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2D miR_HR1_12
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Results for Gata2_Gata1
Z-value: 1.75
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Transcription factors associated with Gata2_Gata1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gata2 | mm10_v2_chr6_+_88198656_88198675 | 0.19 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_58670358 Show fit | 5.40 |
ENSMUST00000057270.7
|
pancreatic lipase |
|
| chr2_+_164403194 Show fit | 4.93 |
ENSMUST00000017151.1
|
recombination signal binding protein for immunoglobulin kappa J region-like |
|
| chr6_+_30639218 Show fit | 4.86 |
ENSMUST00000031806.9
|
carboxypeptidase A1, pancreatic |
|
| chr5_+_115466234 Show fit | 4.01 |
ENSMUST00000145785.1
ENSMUST00000031495.4 ENSMUST00000112071.1 ENSMUST00000125568.1 |
phospholipase A2, group IB, pancreas |
|
| chr6_+_30541582 Show fit | 4.01 |
ENSMUST00000096066.4
|
carboxypeptidase A2, pancreatic |
|
| chr17_-_26199008 Show fit | 3.89 |
ENSMUST00000142410.1
ENSMUST00000120333.1 ENSMUST00000039113.7 |
protein disulfide isomerase associated 2 |
|
| chr6_-_136922169 Show fit | 3.76 |
ENSMUST00000032343.6
|
endoplasmic reticulum protein 27 |
|
| chr6_+_41392356 Show fit | 3.76 |
ENSMUST00000049079.7
|
predicted gene 5771 |
|
| chr6_+_41302265 Show fit | 3.47 |
ENSMUST00000031913.4
|
trypsin 4 |
|
| chr9_+_46228580 Show fit | 3.31 |
ENSMUST00000034588.8
|
apolipoprotein A-I |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gata2_Gata1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.4 | GO:0007586 | digestion(GO:0007586) |
| 0.8 | 10.3 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) |
| 0.6 | 5.6 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.4 | 4.5 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.1 | 4.1 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 1.3 | 4.0 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 0.1 | 3.5 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) |
| 0.0 | 3.4 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.5 | 3.2 | GO:0060586 | multicellular organismal iron ion homeostasis(GO:0060586) |
| 0.0 | 3.1 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 4.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 3.3 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 3.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 2.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 2.6 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.6 | 2.4 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.2 | 2.2 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 2.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.5 | 1.6 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 10.1 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 10.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.2 | 5.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.3 | 5.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 4.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 4.0 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.4 | 3.9 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.8 | 3.3 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 3.2 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.7 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.7 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.3 | 5.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 4.9 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 4.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 4.0 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.2 | 3.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.7 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 1.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 1.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 1.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |