093245 2.57 ENSMUST00000180657.1
SUMO1/sentrin specific peptidase 1
chr2_-_34799618 2.56 ENSMUST00000113086.2
ENSMUST00000118108.1
Rab9 effector protein with kelch motifs
chr8_+_70594466 2.56 ENSMUST00000019283.9
myo-inositol 1-phosphate synthase A1
chrX_+_94234594 2.53 ENSMUST00000153900.1
kelch-like 15
chr10_-_7956223 2.52 ENSMUST00000146444.1
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr10_+_13090788 2.52 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
pleiomorphic adenoma gene-like 1
chr13_-_106936907 2.52 ENSMUST00000080856.7
importin 11
chr11_-_100712429 2.48 ENSMUST00000006973.5
ENSMUST00000103118.3
K(lysine) acetyltransferase 2A
chrX_-_157492280 2.45 ENSMUST00000112529.1
spermine synthase
chr1_+_131910458 2.41 ENSMUST00000062264.6
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_+_32615473 2.40 ENSMUST00000178925.1
ENSMUST00000029950.3
caspase 8 associated protein 2
chr16_-_5255923 2.39 ENSMUST00000139584.1
ENSMUST00000064635.5
family with sequence similarity 86
chr6_+_14901344 2.37 ENSMUST00000115477.1
forkhead box P2
chr17_-_23740301 2.36 ENSMUST00000024702.3
progestin and adipoQ receptor family member IV
chr7_+_110122299 2.35 ENSMUST00000033326.8
WEE 1 homolog 1 (S. pombe)
chr9_-_21291124 2.32 ENSMUST00000086374.6
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr10_+_80356459 2.31 ENSMUST00000039836.8
ENSMUST00000105351.1
polo-like kinase 5
chr7_-_122101735 2.30 ENSMUST00000139456.1
ENSMUST00000106471.2
ENSMUST00000123296.1
ENSMUST00000033157.3
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1
chr2_+_85037212 2.28 ENSMUST00000077798.6
structure specific recognition protein 1
chr2_-_152398046 2.26 ENSMUST00000063332.8
ENSMUST00000182625.1
SRY-box containing gene 12
chr16_-_18876655 2.22 ENSMUST00000023391.8
mitochondrial ribosomal protein L40
chr7_+_110018301 2.15 ENSMUST00000084731.3
importin 7
chr12_+_111166485 2.13 ENSMUST00000139162.1
TNF receptor-associated factor 3
chr3_+_10088173 2.10 ENSMUST00000061419.7
predicted gene 9833
chr15_-_55557748 2.09 ENSMUST00000172387.1
mitochondrial ribosomal protein L13
chr1_-_38129618 2.08 ENSMUST00000027251.6
REV1 homolog (S. cerevisiae)
chr9_-_13827029 2.08 ENSMUST00000148086.1
ENSMUST00000034398.5
centrosomal protein 57
chr11_+_88047302 2.04 ENSMUST00000139129.2
serine/arginine-rich splicing factor 1
chr7_+_66109474 2.01 ENSMUST00000036372.6
chondroitin sulfate synthase 1
chr19_+_46075842 2.00 ENSMUST00000165017.1
nucleolar and coiled-body phosphoprotein 1
chr11_-_72207413 2.00 ENSMUST00000108505.1
RIKEN cDNA 4933427D14 gene
chr4_+_109280365 1.97 ENSMUST00000177089.1
ENSMUST00000175776.1
ENSMUST00000132165.2
epidermal growth factor receptor pathway substrate 15
chr3_+_127553462 1.96 ENSMUST00000043108.4
RIKEN cDNA 4930422G04 gene
chr2_+_55437100 1.95 ENSMUST00000112633.2
ENSMUST00000112632.1
potassium inwardly-rectifying channel, subfamily J, member 3
chr13_-_96132568 1.89 ENSMUST00000161263.1
synaptic vesicle glycoprotein 2c
chr5_-_149051604 1.89 ENSMUST00000093196.4
high mobility group box 1
chrX_+_99821021 1.82 ENSMUST00000096363.2
transmembrane protein 28
chr10_-_60219260 1.80 ENSMUST00000135158.2
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr13_-_47106176 1.76 ENSMUST00000021807.6
ENSMUST00000135278.1
DEK oncogene (DNA binding)
chr16_-_45742888 1.76 ENSMUST00000128348.1
ENSMUST00000066983.6
abhydrolase domain containing 10
chr2_+_25054355 1.75 ENSMUST00000100334.4
ENSMUST00000152122.1
ENSMUST00000116574.3
ENSMUST00000006646.8
NMDA receptor synaptonuclear signaling and neuronal migration factor
chr12_-_80643799 1.75 ENSMUST00000166931.1
enhancer of rudimentary homolog (Drosophila)
chr2_-_154569720 1.74 ENSMUST00000000894.5
E2F transcription factor 1
chrX_+_68678541 1.73 ENSMUST00000088546.5
fragile X mental retardation syndrome 1
chr16_-_18248697 1.73 ENSMUST00000115645.3
RAN binding protein 1
chr17_+_88440711 1.69 ENSMUST00000112238.2
ENSMUST00000155640.1
forkhead box N2
chr5_-_136135989 1.68 ENSMUST00000150406.1
ENSMUST00000006301.4
leucine-rich repeats and WD repeat domain containing 1
chr5_+_143909964 1.68 ENSMUST00000148011.1
ENSMUST00000110709.3
postmeiotic segregation increased 2 (S. cerevisiae)
chr11_+_101119938 1.68 ENSMUST00000043680.8
tubulin, gamma 1
chr4_-_133967893 1.67 ENSMUST00000100472.3
ENSMUST00000136327.1
high mobility group nucleosomal binding domain 2
chr7_+_46397648 1.66 ENSMUST00000160433.1
potassium voltage gated channel, Shaw-related subfamily, member 1
chr17_+_87672523 1.64 ENSMUST00000172855.1
mutS homolog 2 (E. coli)
chr7_-_100121512 1.64 ENSMUST00000032969.7
polymerase (DNA-directed), delta 3, accessory subunit
chr2_-_34913976 1.64 ENSMUST00000028232.3
PHD finger protein 19
chr10_+_107271827 1.62 ENSMUST00000020057.8
ENSMUST00000105280.3
lin-7 homolog A (C. elegans)
chr18_+_31789120 1.62 ENSMUST00000025106.3
polymerase (RNA) II (DNA directed) polypeptide D
chr17_-_94749874 1.60 ENSMUST00000171284.1
methyltransferase like 4
chr11_-_73177002 1.59 ENSMUST00000108480.1
ENSMUST00000054952.3
ER membrane protein complex subunit 6
chr19_-_5457397 1.59 ENSMUST00000179549.1
coiled-coil domain containing 85B
chr8_-_78508876 1.50 ENSMUST00000049245.7
RNA binding motif protein, X linked-like-1
chr7_-_126396715 1.50 ENSMUST00000075671.4
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr11_+_79993062 1.50 ENSMUST00000017692.8
ENSMUST00000163272.1
suppressor of zeste 12 homolog (Drosophila)
chr19_-_7217549 1.48 ENSMUST00000039758.4
cytochrome c oxidase subunit VIIIa
chr12_+_57230406 1.48 ENSMUST00000139049.1
ENSMUST00000145003.1
ENSMUST00000123498.1
phosphoribosyl pyrophosphate synthetase 1-like 3
mirror-image polydactyly gene 1 homolog (human)
chr2_+_18677002 1.47 ENSMUST00000028071.6
Bmi1 polycomb ring finger oncogene
chr15_-_81871883 1.47 ENSMUST00000023117.8
PHD finger protein 5A
chr1_+_181150926 1.46 ENSMUST00000134115.1
ENSMUST00000111059.1
cornichon homolog 4 (Drosophila)
chr9_-_115310421 1.46 ENSMUST00000035010.8
STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
chr7_-_133122615 1.44 ENSMUST00000167218.1
C-terminal binding protein 2
chr1_+_155558112 1.44 ENSMUST00000080138.6
ENSMUST00000097529.3
ENSMUST00000035560.3
acyl-Coenzyme A binding domain containing 6
chr3_-_88950271 1.42 ENSMUST00000174402.1
ENSMUST00000174077.1
death associated protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.8 47.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
10.1 10.1 GO:0045004 DNA replication proofreading(GO:0045004)
8.9 88.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
7.3 29.3 GO:0006272 leading strand elongation(GO:0006272)
4.7 51.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
4.0 35.9 GO:0090166 Golgi disassembly(GO:0090166)
3.9 11.7 GO:1990705 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
3.6 18.0 GO:0034421 post-translational protein acetylation(GO:0034421)
3.6 53.9 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
3.5 24.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
3.4 20.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
3.2 12.9 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
3.2 32.0 GO:1902969 mitotic DNA replication(GO:1902969)
3.1 77.8 GO:0006270 DNA replication initiation(GO:0006270)
2.9 2.9 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
2.6 18.2 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
2.4 14.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.3 13.9 GO:0019985 translesion synthesis(GO:0019985)
2.2 23.8 GO:0033504 floor plate development(GO:0033504)
2.1 6.4 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
2.0 18.2 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
2.0 15.6 GO:2000232 regulation of rRNA processing(GO:2000232)
1.9 7.7 GO:0000076 DNA replication checkpoint(GO:0000076)
1.9 5.7 GO:1904976 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
1.8 9.2 GO:0006545 glycine biosynthetic process(GO:0006545)
1.8 32.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.6 1.6 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
1.3 5.3 GO:0046125 pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
1.3 14.6 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
1.3 6.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.3 3.8 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.2 13.7 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.1 11.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.0 3.1 GO:0099578 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
1.0 11.0 GO:0000212 meiotic spindle organization(GO:0000212)
1.0 9.7 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
1.0 2.9 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.9 2.8 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.9 14.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 2.5 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.8 2.4 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.8 3.8 GO:0043137 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.7 2.2 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.7 4.3 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.7 8.5 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.7 10.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.7 6.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.7 2.0 GO:0060365 orbitofrontal cortex development(GO:0021769) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) coronal suture morphogenesis(GO:0060365)
0.7 5.4 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.6 2.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.6 1.9 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.6 6.1 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.6 1.8 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.6 8.1 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.5 29.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.5 4.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.5 1.5 GO:0043686 co-translational protein modification(GO:0043686)
0.5 16.6 GO:0006284 base-excision repair(GO:0006284)
0.4 1.8 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.4 1.7 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.4 1.6 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.4 1.2 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.4 1.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.4 2.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.4 3.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 2.4 GO:0036337 Fas signaling pathway(GO:0036337)
0.3 2.3 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.3 1.6 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.3 1.0 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) endothelial cell-cell adhesion(GO:0071603)
0.3 2.4 GO:0008215 spermine metabolic process(GO:0008215)
0.3 1.5 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.3 1.5 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.3 1.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.3 2.9 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.3 2.3 GO:0009249 protein lipoylation(GO:0009249)
0.3 2.8 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.3 4.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 3.0 GO:0008063 Toll signaling pathway(GO:0008063)
0.3 3.2 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.3 0.8 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.3 1.8 GO:0044838 cell quiescence(GO:0044838) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 8.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 1.0 GO:0032466 negative regulation of cytokinesis(GO:0032466)
0.2 0.2 GO:0072554 blood vessel lumenization(GO:0072554)
0.2 0.9 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.2 2.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 2.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 0.7 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.2 5.0 GO:0009303 rRNA transcription(GO:0009303)
0.2 2.0 GO:0007000 nucleolus organization(GO:0007000)
0.2 2.6 GO:0006020 inositol metabolic process(GO:0006020)
0.2 6.3 GO:0007099 centriole replication(GO:0007099)
0.2 0.6 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 1.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.7 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 1.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 5.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 1.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 4.1 GO:0043486 histone exchange(GO:0043486)
0.2 0.5 GO:0048377 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) positive regulation of cardiac ventricle development(GO:1904414)
0.2 1.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 2.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.4 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.1 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.1 0.3 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.1 3.4 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 1.7 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 0.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.8 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 1.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 3.1 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 0.6 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 2.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.2 GO:0051571 positive regulation of histone H3-K4 methylation(GO:0051571)
0.1 0.8 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 0.2 GO:0023035 CD40 signaling pathway(GO:0023035)
0.1 2.3 GO:0002347 response to tumor cell(GO:0002347)
0.1 1.5 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.1 0.7 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.7 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 2.1 GO:0034453 microtubule anchoring(GO:0034453)
0.1 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.1 GO:0042407 cristae formation(GO:0042407)
0.1 0.2 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.1 2.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 15.8 GO:0007018 microtubule-based movement(GO:0007018)
0.1 0.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.5 GO:0007343 egg activation(GO:0007343)
0.0 1.3 GO:0019430 removal of superoxide radicals(GO:0019430)
0.0 0.4 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.8 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.6 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.8 GO:0021511 spinal cord patterning(GO:0021511)
0.0 2.3 GO:0021510 spinal cord development(GO:0021510)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.5 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 3.8 GO:0006364 rRNA processing(GO:0006364)
0.0 0.6 GO:0060416 response to growth hormone(GO:0060416)
0.0 0.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 2.3 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.0 1.4 GO:0051225 spindle assembly(GO:0051225)
0.0 0.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.4 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0001921 positive regulation of receptor recycling(GO:0001921)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 133.0 GO:0042555 MCM complex(GO:0042555)
6.5 32.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
4.5 22.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
4.2 12.5 GO:0000811 GINS complex(GO:0000811)
4.0 19.9 GO:0031298 replication fork protection complex(GO:0031298)
3.8 18.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
3.4 10.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
3.1 15.6 GO:0001651 dense fibrillar component(GO:0001651)
2.0 18.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.9 15.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.6 4.7 GO:0035061 interchromatin granule(GO:0035061)
1.5 7.5 GO:0034715 pICln-Sm protein complex(GO:0034715)
1.4 4.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.4 74.6 GO:0005657 replication fork(GO:0005657)
1.3 8.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.2 6.1 GO:0033553 rDNA heterochromatin(GO:0033553)
1.2 6.1 GO:0035189 Rb-E2F complex(GO:0035189)
1.1 11.2 GO:0000796 condensin complex(GO:0000796)
0.8 6.2 GO:0032300 mismatch repair complex(GO:0032300)
0.8 3.1 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.8 42.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 2.2 GO:0018444 translation release factor complex(GO:0018444)
0.7 4.3 GO:0098536 deuterosome(GO:0098536)
0.7 4.9 GO:0030893 meiotic cohesin complex(GO:0030893)
0.7 6.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.7 7.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.6 3.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 2.9 GO:0001740 Barr body(GO:0001740)
0.6 12.9 GO:0000800 lateral element(GO:0000800)
0.6 2.8 GO:0034709 methylosome(GO:0034709)
0.6 2.8 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 3.8 GO:0005638 lamin filament(GO:0005638)
0.4 9.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 2.9 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.4 1.5 GO:1903349 omegasome membrane(GO:1903349)
0.3 60.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.3 23.3 GO:0005871 kinesin complex(GO:0005871)
0.3 5.5 GO:0016580 Sin3 complex(GO:0016580)
0.3 5.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 3.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 1.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 1.7 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 1.7 GO:0005827 polar microtubule(GO:0005827)
0.2 1.6 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 2.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 2.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 5.9 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.2 3.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.2 0.7 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 1.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 9.3 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.7 GO:1904115 axon cytoplasm(GO:1904115)
0.1 2.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 4.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.1 GO:0061617 MICOS complex(GO:0061617)
0.1 3.6 GO:0051233 spindle midzone(GO:0051233)
0.1 0.7 GO:0070187 telosome(GO:0070187)
0.1 6.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.2 GO:0070938 contractile ring(GO:0070938)
0.1 10.5 GO:0005814 centriole(GO:0005814)
0.1 2.6 GO:0071565 nBAF complex(GO:0071565)
0.1 9.4 GO:0016605 PML body(GO:0016605)
0.1 12.5 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 1.5 GO:0005686 U2 snRNP(GO:0005686)
0.1 2.0 GO:0034451 centriolar satellite(GO:0034451)
0.1 6.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 13.0 GO:0005819 spindle(GO:0005819)
0.1 25.6 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.4 GO:0097470 ribbon synapse(GO:0097470)
0.1 3.2 GO:0030686 90S preribosome(GO:0030686)
0.1 1.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 5.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0000801 central element(GO:0000801)
0.1 2.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 3.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 2.0 GO:0015030 Cajal body(GO:0015030)
0.1 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 16.8 GO:0005813 centrosome(GO:0005813)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 2.1 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 6.8 GO:0005874 microtubule(GO:0005874)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 42.5 GO:0005654 nucleoplasm(GO:0005654)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.0 GO:0031251 PAN complex(GO:0031251)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 45.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
7.2 43.0 GO:0031493 nucleosomal histone binding(GO:0031493)
6.5 32.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
3.9 7.9 GO:0000405 bubble DNA binding(GO:0000405)
3.9 54.2 GO:0003688 DNA replication origin binding(GO:0003688)
3.3 19.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
3.1 12.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
2.4 9.6 GO:0048256 flap endonuclease activity(GO:0048256)
2.4 19.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
2.3 40.5 GO:0035173 histone kinase activity(GO:0035173)
2.0 51.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.9 30.8 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
1.8 9.0 GO:0032135 DNA insertion or deletion binding(GO:0032135)
1.8 62.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.6 9.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
1.5 5.9 GO:0036033 mediator complex binding(GO:0036033)
1.4 12.9 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
1.4 12.5 GO:0009008 DNA-methyltransferase activity(GO:0009008)
1.3 5.3 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
1.2 6.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.1 8.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 8.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.9 14.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.9 11.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.9 2.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.8 10.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.7 2.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.7 0.7 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.6 2.6 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.6 1.9 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.6 2.5 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.6 1.8 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.5 11.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.5 4.7 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.5 9.5 GO:0070182 DNA polymerase binding(GO:0070182)
0.5 6.1 GO:0098505 single-stranded telomeric DNA binding(GO:0043047) G-rich strand telomeric DNA binding(GO:0098505)
0.5 3.8 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 4.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 3.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.4 2.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.8 GO:0034481 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) chondroitin sulfotransferase activity(GO:0034481)
0.3 2.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 11.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 76.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 2.9 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 4.4 GO:0031996 thioesterase binding(GO:0031996)
0.3 11.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 1.6 GO:0097016 L27 domain binding(GO:0097016)
0.3 2.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 1.5 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 0.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 23.3 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 10.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.6 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 27.9 GO:0004386 helicase activity(GO:0004386)
0.2 1.2 GO:0051425 PTB domain binding(GO:0051425)
0.2 0.9 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.2 1.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.2 23.4 GO:0042393 histone binding(GO:0042393)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 3.2 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 2.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 2.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 9.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 4.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 3.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 31.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 35.8 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 15.0 GO:0001047 core promoter binding(GO:0001047)
0.1 2.1 GO:0003684 damaged DNA binding(GO:0003684)
0.1 4.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.7 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.6 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.0 GO:0070330 aromatase activity(GO:0070330)
0.1 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.5 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 1.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 19.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 5.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.0 2.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 2.6 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.3 GO:0072341 modified amino acid binding(GO:0072341)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 46.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
3.0 142.0 PID ATR PATHWAY ATR signaling pathway
2.4 33.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.3 105.6 PID E2F PATHWAY E2F transcription factor network
0.8 13.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 23.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.6 16.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.5 53.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 20.8 PID PLK1 PATHWAY PLK1 signaling events
0.4 8.2 PID BARD1 PATHWAY BARD1 signaling events
0.3 8.7 PID ATM PATHWAY ATM pathway
0.3 17.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 2.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 14.8 PID NOTCH PATHWAY Notch signaling pathway
0.2 2.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.0 PID CD40 PATHWAY CD40/CD40L signaling
0.1 1.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 3.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 3.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.2 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.3 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 151.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
6.9 124.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
4.6 46.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
3.1 44.0 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.9 11.7 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
1.5 13.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.4 16.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.1 6.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.1 12.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.9 5.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.9 9.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.8 22.6 REACTOME KINESINS Genes involved in Kinesins
0.4 4.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 6.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.4 4.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.3 4.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.3 16.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 10.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 5.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 7.1 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 1.7 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 4.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 37.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.5 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 0.9 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 2.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.0 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 3.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.8 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.3 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.1 4.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 5.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA