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2D miR_HR1_12
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Results for Wrnip1_Mta3_Rcor1
Z-value: 2.29
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Transcription factors associated with Wrnip1_Mta3_Rcor1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rcor1 | mm10_v2_chr12_+_111039334_111039400 | -0.67 | 1.6e-02 | Click! |
| Wrnip1 | mm10_v2_chr13_+_32802007_32802152 | -0.59 | 4.1e-02 | Click! |
| Mta3 | mm10_v2_chr17_+_83706137_83706169 | -0.50 | 9.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_119086221 Show fit | 3.01 |
ENSMUST00000026665.7
|
chromobox 4 |
|
| chr6_-_48445678 Show fit | 3.00 |
ENSMUST00000114556.1
|
zinc finger protein 467 |
|
| chr6_-_48445373 Show fit | 2.80 |
ENSMUST00000114563.1
ENSMUST00000114558.1 ENSMUST00000101443.3 ENSMUST00000114564.1 |
zinc finger protein 467 |
|
| chr13_-_71963713 Show fit | 2.72 |
ENSMUST00000077337.8
|
Iroquois related homeobox 1 (Drosophila) |
|
| chr11_+_120530688 Show fit | 2.71 |
ENSMUST00000026119.7
|
glucagon receptor |
|
| chr13_-_99900645 Show fit | 2.68 |
ENSMUST00000022150.6
|
CART prepropeptide |
|
| chr11_+_106374820 Show fit | 2.66 |
ENSMUST00000106816.1
|
RIKEN cDNA 2310007L24 gene |
|
| chr7_-_19796789 Show fit | 2.66 |
ENSMUST00000108449.2
ENSMUST00000043822.7 |
Casitas B-lineage lymphoma c |
|
| chr5_+_30588078 Show fit | 2.66 |
ENSMUST00000066295.2
|
potassium channel, subfamily K, member 3 |
|
| chr19_-_10457447 Show fit | 2.62 |
ENSMUST00000171400.2
|
leucine rich repeat containing 10B |
Network of associatons between targets according to the STRING database.
First level regulatory network of Wrnip1_Mta3_Rcor1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.2 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.5 | 6.7 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 6.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.3 | 6.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.2 | 6.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 6.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.4 | 6.1 | GO:0015816 | glycine transport(GO:0015816) |
| 0.3 | 6.0 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.7 | 5.8 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.3 | 5.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 171.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 106.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 17.0 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 11.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.4 | 8.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 7.9 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 7.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 7.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 7.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.3 | 6.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 13.0 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 12.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 10.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.4 | 9.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 9.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 9.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 7.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 7.7 | GO:0019210 | kinase inhibitor activity(GO:0019210) |
| 0.6 | 7.3 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 43.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 28.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 22.3 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 17.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 10.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 7.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 5.9 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.2 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 5.1 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 4.8 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 14.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 13.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 13.7 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 11.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 10.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 8.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 8.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 7.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 6.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |