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avrg: GFI1 WT vs 36n/n vs KD

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Results for Brca1

Z-value: 2.22

Motif logo

Transcription factors associated with Brca1

Gene Symbol Gene ID Gene Info
ENSMUSG00000017146.13 breast cancer 1, early onset

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Brca1mm39_v1_chr11_-_101442663_1014427190.801.0e-01Click!

Activity profile of Brca1 motif

Sorted Z-values of Brca1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_87684548 2.41 ENSMUST00000143021.9
myeloperoxidase
chr18_-_43610829 2.10 ENSMUST00000057110.11
eukaryotic translation initiation factor 3, subunit J2
chr13_+_28441511 1.60 ENSMUST00000223428.2
ribosomal protein S18, pseudogene 5
chr9_+_88209250 1.44 ENSMUST00000034992.8
5' nucleotidase, ecto
chr7_+_100143250 1.39 ENSMUST00000153287.8
uncoupling protein 2 (mitochondrial, proton carrier)
chr13_-_97897139 1.27 ENSMUST00000074072.5
ribosomal protein S18, pseudogene 6
chrX_+_168468186 1.15 ENSMUST00000112107.8
ENSMUST00000112104.8
midline 1
chr5_+_136982100 1.01 ENSMUST00000111094.8
ENSMUST00000111097.8
fission, mitochondrial 1
chr8_+_85696453 0.96 ENSMUST00000125893.8
peroxiredoxin 2
chr12_+_52144511 0.95 ENSMUST00000040090.16
nucleotide binding protein-like
chr17_+_6697511 0.83 ENSMUST00000179569.3
dynein light chain Tctex-type 1B
chr11_-_93776580 0.82 ENSMUST00000066888.10
UTP18 small subunit processome component
chr8_+_85696396 0.80 ENSMUST00000109733.8
peroxiredoxin 2
chr12_+_111005768 0.77 ENSMUST00000084968.14
REST corepressor 1
chr8_+_47070326 0.76 ENSMUST00000211115.2
ENSMUST00000093517.7
caspase 3
chr5_+_137756407 0.73 ENSMUST00000141733.8
ENSMUST00000110985.2
TSC22 domain family, member 4
chr19_-_32443978 0.71 ENSMUST00000078034.5
ribosomal protein L9, pseudogene 6
chr13_-_100912308 0.69 ENSMUST00000075550.4
centromere protein H
chr3_-_107838895 0.69 ENSMUST00000133947.9
ENSMUST00000124215.2
ENSMUST00000106688.8
ENSMUST00000106687.9
glutathione S-transferase, mu 7
chr19_+_10582987 0.68 ENSMUST00000237337.2
damage specific DNA binding protein 1
chrX_+_149377416 0.68 ENSMUST00000112713.3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr8_-_85696369 0.68 ENSMUST00000109736.9
ENSMUST00000140561.8
ribonuclease H2, large subunit
chr1_-_65225572 0.66 ENSMUST00000188109.7
isocitrate dehydrogenase 1 (NADP+), soluble
chr19_-_10181243 0.65 ENSMUST00000142241.2
ENSMUST00000116542.9
ENSMUST00000025651.6
ENSMUST00000156291.2
flap structure specific endonuclease 1
chr13_+_55862437 0.65 ENSMUST00000021959.11
thioredoxin domain containing 15
chrM_+_8603 0.64 ENSMUST00000082409.1
mitochondrially encoded cytochrome c oxidase III
chr1_+_181952302 0.62 ENSMUST00000111018.2
ENSMUST00000027792.6
signal recognition particle 9
chr17_-_34962823 0.62 ENSMUST00000069507.9
complement component 4B (Chido blood group)
chr9_+_108911547 0.62 ENSMUST00000026735.9
coiled-coil domain containing 51
chr7_+_101546059 0.61 ENSMUST00000143835.8
anaphase promoting complex C subunit 15
chr4_+_108336164 0.60 ENSMUST00000155068.2
terminal uridylyl transferase 4
chr7_-_112968533 0.59 ENSMUST00000047091.14
ENSMUST00000119278.8
BTB (POZ) domain containing 10
chr12_+_28699598 0.58 ENSMUST00000020959.9
ribonuclease H1
chr19_-_24202344 0.57 ENSMUST00000099558.5
ENSMUST00000232956.2
tight junction protein 2
chr1_+_52158721 0.56 ENSMUST00000186057.7
signal transducer and activator of transcription 1
chr8_+_34621717 0.56 ENSMUST00000239436.2
ENSMUST00000033933.8
store-operated calcium entry-associated regulatory factor
chr6_+_17693941 0.55 ENSMUST00000115420.8
ENSMUST00000115419.8
suppression of tumorigenicity 7
chr11_-_106205320 0.54 ENSMUST00000167143.2
CD79B antigen
chr2_-_29677634 0.54 ENSMUST00000177467.8
ENSMUST00000113807.10
TruB pseudouridine (psi) synthase family member 2
chr19_+_44551280 0.54 ENSMUST00000040455.5
hypoxia-inducible factor 1, alpha subunit inhibitor
chr12_+_83567240 0.54 ENSMUST00000021645.9
DDB1 and CUL4 associated factor 4
chr15_+_102427149 0.53 ENSMUST00000146756.8
ENSMUST00000142194.3
TARBP2, RISC loading complex RNA binding subunit
chr12_-_86773160 0.53 ENSMUST00000021682.9
angel homolog 1
chr3_-_61273228 0.53 ENSMUST00000066298.3
RIKEN cDNA B430305J03 gene
chr7_-_19449319 0.53 ENSMUST00000032555.10
ENSMUST00000093552.12
translocase of outer mitochondrial membrane 40
chr1_+_52158693 0.50 ENSMUST00000189347.7
signal transducer and activator of transcription 1
chr7_-_46558754 0.50 ENSMUST00000209538.2
tumor susceptibility gene 101
chr4_+_136197066 0.49 ENSMUST00000170102.8
ENSMUST00000105849.9
ENSMUST00000129230.3
leucine zipper protein 1
chr15_+_81900570 0.49 ENSMUST00000069530.13
ENSMUST00000168581.8
ENSMUST00000164779.2
X-ray repair complementing defective repair in Chinese hamster cells 6
chr3_-_86906591 0.49 ENSMUST00000063869.11
ENSMUST00000029717.4
CD1d1 antigen
chr3_+_109481223 0.49 ENSMUST00000106576.3
vav 3 oncogene
chr7_-_55669702 0.48 ENSMUST00000052204.6
non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
chr2_-_34760960 0.48 ENSMUST00000028225.12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr17_+_34129221 0.47 ENSMUST00000174541.9
Fas death domain-associated protein
chrM_+_7758 0.47 ENSMUST00000082407.1
mitochondrially encoded ATP synthase 8
chr2_-_134486039 0.46 ENSMUST00000038228.11
thioredoxin-related transmembrane protein 4
chr11_+_80320558 0.46 ENSMUST00000173565.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr8_-_61407760 0.45 ENSMUST00000110302.8
chloride channel, voltage-sensitive 3
chr6_-_120334400 0.44 ENSMUST00000112703.8
coiled-coil domain containing 77
chr7_-_16761732 0.44 ENSMUST00000142597.2
protein phosphatase 5, catalytic subunit
chr5_-_5564730 0.42 ENSMUST00000115445.8
ENSMUST00000179804.8
ENSMUST00000125110.2
ENSMUST00000115446.8
claudin 12
chr2_+_36026395 0.42 ENSMUST00000028250.9
mitochondrial ribosome recycling factor
chr9_-_96246460 0.40 ENSMUST00000034983.7
ATPase, Na+/K+ transporting, beta 3 polypeptide
chr12_+_83567303 0.40 ENSMUST00000222502.2
DDB1 and CUL4 associated factor 4
chr17_+_71511642 0.40 ENSMUST00000126681.8
lipin 2
chr1_+_179788675 0.40 ENSMUST00000076687.12
ENSMUST00000097450.10
ENSMUST00000212756.2
CDC42 binding protein kinase alpha
chr6_-_108162513 0.40 ENSMUST00000167338.8
ENSMUST00000172188.2
ENSMUST00000032191.16
sulfatase modifying factor 1
chr15_+_36174156 0.39 ENSMUST00000180159.8
ENSMUST00000057177.7
polymerase (RNA) II (DNA directed) polypeptide K
chr6_-_122778598 0.39 ENSMUST00000165884.8
solute carrier family 2 (facilitated glucose transporter), member 3
chr5_+_90638580 0.39 ENSMUST00000042755.7
ENSMUST00000200693.2
alpha fetoprotein
chr13_+_93441447 0.38 ENSMUST00000109497.8
ENSMUST00000109498.8
ENSMUST00000060490.11
ENSMUST00000109492.9
ENSMUST00000109496.8
ENSMUST00000109495.8
homer scaffolding protein 1
chr15_+_79578141 0.38 ENSMUST00000230898.2
ENSMUST00000229046.2
GTP binding protein 1
chr14_-_52248324 0.38 ENSMUST00000226964.2
zinc finger protein 219
chr16_-_22676264 0.38 ENSMUST00000232075.2
ENSMUST00000004576.8
TBCC domain containing 1
chrM_+_9459 0.37 ENSMUST00000082411.1
mitochondrially encoded NADH dehydrogenase 3
chr4_+_10874498 0.37 ENSMUST00000080517.14
RIKEN cDNA 2610301B20 gene
chr11_+_6241660 0.37 ENSMUST00000101554.9
ENSMUST00000093350.10
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_+_101545547 0.36 ENSMUST00000035395.14
ENSMUST00000106973.8
ENSMUST00000144207.9
anaphase promoting complex C subunit 15
chr2_-_155424576 0.36 ENSMUST00000126322.8
glutathione synthetase
chr6_+_115578863 0.36 ENSMUST00000000449.9
makorin, ring finger protein, 2
chr8_+_47070461 0.35 ENSMUST00000210534.2
caspase 3
chrM_+_7779 0.35 ENSMUST00000082408.1
mitochondrially encoded ATP synthase 6
chr6_-_120334382 0.34 ENSMUST00000032283.12
coiled-coil domain containing 77
chr8_+_85598734 0.34 ENSMUST00000170296.2
ENSMUST00000136026.8
synaptonemal complex central element protein 2
chr18_+_36926929 0.33 ENSMUST00000001419.10
zinc finger, matrin type 2
chr19_+_36061096 0.33 ENSMUST00000025714.9
ribonuclease P/MRP 30 subunit
chr10_-_128759817 0.33 ENSMUST00000131271.2
biogenesis of lysosomal organelles complex-1, subunit 1
chr1_-_171108754 0.32 ENSMUST00000073120.11
protoporphyrinogen oxidase
chr4_-_133600308 0.32 ENSMUST00000137486.3
ribosomal protein S6 kinase polypeptide 1
chr19_+_57441332 0.32 ENSMUST00000026073.14
ENSMUST00000026072.5
ENSMUST00000238107.2
TruB pseudouridine (psi) synthase family member 1
chr11_-_84710276 0.31 ENSMUST00000018549.8
mitochondrial rRNA methyltransferase 1
chr3_+_89970088 0.30 ENSMUST00000238911.2
ENSMUST00000029551.3
RIKEN cDNA 1700094D03 gene
chrX_+_149372903 0.30 ENSMUST00000080884.11
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_+_76264695 0.30 ENSMUST00000096385.11
ENSMUST00000160728.8
maestro heat-like repeat family member 1
chr8_+_25507227 0.29 ENSMUST00000033961.7
ENSMUST00000210536.2
TM2 domain containing 2
chr8_+_70583971 0.29 ENSMUST00000211898.2
ENSMUST00000095273.7
nuclear receptor 2C2-associated protein
chr11_+_97594220 0.28 ENSMUST00000103147.5
proteasome (prosome, macropain) subunit, beta type 3
chr5_-_123127346 0.28 ENSMUST00000118027.8
lysine (K)-specific demethylase 2B
chr3_-_137837117 0.27 ENSMUST00000029805.13
microsomal triglyceride transfer protein
chr7_+_25016492 0.27 ENSMUST00000128119.2
multiple EGF-like-domains 8
chr4_+_115641996 0.27 ENSMUST00000177280.8
ENSMUST00000176047.8
ATP synthase mitochondrial F1 complex assembly factor 1
chr4_+_10874537 0.27 ENSMUST00000101504.3
RIKEN cDNA 2610301B20 gene
chrX_+_73352694 0.26 ENSMUST00000130581.2
guanosine diphosphate (GDP) dissociation inhibitor 1
chr7_-_101749433 0.26 ENSMUST00000106937.8
ADP-ribosyltransferase 5
chr9_+_96140781 0.26 ENSMUST00000190104.7
ENSMUST00000179416.8
ENSMUST00000189606.7
transcription factor Dp 2
chr3_-_51184730 0.26 ENSMUST00000195432.2
ENSMUST00000091144.11
ENSMUST00000156983.3
E74-like factor 2
chr17_-_71160477 0.25 ENSMUST00000118283.8
TGFB-induced factor homeobox 1
chr9_+_8544143 0.24 ENSMUST00000050433.8
ENSMUST00000217462.2
transient receptor potential cation channel, subfamily C, member 6
chr11_-_96807233 0.24 ENSMUST00000130774.2
CDK5 regulatory subunit associated protein 3
chr14_-_78970160 0.24 ENSMUST00000226342.3
diacylglycerol kinase, eta
chr16_-_84632513 0.24 ENSMUST00000023608.14
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr6_-_148846247 0.24 ENSMUST00000111562.8
ENSMUST00000081956.12
SIN3-HDAC complex associated factor
chr3_-_51184895 0.24 ENSMUST00000108051.8
ENSMUST00000108053.9
E74-like factor 2
chr13_+_25127127 0.23 ENSMUST00000021773.13
glycosylphosphatidylinositol specific phospholipase D1
chr6_-_120334302 0.23 ENSMUST00000163827.8
coiled-coil domain containing 77
chr16_+_3854806 0.23 ENSMUST00000137748.8
ENSMUST00000006136.11
ENSMUST00000157044.8
ENSMUST00000120009.8
deoxyribonuclease I
chr9_+_43996236 0.22 ENSMUST00000065461.9
ENSMUST00000176416.8
ubiquitin specific peptidase 2
chr12_-_69205882 0.22 ENSMUST00000037023.9
ribosomal protein S29
chr17_-_33904345 0.21 ENSMUST00000234474.2
ENSMUST00000139302.8
ENSMUST00000114385.9
heterogeneous nuclear ribonucleoprotein M
chr11_-_96807273 0.21 ENSMUST00000103152.11
CDK5 regulatory subunit associated protein 3
chr1_-_169358912 0.21 ENSMUST00000192248.2
ENSMUST00000028000.13
NUF2, NDC80 kinetochore complex component
chr11_+_115671523 0.19 ENSMUST00000239299.2
transmembrane protein 94
chr8_+_12965876 0.19 ENSMUST00000110876.9
ENSMUST00000110879.9
mcf.2 transforming sequence-like
chr10_-_118705029 0.19 ENSMUST00000004281.10
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr17_-_25459086 0.19 ENSMUST00000038973.7
ENSMUST00000115154.11
N-acetylglucosamine-1-phosphotransferase, gamma subunit
chr3_-_90340910 0.19 ENSMUST00000196530.2
integrator complex subunit 3
chr13_+_100788087 0.19 ENSMUST00000190165.7
ENSMUST00000185767.7
TATA-box binding protein associated factor 9
chr10_-_126956991 0.18 ENSMUST00000080975.6
ENSMUST00000164259.9
amplified in osteosarcoma
chr11_+_93776650 0.18 ENSMUST00000107853.8
ENSMUST00000107850.8
mbt domain containing 1
chr19_+_53298906 0.18 ENSMUST00000003870.15
MAX interactor 1, dimerization protein
chr2_-_152673585 0.18 ENSMUST00000156688.2
ENSMUST00000007803.12
BCL2-like 1
chr17_+_36152559 0.18 ENSMUST00000174124.2
mediator of DNA damage checkpoint 1
chr7_-_16761790 0.18 ENSMUST00000003183.12
protein phosphatase 5, catalytic subunit
chr7_+_129193581 0.17 ENSMUST00000084519.7
WD repeat domain 11
chr19_-_12742811 0.17 ENSMUST00000112933.2
ciliary neurotrophic factor
chr17_+_47922497 0.15 ENSMUST00000024778.3
mediator complex subunit 20
chr5_+_20112500 0.15 ENSMUST00000101558.10
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_-_59459745 0.15 ENSMUST00000099646.10
ADP-ribosylation factor-like 6
chr9_-_45115381 0.15 ENSMUST00000034599.15
transmembrane protease, serine 4
chr11_-_70537878 0.14 ENSMUST00000014750.15
solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11
chr9_+_119956755 0.14 ENSMUST00000035105.7
ENSMUST00000217317.2
ribosomal protein SA
chr17_-_33904386 0.14 ENSMUST00000087582.13
heterogeneous nuclear ribonucleoprotein M
chr19_-_6191440 0.13 ENSMUST00000025893.7
ADP-ribosylation factor-like 2
chr15_+_102392586 0.13 ENSMUST00000229061.2
poly(rC) binding protein 2
chr17_-_34247016 0.13 ENSMUST00000236627.2
ENSMUST00000237759.2
ENSMUST00000045467.14
ENSMUST00000114303.4
H2-K region expressed gene 6
chr17_+_41121979 0.12 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhesus blood group-associated A glycoprotein
chr9_+_96140750 0.12 ENSMUST00000186609.7
transcription factor Dp 2
chr3_+_87837566 0.12 ENSMUST00000055984.7
interferon stimulated exonuclease gene 20-like 2
chr13_-_113317431 0.12 ENSMUST00000038212.14
granzyme K
chr4_+_98919183 0.11 ENSMUST00000030280.7
angiopoietin-like 3
chr5_-_5564873 0.11 ENSMUST00000060947.14
claudin 12
chr11_+_93776965 0.11 ENSMUST00000063718.11
ENSMUST00000107854.9
mbt domain containing 1
chr10_+_86599836 0.11 ENSMUST00000218802.2
predicted gene, 49358
chr7_-_29772226 0.09 ENSMUST00000183115.8
ENSMUST00000182919.8
ENSMUST00000183190.2
ENSMUST00000080834.15
zinc finger protein 82
chr7_-_80597246 0.09 ENSMUST00000120285.8
SEC11 homolog A, signal peptidase complex subunit
chr7_-_101749140 0.09 ENSMUST00000106934.2
ADP-ribosyltransferase 5
chr15_-_81900335 0.09 ENSMUST00000152227.8
desumoylating isopeptidase 1
chr16_+_44215136 0.08 ENSMUST00000099742.9
cilia and flagella associated protein 44
chr1_-_170695328 0.08 ENSMUST00000027974.7
activating transcription factor 6
chrX_+_41591410 0.08 ENSMUST00000005839.11
SH2 domain containing 1A
chr3_+_20011405 0.08 ENSMUST00000108325.9
ceruloplasmin
chr19_+_10181378 0.08 ENSMUST00000040372.14
transmembrane protein 258
chrX_-_100266032 0.07 ENSMUST00000120389.8
ENSMUST00000156473.8
ENSMUST00000077876.4
sorting nexin 12
chr3_+_20011251 0.07 ENSMUST00000108328.8
ceruloplasmin
chr13_+_55517545 0.07 ENSMUST00000063771.14
regulator of G-protein signaling 14
chr6_-_131667026 0.07 ENSMUST00000080619.3
taste receptor, type 2, member 114
chrX_+_41591476 0.07 ENSMUST00000115070.8
ENSMUST00000153948.2
SH2 domain containing 1A
chr5_-_87240405 0.07 ENSMUST00000132667.2
ENSMUST00000145617.8
ENSMUST00000094649.11
UDP glucuronosyltransferase 2 family, polypeptide B36
chr3_+_5283606 0.07 ENSMUST00000026284.13
zinc finger homeodomain 4
chr15_-_96917804 0.07 ENSMUST00000231039.2
solute carrier family 38, member 4
chr7_-_127048165 0.07 ENSMUST00000106299.2
zinc finger protein 689
chr2_+_29533799 0.06 ENSMUST00000238899.2
Rap guanine nucleotide exchange factor (GEF) 1
chr5_-_148988110 0.06 ENSMUST00000110505.8
high mobility group box 1
chr5_-_72800070 0.06 ENSMUST00000087213.12
cyclic nucleotide gated channel alpha 1
chr3_+_5283577 0.06 ENSMUST00000175866.8
zinc finger homeodomain 4
chr17_+_43671314 0.06 ENSMUST00000226087.2
adhesion G protein-coupled receptor F5
chr2_-_86640362 0.06 ENSMUST00000216117.2
olfactory receptor 141
chr16_-_58930996 0.05 ENSMUST00000076262.4
olfactory receptor 193
chr11_-_99695272 0.05 ENSMUST00000105056.2
predicted gene 11554
chr18_+_65183987 0.05 ENSMUST00000236103.2
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr10_-_41592630 0.05 ENSMUST00000189488.3
coiled-coil domain containing 162
chr4_+_109092459 0.05 ENSMUST00000106631.9
calreticulin 4
chr5_-_135092904 0.05 ENSMUST00000111205.8
ENSMUST00000141309.2
BUD23, rRNA methyltransferase and ribosome maturation factor
chr5_+_20112704 0.04 ENSMUST00000115267.7
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr14_-_61283911 0.04 ENSMUST00000111234.10
ENSMUST00000224371.2
tumor necrosis factor receptor superfamily, member 19
chr7_-_19856504 0.04 ENSMUST00000079099.2
vomeronasal 1 receptor 240
chr8_+_55024446 0.04 ENSMUST00000239166.2
ENSMUST00000239106.2
ENSMUST00000239152.2
ankyrin repeat and SOCs box-containing 5
chr17_+_14087827 0.04 ENSMUST00000239324.2
afadin, adherens junction formation factor
chr1_-_46893206 0.04 ENSMUST00000027131.6
solute carrier family 39 (zinc transporter), member 10
chrX_+_134894573 0.03 ENSMUST00000058119.9
adipocyte-related X-chromosome expressed sequence 2
chr15_-_96918203 0.03 ENSMUST00000166223.2
solute carrier family 38, member 4
chr4_-_118667141 0.03 ENSMUST00000084313.5
ENSMUST00000219094.2
olfactory receptor 1335
chr7_+_51528715 0.03 ENSMUST00000051912.13
growth arrest specific 2
chr14_-_20706556 0.03 ENSMUST00000090469.8
myozenin 1
chr2_-_89313477 0.03 ENSMUST00000099778.2
olfactory receptor 1241
chr7_+_23702516 0.03 ENSMUST00000173571.2
vomeronasal 1 receptor, D19
chr6_+_14901343 0.03 ENSMUST00000115477.8
forkhead box P2
chr19_+_56276343 0.03 ENSMUST00000095948.11
hyaluronic acid binding protein 2
chr6_+_57086439 0.03 ENSMUST00000228270.2
vomeronasal 1 receptor 10
chr2_+_85519775 0.03 ENSMUST00000054868.2
olfactory receptor 1008

Network of associatons between targets according to the STRING database.

First level regulatory network of Brca1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.4 1.4 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.4 1.1 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
0.3 1.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 1.0 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.2 1.1 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 0.5 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 0.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 0.5 GO:0048003 positive regulation of interleukin-4 biosynthetic process(GO:0045404) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.2 0.5 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.4 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.1 1.8 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
0.1 0.5 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.7 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1 0.7 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.1 0.3 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.1 1.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.5 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.1 0.5 GO:0050689 targeting of mRNA for destruction involved in RNA interference(GO:0030423) negative regulation of defense response to virus by host(GO:0050689)
0.1 1.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.6 GO:0045900 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) negative regulation of translational elongation(GO:0045900)
0.1 0.6 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.1 0.4 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 0.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.8 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 1.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.3 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.2 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.2 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.1 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 0.4 GO:0032790 ribosome disassembly(GO:0032790)
0.1 1.0 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0006407 rRNA export from nucleus(GO:0006407)
0.0 0.4 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) response to cycloheximide(GO:0046898)
0.0 0.2 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.4 GO:0006104 succinyl-CoA metabolic process(GO:0006104) olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.1 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0001842 neural fold formation(GO:0001842)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.5 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.8 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270)
0.0 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.0 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.0 0.5 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.4 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.2 GO:0046473 phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0015870 acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 2.4 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 0.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 2.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 0.6 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 1.1 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.5 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.5 GO:0035068 micro-ribonucleoprotein complex(GO:0035068) RISC-loading complex(GO:0070578)
0.0 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.9 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.6 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.3 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.2 0.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 1.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.0 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity(GO:0070039)
0.1 0.6 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 1.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.3 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.4 GO:0055056 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.5 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 1.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 3.1 GO:0004601 peroxidase activity(GO:0004601)
0.1 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.0 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.7 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.0 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035) NADH binding(GO:0070404)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.4 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.5 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID EPO PATHWAY EPO signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.1 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.2 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 1.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 1.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import