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2D miR_HR1_12

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Results for Zfp423

Z-value: 0.46

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Transcription factors associated with Zfp423

Gene Symbol Gene ID Gene Info
ENSMUSG00000045333.9 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_879595950.156.3e-01Click!

Activity profile of Zfp423 motif

Sorted Z-values of Zfp423 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_109459843 1.41 ENSMUST00000173812.1
delta-like 1 homolog (Drosophila)
chr19_-_10101501 0.95 ENSMUST00000025567.7
fatty acid desaturase 2
chr19_+_7268296 0.79 ENSMUST00000066646.4
REST corepressor 2
chr4_-_106464167 0.78 ENSMUST00000049507.5
proprotein convertase subtilisin/kexin type 9
chr7_+_29307924 0.55 ENSMUST00000108230.1
ENSMUST00000065181.5
D4, zinc and double PHD fingers family 1
chr11_+_82101836 0.52 ENSMUST00000000194.3
chemokine (C-C motif) ligand 12
chr19_-_10869757 0.47 ENSMUST00000120524.1
ENSMUST00000025645.7
transmembrane protein 132A
chrX_-_75130844 0.43 ENSMUST00000114092.1
ENSMUST00000132501.1
ENSMUST00000153318.1
ENSMUST00000155742.1
membrane protein, palmitoylated
chr5_+_31297551 0.36 ENSMUST00000072228.5
glucokinase regulatory protein
chr7_-_141443314 0.32 ENSMUST00000106005.2
leucine-rich and death domain containing
chrX_-_75130996 0.31 ENSMUST00000033775.2
membrane protein, palmitoylated
chr18_+_40256960 0.31 ENSMUST00000096572.1
RIKEN cDNA 2900055J20 gene
chr2_+_163547148 0.30 ENSMUST00000109411.1
ENSMUST00000018094.6
hepatic nuclear factor 4, alpha
chr7_-_120670256 0.29 ENSMUST00000033178.2
PDZ domain containing 9
chr4_-_117125618 0.28 ENSMUST00000183310.1
BTB (POZ) domain containing 19
chrX_-_75130914 0.26 ENSMUST00000114091.1
membrane protein, palmitoylated
chr13_-_47106176 0.24 ENSMUST00000021807.6
ENSMUST00000135278.1
DEK oncogene (DNA binding)
chr6_-_124415037 0.23 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
peroxisomal biogenesis factor 5
chr18_+_4920509 0.22 ENSMUST00000126977.1
supervillin
chr4_-_148626756 0.21 ENSMUST00000105699.1
TAR DNA binding protein
chr8_-_83699095 0.20 ENSMUST00000005616.8
protein kinase N1
chr17_+_55986494 0.20 ENSMUST00000011733.8
fibronectin type 3 and SPRY domain-containing protein
chr17_-_10840285 0.19 ENSMUST00000041463.6
PARK2 co-regulated
chr6_-_128200598 0.19 ENSMUST00000071101.6
predicted gene 10010
chr10_+_3973086 0.18 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr9_-_37552904 0.17 ENSMUST00000065668.5
neurogranin
chr6_-_97205549 0.16 ENSMUST00000164744.1
ENSMUST00000089287.5
ubiquitin-like modifier activating enzyme 3
chr12_-_69183986 0.16 ENSMUST00000110620.1
ENSMUST00000110619.1
ribosomal protein L36A-like
chr14_+_119138415 0.15 ENSMUST00000065904.3
heparan sulfate 6-O-sulfotransferase 3
chr4_+_129820198 0.15 ENSMUST00000030578.7
protein tyrosine phosphatase 4a2
chr15_-_78718113 0.15 ENSMUST00000088592.4
leucine rich repeat and fibronectin type III, extracellular 2
chr12_-_69184056 0.15 ENSMUST00000054544.6
ribosomal protein L36A-like
chr8_+_27260327 0.14 ENSMUST00000033880.5
eukaryotic translation initiation factor 4E binding protein 1
chr17_-_36867187 0.14 ENSMUST00000025329.6
ENSMUST00000174195.1
tripartite motif-containing 15
chr5_-_135934590 0.14 ENSMUST00000055808.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr12_+_102948843 0.13 ENSMUST00000101099.5
unc-79 homolog (C. elegans)
chr11_-_76846968 0.13 ENSMUST00000021201.5
carboxypeptidase D
chr10_+_81136223 0.13 ENSMUST00000048128.8
zinc finger and BTB domain containing 7a
chr10_+_60349318 0.12 ENSMUST00000105459.1
RIKEN cDNA 4632428N05 gene
chr7_+_30421724 0.11 ENSMUST00000108176.1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
chr1_+_167598450 0.11 ENSMUST00000111386.1
ENSMUST00000111384.1
retinoid X receptor gamma
chr10_+_81136534 0.11 ENSMUST00000119606.1
ENSMUST00000146895.1
ENSMUST00000121840.1
zinc finger and BTB domain containing 7a
chr7_-_133122615 0.10 ENSMUST00000167218.1
C-terminal binding protein 2
chr10_+_13966268 0.10 ENSMUST00000015645.4
human immunodeficiency virus type I enhancer binding protein 2
chr1_+_167598384 0.09 ENSMUST00000015987.3
retinoid X receptor gamma
chr4_+_154237525 0.08 ENSMUST00000152159.1
multiple EGF-like-domains 6
chr5_+_115429944 0.08 ENSMUST00000067168.5
musashi RNA-binding protein 1
chr18_+_34759551 0.07 ENSMUST00000097622.3
family with sequence similarity 53, member C
chr17_+_86963077 0.07 ENSMUST00000024956.8
ras homolog gene family, member Q
chr4_-_108032069 0.07 ENSMUST00000106709.2
podocan
chr8_+_58912257 0.07 ENSMUST00000160055.1
cDNA sequence BC030500
chr4_+_129513581 0.07 ENSMUST00000062356.6
MARCKS-like 1
chr19_+_10041548 0.06 ENSMUST00000115995.2
fatty acid desaturase 3
chr7_-_105744312 0.06 ENSMUST00000141116.1
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_164785823 0.05 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
sorting nexin family member 21
chr7_-_45694369 0.05 ENSMUST00000040636.6
secretory blood group 1
chr2_+_13573927 0.05 ENSMUST00000141365.1
ENSMUST00000028062.2
vimentin
chr6_+_7844806 0.05 ENSMUST00000040159.4
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr7_-_19458494 0.05 ENSMUST00000085715.5
MAP/microtubule affinity-regulating kinase 4
chr17_+_86963279 0.05 ENSMUST00000139344.1
ras homolog gene family, member Q
chr18_-_80151467 0.04 ENSMUST00000066743.9
ADNP homeobox 2
chr6_+_113471481 0.04 ENSMUST00000113062.1
interleukin 17 receptor C
chr1_-_54926311 0.04 ENSMUST00000179030.1
ENSMUST00000044359.9
ankyrin repeat domain 44
chr4_-_108031938 0.04 ENSMUST00000106708.1
podocan
chr2_-_29055051 0.03 ENSMUST00000113843.1
ENSMUST00000157048.2
RIKEN cDNA 1700101E01 gene
chr17_-_32166879 0.03 ENSMUST00000087723.3
notch 3
chr16_+_58408443 0.03 ENSMUST00000046663.7
discoidin, CUB and LCCL domain containing 2
chr10_-_127620960 0.03 ENSMUST00000121829.1
low density lipoprotein receptor-related protein 1
chr6_-_124756478 0.02 ENSMUST00000088357.5
atrophin 1
chr12_-_14152038 0.02 ENSMUST00000020926.6
family with sequence similarity 84, member A
chr3_-_85887472 0.02 ENSMUST00000154148.1
ENSMUST00000033643.5
ADP-ribosylation factor interacting protein 1
glycosyltransferase 28 domain containing 2
chr7_-_34196608 0.02 ENSMUST00000148381.1
ENSMUST00000002710.3
programmed cell death 2-like
chr10_+_81137953 0.02 ENSMUST00000117956.1
zinc finger and BTB domain containing 7a
chr7_+_64153835 0.02 ENSMUST00000085222.5
ENSMUST00000107525.1
transient receptor potential cation channel, subfamily M, member 1
chr10_-_127620922 0.01 ENSMUST00000118455.1
low density lipoprotein receptor-related protein 1
chr7_+_64153916 0.01 ENSMUST00000107527.2
transient receptor potential cation channel, subfamily M, member 1
chr5_-_136565432 0.01 ENSMUST00000176172.1
cut-like homeobox 1
chr15_+_101293196 0.01 ENSMUST00000071328.6
RIKEN cDNA 6030408B16 gene
chr4_+_150914562 0.01 ENSMUST00000135169.1
tumor necrosis factor receptor superfamily, member 9

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.1 0.5 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.1 0.3 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.1 0.4 GO:0009750 response to fructose(GO:0009750)
0.1 0.2 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.2 GO:0007113 endomitotic cell cycle(GO:0007113)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.2 GO:2001032 cell quiescence(GO:0044838) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.2 GO:0046654 10-formyltetrahydrofolate metabolic process(GO:0009256) tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 1.0 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.2 0.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.3 GO:0070540 stearic acid binding(GO:0070540)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0004488 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 0.1 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.0 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein