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2D miR_HR1_12
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Results for Runx2_Bcl11a
Z-value: 1.88
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Transcription factors associated with Runx2_Bcl11a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bcl11a | mm10_v2_chr11_+_24078173_24078219 | -0.76 | 4.1e-03 | Click! |
| Runx2 | mm10_v2_chr17_-_44814581_44814595 | -0.49 | 1.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_109579056 Show fit | 4.84 |
ENSMUST00000074898.6
|
haptoglobin |
|
| chr10_-_81291227 Show fit | 3.01 |
ENSMUST00000045744.6
|
tight junction protein 3 |
|
| chr16_-_17838173 Show fit | 2.96 |
ENSMUST00000118960.1
|
carbonic anhydrase 15 |
|
| chr7_-_126676357 Show fit | 2.78 |
ENSMUST00000106371.1
ENSMUST00000106372.3 ENSMUST00000155419.1 |
sulfotransferase family 1A, phenol-preferring, member 1 |
|
| chr1_-_164935522 Show fit | 2.42 |
ENSMUST00000027860.7
|
chemokine (C motif) ligand 1 |
|
| chr15_+_9436028 Show fit | 2.33 |
ENSMUST00000042360.3
|
calcyphosine-like |
|
| chr7_-_126676428 Show fit | 2.28 |
ENSMUST00000106373.1
|
sulfotransferase family 1A, phenol-preferring, member 1 |
|
| chr13_+_89540636 Show fit | 2.17 |
ENSMUST00000022108.7
|
hyaluronan and proteoglycan link protein 1 |
|
| chrX_-_101734125 Show fit | 2.10 |
ENSMUST00000056614.6
|
chemokine (C-X-C motif) receptor 3 |
|
| chr7_+_80246375 Show fit | 2.05 |
ENSMUST00000058266.6
|
tubulin tyrosine ligase-like family, member 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Runx2_Bcl11a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.1 | GO:0051923 | sulfation(GO:0051923) |
| 1.5 | 4.5 | GO:2000295 | regulation of hydrogen peroxide catabolic process(GO:2000295) |
| 0.0 | 3.5 | GO:2000045 | regulation of G1/S transition of mitotic cell cycle(GO:2000045) |
| 0.5 | 3.3 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.0 | 2.9 | GO:0071661 | granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) |
| 0.2 | 2.9 | GO:1900118 | negative regulation of execution phase of apoptosis(GO:1900118) |
| 0.3 | 2.6 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 0.3 | 2.5 | GO:0015074 | DNA integration(GO:0015074) |
| 0.3 | 2.4 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.8 | 2.3 | GO:1904328 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 5.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 1.1 | 5.6 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 4.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 4.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 2.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.2 | 2.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 2.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 2.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.6 | 1.8 | GO:0070442 | integrin alphaIIb-beta3 complex(GO:0070442) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.1 | 5.6 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.7 | 5.1 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.0 | 4.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 3.3 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 3.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 2.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.3 | 2.5 | GO:0019158 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.2 | 2.3 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 2.3 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.5 | 5.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 3.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 3.3 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.1 | 3.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 2.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 2.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 1.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |