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2D miR_HR1_12
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Results for Nrf1
Z-value: 6.16
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm10_v2_chr6_+_30047979_30048049 | 0.94 | 6.4e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 38.2 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.6 | 25.2 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 21.4 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.4 | 18.6 | GO:0019985 | translesion synthesis(GO:0019985) |
| 2.9 | 17.7 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 0.1 | 15.4 | GO:0000377 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 3.8 | 15.3 | GO:0051316 | attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316) |
| 0.2 | 14.7 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 2.0 | 14.2 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 3.5 | 14.1 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 64.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 55.5 | GO:0000776 | kinetochore(GO:0000776) |
| 0.3 | 41.8 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.6 | 27.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 25.9 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 1.8 | 23.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 17.9 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.6 | 17.7 | GO:0005642 | annulate lamellae(GO:0005642) |
| 3.5 | 17.4 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 2.4 | 14.7 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 75.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.2 | 36.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 30.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.3 | 26.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 1.1 | 26.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 2.9 | 23.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.8 | 22.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.3 | 19.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.9 | 17.4 | GO:0002135 | CTP binding(GO:0002135) |
| 0.2 | 17.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 54.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 29.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 22.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.0 | 17.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 15.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 9.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 7.8 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 7.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 6.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 6.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 92.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.4 | 31.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 26.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.0 | 22.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 20.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 1.4 | 20.4 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 1.0 | 20.1 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.3 | 18.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 18.3 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.5 | 17.0 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |