ISMARA results: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41

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2D miR_HR1_12

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Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 2.50

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Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol	Gene ID	Gene Info
Tfeb Ensembl NCBI MGI UniProt	ENSMUSG00000023990.12	transcription factor EB
Usf1 Ensembl NCBI MGI UniProt	ENSMUSG00000026641.7	upstream transcription factor 1
Srebf1 Ensembl NCBI MGI UniProt	ENSMUSG00000020538.9	sterol regulatory element binding transcription factor 1
Usf2 Ensembl NCBI MGI UniProt	ENSMUSG00000058239.7	upstream transcription factor 2
Bhlhe41 Ensembl NCBI MGI UniProt	ENSMUSG00000030256.5	basic helix-loop-helix family, member e41
Srebf2 Ensembl NCBI MGI UniProt	ENSMUSG00000022463.7	sterol regulatory element binding factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Srebf2	mm10_v2_chr15_+_82147238_82147275	-0.55	6.4e-02	Click!
Tfeb	mm10_v2_chr17_+_47759175_47759245	-0.53	8.0e-02	Click!
Srebf1	mm10_v2_chr11_-_60210410_60210465	0.44	1.5e-01	Click!
Usf2	mm10_v2_chr7_-_30956742_30956803	-0.41	1.9e-01	Click!
Bhlhe41	mm10_v2_chr6_-_145865483_145865558	-0.35	2.7e-01	Click!
Usf1	mm10_v2_chr1_+_171411343_171411384	0.04	9.1e-01	Click!

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_13159135 Show fit	13.28	ENSMUST00000033824.6	Lamp1 Ensembl NCBI MGI UniProt Show fit	lysosomal-associated membrane protein 1
chr17_-_26939464 Show fit	10.22	ENSMUST00000025027.8 ENSMUST00000114935.1	Cuta Ensembl NCBI MGI UniProt Show fit	cutA divalent cation tolerance homolog (E. coli)
chr11_-_3931960 Show fit	6.75	ENSMUST00000109990.1 ENSMUST00000020710.4 ENSMUST00000109989.3 ENSMUST00000109991.1 ENSMUST00000109993.2	Tcn2 Ensembl NCBI MGI UniProt Show fit	transcobalamin 2
chr11_+_69991061 Show fit	6.52	ENSMUST00000018711.8	Gabarap Ensembl NCBI MGI UniProt Show fit	gamma-aminobutyric acid receptor associated protein
chr4_+_148039035 Show fit	6.16	ENSMUST00000097788.4	Mthfr Ensembl NCBI MGI UniProt Show fit	5,10-methylenetetrahydrofolate reductase
chr11_-_3931789 Show fit	6.13	ENSMUST00000109992.1 ENSMUST00000109988.1	Tcn2 Ensembl NCBI MGI UniProt Show fit	transcobalamin 2
chr5_+_137030275 Show fit	5.90	ENSMUST00000041543.8	Vgf Ensembl NCBI MGI UniProt Show fit	VGF nerve growth factor inducible
chr7_-_126583523 Show fit	5.74	ENSMUST00000125508.1 ENSMUST00000147086.1 ENSMUST00000150587.1	Cln3 Ensembl NCBI MGI UniProt Show fit	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
chr13_-_92131494 Show fit	5.73	ENSMUST00000099326.3 ENSMUST00000146492.1	Rasgrf2 Ensembl NCBI MGI UniProt Show fit	RAS protein-specific guanine nucleotide-releasing factor 2
chr10_+_121365078 Show fit	5.63	ENSMUST00000040344.6	Gns Ensembl NCBI MGI UniProt Show fit	glucosamine (N-acetyl)-6-sulfatase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.6	GO:0008643	carbohydrate transport(GO:0008643)
4.4	13.3	GO:0043323	positive regulation of natural killer cell degranulation(GO:0043323)
2.3	11.3	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.5	10.7	GO:0007035	vacuolar acidification(GO:0007035)
2.6	10.4	GO:0070829	heterochromatin maintenance(GO:0070829)
1.4	8.4	GO:0015889	cobalamin transport(GO:0015889)
0.2	8.0	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.1	8.0	GO:0030203	glycosaminoglycan metabolic process(GO:0030203)
0.6	7.9	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.3	7.7	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)

Showing 1 to 10 of 401 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	25.3	GO:0005615	extracellular space(GO:0005615)
0.1	23.1	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1	16.8	GO:0005770	late endosome(GO:0005770)
0.3	16.4	GO:0005776	autophagosome(GO:0005776)
2.7	13.3	GO:0044194	cytolytic granule(GO:0044194)
0.0	12.5	GO:0000139	Golgi membrane(GO:0000139)
0.1	11.3	GO:0030667	secretory granule membrane(GO:0030667)
1.0	7.9	GO:0005579	membrane attack complex(GO:0005579)
0.5	7.9	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	7.5	GO:0016323	basolateral plasma membrane(GO:0016323)

Showing 1 to 10 of 176 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	13.6	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
1.5	13.2	GO:0031419	cobalamin binding(GO:0031419)
0.1	13.0	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.5	11.1	GO:0005351	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
3.5	10.4	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1	10.1	GO:0005507	copper ion binding(GO:0005507)
0.1	9.9	GO:0019905	syntaxin binding(GO:0019905)
0.5	9.3	GO:0050811	GABA receptor binding(GO:0050811)
0.7	8.0	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	7.6	GO:0004674	protein serine/threonine kinase activity(GO:0004674)

Showing 1 to 10 of 283 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	PID LKB1 PATHWAY	LKB1 signaling events
0.3	7.7	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	6.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	5.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	5.4	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	4.7	PID FOXO PATHWAY	FoxO family signaling
0.1	4.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	4.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	3.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	3.7	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling

Showing 1 to 10 of 53 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	15.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	13.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.8	8.0	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.3	7.9	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.3	7.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	7.8	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3	7.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2	6.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.2	5.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	5.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)

Showing 1 to 10 of 92 entries

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 2.50

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: