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2D miR_HR1_12
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Results for Ascl2
Z-value: 2.04
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Transcription factors associated with Ascl2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ascl2 | mm10_v2_chr7_-_142969238_142969264 | -0.60 | 4.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_128206346 Show fit | 5.87 |
ENSMUST00000033049.7
|
cytochrome c oxidase subunit VIa polypeptide 2 |
|
| chr14_+_33923582 Show fit | 4.43 |
ENSMUST00000168727.1
|
growth differentiation factor 10 |
|
| chr11_-_120648104 Show fit | 4.28 |
ENSMUST00000026134.2
|
myeloid-associated differentiation marker-like 2 |
|
| chr11_+_69965396 Show fit | 3.92 |
ENSMUST00000018713.6
|
claudin 7 |
|
| chr12_-_17176888 Show fit | 3.82 |
ENSMUST00000170580.1
|
potassium voltage-gated channel, subfamily F, member 1 |
|
| chr10_+_127866457 Show fit | 3.59 |
ENSMUST00000092058.3
|
cDNA sequence BC089597 |
|
| chr1_+_120340569 Show fit | 3.32 |
ENSMUST00000037286.8
|
complement component 1, q subcomponent-like 2 |
|
| chr7_-_143074037 Show fit | 2.98 |
ENSMUST00000136602.1
|
transient receptor potential cation channel, subfamily M, member 5 |
|
| chr2_-_25196759 Show fit | 2.84 |
ENSMUST00000081869.6
|
torsin family 4, member A |
|
| chr4_-_138367966 Show fit | 2.74 |
ENSMUST00000030535.3
|
cytidine deaminase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ascl2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.1 | GO:1904219 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.5 | 5.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 4.2 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862) |
| 0.2 | 3.9 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.5 | 3.2 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.1 | 3.0 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.9 | 2.7 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.0 | 2.7 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.4 | 2.6 | GO:0098728 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.3 | 2.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 5.9 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.4 | 4.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 3.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.4 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 2.1 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 6.1 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.2 | 5.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.3 | 4.5 | GO:0019203 | carbohydrate phosphatase activity(GO:0019203) |
| 0.0 | 4.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 4.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 3.6 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.8 | 3.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 2.9 | GO:0005272 | sodium channel activity(GO:0005272) |
| 0.5 | 2.7 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 3.2 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.2 | 3.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 2.7 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 2.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 2.5 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 5.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 2.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.7 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 2.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 2.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 2.2 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |