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2D miR_HR1_12

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Results for Lhx8

Z-value: 0.51

Motif logo

Transcription factors associated with Lhx8

Gene Symbol Gene ID Gene Info
ENSMUSG00000096225.2 LIM homeobox protein 8

Activity profile of Lhx8 motif

Sorted Z-values of Lhx8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_40999479 1.31 ENSMUST00000166306.1
predicted gene 2663
chr6_+_40964760 1.08 ENSMUST00000076638.5
RIKEN cDNA 1810009J06 gene
chr3_-_73056943 0.79 ENSMUST00000059407.7
SLIT and NTRK-like family, member 3
chr4_-_129121889 0.74 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
hippocalcin
chr1_-_130661613 0.67 ENSMUST00000027657.7
complement component 4 binding protein
chr5_-_112392213 0.53 ENSMUST00000031291.7
aspartate beta-hydroxylase domain containing 2
chr5_+_25759987 0.52 ENSMUST00000128727.1
ENSMUST00000088244.4
ARP3 actin-related protein 3B
chr13_-_49652714 0.45 ENSMUST00000021818.7
centromere protein P
chr17_-_35027909 0.44 ENSMUST00000040151.2
suppressor APC domain containing 1
chr2_-_104849876 0.36 ENSMUST00000028593.4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_-_172027251 0.34 ENSMUST00000138714.1
vang-like 2 (van gogh, Drosophila)
chr4_+_126556935 0.34 ENSMUST00000048391.8
claspin
chr5_-_76905390 0.33 ENSMUST00000135954.1
aminoadipate-semialdehyde dehydrogenase
chr14_+_24490678 0.31 ENSMUST00000169826.1
ENSMUST00000112384.3
ribosomal protein S24
chr19_+_11469353 0.28 ENSMUST00000165310.1
membrane-spanning 4-domains, subfamily A, member 6C
chr3_+_54361103 0.27 ENSMUST00000107985.3
ENSMUST00000117373.1
ENSMUST00000073012.6
ENSMUST00000081564.6
periostin, osteoblast specific factor
chr18_-_43687695 0.27 ENSMUST00000082254.6
janus kinase and microtubule interacting protein 2
chr2_+_65620829 0.26 ENSMUST00000028377.7
sodium channel, voltage-gated, type II, alpha 1
chr5_-_100820929 0.24 ENSMUST00000117364.1
ENSMUST00000055245.6
family with sequence similarity 175, member A
chr10_-_67912620 0.23 ENSMUST00000064656.7
zinc finger protein 365
chr3_-_59210881 0.22 ENSMUST00000040622.1
purinergic receptor P2Y, G-protein coupled 13
chr7_-_19359477 0.20 ENSMUST00000047036.8
CD3E antigen, epsilon polypeptide associated protein
chr1_-_149922339 0.20 ENSMUST00000111926.2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr17_+_8182247 0.20 ENSMUST00000161898.1
Fgfr1 oncogene partner
chr8_-_69373383 0.19 ENSMUST00000072427.4
predicted gene 10033
chr5_-_145191566 0.18 ENSMUST00000037056.8
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr19_-_11336107 0.18 ENSMUST00000056035.2
ENSMUST00000067532.4
membrane-spanning 4-domains, subfamily A, member 7
chr18_-_7297901 0.18 ENSMUST00000081275.4
armadillo repeat containing 4
chr19_-_24961545 0.16 ENSMUST00000025815.8
COBW domain containing 1
chr17_+_24632671 0.15 ENSMUST00000047611.2
nth (endonuclease III)-like 1 (E.coli)
chr5_-_62765618 0.15 ENSMUST00000159470.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chrX_-_8074720 0.15 ENSMUST00000115636.3
ENSMUST00000115638.3
suppressor of variegation 3-9 homolog 1 (Drosophila)
chr17_-_31519914 0.14 ENSMUST00000167419.1
ENSMUST00000171291.1
WD repeat domain 4
chrX_+_150589907 0.14 ENSMUST00000080884.4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_+_91231578 0.14 ENSMUST00000109284.2
cDNA sequence CN725425
chr16_-_76022266 0.14 ENSMUST00000114240.1
SAM domain, SH3 domain and nuclear localization signals, 1
chr12_-_20900867 0.14 ENSMUST00000079237.5
zinc finger protein 125
chrM_+_7759 0.14 ENSMUST00000082407.1
ENSMUST00000082408.1
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr11_+_16257706 0.14 ENSMUST00000109645.2
ENSMUST00000109647.2
V-set and transmembrane domain containing 2A
chr3_+_107291215 0.13 ENSMUST00000029502.7
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr10_-_116549101 0.13 ENSMUST00000164088.1
CCR4-NOT transcription complex, subunit 2
chr8_-_57653023 0.12 ENSMUST00000034021.5
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr1_-_172027269 0.12 ENSMUST00000027837.6
ENSMUST00000111264.1
vang-like 2 (van gogh, Drosophila)
chr19_-_4042165 0.12 ENSMUST00000042700.9
glutathione S-transferase, pi 2
chr15_+_51877742 0.12 ENSMUST00000136129.1
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr1_+_72307413 0.12 ENSMUST00000027379.8
X-ray repair complementing defective repair in Chinese hamster cells 5
chr18_+_37341702 0.12 ENSMUST00000053037.3
protocadherin beta 7
chr2_-_114175321 0.11 ENSMUST00000043160.6
aquarius
chr14_+_14328113 0.11 ENSMUST00000100872.1
olfactory receptor 31
chr4_+_126556994 0.11 ENSMUST00000147675.1
claspin
chr15_-_83595111 0.11 ENSMUST00000016901.3
tubulin tyrosine ligase-like family, member 12
chr2_-_119662756 0.10 ENSMUST00000028768.1
ENSMUST00000110801.1
ENSMUST00000110802.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chr1_+_164048214 0.10 ENSMUST00000027874.5
selectin, endothelial cell
chr17_+_17374332 0.10 ENSMUST00000024620.6
RIO kinase 2 (yeast)
chr3_-_144760841 0.09 ENSMUST00000059091.5
chloride channel calcium activated 1
chr1_+_86064619 0.09 ENSMUST00000027432.8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr11_-_102407455 0.09 ENSMUST00000107098.1
ENSMUST00000018821.2
solute carrier family 25, member 39
chr8_-_106573461 0.08 ENSMUST00000073722.5
predicted pseudogene 10073
chr3_+_130617645 0.07 ENSMUST00000163620.1
ethanolamine phosphate phospholyase
chr6_-_3763618 0.07 ENSMUST00000171613.1
calcitonin receptor
chr7_+_27553244 0.07 ENSMUST00000067386.7
RIKEN cDNA 2310022A10 gene
chr15_+_21111452 0.07 ENSMUST00000075132.6
cadherin 12
chr19_+_10206033 0.07 ENSMUST00000166412.1
transmembrane protein 258
chr2_+_21205719 0.06 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
threonine synthase-like 1 (bacterial)
chr1_+_21240597 0.06 ENSMUST00000121676.1
glutathione S-transferase, alpha 3
chr11_+_44617310 0.06 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
early B cell factor 1
chr1_+_131153175 0.06 ENSMUST00000112446.2
ENSMUST00000068805.7
ENSMUST00000068791.4
eukaryotic translation initiation factor 2D
chr3_+_89773562 0.06 ENSMUST00000038356.8
ubiquitin-conjugating enzyme E2Q (putative) 1
chr8_-_57652993 0.06 ENSMUST00000110316.2
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr4_-_41314877 0.05 ENSMUST00000030145.8
DDB1 and CUL4 associated factor 12
chr7_+_44052290 0.05 ENSMUST00000079859.5
kallikrein 1-related peptidase b27
chr3_-_144849301 0.05 ENSMUST00000159989.1
chloride channel calcium activated 4
chr5_-_76905463 0.05 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
aminoadipate-semialdehyde dehydrogenase
chr9_+_44334685 0.05 ENSMUST00000052686.2
H2A histone family, member X
chr3_+_130617448 0.04 ENSMUST00000166187.1
ENSMUST00000072271.6
ethanolamine phosphate phospholyase
chr3_-_100685431 0.04 ENSMUST00000008907.7
mannosidase, alpha, class 1A, member 2
chr13_+_23782572 0.04 ENSMUST00000074067.2
tripartite motif-containing 38
chr2_-_45110336 0.04 ENSMUST00000028229.6
ENSMUST00000152232.1
zinc finger E-box binding homeobox 2
chr3_-_83049797 0.04 ENSMUST00000048246.3
fibrinogen beta chain
chr3_+_106113229 0.04 ENSMUST00000079132.5
ENSMUST00000139086.1
chitinase, acidic
chr7_-_28372233 0.03 ENSMUST00000094644.4
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_+_121953213 0.03 ENSMUST00000037958.7
ENSMUST00000128366.1
Rho GTPase activating protein 29
chr13_+_4574075 0.03 ENSMUST00000021628.3
aldo-keto reductase family 1, member C21
chr13_+_5861489 0.03 ENSMUST00000000080.6
Kruppel-like factor 6
chr4_-_136898803 0.03 ENSMUST00000046285.5
complement component 1, q subcomponent, alpha polypeptide
chr7_-_28372494 0.03 ENSMUST00000119990.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr2_-_110305730 0.03 ENSMUST00000046233.2
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
chr10_-_4432312 0.03 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr18_+_23415400 0.03 ENSMUST00000115832.2
ENSMUST00000047954.7
dystrobrevin alpha
chr10_+_24076500 0.03 ENSMUST00000051133.5
trace amine-associated receptor 8A
chr14_+_54625305 0.02 ENSMUST00000097177.4
proteasome (prosome, macropain) subunit, beta type, 11
chr9_+_58129321 0.02 ENSMUST00000034880.3
stimulated by retinoic acid gene 6
chr5_+_34336289 0.02 ENSMUST00000182709.1
ENSMUST00000030992.6
ring finger protein 4
chr2_+_131491764 0.02 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
spermine oxidase
chr3_-_64719602 0.01 ENSMUST00000168072.1
vomeronasal 2, receptor 7
chr14_-_46831984 0.01 ENSMUST00000181311.1
ENSMUST00000074862.2
predicted gene 10101
chr1_+_6487231 0.01 ENSMUST00000140079.1
ENSMUST00000131494.1
suppression of tumorigenicity 18
chr11_-_109995775 0.01 ENSMUST00000020948.8
ATP-binding cassette, sub-family A (ABC1), member 8b
chr6_+_11926758 0.01 ENSMUST00000133776.1
PHD finger protein 14
chr5_-_35105691 0.01 ENSMUST00000030986.8
low density lipoprotein receptor-related protein associated protein 1
chr11_+_98798653 0.01 ENSMUST00000037930.6
male-specific lethal 1 homolog (Drosophila)
chr12_-_73047179 0.01 ENSMUST00000050029.7
sine oculis-related homeobox 1
chrX_-_157415286 0.01 ENSMUST00000079945.4
ENSMUST00000138396.1
phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)
chr8_+_72219726 0.01 ENSMUST00000003123.8
family with sequence similarity 32, member A
chr11_+_32226481 0.00 ENSMUST00000020528.7
N-methylpurine-DNA glycosylase
chr3_+_76075583 0.00 ENSMUST00000160261.1
follistatin-like 5
chr1_-_59161594 0.00 ENSMUST00000078874.7
ENSMUST00000066374.7
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr4_+_53011916 0.00 ENSMUST00000107665.3
nipsnap homolog 3B (C. elegans)
chr4_+_19818722 0.00 ENSMUST00000035890.7
solute carrier family 7, (cationic amino acid transporter, y+ system) member 13

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.2 0.5 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.3 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.4 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.5 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.0 0.1 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.7 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.4 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.0 0.1 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0 0.2 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 2.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.0 GO:0070401 NADP+ binding(GO:0070401) lithocholic acid binding(GO:1902121)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling