ISMARA results: Tbp

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2D miR_HR1_12

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Results for Tbp

Z-value: 1.89

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Transcription factors associated with Tbp

Gene Symbol	Gene ID	Gene Info
Tbp Ensembl NCBI MGI UniProt	ENSMUSG00000014767.10	TATA box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbp	mm10_v2_chr17_+_15499888_15499960	-0.31	3.3e-01	Click!

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_41377604 Show fit	3.28	ENSMUST00000096003.5	Prss3 Ensembl NCBI MGI UniProt Show fit	protease, serine, 3
chr6_+_78370877 Show fit	3.16	ENSMUST00000096904.3	Reg3b Ensembl NCBI MGI UniProt Show fit	regenerating islet-derived 3 beta
chr3_-_90695706 Show fit	2.82	ENSMUST00000069960.5 ENSMUST00000117167.1	S100a9 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A9 (calgranulin B)
chr7_-_30924169 Show fit	2.71	ENSMUST00000074671.6	Hamp2 Ensembl NCBI MGI UniProt Show fit	hepcidin antimicrobial peptide 2
chr19_-_3414464 Show fit	2.59	ENSMUST00000025842.6	Gal Ensembl NCBI MGI UniProt Show fit	galanin
chr6_-_41314700 Show fit	2.45	ENSMUST00000064324.5	Try5 Ensembl NCBI MGI UniProt Show fit	trypsin 5
chr3_-_106167564 Show fit	2.16	ENSMUST00000063062.8	Chi3l3 Ensembl NCBI MGI UniProt Show fit	chitinase 3-like 3
chr6_+_41392356 Show fit	2.08	ENSMUST00000049079.7	Gm5771 Ensembl NCBI MGI UniProt Show fit	predicted gene 5771
chr16_+_48842552 Show fit	2.05	ENSMUST00000023329.4	Retnla Ensembl NCBI MGI UniProt Show fit	resistin like alpha
chr11_+_82101836 Show fit	1.96	ENSMUST00000000194.3	Ccl12 Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 12

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	GO:0007586	digestion(GO:0007586)
0.1	3.5	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.4	3.2	GO:1903207	neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
1.0	3.1	GO:0051464	positive regulation of cortisol secretion(GO:0051464)
0.9	2.8	GO:0070488	neutrophil aggregation(GO:0070488)
0.7	2.8	GO:0034757	negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.6	2.8	GO:0035747	natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1	2.2	GO:0019731	antibacterial humoral response(GO:0019731)
0.6	1.9	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.4	1.8	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)

Showing 1 to 10 of 119 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	40.8	GO:0005615	extracellular space(GO:0005615)
0.2	5.7	GO:0042588	zymogen granule(GO:0042588)
0.0	2.0	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.3	1.8	GO:0042629	mast cell granule(GO:0042629)
0.0	1.7	GO:0005902	microvillus(GO:0005902)
0.0	1.4	GO:0005882	intermediate filament(GO:0005882)
0.4	1.3	GO:0005584	collagen type I trimer(GO:0005584)
0.4	1.3	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.3	1.3	GO:0005833	hemoglobin complex(GO:0005833)
0.2	1.2	GO:0016012	sarcoglycan complex(GO:0016012)

Showing 1 to 10 of 42 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	6.3	GO:0005179	hormone activity(GO:0005179)
0.0	3.3	GO:0019838	growth factor binding(GO:0019838)
0.1	3.0	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.4	2.8	GO:0035662	Toll-like receptor 4 binding(GO:0035662) RAGE receptor binding(GO:0050786)
0.0	2.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.6	2.6	GO:0004966	galanin receptor activity(GO:0004966)
0.0	2.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	2.3	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.2	2.1	GO:0015250	water channel activity(GO:0015250)

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	2.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	2.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	2.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	2.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	2.1	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	2.0	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	1.8	PID AURORA B PATHWAY	Aurora B signaling
0.1	1.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	3.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	2.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	2.1	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	2.0	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	1.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	1.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	1.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)

Showing 1 to 10 of 38 entries

Results for Tbp

Z-value: 1.89

Motif logo

Transcription factors associated with Tbp

Activity-expression correlation:

Activity profile of Tbp motif

Sorted Z-values of Tbp motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbp

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: