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2D miR_HR1_12
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Results for Ezh2_Atf2_Ikzf1
Z-value: 1.69
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Transcription factors associated with Ezh2_Atf2_Ikzf1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000029687.10 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
| ENSMUSG00000027104.12 | activating transcription factor 2 | |
| ENSMUSG00000018654.11 | IKAROS family zinc finger 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ezh2 | mm10_v2_chr6_-_47594967_47595047 | -0.87 | 2.1e-04 | Click! |
| Ikzf1 | mm10_v2_chr11_+_11684967_11685027 | -0.71 | 1.0e-02 | Click! |
| Atf2 | mm10_v2_chr2_-_73892530_73892555 | -0.55 | 6.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ezh2_Atf2_Ikzf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 5.3 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 4.1 | GO:0046688 | response to copper ion(GO:0046688) |
| 0.1 | 4.1 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 3.5 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.4 | 2.7 | GO:1903278 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) |
| 0.6 | 2.6 | GO:0015801 | aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827) |
| 0.1 | 2.5 | GO:0055078 | sodium ion homeostasis(GO:0055078) |
| 0.0 | 2.5 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
| 0.3 | 2.3 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 3.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 3.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 2.7 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 2.6 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 2.6 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 2.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 2.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.1 | 2.2 | GO:0008305 | integrin complex(GO:0008305) |
| 0.0 | 2.2 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 4.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.6 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 2.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 2.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 2.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.6 | 2.6 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.4 | 2.6 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.1 | 2.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 2.2 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 3.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.7 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 2.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.4 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 2.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 2.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 3.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 3.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 2.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 2.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 2.3 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |