ISMARA results: Foxp1

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2D miR_HR1_12

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Results for Foxp1_Foxj2

Z-value: 1.41

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Transcription factors associated with Foxp1_Foxj2

Gene Symbol	Gene ID	Gene Info
Foxp1 Ensembl NCBI MGI UniProt	ENSMUSG00000030067.11	forkhead box P1
Foxj2 Ensembl NCBI MGI UniProt	ENSMUSG00000003154.9	forkhead box J2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Foxp1	mm10_v2_chr6_-_99266494_99266540	-0.45	1.4e-01	Click!
Foxj2	mm10_v2_chr6_+_122819888_122819938	0.23	4.7e-01	Click!

Activity profile of Foxp1_Foxj2 motif

Sorted Z-values of Foxp1_Foxj2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_164140447 Show fit	4.35	ENSMUST00000073973.4	Ace2 Ensembl NCBI MGI UniProt Show fit	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr16_-_22439719 Show fit	3.35	ENSMUST00000079601.6	Etv5 Ensembl NCBI MGI UniProt Show fit	ets variant gene 5
chr7_-_101869307 Show fit	3.19	ENSMUST00000140584.1 ENSMUST00000134145.1	Folr1 Ensembl NCBI MGI UniProt Show fit	folate receptor 1 (adult)
chr14_-_55560340 Show fit	2.66	ENSMUST00000066106.3	A730061H03Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA A730061H03 gene
chr16_-_22439570 Show fit	2.53	ENSMUST00000170393.1	Etv5 Ensembl NCBI MGI UniProt Show fit	ets variant gene 5
chr19_+_5406815 Show fit	2.52	ENSMUST00000174412.1 ENSMUST00000153017.2	4930481A15Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 4930481A15 gene
chr6_-_5496296 Show fit	2.12	ENSMUST00000019721.4	Pdk4 Ensembl NCBI MGI UniProt Show fit	pyruvate dehydrogenase kinase, isoenzyme 4
chr15_-_101850778 Show fit	2.09	ENSMUST00000023790.3	Krt1 Ensembl NCBI MGI UniProt Show fit	keratin 1
chr4_-_138725262 Show fit	2.09	ENSMUST00000105811.2	Ubxn10 Ensembl NCBI MGI UniProt Show fit	UBX domain protein 10
chr14_+_55560480 Show fit	2.03	ENSMUST00000121622.1 ENSMUST00000143431.1 ENSMUST00000150481.1	Dcaf11 Ensembl NCBI MGI UniProt Show fit	DDB1 and CUL4 associated factor 11

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp1_Foxj2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	5.7	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.4	5.6	GO:0015827	aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.7	3.6	GO:0031438	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.5	3.4	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.3	3.4	GO:0070842	aggresome assembly(GO:0070842)
0.3	3.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.4	3.2	GO:0003147	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.1	2.5	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1	2.2	GO:0061436	establishment of skin barrier(GO:0061436)
0.5	2.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)

Showing 1 to 10 of 379 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	4.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.5	3.7	GO:0005579	membrane attack complex(GO:0005579)
0.0	3.5	GO:0005802	trans-Golgi network(GO:0005802)
0.1	3.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	3.0	GO:0045211	postsynaptic membrane(GO:0045211)
0.0	2.7	GO:0005930	axoneme(GO:0005930)
0.1	2.4	GO:0030992	intraciliary transport particle B(GO:0030992)
0.2	2.1	GO:0001533	cornified envelope(GO:0001533)
0.1	2.1	GO:0045095	keratin filament(GO:0045095)

Showing 1 to 10 of 127 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	5.6	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	5.0	GO:0003924	GTPase activity(GO:0003924)
0.6	3.6	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.3	3.2	GO:0051870	methotrexate binding(GO:0051870)
0.4	3.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.7	2.7	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.1	2.6	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	2.3	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	2.2	GO:0031490	chromatin DNA binding(GO:0031490)
0.7	2.1	GO:0030280	structural constituent of epidermis(GO:0030280)

Showing 1 to 10 of 227 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	3.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	2.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	2.4	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	2.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	2.1	PID MYC PATHWAY	C-MYC pathway
0.0	1.6	PID FOXO PATHWAY	FoxO family signaling
0.0	1.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.4	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	1.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	3.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2	2.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	1.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	1.7	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	1.7	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	1.7	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	1.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	1.5	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	1.5	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway

Showing 1 to 10 of 83 entries

Results for Foxp1_Foxj2

Z-value: 1.41

Motif logo

Transcription factors associated with Foxp1_Foxj2

Activity-expression correlation:

Activity profile of Foxp1_Foxj2 motif

Sorted Z-values of Foxp1_Foxj2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxp1_Foxj2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: