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2D miR_HR1_12

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Results for Nfkb2

Z-value: 0.58

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Transcription factors associated with Nfkb2

Gene Symbol Gene ID Gene Info
ENSMUSG00000025225.8 nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46304709_463048110.039.3e-01Click!

Activity profile of Nfkb2 motif

Sorted Z-values of Nfkb2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_55326913 1.85 ENSMUST00000085754.3
ENSMUST00000034862.4
expressed sequence AI118078
chr7_-_44532064 0.97 ENSMUST00000098483.2
ENSMUST00000035323.4
Spi-B transcription factor (Spi-1/PU.1 related)
chr19_+_7268296 0.92 ENSMUST00000066646.4
REST corepressor 2
chr5_+_37245792 0.82 ENSMUST00000031004.7
collapsin response mediator protein 1
chr2_-_102451792 0.71 ENSMUST00000099678.3
four jointed box 1 (Drosophila)
chr5_+_90891234 0.70 ENSMUST00000031327.8
chemokine (C-X-C motif) ligand 1
chr11_+_70029742 0.70 ENSMUST00000132597.2
discs, large homolog 4 (Drosophila)
chr1_+_34801704 0.68 ENSMUST00000047664.9
Rho guanine nucleotide exchange factor (GEF) 4
chr7_+_29289300 0.68 ENSMUST00000048187.4
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr7_-_126200413 0.59 ENSMUST00000163959.1
exportin 6
chr9_-_44735189 0.51 ENSMUST00000034611.8
pleckstrin homology-like domain, family B, member 1
chr1_+_74791516 0.47 ENSMUST00000006718.8
wingless related MMTV integration site 10a
chr11_+_77686155 0.45 ENSMUST00000100802.4
ENSMUST00000181023.1
nuclear fragile X mental retardation protein interacting protein 2
chr5_+_110544326 0.43 ENSMUST00000040001.7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr14_-_55591077 0.39 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_-_57149633 0.38 ENSMUST00000019633.7
CD70 antigen
chr9_+_5308828 0.37 ENSMUST00000162846.1
ENSMUST00000027012.7
caspase 4, apoptosis-related cysteine peptidase
chr16_+_32914094 0.36 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
leucine-rich repeats and calponin homology (CH) domain containing 3
chr2_-_164473714 0.35 ENSMUST00000017864.2
transformation related protein 53 target 5
chr17_-_35205305 0.32 ENSMUST00000025266.5
lymphotoxin A
chr15_-_101562889 0.31 ENSMUST00000023714.4
RIKEN cDNA 4732456N10 gene
chr7_-_126200474 0.31 ENSMUST00000168189.1
exportin 6
chr13_-_111490028 0.30 ENSMUST00000091236.4
GC-rich promoter binding protein 1
chrX_-_7671341 0.30 ENSMUST00000033486.5
proteolipid protein 2
chr17_+_35424842 0.27 ENSMUST00000174699.1
histocompatibility 2, Q region locus 6
chr18_-_77565050 0.26 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
ring finger protein 165
chr11_-_70015346 0.26 ENSMUST00000018718.7
ENSMUST00000102574.3
acyl-Coenzyme A dehydrogenase, very long chain
chr7_+_30422389 0.26 ENSMUST00000108175.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr7_+_16309577 0.26 ENSMUST00000002152.6
BCL2 binding component 3
chr1_+_135132693 0.26 ENSMUST00000049449.4
protein tyrosine phosphatase, non-receptor type 7
chr3_-_107760221 0.25 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
colony stimulating factor 1 (macrophage)
chr19_-_46338632 0.25 ENSMUST00000051234.8
ENSMUST00000167861.1
CUE domain containing 2
chr1_+_135133272 0.24 ENSMUST00000167080.1
protein tyrosine phosphatase, non-receptor type 7
chr2_-_32312162 0.24 ENSMUST00000155269.1
dynamin 1
chr8_+_79028587 0.24 ENSMUST00000119254.1
zinc finger protein 827
chr13_+_43785107 0.22 ENSMUST00000015540.2
CD83 antigen
chr11_-_23770953 0.22 ENSMUST00000102864.3
reticuloendotheliosis oncogene
chr7_-_126200397 0.21 ENSMUST00000009344.9
exportin 6
chr10_-_59221757 0.20 ENSMUST00000165971.1
septin 10
chr1_+_150100093 0.20 ENSMUST00000035065.7
prostaglandin-endoperoxide synthase 2
chr10_+_127421208 0.19 ENSMUST00000168780.1
R3H domain containing 2
chr7_+_30421724 0.19 ENSMUST00000108176.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr5_+_90759299 0.17 ENSMUST00000031318.4
chemokine (C-X-C motif) ligand 5
chr10_-_89686250 0.17 ENSMUST00000092227.5
ENSMUST00000174252.1
SCY1-like 2 (S. cerevisiae)
chr11_-_33147400 0.16 ENSMUST00000020507.7
fibroblast growth factor 18
chr1_+_153740344 0.15 ENSMUST00000027748.7
regulator of G-protein signaling 16
chr13_-_111490111 0.15 ENSMUST00000047627.7
GC-rich promoter binding protein 1
chr8_-_104631312 0.15 ENSMUST00000034351.6
Ras-related associated with diabetes
chr11_-_72037474 0.14 ENSMUST00000048207.3
aryl hydrocarbon receptor-interacting protein-like 1
chr2_+_10153563 0.12 ENSMUST00000026886.7
inter-alpha (globulin) inhibitor H5
chr4_+_141088333 0.11 ENSMUST00000051907.2
spermatogenesis associated 21
chr8_+_120002720 0.10 ENSMUST00000108972.3
cysteine-rich secretory protein LCCL domain containing 2
chr17_+_35866606 0.09 ENSMUST00000113814.4
protein phosphatase 1, regulatory subunit 18
chr2_-_120314141 0.09 ENSMUST00000054651.7
phospholipase A2, group IVF
chr7_-_101302020 0.08 ENSMUST00000122116.1
ENSMUST00000120267.1
autophagy related 16-like 2 (S. cerevisiae)
chr5_+_125475814 0.08 ENSMUST00000031445.3
acetoacetyl-CoA synthetase
chr11_-_70656467 0.08 ENSMUST00000131642.1
predicted gene 12319
chr9_-_107609182 0.08 ENSMUST00000102531.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr2_+_172550991 0.07 ENSMUST00000170744.1
transcription factor AP-2, gamma
chr2_-_37422869 0.06 ENSMUST00000112936.1
ENSMUST00000112934.1
ring finger and CCCH-type zinc finger domains 2
chr9_-_107609215 0.06 ENSMUST00000102532.3
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr4_+_129984833 0.06 ENSMUST00000120204.1
brain-specific angiogenesis inhibitor 2
chr5_-_137530990 0.06 ENSMUST00000132525.1
guanine nucleotide binding protein (G protein), beta 2
chr8_+_79028317 0.05 ENSMUST00000087927.4
ENSMUST00000098614.2
zinc finger protein 827
chr1_-_152902628 0.05 ENSMUST00000111836.2
ENSMUST00000073441.6
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr11_-_84870646 0.05 ENSMUST00000018547.2
gametogenetin binding protein 2
chr17_+_34898931 0.04 ENSMUST00000097342.3
ENSMUST00000013931.5
euchromatic histone lysine N-methyltransferase 2
chr11_-_84870812 0.03 ENSMUST00000168434.1
gametogenetin binding protein 2
chr1_-_155742120 0.03 ENSMUST00000027740.7
LIM homeobox protein 4
chr19_+_45015198 0.03 ENSMUST00000179108.1
leucine zipper, putative tumor suppressor 2
chr11_-_84870712 0.03 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
gametogenetin binding protein 2
chr6_-_28134545 0.03 ENSMUST00000115323.1
glutamate receptor, metabotropic 8
chr5_-_114690906 0.02 ENSMUST00000112212.1
ENSMUST00000112214.1
glycolipid transfer protein
chr3_+_97658212 0.02 ENSMUST00000045743.6
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr17_-_35980197 0.02 ENSMUST00000055454.7
proline-rich polypeptide 3
chr15_-_76918010 0.00 ENSMUST00000048854.7
zinc finger protein 647
chr2_+_172550761 0.00 ENSMUST00000099058.3
transcription factor AP-2, gamma

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfkb2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.2 0.8 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.3 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1 0.3 GO:1903972 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.7 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.2 GO:1902219 positive regulation of fibroblast growth factor production(GO:0090271) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.4 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.5 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.5 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.2 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 1.0 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.0 0.0 GO:0071314 cellular response to cocaine(GO:0071314)
0.0 0.1 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 1.1 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.7 GO:0035690 cellular response to drug(GO:0035690)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.7 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.8 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation