ISMARA results: Hnf1b

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2D miR_HR1_12

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Results for Hnf1b

Z-value: 1.23

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Transcription factors associated with Hnf1b

Gene Symbol	Gene ID	Gene Info
Hnf1b Ensembl NCBI MGI UniProt	ENSMUSG00000020679.5	HNF1 homeobox B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1b	mm10_v2_chr11_+_83852135_83852242	-0.35	2.7e-01	Click!

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_158814469 Show fit	5.09	ENSMUST00000161589.2	Pappa2 Ensembl NCBI MGI UniProt Show fit	pappalysin 2
chr7_+_30493622 Show fit	2.04	ENSMUST00000058280.6 ENSMUST00000133318.1 ENSMUST00000142575.1 ENSMUST00000131040.1	Prodh2 Ensembl NCBI MGI UniProt Show fit	proline dehydrogenase (oxidase) 2
chr5_+_90518932 Show fit	1.77	ENSMUST00000113179.2 ENSMUST00000128740.1	Afm Ensembl NCBI MGI UniProt Show fit	afamin
chr16_-_45492962 Show fit	1.72	ENSMUST00000114585.2	Gm609 Ensembl NCBI MGI UniProt Show fit	predicted gene 609
chr3_+_115080965 Show fit	1.56	ENSMUST00000051309.8	Olfm3 Ensembl NCBI MGI UniProt Show fit	olfactomedin 3
chrX_+_52791179 Show fit	1.49	ENSMUST00000101588.1	Ccdc160 Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 160
chrX_+_164140447 Show fit	1.49	ENSMUST00000073973.4	Ace2 Ensembl NCBI MGI UniProt Show fit	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr6_-_52183828 Show fit	1.46	ENSMUST00000134831.1	Hoxa3 Ensembl NCBI MGI UniProt Show fit	homeobox A3
chr13_-_53286052 Show fit	1.45	ENSMUST00000021918.8	Ror2 Ensembl NCBI MGI UniProt Show fit	receptor tyrosine kinase-like orphan receptor 2
chr13_+_89540636 Show fit	1.43	ENSMUST00000022108.7	Hapln1 Ensembl NCBI MGI UniProt Show fit	hyaluronan and proteoglycan link protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.5	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0	5.1	GO:0060349	bone morphogenesis(GO:0060349)
0.7	2.0	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.6	1.7	GO:1903903	regulation of establishment of T cell polarity(GO:1903903)
0.6	1.7	GO:0033189	response to vitamin A(GO:0033189)
0.0	1.7	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4	1.5	GO:0015827	aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.3	1.5	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2	1.5	GO:0021615	specification of organ position(GO:0010159) glossopharyngeal nerve morphogenesis(GO:0021615)
0.2	1.5	GO:0019375	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)

Showing 1 to 10 of 90 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	GO:0005923	bicellular tight junction(GO:0005923)
0.1	1.7	GO:0001931	uropod(GO:0001931) flotillin complex(GO:0016600) cell trailing edge(GO:0031254)
0.0	1.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.2	1.4	GO:0071438	invadopodium membrane(GO:0071438)
0.1	1.4	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	1.2	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	1.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	1.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	1.0	GO:0031526	brush border membrane(GO:0031526)
0.1	0.8	GO:0046581	intercellular canaliculus(GO:0046581)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.8	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	4.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.4	GO:0030165	PDZ domain binding(GO:0030165)
0.1	2.0	GO:0071949	FAD binding(GO:0071949)
0.0	1.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	1.8	GO:0008431	vitamin E binding(GO:0008431)
0.4	1.8	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.3	1.8	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	1.7	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	1.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.3	PID P73PATHWAY	p73 transcription factor network
0.1	1.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	1.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.9	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.6	PID FGF PATHWAY	FGF signaling pathway
0.0	0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	PID CONE PATHWAY	Visual signal transduction: Cones

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	3.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	1.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	1.4	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	1.3	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.0	1.0	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	1.0	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	0.9	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.9	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Showing 1 to 10 of 26 entries

Results for Hnf1b

Z-value: 1.23

Motif logo

Transcription factors associated with Hnf1b

Activity-expression correlation:

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: