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2D miR_HR1_12
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Results for Etv1_Etv5_Gabpa
Z-value: 3.65
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Transcription factors associated with Etv1_Etv5_Gabpa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Etv5 | mm10_v2_chr16_-_22439719_22439733 | -0.86 | 3.9e-04 | Click! |
| Gabpa | mm10_v2_chr16_+_84835070_84835124 | 0.83 | 7.8e-04 | Click! |
| Etv1 | mm10_v2_chr12_+_38780817_38780854 | 0.47 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv1_Etv5_Gabpa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 93.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.5 | 50.7 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.2 | 43.1 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 2.4 | 42.6 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.5 | 41.9 | GO:0006413 | translational initiation(GO:0006413) |
| 1.0 | 33.6 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.9 | 31.6 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.3 | 29.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.2 | 29.4 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.2 | 28.9 | GO:0007059 | chromosome segregation(GO:0007059) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 111.1 | GO:0005730 | nucleolus(GO:0005730) |
| 1.3 | 95.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.3 | 63.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.3 | 42.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.5 | 40.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 1.0 | 36.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 1.1 | 35.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 34.1 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.6 | 32.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 2.4 | 28.9 | GO:0005687 | U4 snRNP(GO:0005687) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 130.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 114.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 56.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.9 | 42.8 | GO:0019843 | rRNA binding(GO:0019843) |
| 3.1 | 28.3 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.9 | 26.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.4 | 26.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.8 | 24.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.3 | 24.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.4 | 21.7 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 45.1 | PID ATR PATHWAY | ATR signaling pathway |
| 1.0 | 44.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.7 | 30.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 24.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 23.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 17.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 11.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 8.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 7.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 7.6 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 74.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.1 | 74.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.5 | 45.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.4 | 39.1 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 1.4 | 36.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.1 | 36.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.7 | 33.7 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.4 | 29.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.5 | 29.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.8 | 28.2 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |