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2D miR_HR1_12
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Results for Rela_Rel_Nfkb1
Z-value: 1.94
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Transcription factors associated with Rela_Rel_Nfkb1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSMUSG00000024927.7 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | |
| ENSMUSG00000020275.8 | reticuloendotheliosis oncogene | |
| ENSMUSG00000028163.11 | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rela | mm10_v2_chr19_+_5637475_5637486 | -0.72 | 8.8e-03 | Click! |
| Rel | mm10_v2_chr11_-_23770953_23771028 | -0.54 | 6.9e-02 | Click! |
| Nfkb1 | mm10_v2_chr3_-_135691512_135691564 | -0.40 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_165234689 Show fit | 3.73 |
ENSMUST00000065438.6
|
cadherin 22 |
|
| chr1_+_193301953 Show fit | 3.61 |
ENSMUST00000016315.9
|
laminin, beta 3 |
|
| chr4_+_150927918 Show fit | 3.44 |
ENSMUST00000139826.1
ENSMUST00000116257.1 |
tumor necrosis factor receptor superfamily, member 9 |
|
| chr10_+_79664553 Show fit | 3.23 |
ENSMUST00000020554.6
|
mucosal vascular addressin cell adhesion molecule 1 |
|
| chr7_+_99535439 Show fit | 2.85 |
ENSMUST00000098266.2
ENSMUST00000179755.1 |
arrestin, beta 1 |
|
| chr9_-_7873157 Show fit | 2.51 |
ENSMUST00000159323.1
ENSMUST00000115673.2 |
baculoviral IAP repeat-containing 3 |
|
| chr4_+_100776664 Show fit | 2.40 |
ENSMUST00000030257.8
ENSMUST00000097955.2 |
cache domain containing 1 |
|
| chr12_+_79130777 Show fit | 2.34 |
ENSMUST00000021550.6
|
arginase type II |
|
| chr7_+_28766747 Show fit | 2.33 |
ENSMUST00000170068.1
ENSMUST00000072965.4 |
sirtuin 2 |
|
| chr19_+_6341121 Show fit | 2.26 |
ENSMUST00000025897.6
ENSMUST00000130382.1 |
mitogen-activated protein kinase kinase kinase kinase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rela_Rel_Nfkb1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.2 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.1 | 5.7 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.8 | 5.0 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.2 | 4.8 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 4.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.8 | 4.1 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.5 | 3.8 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.1 | 3.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.9 | 3.4 | GO:2001183 | negative regulation of interleukin-12 secretion(GO:2001183) |
| 0.0 | 3.4 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 8.0 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.3 | 4.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 4.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.3 | 4.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.9 | 3.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 2.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 2.4 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.0 | 2.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 6.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 5.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 5.1 | GO:0005178 | integrin binding(GO:0005178) |
| 1.7 | 5.0 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.0 | 4.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 4.0 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 3.6 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 3.3 | GO:0001968 | fibronectin binding(GO:0001968) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.7 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 6.6 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 5.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 5.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 5.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 4.5 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.3 | 3.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 3.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 2.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 2.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 6.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 5.8 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 5.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 5.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 4.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 3.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 3.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 2.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |