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2D miR_HR1_12

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Results for Hnf1a

Z-value: 0.50

Motif logo

Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
ENSMUSG00000029556.6 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm10_v2_chr5_-_114971056_114971079-0.411.9e-01Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_101870711 0.94 ENSMUST00000151706.1
folate receptor 1 (adult)
chrX_+_164140447 0.71 ENSMUST00000073973.4
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr10_+_115817247 0.64 ENSMUST00000035563.7
ENSMUST00000080630.3
ENSMUST00000179196.1
tetraspanin 8
chr13_-_53286052 0.54 ENSMUST00000021918.8
receptor tyrosine kinase-like orphan receptor 2
chr5_+_102845007 0.52 ENSMUST00000070000.4
Rho GTPase activating protein 24
chr1_+_88138364 0.50 ENSMUST00000014263.4
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr19_+_56287911 0.48 ENSMUST00000095948.4
hyaluronic acid binding protein 2
chr2_-_35100677 0.46 ENSMUST00000045776.4
ENSMUST00000113050.3
expressed sequence AI182371
chr18_+_33464163 0.46 ENSMUST00000097634.3
predicted gene 10549
chr10_+_34483400 0.45 ENSMUST00000019913.7
ENSMUST00000170771.1
fyn-related kinase
chr2_-_62412219 0.45 ENSMUST00000047812.7
dipeptidylpeptidase 4
chr12_-_103657159 0.43 ENSMUST00000044159.6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr14_-_70630149 0.43 ENSMUST00000022694.9
dematin actin binding protein
chr4_-_140617062 0.42 ENSMUST00000154979.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr9_+_21835506 0.42 ENSMUST00000058777.6
predicted gene 6484
chr13_+_54701457 0.40 ENSMUST00000037145.7
cadherin-related family member 2
chr1_-_20617992 0.40 ENSMUST00000088448.5
polycystic kidney and hepatic disease 1
chr8_-_107065632 0.39 ENSMUST00000034393.5
transmembrane emp24 protein transport domain containing 6
chr1_+_88211956 0.38 ENSMUST00000073049.6
UDP glucuronosyltransferase 1 family, polypeptide A1
chr1_+_125676969 0.38 ENSMUST00000027581.6
G protein-coupled receptor 39
chr7_+_30493622 0.36 ENSMUST00000058280.6
ENSMUST00000133318.1
ENSMUST00000142575.1
ENSMUST00000131040.1
proline dehydrogenase (oxidase) 2
chr8_-_93535707 0.36 ENSMUST00000077816.6
carboxylesterase 5A
chr3_+_3508024 0.34 ENSMUST00000108393.1
ENSMUST00000017832.8
hepatocyte nuclear factor 4, gamma
chrX_+_101377267 0.34 ENSMUST00000052130.7
gap junction protein, beta 1
chr5_+_33104219 0.34 ENSMUST00000011178.2
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr5_+_24428208 0.33 ENSMUST00000115049.2
solute carrier family 4 (anion exchanger), member 2
chr3_-_75270073 0.33 ENSMUST00000039047.4
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr3_-_83049797 0.31 ENSMUST00000048246.3
fibrinogen beta chain
chr6_-_137571007 0.30 ENSMUST00000100841.2
epidermal growth factor receptor pathway substrate 8
chrX_+_101376359 0.30 ENSMUST00000119080.1
gap junction protein, beta 1
chr10_-_30842765 0.30 ENSMUST00000019924.8
hairy/enhancer-of-split related with YRPW motif 2
chr5_+_90518932 0.29 ENSMUST00000113179.2
ENSMUST00000128740.1
afamin
chr13_+_55152640 0.28 ENSMUST00000005452.5
fibroblast growth factor receptor 4
chr4_+_11758147 0.28 ENSMUST00000029871.5
ENSMUST00000108303.1
cadherin 17
chr11_+_101367542 0.27 ENSMUST00000019469.2
glucose-6-phosphatase, catalytic
chr7_-_79842287 0.27 ENSMUST00000049004.6
alanyl (membrane) aminopeptidase
chr6_-_116716888 0.26 ENSMUST00000056623.6
transmembrane protein 72
chr6_-_52183828 0.26 ENSMUST00000134831.1
homeobox A3
chr2_+_74727074 0.26 ENSMUST00000111980.2
homeobox D3
chr17_-_35046726 0.25 ENSMUST00000097338.4
mutS homolog 5 (E. coli)
chr3_-_72967854 0.25 ENSMUST00000167334.1
sucrase isomaltase (alpha-glucosidase)
chr19_+_56287943 0.25 ENSMUST00000166049.1
hyaluronic acid binding protein 2
chr18_-_43737186 0.24 ENSMUST00000025381.2
serine peptidase inhibitor, Kazal type 3
chr4_-_139968026 0.24 ENSMUST00000105031.2
kelch domain containing 7A
chr5_+_8046077 0.24 ENSMUST00000088786.4
sorcin
chr11_-_6230127 0.24 ENSMUST00000004505.2
NPC1-like 1
chr16_-_52296924 0.23 ENSMUST00000167115.1
activated leukocyte cell adhesion molecule
chr3_-_69859875 0.22 ENSMUST00000051239.7
ENSMUST00000171529.1
serine palmitoyltransferase, small subunit B
chr7_+_141215852 0.19 ENSMUST00000046890.5
ENSMUST00000133763.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr15_-_42676967 0.19 ENSMUST00000022921.5
angiopoietin 1
chr9_-_77045788 0.19 ENSMUST00000034911.6
tubulointerstitial nephritis antigen
chr14_+_80000292 0.19 ENSMUST00000088735.3
olfactomedin 4
chr5_-_114658414 0.18 ENSMUST00000112225.1
ENSMUST00000071968.2
transient receptor potential cation channel, subfamily V, member 4
chr1_+_88070765 0.18 ENSMUST00000073772.4
UDP glucuronosyltransferase 1 family, polypeptide A9
chr11_+_3983636 0.18 ENSMUST00000078757.1
galactose-3-O-sulfotransferase 1
chr8_+_64947177 0.18 ENSMUST00000079896.7
ENSMUST00000026595.5
transmembrane protein 192
chr4_+_150853919 0.18 ENSMUST00000073600.2
ERBB receptor feedback inhibitor 1
chr1_-_82768449 0.17 ENSMUST00000027331.2
transmembrane 4 L six family member 20
chr4_+_138967112 0.17 ENSMUST00000116094.2
ring finger protein 186
chr3_+_90537306 0.17 ENSMUST00000107335.1
S100 calcium binding protein A16
chr18_-_33464007 0.17 ENSMUST00000168890.1
neuronal regeneration related protein
chr16_-_79091078 0.16 ENSMUST00000023566.4
ENSMUST00000060402.5
transmembrane protease, serine 15
chr11_+_3983704 0.16 ENSMUST00000063004.7
galactose-3-O-sulfotransferase 1
chr7_-_119479249 0.15 ENSMUST00000033263.4
uromodulin
chr11_+_83852135 0.15 ENSMUST00000146786.1
HNF1 homeobox B
chr16_+_24448082 0.15 ENSMUST00000078988.2
LIM domain containing preferred translocation partner in lipoma
chr3_+_90537242 0.14 ENSMUST00000098911.3
S100 calcium binding protein A16
chr5_-_87337165 0.14 ENSMUST00000031195.2
UDP glucuronosyltransferase 2 family, polypeptide A3
chr18_-_33463747 0.14 ENSMUST00000171533.1
neuronal regeneration related protein
chr2_+_91265252 0.13 ENSMUST00000028691.6
ADP-ribosylation factor GTPase activating protein 2
chr16_-_38433145 0.13 ENSMUST00000002926.6
phospholipase A1 member A
chr12_+_76533540 0.13 ENSMUST00000075249.4
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_54952939 0.12 ENSMUST00000181704.1
predicted gene, 26684
chrX_+_164090187 0.12 ENSMUST00000015545.3
transmembrane protein 27
chr7_-_144751968 0.12 ENSMUST00000155175.1
anoctamin 1, calcium activated chloride channel
chr10_+_87859062 0.11 ENSMUST00000095360.4
insulin-like growth factor 1
chr11_+_7197780 0.11 ENSMUST00000020704.7
insulin-like growth factor binding protein 1
chr7_+_141216626 0.11 ENSMUST00000141804.1
ENSMUST00000148975.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr6_+_29859374 0.11 ENSMUST00000115238.3
S-adenosylhomocysteine hydrolase-like 2
chr7_+_45062429 0.10 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
nitric oxide synthase interacting protein
chr19_-_47919269 0.10 ENSMUST00000095998.5
inositol 1,4,5-triphosphate receptor interacting protein
chr4_-_103026709 0.10 ENSMUST00000084382.5
ENSMUST00000106869.2
insulin-like 5
chr10_+_87859255 0.09 ENSMUST00000105300.2
insulin-like growth factor 1
chr4_-_99654983 0.09 ENSMUST00000136525.1
predicted gene 12688
chr15_-_36879816 0.09 ENSMUST00000100713.2
predicted gene 10384
chr4_-_94650134 0.08 ENSMUST00000053419.2
leucine rich repeat containing 19
chr5_-_114444036 0.08 ENSMUST00000031560.7
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr12_+_59095653 0.07 ENSMUST00000021384.4
melanoma inhibitory activity 2
chr12_-_103631404 0.07 ENSMUST00000121625.1
ENSMUST00000044231.5
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr9_-_71163224 0.06 ENSMUST00000074465.2
aquaporin 9
chr11_+_115912001 0.06 ENSMUST00000132961.1
small integral membrane protein 6
chr7_-_45062393 0.06 ENSMUST00000129101.1
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr18_-_6516089 0.04 ENSMUST00000115870.2
enhancer of polycomb homolog 1 (Drosophila)
chr2_-_32424005 0.04 ENSMUST00000113307.2
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr10_+_63061582 0.03 ENSMUST00000020266.8
ENSMUST00000178684.1
phenazine biosynthesis-like protein domain containing 1
chr10_-_44458715 0.03 ENSMUST00000039174.4
PR domain containing 1, with ZNF domain
chr7_-_119895446 0.03 ENSMUST00000098080.2
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr5_+_32247351 0.03 ENSMUST00000101376.2
phospholipase B1
chr2_-_155357392 0.03 ENSMUST00000165234.1
ENSMUST00000077626.6
phosphatidylinositol glycan anchor biosynthesis, class U
chr19_+_42045792 0.03 ENSMUST00000172244.1
ENSMUST00000081714.4
4-hydroxy-2-oxoglutarate aldolase 1
chr4_+_19818722 0.03 ENSMUST00000035890.7
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
chrX_-_43167817 0.03 ENSMUST00000115058.1
ENSMUST00000115059.1
teneurin transmembrane protein 1
chr6_+_52177498 0.02 ENSMUST00000070587.3
RIKEN cDNA 5730596B20 gene
chr2_-_68472138 0.02 ENSMUST00000102715.3
serine/threonine kinase 39
chr8_-_104624266 0.02 ENSMUST00000163783.2
cadherin 16
chrX_-_139085211 0.02 ENSMUST00000033626.8
ENSMUST00000060824.3
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_+_83026147 0.02 ENSMUST00000166581.1
ENSMUST00000029630.9
fibrinogen alpha chain
chr3_+_129836729 0.01 ENSMUST00000077918.5
complement component factor i
chr15_+_7811011 0.01 ENSMUST00000022744.3
glial cell line derived neurotrophic factor
chr5_-_114443993 0.01 ENSMUST00000112245.1
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr6_+_38918969 0.01 ENSMUST00000003017.6
thromboxane A synthase 1, platelet
chr9_-_70934808 0.00 ENSMUST00000034731.8
lipase, hepatic

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.4 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.1 0.4 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.1 0.4 GO:0035483 gastric emptying(GO:0035483)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.5 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 0.9 GO:0071231 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1 0.3 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 1.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.4 GO:1904970 brush border assembly(GO:1904970)
0.1 0.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.3 GO:2000820 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.3 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0042539 positive regulation of microtubule depolymerization(GO:0031117) hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.6 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.3 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.1 GO:0061295 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.2 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.2 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.0 0.2 GO:1904220 regulation of serine C-palmitoyltransferase activity(GO:1904220)
0.0 0.3 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.3 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 0.4 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.4 GO:0008211 glucocorticoid metabolic process(GO:0008211)
0.0 0.1 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.3 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.9 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 0.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.2 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.6 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0015205 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins