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2D miR_HR1_12
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Results for Chd1_Pml
Z-value: 2.59
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Transcription factors associated with Chd1_Pml
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Chd1 | mm10_v2_chr17_+_15704963_15704994 | -0.41 | 1.8e-01 | Click! |
| Pml | mm10_v2_chr9_-_58249702_58249791 | 0.21 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_71963713 Show fit | 5.61 |
ENSMUST00000077337.8
|
Iroquois related homeobox 1 (Drosophila) |
|
| chr11_+_120530688 Show fit | 5.21 |
ENSMUST00000026119.7
|
glucagon receptor |
|
| chr17_+_8801742 Show fit | 4.57 |
ENSMUST00000089085.2
|
phosphodiesterase 10A |
|
| chr4_+_137277489 Show fit | 4.54 |
ENSMUST00000045747.4
|
wingless-related MMTV integration site 4 |
|
| chr15_+_87625214 Show fit | 4.47 |
ENSMUST00000068088.6
|
family with sequence similarity 19, member A5 |
|
| chr12_-_84698769 Show fit | 4.42 |
ENSMUST00000095550.2
|
synapse differentiation inducing 1 like |
|
| chr11_-_119086221 Show fit | 4.38 |
ENSMUST00000026665.7
|
chromobox 4 |
|
| chr2_+_130295148 Show fit | 4.36 |
ENSMUST00000110288.2
|
early B cell factor 4 |
|
| chr13_+_48968287 Show fit | 4.05 |
ENSMUST00000180775.1
|
family with sequence similarity 120A opposite strand |
|
| chr5_+_30588078 Show fit | 4.05 |
ENSMUST00000066295.2
|
potassium channel, subfamily K, member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Chd1_Pml
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 1.9 | 7.7 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.2 | 7.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.5 | 6.1 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 1.0 | 5.9 | GO:0032439 | endosome localization(GO:0032439) |
| 0.8 | 5.9 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.6 | 5.9 | GO:0032811 | negative regulation of epinephrine secretion(GO:0032811) |
| 0.1 | 5.6 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.4 | 5.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.3 | 5.3 | GO:0007413 | axonal fasciculation(GO:0007413) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 56.8 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 43.2 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.4 | 13.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 8.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 7.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 7.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 7.1 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.4 | 7.0 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 6.4 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.4 | 6.2 | GO:0045179 | apical cortex(GO:0045179) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.2 | 10.5 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 10.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 8.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 8.5 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.2 | 8.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.3 | 6.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 1.5 | 5.9 | GO:0004104 | cholinesterase activity(GO:0004104) |
| 0.8 | 5.6 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 5.3 | GO:0005158 | insulin receptor binding(GO:0005158) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.2 | 9.1 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 7.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 7.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 6.5 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 5.5 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 5.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 5.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 5.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.2 | 5.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.9 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.2 | 8.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 8.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 7.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 7.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 7.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.3 | 7.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 6.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 6.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.4 | 6.2 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |