ISMARA results: Snai1_Zeb1

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2D miR_HR1_12

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Results for Snai1_Zeb1_Snai2

Z-value: 4.03

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Transcription factors associated with Snai1_Zeb1_Snai2

Gene Symbol	Gene ID	Gene Info
Snai1 Ensembl NCBI MGI UniProt	ENSMUSG00000042821.7	snail family zinc finger 1
Zeb1 Ensembl NCBI MGI UniProt	ENSMUSG00000024238.7	zinc finger E-box binding homeobox 1
Snai2 Ensembl NCBI MGI UniProt	ENSMUSG00000022676.6	snail family zinc finger 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zeb1	mm10_v2_chr18_+_5591860_5591902	-0.85	4.5e-04	Click!
Snai1	mm10_v2_chr2_+_167538192_167538210	-0.71	1.0e-02	Click!
Snai2	mm10_v2_chr16_+_14705832_14705858	-0.66	1.9e-02	Click!

Activity profile of Snai1_Zeb1_Snai2 motif

Sorted Z-values of Snai1_Zeb1_Snai2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_69965396 Show fit	31.14	ENSMUST00000018713.6	Cldn7 Ensembl NCBI MGI UniProt Show fit	claudin 7
chr11_+_68556186 Show fit	13.73	ENSMUST00000053211.6	Mfsd6l Ensembl NCBI MGI UniProt Show fit	major facilitator superfamily domain containing 6-like
chr11_+_69964758 Show fit	13.08	ENSMUST00000108597.1 ENSMUST00000060651.5 ENSMUST00000108596.1	Cldn7 Ensembl NCBI MGI UniProt Show fit	claudin 7
chr13_-_57907587 Show fit	12.27	ENSMUST00000172326.1	Spock1 Ensembl NCBI MGI UniProt Show fit	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr12_-_73546383 Show fit	12.03	ENSMUST00000042975.5	Tmem30b Ensembl NCBI MGI UniProt Show fit	transmembrane protein 30B
chr8_-_113848615 Show fit	10.15	ENSMUST00000093113.4	Adamts18 Ensembl NCBI MGI UniProt Show fit	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr7_-_143074037 Show fit	10.05	ENSMUST00000136602.1	Trpm5 Ensembl NCBI MGI UniProt Show fit	transient receptor potential cation channel, subfamily M, member 5
chr18_+_74442551 Show fit	9.09	ENSMUST00000121875.1	Myo5b Ensembl NCBI MGI UniProt Show fit	myosin VB
chr1_-_134234492 Show fit	8.81	ENSMUST00000169927.1	Adora1 Ensembl NCBI MGI UniProt Show fit	adenosine A1 receptor
chr2_+_180725263 Show fit	8.32	ENSMUST00000094218.3	Slc17a9 Ensembl NCBI MGI UniProt Show fit	solute carrier family 17, member 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Snai1_Zeb1_Snai2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	43.7	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
1.4	16.8	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
2.7	16.5	GO:0032439	endosome localization(GO:0032439)
0.5	16.4	GO:0050909	sensory perception of taste(GO:0050909)
0.9	15.2	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.3	12.4	GO:0061098	positive regulation of protein tyrosine kinase activity(GO:0061098)
1.1	12.3	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3	12.2	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
4.0	12.0	GO:0032242	positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.3	11.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)

Showing 1 to 10 of 967 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	117.0	GO:0016021	integral component of membrane(GO:0016021)
0.1	62.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	61.3	GO:0005615	extracellular space(GO:0005615)
1.7	43.8	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	22.3	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.5	19.3	GO:0030673	axolemma(GO:0030673)
1.1	15.6	GO:0045179	apical cortex(GO:0045179)
0.7	14.7	GO:0005922	connexon complex(GO:0005922)
0.1	14.2	GO:0070160	occluding junction(GO:0070160)
0.5	12.2	GO:0034706	sodium channel complex(GO:0034706)

Showing 1 to 10 of 294 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.2	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.1	24.1	GO:0008236	serine-type peptidase activity(GO:0008236)
0.3	18.6	GO:0005158	insulin receptor binding(GO:0005158)
1.6	18.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.5	17.0	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.3	15.0	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.2	13.8	GO:0005179	hormone activity(GO:0005179)
0.9	13.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.2	12.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.8	11.9	GO:0005243	gap junction channel activity(GO:0005243)

Showing 1 to 10 of 552 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	40.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	14.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	14.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	11.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	10.4	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	8.8	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	8.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	7.0	PID EPO PATHWAY	EPO signaling pathway
0.1	6.9	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.1	6.5	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 92 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	73.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	29.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
1.0	18.3	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.9	14.9	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	13.5	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.6	9.8	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.2	9.3	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.4	9.0	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.4	8.8	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.5	7.8	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin

Showing 1 to 10 of 146 entries

Results for Snai1_Zeb1_Snai2

Z-value: 4.03

Motif logo

Transcription factors associated with Snai1_Zeb1_Snai2

Activity-expression correlation:

Activity profile of Snai1_Zeb1_Snai2 motif

Sorted Z-values of Snai1_Zeb1_Snai2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Snai1_Zeb1_Snai2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: