ISMARA results: Hnf4a

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2D miR_HR1_12

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Results for Hnf4a

Z-value: 2.48

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Transcription factors associated with Hnf4a

Gene Symbol	Gene ID	Gene Info
Hnf4a Ensembl NCBI MGI UniProt	ENSMUSG00000017950.10	hepatic nuclear factor 4, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf4a	mm10_v2_chr2_+_163547148_163547188	-0.62	3.2e-02	Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_122895072 Show fit	8.26	ENSMUST00000023820.5	Fabp2 Ensembl NCBI MGI UniProt Show fit	fatty acid binding protein 2, intestinal
chr9_+_46240696 Show fit	4.66	ENSMUST00000034585.6	Apoa4 Ensembl NCBI MGI UniProt Show fit	apolipoprotein A-IV
chr18_+_21072329 Show fit	4.45	ENSMUST00000082235.4	Mep1b Ensembl NCBI MGI UniProt Show fit	meprin 1 beta
chr2_+_174760619 Show fit	3.55	ENSMUST00000029030.2	Edn3 Ensembl NCBI MGI UniProt Show fit	endothelin 3
chr4_+_118527229 Show fit	3.51	ENSMUST00000030261.5	2610528J11Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2610528J11 gene
chr1_-_87101590 Show fit	3.37	ENSMUST00000113270.2	Alpi Ensembl NCBI MGI UniProt Show fit	alkaline phosphatase, intestinal
chr15_-_78855517 Show fit	3.30	ENSMUST00000044584.4	Lgals2 Ensembl NCBI MGI UniProt Show fit	lectin, galactose-binding, soluble 2
chr11_-_3931960 Show fit	3.20	ENSMUST00000109990.1 ENSMUST00000020710.4 ENSMUST00000109989.3 ENSMUST00000109991.1 ENSMUST00000109993.2	Tcn2 Ensembl NCBI MGI UniProt Show fit	transcobalamin 2
chr11_-_3931789 Show fit	2.97	ENSMUST00000109992.1 ENSMUST00000109988.1	Tcn2 Ensembl NCBI MGI UniProt Show fit	transcobalamin 2
chr6_+_71199827 Show fit	2.80	ENSMUST00000067492.7	Fabp1 Ensembl NCBI MGI UniProt Show fit	fatty acid binding protein 1, liver

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.6	GO:0050892	intestinal absorption(GO:0050892)
1.1	6.7	GO:0015889	cobalamin transport(GO:0015889)
1.0	6.2	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826)
0.5	5.6	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.3	5.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
1.6	4.7	GO:0034443	regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) multicellular organism lipid catabolic process(GO:0044240)
0.5	4.6	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.1	4.5	GO:1901998	toxin transport(GO:1901998)
0.1	4.5	GO:0007566	embryo implantation(GO:0007566)
0.0	4.5	GO:0046889	positive regulation of lipid biosynthetic process(GO:0046889)

Showing 1 to 10 of 132 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	11.1	GO:0045179	apical cortex(GO:0045179)
0.4	6.9	GO:0042627	chylomicron(GO:0042627)
0.0	4.5	GO:0005814	centriole(GO:0005814)
0.1	4.1	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	4.1	GO:0005811	lipid particle(GO:0005811)
0.2	3.6	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	3.4	GO:0009897	external side of plasma membrane(GO:0009897)
0.4	3.2	GO:0097427	microtubule bundle(GO:0097427)
0.0	2.7	GO:0070382	exocytic vesicle(GO:0070382)
0.0	2.6	GO:0005903	brush border(GO:0005903)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	12.6	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.7	6.7	GO:0031419	cobalamin binding(GO:0031419)
1.6	6.2	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	5.7	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.7	4.6	GO:0016936	galactoside binding(GO:0016936)
0.8	4.2	GO:0008453	alanine-glyoxylate transaminase activity(GO:0008453)
0.6	3.5	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.6	3.4	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	3.4	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.2	3.3	GO:0070330	aromatase activity(GO:0070330)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	6.6	PID ENDOTHELIN PATHWAY	Endothelins
0.0	5.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	4.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	2.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	2.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	2.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	2.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	1.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.6	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	7.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.3	5.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.9	2.6	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	2.5	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	2.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	2.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	2.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	2.4	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.0	2.4	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing

Showing 1 to 10 of 45 entries

Results for Hnf4a

Z-value: 2.48

Motif logo

Transcription factors associated with Hnf4a

Activity-expression correlation:

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: