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2D miR_HR1_12

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Results for Srf

Z-value: 0.80

Motif logo

Transcription factors associated with Srf

Gene Symbol Gene ID Gene Info
ENSMUSG00000015605.5 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_465561880.745.8e-03Click!

Activity profile of Srf motif

Sorted Z-values of Srf motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_85513586 1.89 ENSMUST00000095759.3
early growth response 4
chr2_+_127336152 1.86 ENSMUST00000028846.6
dual specificity phosphatase 2
chr14_+_3652030 1.51 ENSMUST00000167430.1
predicted gene 3020
chr14_+_3412614 1.47 ENSMUST00000170123.1
predicted gene 10409
chr14_+_4415448 1.39 ENSMUST00000168866.1
predicted gene 3164
chr14_+_3049285 1.31 ENSMUST00000166494.1
predicted gene 2897
chr14_+_4334763 1.18 ENSMUST00000165466.1
RIKEN cDNA 2610042L04 gene
chr14_+_4855576 1.18 ENSMUST00000166776.1
predicted gene 3264
chr14_-_6287250 1.12 ENSMUST00000170104.2
predicted gene 3411
chr14_-_7027449 1.11 ENSMUST00000170738.2
predicted gene 10406
chr14_-_7568566 1.08 ENSMUST00000163790.1
predicted gene 3558
chr7_+_101896817 1.06 ENSMUST00000143835.1
anaphase prompoting complex C subunit 15
chr11_-_94973447 1.04 ENSMUST00000100551.4
ENSMUST00000152042.1
sarcoglycan, alpha (dystrophin-associated glycoprotein)
chr4_+_148000722 1.03 ENSMUST00000103230.4
natriuretic peptide type A
chr14_+_3810074 1.02 ENSMUST00000170480.1
predicted gene 3002
chr14_+_5501674 0.90 ENSMUST00000181562.1
predicted gene, 3488
chr18_+_34861200 0.89 ENSMUST00000165033.1
early growth response 1
chr4_-_132351636 0.86 ENSMUST00000105951.1
regulator of chromosome condensation 1
chr14_-_5389049 0.83 ENSMUST00000177986.1
predicted gene 3500
chr12_+_86678685 0.76 ENSMUST00000021681.3
vasohibin 1
chr1_-_43163891 0.74 ENSMUST00000008280.7
four and a half LIM domains 2
chr7_+_101896340 0.72 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
anaphase prompoting complex C subunit 15
chr17_+_7925990 0.70 ENSMUST00000036370.7
T cell activation Rho GTPase activating protein
chr2_+_125068118 0.67 ENSMUST00000070353.3
solute carrier family 24, member 5
chr3_+_68468162 0.63 ENSMUST00000182532.1
schwannomin interacting protein 1
chr3_+_14863495 0.63 ENSMUST00000029076.4
carbonic anhydrase 3
chr11_-_12412136 0.52 ENSMUST00000174874.1
cordon-bleu WH2 repeat
chr11_-_101424519 0.49 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
predicted gene, 27029
prostaglandin E synthase 3 (cytosolic)-like
chr12_-_103355967 0.49 ENSMUST00000021617.7
ankyrin repeat and SOCS box-containing 2
chr1_-_33757711 0.48 ENSMUST00000044691.7
BCL2-associated athanogene 2
chr14_+_20929416 0.47 ENSMUST00000022369.7
vinculin
chr10_-_111997204 0.47 ENSMUST00000074805.5
GLI pathogenesis-related 1 (glioma)
chr14_-_5741577 0.47 ENSMUST00000177556.1
predicted gene 3373
chr3_+_90072641 0.44 ENSMUST00000121503.1
ENSMUST00000119570.1
ENSMUST00000062193.9
tropomyosin 3, gamma
chr14_-_5880382 0.44 ENSMUST00000164484.1
predicted gene 8237
chr9_+_75051977 0.43 ENSMUST00000170310.1
ENSMUST00000166549.1
cAMP-regulated phosphoprotein 19
chr2_+_31759993 0.36 ENSMUST00000124089.1
c-abl oncogene 1, non-receptor tyrosine kinase
chr12_-_110695860 0.34 ENSMUST00000149189.1
heat shock protein 90, alpha (cytosolic), class A member 1
chr7_-_105600103 0.31 ENSMUST00000033185.8
hemopexin
chr11_+_33963013 0.30 ENSMUST00000020362.2
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr5_-_112896350 0.28 ENSMUST00000086617.4
myosin XVIIIb
chr1_+_63176818 0.27 ENSMUST00000129339.1
eukaryotic translation elongation factor 1 beta 2
chr4_+_132351768 0.26 ENSMUST00000172202.1
predicted gene, 17300
chr12_-_110696248 0.26 ENSMUST00000124156.1
heat shock protein 90, alpha (cytosolic), class A member 1
chr6_+_113378113 0.25 ENSMUST00000171058.1
ENSMUST00000156898.1
actin related protein 2/3 complex, subunit 4
chr17_-_46153517 0.25 ENSMUST00000171172.1
MAD2L1 binding protein
chr12_-_110696289 0.25 ENSMUST00000021698.6
heat shock protein 90, alpha (cytosolic), class A member 1
chr15_-_77842133 0.24 ENSMUST00000016771.6
myosin, heavy polypeptide 9, non-muscle
chr14_-_7174533 0.24 ENSMUST00000172431.1
predicted gene 3512
chr5_-_145191511 0.24 ENSMUST00000161845.1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr15_-_76229492 0.24 ENSMUST00000074834.5
plectin
chr12_+_85473883 0.23 ENSMUST00000021674.6
FBJ osteosarcoma oncogene
chr2_+_154548888 0.23 ENSMUST00000045116.4
ENSMUST00000109709.3
RIKEN cDNA 1700003F12 gene
chr7_-_19310035 0.23 ENSMUST00000003640.2
FBJ osteosarcoma oncogene B
chr3_-_95891938 0.22 ENSMUST00000036360.6
ENSMUST00000090476.3
cDNA sequence BC028528
chr8_+_15057646 0.21 ENSMUST00000033842.3
myomesin 2
chr7_+_119895836 0.19 ENSMUST00000106518.1
ENSMUST00000054440.3
LYR motif containing 1
chr14_-_45529964 0.18 ENSMUST00000150660.1
fermitin family homolog 2 (Drosophila)
chr7_+_119896292 0.18 ENSMUST00000106517.1
LYR motif containing 1
chr4_+_43957401 0.18 ENSMUST00000030202.7
GLI pathogenesis-related 2
chr15_-_36794498 0.17 ENSMUST00000110361.1
ENSMUST00000022894.7
ENSMUST00000110359.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_120677579 0.17 ENSMUST00000060175.6
cDNA sequence BC030336
chr14_+_55575617 0.15 ENSMUST00000022826.5
fat storage-inducing transmembrane protein 1
chr3_-_95891929 0.15 ENSMUST00000171519.1
cDNA sequence BC028528
chr1_-_131097535 0.14 ENSMUST00000016672.4
MAP kinase-activated protein kinase 2
chr12_-_80968075 0.14 ENSMUST00000095572.4
solute carrier family 10 (sodium/bile acid cotransporter family), member 1
chr3_-_19311269 0.14 ENSMUST00000099195.3
phosphodiesterase 7A
chr7_-_142661858 0.13 ENSMUST00000145896.2
insulin-like growth factor 2
chr1_+_67123015 0.13 ENSMUST00000027144.7
carbamoyl-phosphate synthetase 1
chrX_+_11321423 0.13 ENSMUST00000178196.1
predicted gene 14478
chr17_-_46556158 0.12 ENSMUST00000015749.5
serum response factor
chr9_-_66514567 0.12 ENSMUST00000056890.8
F-box and leucine-rich repeat protein 22
chrX_+_11308824 0.12 ENSMUST00000178595.1
predicted gene 14476
chr2_+_69380431 0.12 ENSMUST00000063690.3
dehydrogenase/reductase (SDR family) member 9
chr3_-_152266320 0.11 ENSMUST00000046045.8
nexilin
chr2_-_60673654 0.11 ENSMUST00000059888.8
ENSMUST00000154764.1
integrin beta 6
chrX_+_11324659 0.11 ENSMUST00000164729.2
predicted gene 14475
chr14_+_74732384 0.11 ENSMUST00000176957.1
esterase D/formylglutathione hydrolase
chr16_+_11313812 0.11 ENSMUST00000023140.5
tumor necrosis factor receptor superfamily, member 17
chr14_-_54966570 0.10 ENSMUST00000124930.1
ENSMUST00000134256.1
ENSMUST00000081857.6
ENSMUST00000145322.1
myosin, heavy polypeptide 6, cardiac muscle, alpha
chr2_+_127208358 0.10 ENSMUST00000103220.3
small nuclear ribonucleoprotein 200 (U5)
chr1_+_78816909 0.10 ENSMUST00000057262.6
potassium voltage-gated channel, Isk-related subfamily, gene 4
chrX_+_11315158 0.09 ENSMUST00000179004.1
predicted gene 14479
chr5_+_24413406 0.09 ENSMUST00000049346.5
acid-sensing (proton-gated) ion channel 3
chr11_-_99493112 0.09 ENSMUST00000006969.7
keratin 23
chr11_-_5898771 0.08 ENSMUST00000102921.3
myosin, light polypeptide 7, regulatory
chr5_-_142905928 0.08 ENSMUST00000106216.2
actin, beta
chr7_+_19131686 0.07 ENSMUST00000165913.1
F-box protein 46
chr18_+_45268876 0.07 ENSMUST00000183850.1
ENSMUST00000066890.7
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr16_-_4880284 0.07 ENSMUST00000037843.6
UBA-like domain containing 1
chr2_-_152415044 0.07 ENSMUST00000099207.3
zinc finger, CCHC domain containing 3
chr4_+_43957678 0.07 ENSMUST00000107855.1
GLI pathogenesis-related 2
chr8_-_71381907 0.07 ENSMUST00000002466.8
nuclear receptor subfamily 2, group F, member 6
chrX_-_79434418 0.07 ENSMUST00000179788.1
calponin homology domain containing 2
chr14_-_78308031 0.07 ENSMUST00000022592.7
tumor necrosis factor (ligand) superfamily, member 11
chrX_-_166518567 0.06 ENSMUST00000112187.1
transcription elongation factor A (SII) N-terminal and central domain containing
chr11_-_120731944 0.06 ENSMUST00000154565.1
ENSMUST00000026148.2
carbonyl reductase 2
chr11_-_70669283 0.06 ENSMUST00000129434.1
ENSMUST00000018431.6
sperm associated antigen 7
chr19_+_5447692 0.06 ENSMUST00000025850.5
fos-like antigen 1
chr13_+_109260481 0.05 ENSMUST00000153234.1
phosphodiesterase 4D, cAMP specific
chr6_-_83536215 0.05 ENSMUST00000075161.5
actin, gamma 2, smooth muscle, enteric
chr11_-_70687917 0.04 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
calmodulin binding transcription activator 2
chr11_+_101331069 0.03 ENSMUST00000017316.6
amine oxidase, copper containing 3
chr19_-_4928241 0.02 ENSMUST00000025851.3
dipeptidylpeptidase 3
chr11_-_69662564 0.02 ENSMUST00000129224.1
ENSMUST00000155200.1
mannose-P-dolichol utilization defect 1
chr14_-_6889962 0.02 ENSMUST00000171906.1
predicted gene 3667
chrX_+_11311934 0.02 ENSMUST00000178979.1
predicted gene 14484
chr14_-_76010863 0.02 ENSMUST00000088922.4
general transcription factor IIF, polypeptide 2
chr4_-_63403330 0.01 ENSMUST00000035724.4
AT-hook transcription factor
chr2_+_31759932 0.00 ENSMUST00000028190.6
c-abl oncogene 1, non-receptor tyrosine kinase
chr5_-_26089291 0.00 ENSMUST00000094946.4
predicted gene 10471
chr11_+_101330605 0.00 ENSMUST00000103105.3
amine oxidase, copper containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Srf

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0060025 regulation of synaptic activity(GO:0060025)
0.3 0.9 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.3 0.8 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 1.0 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.7 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.8 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1 0.4 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.1 1.8 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.3 GO:0015886 heme transport(GO:0015886)
0.1 0.5 GO:0001757 somite specification(GO:0001757)
0.1 0.9 GO:0060347 heart trabecula formation(GO:0060347)
0.0 0.2 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.0 0.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.0 0.6 GO:0001553 luteinization(GO:0001553)
0.0 0.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 1.0 GO:0001706 endoderm formation(GO:0001706)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.1 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.1 GO:0071847 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466) TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.1 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.4 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.1 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.9 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.1 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.0 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 1.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.5 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.0 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.8 GO:0002135 CTP binding(GO:0002135)
0.1 0.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.3 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0016151 nickel cation binding(GO:0016151)
0.1 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.1 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.0 0.1 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 1.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.0 GO:0052596 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 3.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis