ISMARA results: Rfx2

Project

2D miR_HR1_12

Navigation

Downloads

Results for Rfx2_Rfx7

Z-value: 1.79

Motif logo

Transcription factors associated with Rfx2_Rfx7

Gene Symbol	Gene ID	Gene Info
Rfx2 Ensembl NCBI MGI UniProt	ENSMUSG00000024206.8	regulatory factor X, 2 (influences HLA class II expression)
Rfx7 Ensembl NCBI MGI UniProt	ENSMUSG00000037674.9	regulatory factor X, 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rfx7	mm10_v2_chr9_+_72532214_72532271	-0.53	7.8e-02	Click!
Rfx2	mm10_v2_chr17_-_56830916_56831008	0.06	8.6e-01	Click!

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_44468051 Show fit	3.53	ENSMUST00000118493.1	Josd2 Ensembl NCBI MGI UniProt Show fit	Josephin domain containing 2
chr2_-_3419019 Show fit	3.39	ENSMUST00000115084.1 ENSMUST00000115083.1	Meig1 Ensembl NCBI MGI UniProt Show fit	meiosis expressed gene 1
chr1_-_10009098 Show fit	3.13	ENSMUST00000176398.1 ENSMUST00000027049.3	Ppp1r42 Ensembl NCBI MGI UniProt Show fit	protein phosphatase 1, regulatory subunit 42
chr17_+_24696234 Show fit	3.10	ENSMUST00000019464.7	Noxo1 Ensembl NCBI MGI UniProt Show fit	NADPH oxidase organizer 1
chr2_-_3419066 Show fit	2.97	ENSMUST00000115082.3	Meig1 Ensembl NCBI MGI UniProt Show fit	meiosis expressed gene 1
chr2_-_28466266 Show fit	2.81	ENSMUST00000127683.1 ENSMUST00000086370.4	1700007K13Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 1700007K13 gene
chr2_-_152831665 Show fit	2.77	ENSMUST00000156688.1 ENSMUST00000007803.5	Bcl2l1 Ensembl NCBI MGI UniProt Show fit	BCL2-like 1
chr11_+_114727384 Show fit	2.72	ENSMUST00000069325.7	Dnaic2 Ensembl NCBI MGI UniProt Show fit	dynein, axonemal, intermediate chain 2
chr7_+_44896125 Show fit	2.62	ENSMUST00000166552.1 ENSMUST00000168207.1	Fuz Ensembl NCBI MGI UniProt Show fit	fuzzy homolog (Drosophila)
chr5_+_30466044 Show fit	2.52	ENSMUST00000031078.3 ENSMUST00000114743.1	1700001C02Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 1700001C02 gene

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	10.1	GO:0036159	inner dynein arm assembly(GO:0036159)
0.1	7.9	GO:0016579	protein deubiquitination(GO:0016579)
0.5	6.9	GO:0070286	axonemal dynein complex assembly(GO:0070286)
1.2	4.9	GO:0046898	response to cycloheximide(GO:0046898)
1.5	4.6	GO:2000314	negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1	4.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	3.1	GO:0010921	regulation of phosphatase activity(GO:0010921)
0.1	2.4	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.5	2.0	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.5	1.9	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.1	GO:0036157	outer dynein arm(GO:0036157)
0.4	4.9	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.3	3.3	GO:0002177	manchette(GO:0002177)
0.3	3.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.4	1.8	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3	1.7	GO:1990769	proximal neuron projection(GO:1990769)
0.0	1.7	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.2	1.6	GO:0036156	inner dynein arm(GO:0036156)
0.2	1.5	GO:1990075	periciliary membrane compartment(GO:1990075)
0.0	1.5	GO:0008305	integrin complex(GO:0008305)

Showing 1 to 10 of 55 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.5	4.9	GO:0051434	BH3 domain binding(GO:0051434)
0.2	4.4	GO:0045504	dynein heavy chain binding(GO:0045504)
0.3	3.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	3.0	GO:0070840	dynein complex binding(GO:0070840)
0.1	2.9	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.0	2.9	GO:0030276	clathrin binding(GO:0030276)
0.0	2.9	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.0	2.1	GO:0030331	estrogen receptor binding(GO:0030331)
0.4	1.8	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)

Showing 1 to 10 of 77 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	2.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	2.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	2.1	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.1	1.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	1.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	1.0	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.9	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.7	ST G ALPHA S PATHWAY	G alpha s Pathway

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.9	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.1	1.8	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	1.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	1.2	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	1.2	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.0	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.7	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	0.6	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Showing 1 to 10 of 23 entries

Results for Rfx2_Rfx7

Z-value: 1.79

Motif logo

Transcription factors associated with Rfx2_Rfx7

Activity-expression correlation:

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: